Research

This study will evaluate the efficacy and safety of tenecteplase compared with placebo in acute ischemic stroke patients with a large vessel occlusion (ICA or MCA) and outside the window of tPA until 24 hours. All patients will receive standard-of-care therapy according to American Heart Association / American Stroke Association clinical guidelines (2018). To determine eligibility for randomization, all patients will undergo multimodal CT or MRI at baseline.

The purpose of this study is to learn more about how participants heal from acute spinal cord injury. The study will evaluate the efficacy and safety of early targeted blood pressure management (TPM) on participants healing from acute spinal cord injury and examines the effect of two types of TPM on long term motor and sensory outcomes.

This study will assess the impact of fever prevention on fever burden and short and long-term neurologic outcomes in brain injured patients. Half of the participants will undergo fever prevention using a targeted temperature management system and half will be treated for fever should it develop.

Objectives

• Primary: To test the hypothesis that apixaban is superior to aspirin for the prevention of recurrent stroke in patients with cryptogenic ischemic stroke and atrial cardiopathy.
• Secondary: To test the hypothesis that the relative efficacy of apixaban over aspirin increases with the severity of atrial cardiopathy.

CSI is an ancillary study to ARCADIA, to determine the effect of ARCADIA study treatments of (anticoagulation and antiplatelet therapy) on the incidence of silent infarction and cognitive decline after stroke. The study includes MRI imaging of the brain and cognitive assessments

We aim to determine whether cognitive impairment attributable to cerebral hemodynamic impairment in patients with high-grade asymptomatic carotid artery stenosis is reversible with restoration of flow. To accomplish this aim CREST-H will add on to the NINDS-sponsored CREST-2 trial (parallel, outcome-blinded Phase 3 clinical trials for patients with asymptomatic high-grade carotid artery stenosis which will compare carotid endarterectomy plus intensive medical management (IMM) versus IMM alone (n=1,240), and carotid artery stenting plus IMM versus IMM alone (n=1,240) to prevent stroke and death).