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Brian Applegate, PhD

Professor of Otolaryngology - Head & Neck Surgery, Ophthalmology, Biomedical Engineering and Electrical and Computer Engineering

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Overview

Our research interests are broadly to develop novel biophotonic technologies for point-of-care diagnosis and monitoring of human disease as well as the basic scientific understanding of human disease.

Education and Training

  • The Ohio State University, Columbus, OH — PhD — 12/2000 — Chemistry

Research Funding

  • New technologies for imaging of the human cochlea
    NIH · R01DC023511 · Jul 1, 2026 – Apr 30, 2031 · Role: Principal Investigator
  • New low cost technology for early detection of ear disorders
    NIH · R21DC023404 · Sep 17, 2025 – Aug 31, 2027 · Role: Principal Investigator
  • Ultra-stable, phase sensitive, snapshot OCT system enabled by 2-Photon additive manufacturing
    NIH · R21GM149078 · Sep 15, 2023 – Aug 31, 2025 · Role: Principal Investigator
  • High-Speed, Low-Cost, Image Remapping Spectral Domain Full-Field Optical Coherence Tomography for Retinal Imaging
    NIH · R21EY035108 · Jul 1, 2023 – Jun 30, 2025 · Role: Principal Investigator
  • Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography
    NIH · R21GM135530 · Sep 1, 2020 – Aug 31, 2022 · Role: Principal Investigator
  • Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
    NIH · R01EB027113 · Apr 1, 2019 – Dec 31, 2023 · Role: Principal Investigator
  • Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
    NIH · R01HL111361 · Apr 1, 2012 – Mar 31, 2019 · Role: Principal Investigator
  • Development of high-resolution molecular imaging of endogenous chromophores with
    NIH · R21RR025799 · May 15, 2009 – Apr 30, 2013 · Role: Principal Investigator
  • New Technologies for high resolution optical molecular imaging
    NIH · R21EB007729 · Jun 1, 2008 – May 31, 2011 · Role: Principal Investigator
  • Bringing Molecular Contrast to OCT
    NIH · F32EB004237 · Sep 1, 2004 – Aug 31, 2006 · Role: Principal Investigator

Publications

  • A bioluminescence-based assay for enumeration of lytic bacteriophage. J Microbiol Methods. 2009 Oct; 79(1):18-22.. View in PubMed
  • Spectral domain phase microscopy for local measurements of cytoskeletal rheology in single cells. J Biomed Opt. 2007 Jul-Aug; 12(4):044008.. View in PubMed
  • Molecular imaging of endogenous and exogenous chromophores using ground state recovery pump-probe optical coherence tomography. Opt Express. 2006 Oct 02; 14(20):9142-55.. View in PubMed
  • Real-time quadrature projection complex conjugate resolved Fourier domain optical coherence tomography. Opt Lett. 2006 Aug 15; 31(16):2426-8.. View in PubMed
  • Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques. Opt Express. 2005 Oct 03; 13(20):8146-63.. View in PubMed
  • Spectral domain second-harmonic optical coherence tomography. Opt Lett. 2005 Sep 15; 30(18):2391-3.. View in PubMed
  • Influence of irrigant needle depth in removing bioluminescent bacteria inoculated into instrumented root canals using real-time imaging in vitro. Int Endod J. 2005 Feb; 38(2):97-104.. View in PubMed
  • Polarization-resolved second-harmonic-generation optical coherence tomography in collagen. Opt Lett. 2004 Oct 01; 29(19):2252-4.. View in PubMed
  • Electron impact ionization in helium nanodroplets: controlling fragmentation by active cooling of molecular ions. J Am Chem Soc. 2004 Sep 15; 126(36):11283-92.. View in PubMed
  • Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Opt Lett. 2004 Sep 01; 29(17):2016-8.. View in PubMed

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