Keck School Faculty

Christopher Haiman

Christopher Haiman

Professor of Population and Public Health Sciences
AFLAC Chair in Cancer Research
Medicine
NRT 1504 1450 Biggy St. Health Sciences Campus Los Angeles

Deconstructing, Addressing, and Eliminating Racial and Ethnic Inequities in Prostate Cancer Care Eur Urol. 2022 Oct; 82(4):341-351. . View in PubMed

Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study Cancer Res. 2022 Sep 16; 82(18):3201-3208. . View in PubMed

Polygenic risk scores for prediction of breast cancer risk in women of African ancestry: a cross-ancestry approach Hum Mol Genet. 2022 Sep 10; 31(18):3133-3143. . View in PubMed

Risk of Alzheimer's disease and related dementia by sex and race/ethnicity: The Multiethnic Cohort Study Alzheimers Dement. 2022 Sep; 18(9):1625-1634. . View in PubMed

Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis Int J Epidemiol. 2022 Jun 21. . View in PubMed

Distinct reproductive risk profiles for intrinsic-like breast cancer subtypes: pooled analysis of population-based studies J Natl Cancer Inst. 2022 Jun 20. . View in PubMed

A Healthy Lifestyle in Men at Increased Genetic Risk for Prostate Cancer Eur Urol. 2022 May 27. . View in PubMed

Correction: Polygenic risk modeling for prediction of epithelial ovarian cancer risk Eur J Hum Genet. 2022 May; 30(5):630-631. . View in PubMed

Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimer's disease and related dementias Alzheimers Dement. 2022 Apr 27. . View in PubMed

Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits-The Hispanic/Latino Anthropometry Consortium HGG Adv. 2022 Apr 14; 3(2):100099. . View in PubMed

Change in the inflammatory potential of diet over 10 years and subsequent mortality: the Multiethnic Cohort Study Br J Nutr. 2022 Apr 08; 1-23. . View in PubMed

Urinary 6-sulfatoxymelatonin Levels and Prostate Cancer Risk among Men in the Multiethnic Cohort Cancer Epidemiol Biomarkers Prev. 2022 Mar 01; 31(3):688-691. . View in PubMed

Diet quality and all-cause and cancer-specific mortality in cancer survivors and non-cancer individuals: the Multiethnic Cohort Study Eur J Nutr. 2022 Mar; 61(2):925-933. . View in PubMed

Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score Prostate Cancer Prostatic Dis. 2022 Feb 12. . View in PubMed

Evaluating breast cancer predisposition genes in women of African ancestry Genet Med. 2022 07; 24(7):1468-1475. . View in PubMed

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation Nat Genet. 2022 05; 54(5):560-572. . View in PubMed

Modifiable Factors and Incident Gout Across Ethnicity Within a Large Multiethnic Cohort of Older Adults J Rheumatol. 2022 05; 49(5):504-512. . View in PubMed

A Rare Germline HOXB13 Variant Contributes to Risk of Prostate Cancer in Men of African Ancestry Eur Urol. 2022 05; 81(5):458-462. . View in PubMed

Prognostic utility of self-reported sarcopenia (SARC-F) in the Multiethnic Cohort J Cachexia Sarcopenia Muscle. 2022 04; 13(2):987-1002. . View in PubMed

Polygenic risk modeling for prediction of epithelial ovarian cancer risk Eur J Hum Genet. 2022 03; 30(3):349-362. . View in PubMed

Multi-ethnic GWAS and fine-mapping of glycaemic traits identify novel loci in the PAGE Study Diabetologia. 2022 03; 65(3):477-489. . View in PubMed

Contributions of Social Factors to Disparities in Prostate Cancer Risk Profiles among Black Men and Non-Hispanic White Men with Prostate Cancer in California Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):404-412. . View in PubMed

Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer J Natl Cancer Inst. 2022 05 09; 114(5):771-774. . View in PubMed

Predicted gene expression in ancestrally diverse populations leads to discovery of susceptibility loci for lifestyle and cardiometabolic traits Am J Hum Genet. 2022 04 07; 109(4):669-679. . View in PubMed

Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations Elife. 2022 07 08; 11. . View in PubMed

