Faculty

Louis Dubeau, MD, PhD
Louis Dubeau, MD, PhD
Professor of Pathology
Pathology
NOR 6338. 1441 Eastlake Avenue Health Sciences Campus Los Angeles
For many years, Dr. Dubeau has been a leading practitioner, educator and researcher in the field of ovarian cancer biology. A native of Canada, Dr. Dubeau first came to USC as a post-doctoral fellow at the Norris Comprehensive Cancer Center. During his time at USC, Dr. Dubeau has achieved the status of full professor, become director of the Molecular Diagnostics Laboratory at USC/Norris Comprehensive Cancer Center published numerous peer-reviewed articles for medical journals and lectured at medical conferences and seminars across the United States, Canada, United Kingdom, Hungary, Turkey and Greece. Dr. Dubeau is a renowned researcher and has been awarded over fourteen million dollars in research grants, many dealing with either ovarian cancer biology and genetics or with environmental issues such as exposure to and effects of air pollution. A devoted educator, Dr. Dubeau has mentored over fifty students, either as a member of their PhD advisory committee or by training doctoral and graduate students. Dr. Dubeau also has found time throughout his career to give lectures on health related subjects to area public school students.

Mechanism of cytokinesis failure in ovarian cystadenomas with defective BRCA1 and P53 pathways Int J Cancer. 2018 Dec 01; 143(11):2932-2942. . View in PubMed

Association between AXL promoter methylation and lung function growth during adolescence Epigenetics. 2018 Oct 02. . View in PubMed

Association between AXL promoter methylation and lung function growth during adolescence Epigenetics. 2018 Oct 02; 1-12. . View in PubMed

Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes Clin Epigenetics. 2018 Jul 20; 10(1):98. . View in PubMed

Mechanism of cytokinesis failure in ovarian cystadenomas with defective brca1 and p53 pathways Int J Cancer. 2018 Jul 06. . View in PubMed

Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer Oncotarget. 2017 Nov 28; 8(61):103543-103556. . View in PubMed

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice Sci Rep. 2017 Feb 01; 7:40919. . View in PubMed

Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer Oncotarget. 2017 Jan 17; 8(3):3811-3825. . View in PubMed

Epigenetic regulation of AXL and risk of childhood asthma symptoms Clin Epigenetics. 2017; 9:121. . View in PubMed

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice Sci Rep. 2017 02 01; 7:40919. . View in PubMed

GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice Proc Natl Acad Sci U S A. 2017 05 16; 114(20):E4020-E4029. . View in PubMed

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution Nat Commun. 2016 May 24; 7:11620. . View in PubMed

Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development Oncotarget. 2016 Mar 22; 7(12):14885-97. . View in PubMed

Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution Nat Commun. 2016 05 24; 7:11620. . View in PubMed

HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer Genome Med. 2015 Oct 24; 7:108. . View in PubMed

A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State EBioMedicine. 2015 Oct; 2(10):1318-30. . View in PubMed

EBioMedicine. 2015 Oct; 2(10):1331-9. . View in PubMed

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan Cell Metab. 2015 Jul 07; 22(1):86-99. . View in PubMed

Pathogenesis of serous, extra-uterine Müllerian epithelial cancer and therapeutic implications Transl Cancer Res. 2015 Feb; 4(1):3-13. . View in PubMed

Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent PLoS One. 2015; 10(10):e0139013. . View in PubMed

Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism PLoS Genet. 2014 Dec; 10(12):e1004789. . View in PubMed

NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas Mol Cancer Ther. 2014 Aug; 13(8):2004-17. . View in PubMed

The sex hormone system in carriers of BRCA1/2 mutations: a case-control study Lancet Oncol. 2013 Nov; 14(12):1226-32. . View in PubMed

The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival Gynecol Oncol. 2013 Mar; 128(3):552-9. . View in PubMed

Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs Lab Invest. 2012 Jun; 92(6):802-11. . View in PubMed

Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells Int J Cancer. 2012 Jun 01; 130(11):2495-504. . View in PubMed

Pathological characteristics of BRCA-associated breast cancers in Hispanics Breast Cancer Res Treat. 2011 Nov; 130(1):281-9. . View in PubMed

