Faculty

Back to Index
Vaia Lida Chatzi
Associate Professor of Preventive Medicine
Preventive Medicine
2001 N. Soto Street Health Sciences Campus Los Angeles

Overview

Dr Chatzi is a physician-environmental epidemiologist with expertise in birth cohort research. Her research focuses on the influence of nutrition and obesogenic chemical exposures during pregnancy and early childhood on long-term maternal and child health, especially obesity, asthma and cognitive development. She has published widely on the effects of early life exposure to endocrine disrupting chemicals on obesity and metabolic outcomes in children. In support of this work, she has led studies examining maternal and infant diet and their associations with the risk of adiposity and asthma in childhood. She is the principal investigator and co-leader of the “Rhea” pregnancy cohort in Greece and she has had significant leadership roles in major cohort studies studying environmental exposures early in life.

Awards

Harvard Medical School: Fulbright Scholarship, 2014-2014

Centre for Environmental Research, Spain: Erasmus Fellowship, 2012-2012

Department of Public Health, University of Sheffield, UK: Marie Curie Fellowship, 2003-2003

Publications

DNA methylation in childhood asthma: an epigenome-wide meta-analysis. Lancet Respir Med. 2018 May; 6(5):379-388. View in: PubMed

DNA Methylome Marks of Exposure to Particulate Matter at Three Time Points in Early Life. Environ Sci Technol. 2018 Apr 11. View in: PubMed

Air pollution during pregnancy and childhood obesity risk: Potential protective effect of diet. Clin Nutr ESPEN. 2018 Apr; 24:187. View in: PubMed

Genome-wide association study of offspring birth weight in 86 577 women identifies five novel loci and highlights maternal genetic effects that are independent of fetal genetics. Hum Mol Genet. 2018 Feb 15; 27(4):742-756. View in: PubMed

Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood? Int J Obes (Lond). Is early life exposure to polyomaviruses and herpesviruses associated with obesity indices and metabolic traits in childhood? Int J Obes (Lond). 2018 Jan 30. View in: PubMed

Low maternal vitamin D status in pregnancy increases the risk of childhood obesity. Pediatr Obes. 2018 Jan 28. View in: PubMed

PUFA status at birth and allergy-related phenotypes in childhood: a pooled analysis of the Maastricht Essential Fatty Acid Birth (MEFAB) and RHEA birth cohorts. Br J Nutr. 2018 Jan; 119(2):202-210. View in: PubMed

Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study. J Proteome Res. 2018 03 02; 17(3):1235-1247. View in: PubMed

Epidemiology and burden of systemic lupus erythematosus in a Southern European population: data from the community-based lupus registry of Crete, Greece. Ann Rheum Dis. 2017 Dec; 76(12):1992-2000. View in: PubMed

Polyunsaturated fatty acid levels at birth and child-to-adult growth: Results from the MEFAB cohort. Prostaglandins Leukot Essent Fatty Acids. 2017 Nov; 126:72-78. View in: PubMed

Associations of cord blood metabolites with perinatal characteristics, newborn anthropometry, and cord blood hormones in project viva. Metabolism. 2017 Nov; 76:11-22. View in: PubMed

Maternal and fetal genetic contribution to gestational weight gain. Int J Obes (Lond). 2017 Oct 09. View in: PubMed

Fish and seafood consumption during pregnancy and the risk of asthma and allergic rhinitis in childhood: a pooled analysis of 18 European and US birth cohorts. Int J Epidemiol. 2017 Oct 01; 46(5):1465-1477. View in: PubMed

Cohort Profile: The Mother-Child Cohort in Crete, Greece (Rhea Study). Int J Epidemiol. 2017 Oct 01; 46(5):1392-1393k. View in: PubMed

Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium. Int J Epidemiol. 2017 Sep 13. View in: PubMed

Association of light-to-moderate alcohol drinking in pregnancy with preterm birth and birth weight: elucidating bias by pooling data from nine European cohorts. Eur J Epidemiol. 2017 Sep; 32(9):751-764. View in: PubMed

Maternal depression and personality traits in association with child neuropsychological and behavioral development in preschool years: Mother-child cohort (Rhea Study) in Crete, Greece. J Affect Disord. 2017 Aug 01; 217:89-98. View in: PubMed

Vitamin D insufficient levels during pregnancy and micronuclei frequency in peripheral blood T lymphocytes mothers and newborns (Rhea cohort, Crete). Clin Nutr. 2017 Aug; 36(4):1029-1035. View in: PubMed