Enrichment analyses identify shared associations for 25 quantitative traits in over 600,000 individuals from seven diverse ancestries Am J Hum Genet. 2022 05 05; 109(5):871-884. . View in PubMed

A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk Int J Cancer. 2022 01 01; 150(1):80-90. . View in PubMed

Common variants in breast cancer risk loci predispose to distinct tumor subtypes Breast Cancer Res. 2022 01 04; 24(1):2. . View in PubMed

Joint Associations of Race, Ethnicity, and Socioeconomic Status With Mortality in the Multiethnic Cohort Study JAMA Netw Open. 2022 04 01; 5(4):e226370. . View in PubMed

Genome-wide and transcriptome-wide association studies of mammographic density phenotypes reveal novel loci Breast Cancer Res. 2022 04 12; 24(1):27. . View in PubMed

Genome-wide interaction analysis of menopausal hormone therapy use and breast cancer risk among 62,370 women Sci Rep. 2022 04 13; 12(1):6199. . View in PubMed

Rare germline copy number variants (CNVs) and breast cancer risk Commun Biol. 2022 01 18; 5(1):65. . View in PubMed

Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort J Natl Cancer Inst. 2022 07 11; 114(7):959-968. . View in PubMed

Circulating free testosterone and risk of aggressive prostate cancer: Prospective and Mendelian randomisation analyses in international consortia Int J Cancer. 2022 10 01; 151(7):1033-1046. . View in PubMed

Cholesterol lowering drug use and breast cancer survival: the Multiethnic Cohort Study Breast Cancer Res Treat. 2021 Nov; 190(1):165-173. . View in PubMed

Hum Genet. 2021 Oct; 140(10):1449-1457. . View in PubMed

Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation EClinicalMedicine. 2021 Oct; 40:101093. . View in PubMed

White Rice Consumption and Risk for Colorectal Cancer among Japanese Americans: The Multiethnic Cohort Study J Epidemiol. 2021 Aug 12. . View in PubMed

Race, ethnicity, community-level socioeconomic factors, and risk of COVID-19 in the United States and the United Kingdom EClinicalMedicine. 2021 Aug; 38:101029. . View in PubMed

Large-scale cross-cancer fine-mapping of the 5p1533 region reveals multiple independent signals. HGG Adv. 2021 Jul 08; 2(3):100041. . View in PubMed

Comparison of the Prevalence of Pathogenic Variants in Cancer Susceptibility Genes in Black Women and Non-Hispanic White Women With Breast Cancer in the United States JAMA Oncol. 2021 Jul 01; 7(7):1045-1050. . View in PubMed

Gene-Environment Interactions Relevant to Estrogen and Risk of Breast Cancer: Can Gene-Environment Interactions Be Detected Only among Candidate SNPs from Genome-Wide Association Studies? Cancers (Basel). 2021 May 14; 13(10).. View in PubMed

Author Correction: A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers Nat Commun. 2021 May 14; 12(1):2986. . View in PubMed

Diet Quality and Risk of Lung Cancer in the Multiethnic Cohort Study Nutrients. 2021 May 12; 13(5). . View in PubMed

Genetic discovery and risk characterization in type 2 diabetes across diverse populations HGG Adv. 2021 Apr 08; 2(2). . View in PubMed

Techniques and Outcomes of MRI-TRUS Fusion Prostate Biopsy Curr Urol Rep. 2021 Mar 22; 22(4):27. . View in PubMed

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 Mar; 53(3):413. . View in PubMed

Alcohol Intake and Alcohol-SNP Interactions Associated with Prostate Cancer Aggressiveness J Clin Med. 2021 Feb 02; 10(3). . View in PubMed

Novel strategy for disease risk prediction incorporating predicted gene expression and DNA methylation data: a multi-phased study of prostate cancer Cancer Commun (Lond). 2021 12; 41(12):1387-1397. . View in PubMed

Mendelian randomisation study of smoking exposure in relation to breast cancer risk Br J Cancer. 2021 10; 125(8):1135-1145. . View in PubMed

Association of Genetic Risk Score With NAFLD in An Ethnically Diverse Cohort Hepatol Commun. 2021 10; 5(10):1689-1703. . View in PubMed

