Christopher Ching

Assistant Professor Of Research Neurology

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Overview

Dr. Ching is an Assistant Professor at The Imaging Genetics Center, part of the Mark and Mary Stevens Neuroimaging and Informatics Institute, where his research focuses on neuroimaging and genomic markers of psychiatric and neurodegenerative disorders. As a core organizing member of the Enhancing Neuro Imaging Genetics through Meta-Analysis Consortium (ENIGMA), he designs and implements standardized processing and analysis techniques for large-scale, international neuroimaging studies for a wide range of brain conditions. He leads the ENIGMA Bipolar Disorder Working Group, an effort including >200 researchers from around the world pooling data and resources to improve our understanding of the biological processes driving bipolar disorder. In complementary work, he studies rare copy number variants like 22q11.2 Deletion Syndrome to understand how certain rare genetic mutations can lead to increased risk for developing psychiatric illness. Finally, he leads several large-scale transdiagnostic neuroimaging and genomic initiatives mapping the common and distinct brain and clinical factors across a range of serious mental illnesses.

Awards

  • USC: Postdoctoral Fellowship in Biomarkers in Alzheimer’s Disease NIAT32AG058507, 2019
     – 2021
  • UCLA: Neurobehavioral Genetics Predoctoral Fellowship, NIH/NIMH 5T32MH073526, 2015
     – 2016
  • UCLA: Neuroimaging Training Program, National Institutes of Health, R90 DA022768 and T90 DA023422, 2012
     – 2013
  • UCLA: National Science Foundation Alliance for Graduate Education and the Professoriate Grant, 2012
     – 2012

Education and Training

  • UCLA — PhD — Neuroscience
  • Pomona College — BA — Neuroscience/Philosophy

Research Keywords

  • Neuroscience
  • Neuoroimaging
  • Psychiatric Disorders
  • Genetics
  • Neurodegenerative Disease

Publications

  • Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study. Mol Psychiatry. 2020 11; 25(11):2818-2831.. View in PubMed
  • Striatal morphology and neurocognitive dysfunction in Huntington disease: The IMAGE-HD study. Psychiatry Res Neuroimaging. 2019 09 30; 291:1-8.. View in PubMed
  • The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder. Biol Psychiatry. 2019 10 01; 86(7):545-556.. View in PubMed
  • Progressive brain atrophy in chronically infected and treated HIV+ individuals. J Neurovirol. 2019 06; 25(3):342-353.. View in PubMed
  • Using structural MRI to identify bipolar disorders – 13 site machine learning study in 3020 individuals from the ENIGMA Bipolar Disorders Working Group. Mol Psychiatry. 2020 09; 25(9):2130-2143.. View in PubMed
  • Large-scale mapping of cortical alterations in 22q11.2 deletion syndrome: Convergence with idiopathic psychosis and effects of deletion size. Mol Psychiatry. 2020 08; 25(8):1822-1834.. View in PubMed
  • Machine Learning for Large-Scale Quality Control of 3D Shape Models in Neuroimaging. Mach Learn Med Imaging. 2017 Sep; 10541:371-378.. View in PubMed
  • Mapping 22q11.2 Gene Dosage Effects on Brain Morphometry. J Neurosci. 2017 06 28; 37(26):6183-6199.. View in PubMed
  • Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group. Mol Psychiatry. 2018 04; 23(4):932-942.. View in PubMed
  • Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 01 18; 8:13624.. View in PubMed