Adherence to the Mediterranean diet during pregnancy and offspring adiposity and cardiometabolic traits in childhood. Pediatr Obes. 2017 Aug; 12 Suppl 1:47-56. View in: PubMed

High maternal vitamin D levels in early pregnancy may protect against behavioral difficulties at preschool age: the Rhea mother-child cohort, Crete, Greece. Eur Child Adolesc Psychiatry. 2017 Jul 06. View in: PubMed

Helicobacter pylori Seropositivity and Childhood Neurodevelopment, the Rhea Birth Cohort in Crete, Greece. Paediatr Perinat Epidemiol. 2017 Jul; 31(4):374-384. View in: PubMed

Variations in the prevalence of childhood asthma and wheeze in MeDALL cohorts in Europe. ERJ Open Res. 2017 Jul; 3(3). View in: PubMed

Effect of parental obesity and gestational diabetes on child neuropsychological and behavioral development at 4 years of age: the Rhea mother-child cohort, Crete, Greece. Eur Child Adolesc Psychiatry. 2017 Jun; 26(6):703-714. View in: PubMed

Air pollution, weight loss and metabolic benefits of bariatric surgery: a potential model for study of metabolic effects of environmental exposures. Pediatr Obes. 2017 Apr 21. View in: PubMed

Patterns of Early-Life Social and Environmental Exposures and Child Cognitive Development, Rhea Birth Cohort, Crete, Greece. Child Dev. 2017 Mar 28. View in: PubMed

Land Use Regression Models for Ultrafine Particles in Six European Areas. Environ Sci Technol. 2017 Mar 21; 51(6):3336-3345. View in: PubMed

Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes. J Allergy Clin Immunol. 2017 Feb; 139(2):388-399. View in: PubMed

Erratum to: Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5). Clin Transl Allergy. 2017; 7:5. View in: PubMed

Persistent organic pollutants in early pregnancy and risk of gestational diabetes mellitus. Environ Int. 2017 Jan; 98:89-95. View in: PubMed

The Influence of Meteorological Factors and Atmospheric Pollutants on the Risk of Preterm Birth. Am J Epidemiol. 2017 02 15; 185(4):247-258. View in: PubMed

Pregnancy, perinatal and postpartum complications as determinants of postpartum depression: the Rhea mother-child cohort in Crete, Greece. Epidemiol Psychiatr Sci. 2016 Dec 22; 1-12. View in: PubMed

Prenatal exposure to persistent organic pollutants in association with offspring neuropsychological development at 4years of age: The Rhea mother-child cohort, Crete, Greece. Environ Int. 2016 Dec; 97:204-211. View in: PubMed

Leptin, acylcarnitine metabolites and development of adiposity in the Rhea mother-child cohort in Crete, Greece. Obes Sci Pract. 2016 Dec; 2(4):471-476. View in: PubMed

Impact of prenatal exposure to cadmium on cognitive development at preschool age and the importance of selenium and iodine. Eur J Epidemiol. 2016 Nov; 31(11):1123-1134. View in: PubMed

Common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the Rhea birth cohort in Crete, Greece. J Child Psychol Psychiatry. 2016 Nov; 57(11):1268-1276. View in: PubMed

Paving the way of systems biology and precision medicine in allergic diseases: the MeDALL success story: Mechanisms of the Development of ALLergy; EU FP7-CP-IP; Project No: 261357; 2010-2015. Allergy. 2016 Nov; 71(11):1513-1525. View in: PubMed

Maternal diet during pregnancy and micronuclei frequency in peripheral blood T lymphocytes in mothers and newborns (Rhea cohort, Crete). Eur J Nutr. 2016 Sep 21. View in: PubMed

Fish Intake During Pregnancy and Offspring Adiposity-Reply. JAMA Pediatr. 2016 Aug 01; 170(8):809-10. View in: PubMed

The independent role of prenatal and postnatal exposure to active and passive smoking on the development of early wheeze in children. Eur Respir J. 2016 Jul; 48(1):115-24. View in: PubMed

Classification of neck/shoulder pain in epidemiological research: a comparison of personal and occupational characteristics, disability, and prognosis among 12,195 workers from 18 countries. Pain. 2016 May; 157(5):1028-36. View in: PubMed

The Natural History of Human Polyomaviruses and Herpesviruses in Early Life--The Rhea Birth Cohort in Greece. Am J Epidemiol. 2016 Apr 01; 183(7):671-9. View in: PubMed