Combined Effect of a Polygenic Risk Score and Rare Genetic Variants on Prostate Cancer Risk Eur Urol. 2021 08; 80(2):134-138. . View in PubMed

Genetic insights into biological mechanisms governing human ovarian ageing Nature. 2021 08; 596(7872):393-397. . View in PubMed

Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer Prostate Cancer Prostatic Dis. 2021 06; 24(2):532-541. . View in PubMed

Prediagnostic Antibody Responses to Fusobacterium nucleatum Proteins Are Not Associated with Risk of Colorectal Cancer in a Large US. Consortium. Cancer Epidemiol Biomarkers Prev. 2021 06; 30(6):1279-1282. . View in PubMed

Breast Cancer Risk Factors and Survival by Tumor Subtype: Pooled Analyses from the Breast Cancer Association Consortium Cancer Epidemiol Biomarkers Prev. 2021 04; 30(4):623-642. . View in PubMed

The impact of global and local Polynesian genetic ancestry on complex traits in Native Hawaiians PLoS Genet. 2021 02; 17(2):e1009273. . View in PubMed

CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers Br J Cancer. 2021 02; 124(4):842-854. . View in PubMed

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 01; 53(1):65-75. . View in PubMed

Germline Pathogenic Variants in Cancer Predisposition Genes Among Women With Invasive Lobular Carcinoma of the Breast J Clin Oncol. 2021 12 10; 39(35):3918-3926. . View in PubMed

A Population-Based Study of Genes Previously Implicated in Breast Cancer N Engl J Med. 2021 02 04; 384(5):440-451. . View in PubMed

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes Nat Commun. 2021 06 09; 12(1):3505. . View in PubMed

Germline Sequencing DNA Repair Genes in 5545 Men With Aggressive and Nonaggressive Prostate Cancer J Natl Cancer Inst. 2021 05 04; 113(5):616-625. . View in PubMed

Germline variants and breast cancer survival in patients with distant metastases at primary breast cancer diagnosis Sci Rep. 2021 10 05; 11(1):19787. . View in PubMed

Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer Int J Cancer. 2021 01 15; 148(2):307-319. . View in PubMed

Risk of Late-Onset Breast Cancer in Genetically Predisposed Women J Clin Oncol. 2021 11 01; 39(31):3430-3440. . View in PubMed

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score J Clin Oncol. 2021 08 10; 39(23):2564-2573. . View in PubMed

Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry J Natl Cancer Inst. 2021 09 04; 113(9):1168-1176. . View in PubMed

KLK3 SNP-SNP interactions for prediction of prostate cancer aggressiveness Sci Rep. 2021 04 29; 11(1):9264. . View in PubMed

Pre-HCT mosaicism increases relapse risk and lowers survival in acute lymphoblastic leukemia patients post-unrelated HCT Blood Adv. 2021 01 12; 5(1):66-70. . View in PubMed

Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry Am J Hum Genet. 2021 04 01; 108(4):564-582. . View in PubMed

Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study Breast Cancer Res. 2021 04 06; 23(1):44. . View in PubMed

Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element Am J Hum Genet. 2021 07 01; 108(7):1190-1203. . View in PubMed

Cross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women Nat Commun. 2021 07 07; 12(1):4198. . View in PubMed

Genome-Wide Association Analyses Identify Variants in IRF4 Associated With Acute Myeloid Leukemia and Myelodysplastic Syndrome Susceptibility Front Genet. 2021; 12:554948. . View in PubMed

Genome-wide association study of pancreatic fat: The Multiethnic Cohort Adiposity Phenotype Study PLoS One. 2021; 16(7):e0249615. . View in PubMed

Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk J Natl Cancer Inst. 2021 03 01; 113(3):329-337. . View in PubMed

Risk of breast cancer and prediagnostic urinary excretion of bisphenol A, triclosan and parabens: The Multiethnic Cohort Study Int J Cancer. 2021 10 01; 149(7):1426-1434. . View in PubMed

Association of Anthropometric Measures With the Risk of Prostate Cancer in the Multiethnic Cohort Am J Epidemiol. 2021 09 01; 190(9):1770-1783. . View in PubMed