Genome-scale screen for DNA methylation-based detection markers for ovarian cancer PLoS One. 2011; 6(12):e28141. . View in PubMed

Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer Cancer Res. 2010 Jan 01; 70(1):221-8. . View in PubMed

HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study Int J Cancer. 2009 Nov 01; 125(9):2214-8. . View in PubMed

Hemimethylation footprints of DNA demethylation in cancer Epigenetics. 2009 Apr 01; 4(3):165-75. . View in PubMed

The cell of origin of ovarian epithelial tumours Lancet Oncol. 2008 Dec; 9(12):1191-7. . View in PubMed

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice Cancer Prev Res (Phila). 2008 Sep; 1(4):233-40. . View in PubMed

Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation J Biol Chem. 2008 Jul 11; 283(28):19184-91. . View in PubMed

Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development Cancer Res. 2008 Jan 15; 68(2):498-505. . View in PubMed

BRCA1-induced ovarian oncogenesis Adv Exp Med Biol. 2008; 622:89-97. . View in PubMed

Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain Hum Mol Genet. 2007 May 15; 16(10):1133-42. . View in PubMed

Associations of tumor necrosis factor G-308A with childhood asthma and wheezing Am J Respir Crit Care Med. 2006 May 01; 173(9):970-6. . View in PubMed

TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences Am J Respir Crit Care Med. 2005 Dec 15; 172(12):1563-8. . View in PubMed

Intercellular adhesion molecule-1 and childhood asthma Hum Genet. 2005 Sep; 117(5):476-84. . View in PubMed

Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer Genes Chromosomes Cancer. 2005 May; 43(1):11-24. . View in PubMed

A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others Cancer Biol Ther. 2005 Apr; 4(4):440-8. . View in PubMed

Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells Curr Biol. 2005 Mar 29; 15(6):561-5. . View in PubMed

Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors Hum Gene Ther. 2004 Jun; 15(6):553-61. . View in PubMed

Detection of residual subclinical ovarian carcinoma after completion of adjuvant chemotherapy Clin Cancer Res. 2004 Apr 15; 10(8):2681-6. . View in PubMed

Suppression of the transformed phenotype and induction of differentiation-like characteristics in cultured ovarian tumor cells by chronic treatment with progesterone Mol Carcinog. 2003 Dec; 38(4):160-9. . View in PubMed

Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells Cancer Res. 2003 Sep 15; 63(18):5813-20. . View in PubMed

The TATA-binding protein as a regulator of cellular transformation Cell Cycle. 2003 Sep-Oct; 2(5):442-4. . View in PubMed

Huntington disease expansion mutations in humans can occur before meiosis is completed Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8834-8. . View in PubMed

Increased expression of TATA-binding protein, the central transcription factor, can contribute to oncogenesis Mol Cell Biol. 2003 May; 23(9):3043-51. . View in PubMed

Cancer-inducible transgene expression by the Grp94 promoter: spontaneous activation in tumors of various origins and cancer-associated macrophages Cancer Res. 2002 Dec 15; 62(24):7207-12. . View in PubMed

p53: a key player in the telomere dynamics Cancer Biol Ther. 2002 Sep-Oct; 1(5):518-9. . View in PubMed

Effects of glutathione-S-transferase M1, T1, and P1 on childhood lung function growth Am J Respir Crit Care Med. 2002 Sep 01; 166(5):710-6. . View in PubMed

Effects of glutathione S-transferase M1, maternal smoking during pregnancy, and environmental tobacco smoke on asthma and wheezing in children Am J Respir Crit Care Med. 2002 Aug 15; 166(4):457-63. . View in PubMed

Effects of glutathione S-transferase P1, M1, and T1 on acute respiratory illness in school children Am J Respir Crit Care Med. 2002 Aug 01; 166(3):346-51. . View in PubMed

Effect of reproductive hormones on ovarian epithelial tumors: IEffect on cell cycle activity. Cancer Biol Ther. 2002 May-Jun; 1(3):300-6. . View in PubMed

Effect of reproductive hormones on ovarian epithelial tumors: IIEffect on angiogenic activity. Cancer Biol Ther. 2002 May-Jun; 1(3):307-12. . View in PubMed

Telomerase and malignant transformation Cancer Treat Res. 2002; 107:213-28. . View in PubMed

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