Fish Intake in Pregnancy and Child Growth: A Pooled Analysis of 15 European and US Birth Cohorts. JAMA Pediatr. 2016 Apr; 170(4):381-90. View in: PubMed

Association of early life exposure to bisphenol A with obesity and cardiometabolic traits in childhood. Environ Res. 2016 Apr; 146:379-87. View in: PubMed

Dietary patterns in early childhood and child cognitive and psychomotor development: the Rhea mother-child cohort study in Crete. Br J Nutr. 2016 Apr; 115(8):1431-7. View in: PubMed

Exposure of Preschool-Age Greek Children (RHEA Cohort) to Bisphenol A, Parabens, Phthalates, and Organophosphates. Environ Sci Technol. 2016 Jan 19; 50(2):932-41. View in: PubMed

Cord blood leptin levels in relation to child growth trajectories. Metabolism. 2016 06; 65(6):874-82. View in: PubMed

Is there an association between eating behaviour and attention-deficit/hyperactivity disorder symptoms in preschool children? J Child Psychol Psychiatry. Is there an association between eating behaviour and attention-deficit/hyperactivity disorder symptoms in preschool children? J Child Psychol Psychiatry. 2016 06; 57(6):676-84. View in: PubMed

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle. Clin Transl Allergy. 2016; 6:47. View in: PubMed

Descriptive Epidemiology of Somatising Tendency: Findings from the CUPID Study. PLoS One. 2016; 11(4):e0153748. View in: PubMed

Erratum: "Environmental, Dietary, Maternal, and Fetal Predictors of Bulky DNA Adducts in Cord Blood: A European Mother-Child Study (NewGeneris)". Environ Health Perspect. 2016 Jan; 124(1):A12. View in: PubMed

Scaling up strategies of the chronic respiratory disease programme of the European Innovation Partnership on Active and Healthy Ageing (Action Plan B3: Area 5). Clin Transl Allergy. 2016; 6:29. View in: PubMed

Early life determinants of dietary patterns in preschool children: Rhea mother-child cohort, Crete, Greece. Eur J Clin Nutr. 2016 Jan; 70(1):60-5. View in: PubMed

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy. 2015 Nov; 70(11):1372-92. View in: PubMed

Outdoor air pollution exposures and micronuclei frequencies in lymphocytes from pregnant women and newborns in Crete, Greece (Rhea cohort). Environ Res. 2015 Nov; 143(Pt A):170-6. View in: PubMed

Association of Prenatal Exposure to Persistent Organic Pollutants with Obesity and Cardiometabolic Traits in Early Childhood: The Rhea Mother-Child Cohort (Crete, Greece). Environ Health Perspect. 2015 Oct; 123(10):1015-21. View in: PubMed

Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis. Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis. Allergy. 2015 Sep; 70(9):1062-78. View in: PubMed

Prenatal Second-Hand Smoke Exposure Measured with Urine Cotinine May Reduce Gross Motor Development at 18 Months of Age. J Pediatr. 2015 Aug; 167(2):246-52. e2. View in: PubMed

Pregestational excess weight, maternal obstetric complications and mode of delivery in the Rhea cohort in Crete. Eur J Public Health. 2015 Aug; 25(4):632-7. View in: PubMed

Social capital, tolerance of diversity and adherence to Mediterranean diet: the Rhea Mother-Child Cohort in Crete, Greece. Public Health Nutr. 2015 May; 18(7):1300-7. View in: PubMed

Environmental, dietary, maternal, and fetal predictors of bulky DNA adducts in cord blood: a European mother-child study (NewGeneris). Environ Health Perspect. 2015 Apr; 123(4):374-80. View in: PubMed

Association of trimester-specific gestational weight gain with fetal growth, offspring obesity, and cardiometabolic traits in early childhood. Am J Obstet Gynecol. 2015 Apr; 212(4):502. e1-14. View in: PubMed

Breastfeeding duration and cognitive, language and motor development at 18 months of age: Rhea mother-child cohort in Crete, Greece. J Epidemiol Community Health. 2015 Mar; 69(3):232-9. View in: PubMed

Relative validity of an FFQ for pre-school children in the mother-child 'Rhea' birth cohort in Crete, Greece. Public Health Nutr. 2015 Feb; 18(3):421-7. View in: PubMed