Prognostic impact of pre-transplant chromosomal aberrations in peripheral blood of patients undergoing unrelated donor hematopoietic cell transplant for acute myeloid leukemia Sci Rep. 2021 07 22; 11(1):15004. . View in PubMed

Genetic variants in anti-Müllerian hormone-related genes and breast cancer risk: results from the AMBER consortium Breast Cancer Res Treat. 2021 Jan; 185(2):469-478. . View in PubMed

Association of germline genetic variants with breast cancer-specific survival in patient subgroups defined by clinic-pathological variables related to tumor biology and type of systemic treatment Breast Cancer Res. 2021 08 18; 23(1):86. . View in PubMed

A case-only study to identify genetic modifiers of breast cancer risk for BRCA1/BRCA2 mutation carriers Nat Commun. 2021 02 17; 12(1):1078. . View in PubMed

The CHEK2 Variant C349A>G Is Associated with Prostate Cancer Risk and Carriers Share a Common Ancestor. Cancers (Basel). 2020 Nov 04; 12(11). . View in PubMed

Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer Microorganisms. 2020 Oct 30; 8(11). . View in PubMed

Genome-Wide Association Study of Liver Fat: The Multiethnic Cohort Adiposity Phenotype Study Hepatol Commun. 2020 Aug; 4(8):1112-1123. . View in PubMed

Prediction of contralateral breast cancer: external validation of risk calculators in 20 international cohorts Breast Cancer Res Treat. 2020 Jun; 181(2):423-434. . View in PubMed

Replication and Genetic Risk Score Analysis for Pancreatic Cancer in a Diverse Multiethnic Population Cancer Epidemiol Biomarkers Prev. 2020 12; 29(12):2686-2692. . View in PubMed

Variability in Cytogenetic Testing for Multiple Myeloma: A Comprehensive Analysis From Across the United States JCO Oncol Pract. 2020 10; 16(10):e1169-e1180. . View in PubMed

Racial Differences in Helicobacter pylori CagA Sero-prevalence in a Consortium of Adult Cohorts in the United States Cancer Epidemiol Biomarkers Prev. 2020 10; 29(10):2084-2092. . View in PubMed

Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci Mol Psychiatry. 2020 10; 25(10):2392-2409. . View in PubMed

A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry Eur Urol. 2020 09; 78(3):316-320. . View in PubMed

The COronavirus Pandemic Epidemiology (COPE) Consortium: A Call to Action Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1283-1289. . View in PubMed

The Four-Kallikrein Panel Is Effective in Identifying Aggressive Prostate Cancer in a Multiethnic Population Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1381-1388. . View in PubMed

Transcriptome-wide association study of breast cancer risk by estrogen-receptor status Genet Epidemiol. 2020 07; 44(5):442-468. . View in PubMed

Associations between Genetically Predicted Blood Protein Biomarkers and Pancreatic Cancer Risk Cancer Epidemiol Biomarkers Prev. 2020 07; 29(7):1501-1508. . View in PubMed

Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses Nat Genet. 2020 06; 52(6):572-581. . View in PubMed

Cumulative Burden of Colorectal Cancer-Associated Genetic Variants Is More Strongly Associated With Early-Onset vs Late-Onset CancerGastroenterology. 2020 04; 158(5):1274-1286. e12. . View in PubMed

Minority-centric meta-analyses of blood lipid levels identify novel loci in the Population Architecture using Genomics and Epidemiology (PAGE) study PLoS Genet. 2020 03; 16(3):e1008684. . View in PubMed

Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes Nat Genet. 2020 01; 52(1):56-73. . View in PubMed

Association between sleep duration and breast cancer incidence: The multiethnic cohort Int J Cancer. 2020 02 01; 146(3):664-670. . View in PubMed

An integrative multi-omics analysis to identify candidate DNA methylation biomarkers related to prostate cancer risk Nat Commun. 2020 08 06; 11(1):3905. . View in PubMed

A meta-analysis of genome-wide association studies of multiple myeloma among men and women of African ancestry Blood Adv. 2020 01 14; 4(1):181-190. . View in PubMed

A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer J Natl Cancer Inst. 2020 10 01; 112(10):1003-1012. . View in PubMed

Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women J Natl Cancer Inst. 2020 12 14; 112(12):1213-1221. . View in PubMed

