Keck School Faculty

Brian Applegate, PhD
Brian Applegate, PhD
Visiting Professor of Otolaryngology - Head & Neck Surgery
Otolaryngology
1500 San Pablo Street Health Sciences Campus Los Angeles

Automated detection of superficial macrophages in atherosclerotic plaques using autofluorescence lifetime imaging Atherosclerosis. 2019 Jun; 285:120-127. . View in PubMed

Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces J Neurosci. 2019 Mar 06; 39(10):1805-1816. . View in PubMed

Amplification and suppression of traveling waves along the mouse organ of Corti: evidence for spatial variation in the longitudinal coupling of outer hair cell-generated forces J Neurosci. 2019 Jan 16. . View in PubMed

Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry J Neurophysiol. 2018 Dec 01; 120(6):2847-2857. . View in PubMed

Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry J Neurophysiol. 2018 Oct 03. . View in PubMed

Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea Cell Rep. 2018 Jun 05; 23(10):2915-2927. . View in PubMed

Osmotic stabilization prevents cochlear synaptopathy after blast trauma Proc Natl Acad Sci U S A. 2018 May 07. . View in PubMed

Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window Opt Lett. 2018 May 01; 43(9):1966-1969. . View in PubMed

Osmotic stabilization prevents cochlear synaptopathy after blast trauma Proc Natl Acad Sci U S A. 2018 05 22; 115(21):E4853-E4860. . View in PubMed

ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography Biomed Opt Express. 2017 Oct 01; 8(10):4579-4594. . View in PubMed

Hybrid nonlinear photoacoustic and reflectance confocal microscopy for label-free subcellular imaging with a single light source Opt Lett. 2017 Oct 01; 42(19):4028-4031. . View in PubMed

Enhanced coupling of light into a turbid medium through microscopic interface engineering Proc Natl Acad Sci U S A. 2017 07 25; 114(30):7941-7946. . View in PubMed

Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography J Biomed Opt. 2017 07 01; 22(7):76002. . View in PubMed

Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla Nat Commun. 2016 Oct 31; 7:13133. . View in PubMed

Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence Biomed Opt Express. 2016 Sep 01; 7(9):3184-3197. . View in PubMed

Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model Biomed Opt Express. 2016 May 01; 7(5):2000-15. . View in PubMed

Lensless, ultra-wideband fiber optic rotary joint for biomedical applications Opt Lett. 2016 May 01; 41(9):1973-6. . View in PubMed

High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography Biomed Opt Express. 2016 Apr 01; 7(4):1430-44. . View in PubMed

Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo Methods Mol Biol. 2016; 1427:449-62. . View in PubMed

Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti J Neurosci. 2016 08 03; 36(31):8160-73. . View in PubMed

Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla Nat Commun. 2016 10 31; 7:13133. . View in PubMed

Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis Eur Heart J Cardiovasc Imaging. 2015 Aug; 16(8):910-8. . View in PubMed

Miniature, minimally invasive, tunable endoscope for investigation of the middle ear Biomed Opt Express. 2015 Jun 01; 6(6):2246-57. . View in PubMed

In vivo molecular contrast OCT imaging of methylene blue Opt Lett. 2015 Apr 01; 40(7):1426-9. . View in PubMed

Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3128-33. . View in PubMed

In vivo pump-probe optical coherence tomography imaging in Xenopus laevis J Biophotonics. 2015 Jan; 8(1-2):25-35. . View in PubMed

Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear Opt Lett. 2014 Nov 01; 39(21):6233-6. . View in PubMed

Volumetric imaging of erythrocytes using label-free multiphoton photoacoustic microscopy J Biophotonics. 2014 Oct; 7(10):834-40. . View in PubMed

Vibration of the organ of Corti within the cochlear apex in mice J Neurophysiol. 2014 Sep 01; 112(5):1192-204. . View in PubMed

Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch J Biomed Opt. 2014 Aug; 19(8):086022. . View in PubMed

Simplified method for ultra high-resolution photoacoustic microscopy via transient absorption Opt Lett. 2014 Aug 01; 39(15):4474-7. . View in PubMed

Molecular Imaging in Optical Coherence Tomography Curr Mol Imaging. 2014 Jul 01; 3(2):88-105. . View in PubMed

Molecular specificity in photoacoustic microscopy by time-resolved transient absorption Opt Lett. 2014 Jun 01; 39(11):3102-5. . View in PubMed

Chromatic confocal microscopy for multi-depth imaging of epithelial tissue Biomed Opt Express. 2013 May 01; 4(5):732-40. . View in PubMed

In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography Biomed Opt Express. 2013 Feb 01; 4(2):230-40. . View in PubMed

Continuous real-time photoacoustic demodulation via field programmable gate array for dynamic imaging of zebrafish cardiac cycle Biomed Opt Express. 2013; 4(8):1451-63. . View in PubMed

Application of non-negative matrix factorization to multispectral FLIM data analysis Biomed Opt Express. 2012 Sep 01; 3(9):2244-62. . View in PubMed

Biochemical characterization of atherosclerotic plaques by endogenous multispectral fluorescence lifetime imaging microscopy Atherosclerosis. 2012 Feb; 220(2):394-401. . View in PubMed

Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography Opt Lett. 2011 Dec 01; 36(23):4716-8. . View in PubMed

Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography Opt Express. 2011 Aug 01; 19(16):15415-28. . View in PubMed