Metabolic profile in early pregnancy is associated with offspring adiposity at 4 years of age: the Rhea pregnancy cohort Crete, Greece. PLoS One. 2015; 10(5):e0126327. View in: PubMed

Postnatal weight growth and trihalomethane exposure during pregnancy. Environ Res. 2015 Jan; 136:280-8. View in: PubMed

Prenatal exposure to PCB-153, p,p'-DDE and birth outcomes in 9000 mother-child pairs: exposure-response relationship and effect modifiers. Environ Int. 2015 Jan; 74:23-31. View in: PubMed

Effect of maternal n-3 long-chain polyunsaturated fatty acid supplementation during pregnancy and/or lactation on adiposity in childhood: a systematic review and meta-analysis of randomized controlled trials. Eur J Clin Nutr. 2014 Dec; 68(12):1277-87. View in: PubMed

The effect of dietary estimates calculated using food frequency questionnaires on micronuclei formation in European pregnant women: a NewGeneris study. Mutagenesis. 2014 Nov; 29(6):393-400. View in: PubMed

Caesarean deliveries in the Mother-Child (Rhea) cohort in Crete, Greece: almost as frequent as vaginal births and even more common in first-time mothers. Hippokratia. 2014 Oct-Dec; 18(4):298-305. View in: PubMed

Air pollution during pregnancy and childhood cognitive and psychomotor development: six European birth cohorts. Epidemiology. 2014 Sep; 25(5):636-47. View in: PubMed

Urinary metabolic profiles in early pregnancy are associated with preterm birth and fetal growth restriction in the Rhea mother-child cohort study. BMC Med. 2014 Jul 11; 12:110. View in: PubMed

Prenatal exposure to DDE and PCB 153 and respiratory health in early childhood: a meta-analysis. Epidemiology. 2014 Jul; 25(4):544-53. View in: PubMed

Smoking and caesarean deliveries: major negative predictors for breastfeeding in the mother-child cohort in Crete, Greece (Rhea study). Matern Child Nutr. 2014 Jul; 10(3):335-46. View in: PubMed

Maternal diet, prenatal exposure to dioxin-like compounds and birth outcomes in a European prospective mother-child study (NewGeneris). Sci Total Environ. 2014 Jun 15; 484:121-8. View in: PubMed

The human early-life exposome (HELIX): project rationale and design. Environ Health Perspect. 2014 Jun; 122(6):535-44. View in: PubMed

Antenatal maternal mental health as determinant of postpartum depression in a population based mother-child cohort (Rhea Study) in Crete, Greece. Soc Psychiatry Psychiatr Epidemiol. 2014 May; 49(5):711-21. View in: PubMed

Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children. J Allergy Clin Immunol. 2014 May; 133(5):1317-29. View in: PubMed

Persistent organic pollutants exposure during pregnancy, maternal gestational weight gain, and birth outcomes in the mother-child cohort in Crete, Greece (RHEA study). Environ Int. 2014 Mar; 64:116-23. View in: PubMed

In utero exposure to compounds with dioxin-like activity and birth outcomes. Epidemiology. 2014 Mar; 25(2):215-24. View in: PubMed

Fish intake during pregnancy, fetal growth, and gestational length in 19 European birth cohort studies. Am J Clin Nutr. 2014 Mar; 99(3):506-16. View in: PubMed

Micronuclei in cord blood lymphocytes and associations with biomarkers of exposure to carcinogens and hormonally active factors, gene polymorphisms, and gene expression: the NewGeneris cohort. Environ Health Perspect. 2014 Feb; 122(2):193-200. View in: PubMed

Exposure to brominated trihalomethanes in water during pregnancy and micronuclei frequency in maternal and cord blood lymphocytes. Environ Health Perspect. 2014 Jan; 122(1):100-6. View in: PubMed

Mediterranean diet adherence during pregnancy and risk of wheeze and eczema in the first year of life: INMA (Spain) and RHEA (Greece) mother-child cohort studies. Br J Nutr. 2013 Dec 14; 110(11):2058-68. View in: PubMed

Increased frequency of micronuclei in mononucleated lymphocytes and cytome analysis in healthy newborns as an early warning biomarkers of possible future health risks. Reprod Toxicol. 2013 Dec; 42:110-5. View in: PubMed

Ambient air pollution and low birthweight: a European cohort study (ESCAPE). Lancet Respir Med. 2013 Nov; 1(9):695-704. View in: PubMed