A genome-wide association study of prostate cancer in Latinos Int J Cancer. 2020 04 01; 146(7):1819-1826. . View in PubMed

Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians Hum Mol Genet. 2020 08 03; 29(13):2275-2284. . View in PubMed

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk Am J Hum Genet. 2020 11 05; 107(5):837-848. . View in PubMed

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis Nat Commun. 2020 01 16; 11(1):312. . View in PubMed

Pathogenic Variants in Cancer Predisposition Genes and Prostate Cancer Risk in Men of African Ancestry JCO Precis Oncol. 2020; 4:32-43. . View in PubMed

Circulating markers of cellular immune activation in prediagnostic blood sample and lung cancer risk in the Lung Cancer Cohort Consortium (LC3) Int J Cancer. 2020 05 01; 146(9):2394-2405. . View in PubMed

A rare variant of African ancestry activates 8q24 lncRNA hub by modulating cancer associated enhancer Nat Commun. 2020 07 17; 11(1):3598. . View in PubMed

A Polygenic Risk Score for Breast Cancer in US Latinas and Latin American Women J Natl Cancer Inst. 2020 06 01; 112(6):590-598. . View in PubMed

Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers Nat Commun. 2020 07 03; 11(1):3353. . View in PubMed

Identification of novel epithelial ovarian cancer loci in women of African ancestry Int J Cancer. 2020 06 01; 146(11):2987-2998. . View in PubMed

Genome-wide association meta-analysis identifies GP2 gene risk variants for pancreatic cancer Nat Commun. 2020 06 24; 11(1):3175. . View in PubMed

Germline HOXB13 mutations pG84E and p. R217C do not confer an increased breast cancer risk. Sci Rep. 2020 06 16; 10(1):9688. . View in PubMed

Protein-altering germline mutations implicate novel genes related to lung cancer development Nat Commun. 2020 05 11; 11(1):2220. . View in PubMed

Smoking-Related Risks of Colorectal Cancer by Anatomical Subsite and Sex Am J Epidemiol. 2020 06 01; 189(6):543-553. . View in PubMed

Publisher Correction: Shared heritability and functional enrichment across six solid cancers Nat Commun. 2019 Sep 23; 10(1):4386. . View in PubMed

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer J Natl Cancer Inst. 2019 Jun 01; 111(6):557-567. . View in PubMed

Correction: Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease Br J Cancer. 2019 Apr; 120(8):867. . View in PubMed

High-Quality Diets Are Associated With Reduced Risk of Hepatocellular Carcinoma and Chronic Liver Disease: The Multiethnic Cohort Hepatol Commun. 2019 Mar; 3(3):437-447. . View in PubMed

Type 2 diabetes as a predictor of survival among breast cancer patients: the multiethnic cohort Breast Cancer Res Treat. 2019 Feb; 173(3):637-645. . View in PubMed

Interethnic differences in pancreatic cancer incidence and risk factors: The Multiethnic Cohort Cancer Med. 2019 07; 8(7):3592-3603. . View in PubMed

Prediagnostic circulating markers of inflammation and risk of oesophageal adenocarcinoma: a study within the National Cancer Institute Cohort Consortium Gut. 2019 06; 68(6):960-968. . View in PubMed

Genetic analyses of diverse populations improves discovery for complex traits Nature. 2019 06; 570(7762):514-518. . View in PubMed

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls Nature. 2019 06; 570(7759):71-76. . View in PubMed

Intake of cocoa products and risk of type-2 diabetes: the multiethnic cohort Eur J Clin Nutr. 2019 05; 73(5):671-678. . View in PubMed

Physical Activity and Colorectal Cancer Risk by Sex, Race/Ethnicity, and Subsite: The Multiethnic Cohort Study Cancer Prev Res (Phila). 2019 05; 12(5):315-326. . View in PubMed

Evaluation of vitamin D biosynthesis and pathway target genes reveals UGT2A1/2 and EGFR polymorphisms associated with epithelial ovarian cancer in African American Women Cancer Med. 2019 05; 8(5):2503-2513. . View in PubMed