Cornea microstructure and mechanical responses measured with nonlinear optical and optical coherence microscopy using sub-10-fs pulses Biomed Opt Express. 2011 Apr 11; 2(5):1135-46. . View in PubMed

In vivo simultaneous morphological and biochemical optical imaging of oral epithelial cancer IEEE Trans Biomed Eng. 2010 Oct; 57(10):2596-9. . View in PubMed

Ultrahigh resolution photoacoustic microscopy via transient absorption Biomed Opt Express. 2010 Aug 23; 1(2):676-686. . View in PubMed

Off-axis photoacoustic microscopy IEEE Trans Biomed Eng. 2010 Aug; 57(8):1835-8. . View in PubMed

High-speed multispectral fluorescence lifetime imaging implementation for in vivo applications Opt Lett. 2010 Aug 01; 35(15):2558-60. . View in PubMed

A dual-modality optical coherence tomography and fluorescence lifetime imaging microscopy system for simultaneous morphological and biochemical tissue characterization Biomed Opt Express. 2010 Jul 16; 1(1):186-200. . View in PubMed

Fourier domain Pump-Probe Optical Coherence Tomography imaging of melanin Opt Express. 2010 Jun 07; 18(12):12399-410. . View in PubMed

Multiphoton coherence domain molecular imaging with pump-probe optical coherence microscopy Opt Lett. 2010 Feb 15; 35(4):532-4. . View in PubMed

Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1970-3. . View in PubMed

A bioluminescence-based assay for enumeration of lytic bacteriophage J Microbiol Methods. 2009 Oct; 79(1):18-22. . View in PubMed

Spectral domain phase microscopy for local measurements of cytoskeletal rheology in single cells J Biomed Opt. 2007 Jul-Aug; 12(4):044008. . View in PubMed

Molecular imaging of endogenous and exogenous chromophores using ground state recovery pump-probe optical coherence tomography Opt Express. 2006 Oct 02; 14(20):9142-55. . View in PubMed

Real-time quadrature projection complex conjugate resolved Fourier domain optical coherence tomography Opt Lett. 2006 Aug 15; 31(16):2426-8. . View in PubMed

Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques Opt Express. 2005 Oct 03; 13(20):8146-63. . View in PubMed

Spectral domain second-harmonic optical coherence tomography Opt Lett. 2005 Sep 15; 30(18):2391-3. . View in PubMed

Polarization-resolved second-harmonic-generation optical coherence tomography in collagen Opt Lett. 2004 Oct 01; 29(19):2252-4. . View in PubMed

Electron impact ionization in helium nanodroplets: controlling fragmentation by active cooling of molecular ions J Am Chem Soc. 2004 Sep 15; 126(36):11283-92. . View in PubMed

Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent Opt Lett. 2004 Sep 01; 29(17):2016-8. . View in PubMed

Explorations of conical intersections and their ramifications for chemistry through the Jahn-Teller effect Chem Soc Rev. 2003 Jan; 32(1):38-49. . View in PubMed

Validity of DSM-IV ADHD J Am Acad Child Adolesc Psychiatry. 2001 May; 40(5):502-4. . View in PubMed

Relation of age of onset to the type and severity of child and adolescent conduct problems J Abnorm Child Psychol. 1999 Aug; 27(4):247-60. . View in PubMed

Validity of DSM-IV subtypes of conduct disorder based on age of onset J Am Acad Child Adolesc Psychiatry. 1998 Apr; 37(4):435-42. . View in PubMed

Validity of the age-of-onset criterion for ADHD: a report from the DSM-IV field trials J Am Acad Child Adolesc Psychiatry. 1997 Sep; 36(9):1211-21. . View in PubMed

Twenty-one-month follow-up study of school-age children exposed to Hurricane Andrew J Am Acad Child Adolesc Psychiatry. 1996 Mar; 35(3):359-64. . View in PubMed

Developmental change in attention-deficit hyperactivity disorder in boys: a four-year longitudinal study J Abnorm Child Psychol. 1995 Dec; 23(6):729-49. . View in PubMed

Psychological effects of Hurricane Andrew on an elementary school population J Am Acad Child Adolesc Psychiatry. 1995 Sep; 34(9):1185-92. . View in PubMed

DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents Am J Psychiatry. 1994 Nov; 151(11):1673-85. . View in PubMed

DSM-IV field trials for oppositional defiant disorder and conduct disorder in children and adolescents Am J Psychiatry. 1994 Aug; 151(8):1163-71. . View in PubMed

DSM-IV field trials for the disruptive behavior disorders: symptom utility estimates J Am Acad Child Adolesc Psychiatry. 1994 May; 33(4):529-39. . View in PubMed

Young boys who commit serious sexual offenses: demographics, psychometrics, and phenomenology Bull Am Acad Psychiatry Law. 1993; 21(4):399-408. . View in PubMed

An investigation of somatic anxiety and intelligence in children using the Kaufman-ABC and an Apple IIe program measuring heart rate Percept Mot Skills. 1990 Apr; 70(2):387-94. . View in PubMed

Effects of background event rate on sustained attention of mentally retarded and nonretarded adults Am J Ment Retard. 1990 Mar; 94(5):499-508. . View in PubMed

A modified technique for semen collection by electroejaculation in the domestic cat Theriogenology. 1986 Sep; 26(3):357-64. . View in PubMed

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