Bulky dna adducts in cord blood, maternal fruit-and-vegetable consumption, and birth weight in a European mother-child study (NewGeneris). Environ Health Perspect. 2013 Oct; 121(10):1200-6. View in: PubMed

Maternal weight status, cord blood leptin and fetal growth: a prospective mother-child cohort study (Rhea study). Paediatr Perinat Epidemiol. 2013 Sep; 27(5):461-71. View in: PubMed

Patterns of multisite pain and associations with risk factors. Pain. 2013 Sep; 154(9):1769-77. View in: PubMed

Maternal diet, prenatal exposure to dioxins and other persistent organic pollutants and anogenital distance in children. Sci Total Environ. 2013 Sep 01; 461-462:222-9. View in: PubMed

Antenatal and postnatal maternal mental health as determinants of infant neurodevelopment at 18 months of age in a mother-child cohort (Rhea Study) in Crete, Greece. Soc Psychiatry Psychiatr Epidemiol. 2013 Aug; 48(8):1335-45. View in: PubMed

Disabling musculoskeletal pain in working populations: is it the job, the person, or the culture? Pain. Disabling musculoskeletal pain in working populations: is it the job, the person, or the culture? Pain. 2013 Jun; 154(6):856-63. View in: PubMed

Maternal personality traits and risk of preterm birth and fetal growth restriction. Eur Psychiatry. 2013 May; 28(4):213-8. View in: PubMed

Exposure to different sources of second-hand smoke during pregnancy and its effect on urinary cotinine and tobacco-specific nitrosamine (NNAL) concentrations. Tob Control. 2013 May; 22(3):194-200. View in: PubMed

Maternal pre-pregnancy overweight and obesity, and child neuropsychological development: two Southern European birth cohort studies. Int J Epidemiol. 2013 Apr; 42(2):506-17. View in: PubMed

The effect of high doses of folic acid and iron supplementation in early-to-mid pregnancy on prematurity and fetal growth retardation: the mother-child cohort study in Crete, Greece (Rhea study). Eur J Nutr. 2013 Feb; 52(1):327-36. View in: PubMed

In utero exposure to dioxins and dioxin-like compounds and anogenital distance in newborns and infants. Environ Health Perspect. 2013 Jan; 121(1):125-30. View in: PubMed

Social capital in pregnancy and postpartum depressive symptoms: a prospective mother-child cohort study (the Rhea study). Int J Nurs Stud. 2013 Jan; 50(1):63-72. View in: PubMed

Anogenital distances in newborns and children from Spain and Greece: predictors, tracking and reliability. Paediatr Perinat Epidemiol. 2013 Jan; 27(1):89-99. View in: PubMed

Risk factors for new onset and persistence of multi-site musculoskeletal pain in a longitudinal study of workers in Crete. Occup Environ Med. 2013 Jan; 70(1):29-34. View in: PubMed

Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes. J Clin Endocrinol Metab. 2012 Dec; 97(12):4464-72. View in: PubMed

Gender-specific reference intervals for cord blood leptin in Crete, Greece. Eur J Pediatr. 2012 Oct; 171(10):1563-6. View in: PubMed

Effect of high doses of folic acid supplementation in early pregnancy on child neurodevelopment at 18 months of age: the mother-child cohort 'Rhea' study in Crete, Greece. Public Health Nutr. 2012 Sep; 15(9):1728-36. View in: PubMed

Exposure to second-hand smoke and reproductive outcomes depending on maternal asthma. Eur Respir J. 2012 Aug; 40(2):371-6. View in: PubMed

Influence of fetal glutathione S-transferase copy number variants on adverse reproductive outcomes. BJOG. 2012 Aug; 119(9):1141-6. View in: PubMed

Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: a Mechanisms of the Development of Allergy (MeDALL) seminar. J Allergy Clin Immunol. 2012 Apr; 129(4):943-54. e4. View in: PubMed

Birth weight, head circumference, and prenatal exposure to acrylamide from maternal diet: the European prospective mother-child study (NewGeneris). Environ Health Perspect. 2012 12; 120(12):1739-45. View in: PubMed

The CUPID (Cultural and Psychosocial Influences on Disability) study: methods of data collection and characteristics of study sample. PLoS One. 2012; 7(7):e39820. View in: PubMed

Epidemiological Differences Between Localized and Nonlocalized Low Back Pain. Spine (Phila Pa 1976). 2017 May 15; 42(10):740-747. View in: PubMed

Powered bySC CTSI