Diet quality measured by four a priori-defined diet quality indices is associated with lipid-soluble micronutrients in the Multiethnic Cohort Study (MEC) Eur J Clin Nutr. 2019 05; 73(5):703-713. . View in PubMed

Genome-wide association study of germline variants and breast cancer-specific mortality Br J Cancer. 2019 03; 120(6):647-657. . View in PubMed

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2019 02; 51(2):363. . View in PubMed

Association of Hypothyroidism With Nonmelanoma Skin Cancer in the Multiethnic Cohort Population-Based Study Dermatol Surg. 2019 01; 45(1):154-158. . View in PubMed

Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study Cancer Epidemiol Biomarkers Prev. 2019 01; 28(1):208-216. . View in PubMed

Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United StatesGastroenterology. 2019 01; 156(1):175-186. e2. . View in PubMed

The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies Int J Cancer. 2019 12 15; 145(12):3244-3256. . View in PubMed

The FANCM:pArg658* truncating variant is associated with risk of triple-negative breast cancer. NPJ Breast Cancer. 2019; 5:38. . View in PubMed

A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk Cancer Res. 2019 01 01; 79(1):274-285. . View in PubMed

Association between mitochondrial genetic variation and breast cancer risk: The Multiethnic Cohort PLoS One. 2019; 14(10):e0222284. . View in PubMed

Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study Am J Epidemiol. 2019 01 01; 188(1):67-76. . View in PubMed

12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population Nat Commun. 2019 09 27; 10(1):4422. . View in PubMed

A phenome-wide association study (PheWAS) in the Population Architecture using Genomics and Epidemiology (PAGE) study reveals potential pleiotropy in African Americans PLoS One. 2019; 14(12):e0226771. . View in PubMed

Analysis of Over 140,000 European Descendants Identifies Genetically Predicted Blood Protein Biomarkers Associated with Prostate Cancer Risk Cancer Res. 2019 09 15; 79(18):4592-4598. . View in PubMed

Prediction and clinical utility of a contralateral breast cancer risk model Breast Cancer Res. 2019 12 17; 21(1):144. . View in PubMed

Multiple functional variants in the IL1RL1 region are pretransplant markers for risk of GVHD and infection deaths Blood Adv. 2019 08 27; 3(16):2512-2524. . View in PubMed

Two truncating variants in FANCC and breast cancer risk Sci Rep. 2019 08 29; 9(1):12524. . View in PubMed

Validation of genetic associations with acute GVHD and nonrelapse mortality in DISCOVeRY-BMT Blood Adv. 2019 08 13; 3(15):2337-2341. . View in PubMed

Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants Cancer Res. 2019 07 01; 79(13):3192-3204. . View in PubMed

Pathogenic and likely pathogenic variants in PALB2, CHEK2, and other known breast cancer susceptibility genes among 1054 BRCA-negative Hispanics with breast cancer Cancer. 2019 08 15; 125(16):2829-2836. . View in PubMed

The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis Int J Epidemiol. 2019 06 01; 48(3):781-794. . View in PubMed

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer Nat Commun. 2019 04 15; 10(1):1741. . View in PubMed

Data-adaptive multi-locus association testing in subjects with arbitrary genealogical relationships Stat Appl Genet Mol Biol. 2019 04 08; 18(3). . View in PubMed

Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk Breast Cancer Res. 2019 05 22; 21(1):68. . View in PubMed

Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update J Natl Cancer Inst. 2019 08 01; 111(8):811-819. . View in PubMed

Shared heritability and functional enrichment across six solid cancers Nat Commun. 2019 01 25; 10(1):431. . View in PubMed

Smoking and breast cancer risk by race/ethnicity and oestrogen and progesterone receptor status: the Multiethnic Cohort (MEC) study Int J Epidemiol. 2019 04 01; 48(2):501-511. . View in PubMed

Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use Biol Psychiatry. 2019 06 01; 85(11):946-955. . View in PubMed

Associations of autozygosity with a broad range of human phenotypes Nat Commun. 2019 10 31; 10(1):4957. . View in PubMed

Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 09 15; 145(6):1499-1503.. View in PubMed

Identification of novel common breast cancer risk variants at the 6q25 locus among Latinas Breast Cancer Res. 2019 01 14; 21(1):3. . View in PubMed

