Research

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Focused on cutting-edge, disease-focused, multidisciplinary basic and translational research

The Division of Nephrology and Hypertension is committed to basic as well as clinical research. Current areas of investigation include the noradrenergic control of blood pressure in kidney disease, mechanisms and management of vascular calcifications in dialysis patients, detection and management of cardiovascular disease in dialysis patients and prevention of progressive renal disease in African-Americans. The Division has also developed an urgent-start peritoneal dialysis program, which is the largest of its kind in the country. In addition, research is ongoing to enhance assessment of intravascular volume and response to ultrafiltration in critically ill patients. The faculty have a variety of clinical protocols dealing with diabetic nephropathy, bone disease, progression of kidney disease, kidney transplantation, vitamin deficiency in chronic kidney disease, end-stage renal disease, transplantation and nutrition in patients with acute kidney injury.
We are proud to announce the recent opening of the USC/UKRO Kidney Research Center, located on the 5th and 6th floors of the Mudd Memorial Research Building on the Keck School of Medicine campus. Under the direction of Kenneth R. Hallows, MD, PhD, Chief of the Division of Nephrology and Hypertension , the USC/UKRO Kidney Research Center will focus on cutting-edge, disease-focused, multidisciplinary basic and translational research on the causes of and treatments for kidney diseases with a particular focus on the areas of acute kidney injury, kidney regeneration and repair, polycystic kidney disease and other chronic kidney diseases, hypertension, acid-base regulation and kidney cancer.

Faculty Research Areas

Vito M. Campese, MD
Interactions between the Kidney and the Central Noradrenergic Control of Blood Pressure
Microalbuminuria in Essential Hypertension
Role of Aldosterone in the Progression of CKD
Role of Dyslipidemia in the Progression of CKD
Renal Denervation in the Management of Resistant Hypertension

Arshia Ghaffari, DO
Home Dialysis Modalities: Benefits and Cost
Management of Glomerular Diseases
Optimizing Clinical Outcomes in Hemodialysis and Peritoneal Dialysis
Urgent Start Peritoneal Dialysis
Effect of Hemodialysis on Obstructive Sleep Apnea
Optimal Practices in Managing Kidney Stones

Kenneth R. Hallows, MD, PhD
Regulation of the CFTR chloride channel by AMPK
Regulation of the epithelial Na+ channel (ENaC) by AMPK
Regulation of AMPK function by CFTR in polarized airway epithelial cells
Regulation of Nedd4-2 by kinases
Regulation of other ion transport proteins by AMPK
AMPK activation by metformin as a novel therapeutic strategy for autosomal dominant polycystic kidney disease (ADPKD)
Role of AMPK in acute kidney injury (AKI) and chronic kidney disease (CKD)

Kausar Hamiduzzaman, MD
AKI in ICU
Evaluating volume status in the ICU
Kidney stones

Elaine M. Kaptein, MD
Inferior Vena Cava Ultrasound to Assess Intravascular Volume and Response to Ultrafiltration
Vitamin D Deficiency and Effects of Treatment in CKD
Diagnosing Adrenocortical Insufficiency in Critically Ill Patients
Thyroid Hormone and Iodine Metabolism in Health and Disease and in Renal Failure Patients

Osun Kwon, MD
Kidney transplant
Pancreas transplant
Chronic Kidney Disease in recipients of non-renal solid organ transplant
Acute Kidney Injury

Mitra K. Nadim, MD
Acute Renal Failure in Patients with Liver Failure
Continuous Renal Replacement Therapy
Renovascular Disease

Saeid M. Nosrati, MD
Chronic Renal Failure
Renal Osteodystrophy
Anemia
Proteinuria
Hypercoagulopathy Related to Nephritic Syndrome

Thin Thin Maw, MD
Kidney and pancreas transplant
Outcomes of Live donors
Antibody mediated rejection
Biomarkers in kidney transplant
Recurrent glomerulonephritis in post kidney transplant recipients
Malignancies in post-transplant recipients
Onco-nephrology

Nuria M. Pastor-Soler, MD, PhD
Regulation of the vacuolar H+-ATPase (V-ATPase) in the male reproductive tract
Regulation of Na+ transport in the collecting duct by bicarbonate-regulated sAC
Regulation of the V-ATPase in the kidney collecting duct and proximal tubule by PKA and AMPK
Regulation of the V-ATPase by Aurora Kinase A (AURKA) in kidney and breast malignancies
Regulation of Aquaporin-2 (AQP2) by AMPK in the Kidney Collecting Duct
Regulation of Epithelial Transport Proteins in Sepsis-induced AKI
Regulation of Muc-1 in Kidney Epithelial Cells
Regulation of Kidney Epithelial Apical Endocytosis by Flow
Renal Salt Transport Regulation by WNK Kinases

Yasir A. Qazi, MD
Estimation of Glomerular Filtration Rate in the Transplanted Kidney
Neopterin as a Marker of BK Virus Nephropathy

Miroslaw J. Smogorzewski, MD, PhD
Effect of Elevated Cytosolic Calcium on Cell Function
Mechanisms of Heart Hypertrophy in Chronic Renal Failure
Mechanisms Underlying the Uremic Syndrome
Pancreatic Islets Transplantation for Treatment of Diabetic Nephropathy
Role of Excess PTH in the Genesis of Uremia
Hypertensive Nephrosclerosis in African- Americans (AASK Study)
History of Nephrology
BK Nephropathy in Post-Transplant Kidney

USC Nephrology and Hypertension Staff
Jennifer Severa, MPA
Senior Administrator
Email address: severa@med.usc.edu

Elisa Serrato
Fellowship Coordinator
Email address: Elisa.Serrato@med.usc.edu
(323) 409-7307