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry Nat Commun. 2019 01 17; 10(1):382. . View in PubMed

Author Correction: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions Nat Commun. 2019 01 08; 10(1):171. . View in PubMed

Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes Am J Hum Genet. 2019 01 03; 104(1):21-34. . View in PubMed

Genetic susceptibility to radiation-induced breast cancer after Hodgkin lymphoma Blood. 2019 03 07; 133(10):1130-1139. . View in PubMed

Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts J Natl Cancer Inst. 2019 02 01; 111(2):158-169. . View in PubMed

Novel Common Genetic Susceptibility Loci for Colorectal Cancer J Natl Cancer Inst. 2019 02 01; 111(2):146-157. . View in PubMed

Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort J Natl Cancer Inst. 2019 01 01; 111(1):27-33. . View in PubMed

The Dietary Inflammatory Index and All-Cause, Cardiovascular Disease, and Cancer Mortality in the Multiethnic Cohort Study Nutrients. 2018 Dec 01; 10(12). . View in PubMed

Genetic modifiers of radon-induced lung cancer risk: a genome-wide interaction study in former uranium miners Int Arch Occup Environ Health. 2018 Nov; 91(8):937-950. . View in PubMed

Stepwise approach to SNP-set analysis illustrated with the Metabochip and colorectal cancer in Japanese Americans of the Multiethnic Cohort BMC Genomics. 2018 Jul 09; 19(1):524. . View in PubMed

Testing the Predictive Validity of the Healthy Eating Index-2015 in the Multiethnic Cohort: Is the Score Associated with a Reduced Risk of All-Cause and Cause-Specific Mortality? Nutrients. 2018 Apr 05; 10(4).. View in PubMed

Antibody Responses to Streptococcus Gallolyticus Subspecies Gallolyticus Proteins in a Large Prospective Colorectal Cancer Cohort Consortium Cancer Epidemiol Biomarkers Prev. 2018 10; 27(10):1186-1194. . View in PubMed

Prospective Study of Coffee Consumption and Cancer Incidence in Non-White Populations Cancer Epidemiol Biomarkers Prev. 2018 08; 27(8):928-935. . View in PubMed

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer Nat Genet. 2018 07; 50(7):968-978. . View in PubMed

Rare germline variants in DNA repair genes and the angiogenesis pathway predispose prostate cancer patients to develop metastatic disease Br J Cancer. 2018 07; 119(1):96-104. . View in PubMed

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2018 07; 50(7):928-936. . View in PubMed

Low diet quality and the risk of stroke mortality: the multiethnic cohort study Eur J Clin Nutr. 2018 07; 72(7):1035-1045. . View in PubMed

The BRCA2 c68-7T > A variant is not pathogenic: A model for clinical calibration of spliceogenicity. Hum Mutat. 2018 05; 39(5):729-741. . View in PubMed

Genome-Wide Association Studies of Cancer in Diverse Populations Cancer Epidemiol Biomarkers Prev. 2018 04; 27(4):405-417. . View in PubMed

Genetic risk of prostate cancer in Ugandan men Prostate. 2018 04; 78(5):370-376. . View in PubMed

Trans-ethnic analysis of metabochip data identifies two new loci associated with BMI Int J Obes (Lond). 2018 03; 42(3):384-390. . View in PubMed

Genetic Variants in Immune-Related Pathways and Breast Cancer Risk in African American Women in the AMBER Consortium Cancer Epidemiol Biomarkers Prev. 2018 03; 27(3):321-330. . View in PubMed

Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci Pharmacogenet Genomics. 2018 02; 28(2):49-55. . View in PubMed

Sleep duration and incidence of type 2 diabetes: the Multiethnic Cohort Sleep Health. 2018 02; 4(1):27-32. . View in PubMed

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High-Quality Diets Associate With Reduced Risk of Colorectal Cancer: Analyses of Diet Quality Indexes in the Multiethnic CohortGastroenterology. 2017 08; 153(2):386-394. e2. . View in PubMed

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SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns Bioinformatics. 2017 03 15; 33(6):822-833. . View in PubMed

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Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits Nat Commun. 2017 04 26; 8:14977. . View in PubMed

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Three new pancreatic cancer susceptibility signals identified on chromosomes 1q321, 5p15. 33 and 8q24. 21. Oncotarget. 2016 Oct 11; 7(41):66328-66343. . View in PubMed

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation Am J Hum Genet. 2016 Oct 06; 99(4):903-911. . View in PubMed

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A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618. . View in PubMed

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Mapping adipose and muscle tissue expression quantitative trait loci in African Americans to identify genes for type 2 diabetes and obesity Hum Genet. 2016 08; 135(8):869-80. . View in PubMed

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Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent PLoS Med. 2016 08; 13(8):e1002105. . View in PubMed

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No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer Gynecol Oncol. 2016 05; 141(2):386-401. . View in PubMed

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A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11 Hum Mol Genet. 2012 Dec 15; 21(24):5373-84. . View in PubMed

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The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study Am J Epidemiol. 2011 Oct 01; 174(7):849-59. . View in PubMed

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Large-scale fine mapping of the HNF1B locus and prostate cancer risk Hum Mol Genet. 2011 Aug 15; 20(16):3322-9. . View in PubMed

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Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study Nat Genet. 2011 Jul 10; 43(8):785-91. . View in PubMed

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Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project PLoS Genet. 2011 Feb 10; 7(2):e1001300. . View in PubMed

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GWAS identifies a common breast cancer risk allele among BRCA1 carriers Nat Genet. 2010 Oct; 42(10):819-20. . View in PubMed

A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations Cancer Epidemiol Biomarkers Prev. 2010 Oct; 19(10):2639-46. . View in PubMed

The potential for enhancing the power of genetic association studies in African Americans through the reuse of existing genotype data PLoS Genet. 2010 Sep 02; 6(9):e1001096. . View in PubMed

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Refining the prostate cancer genetic association within the JAZF1 gene on chromosome 7p152. Cancer Epidemiol Biomarkers Prev. 2010 May; 19(5):1349-55. . View in PubMed

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Screening and association testing of common coding variation in steroid hormone receptor co-activator and co-repressor genes in relation to breast cancer risk: the Multiethnic Cohort BMC Cancer. 2009 Jan 30; 9:43. . View in PubMed

Two estrogen-related variants in CYP19A1 and endometrial cancer risk: a pooled analysis in the Epidemiology of Endometrial Cancer Consortium Cancer Epidemiol Biomarkers Prev. 2009 Jan; 18(1):242-7. . View in PubMed

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A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort BMC Med Genet. 2007 Dec 01; 8:72. . View in PubMed

A high-density admixture scan in 1,670 African Americans with hypertension PLoS Genet. 2007 Nov; 3(11):e196. . View in PubMed

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Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer Nat Genet. 2007 Jul; 39(7):865-9. . View in PubMed

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A genomewide admixture map for Latino populations Am J Hum Genet. 2007 Jun; 80(6):1024-36. . View in PubMed

Multiple regions within 8q24 independently affect risk for prostate cancer Nat Genet. 2007 May; 39(5):638-44. . View in PubMed

Established risk factors account for most of the racial differences in cardiovascular disease mortality PLoS One. 2007 Apr 18; 2(4):e377. . View in PubMed

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A common 8q24 variant in prostate and breast cancer from a large nested case-control study Cancer Res. 2007 Apr 01; 67(7):2951-6. . View in PubMed

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Common genetic variation in IGF1, IGFBP-1, and IGFBP-3 in relation to mammographic density: a cross-sectional study Breast Cancer Res. 2007; 9(1):R18. . View in PubMed

A systematic assessment of common genetic variation in CYP11A and risk of breast cancer Cancer Res. 2006 Dec 15; 66(24):12019-25. . View in PubMed

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Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort Cancer Epidemiol Biomarkers Prev. 2006 Oct; 15(10):1993-7. . View in PubMed

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):14068-73. . View in PubMed

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Cyclin D1: polymorphism, aberrant splicing and cancer risk Oncogene. 2006 Mar 13; 25(11):1620-8. . View in PubMed

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Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies Cancer Res. 2006 Feb 15; 66(4):2468-75. . View in PubMed

Cyclin D1b variant influences prostate cancer growth through aberrant androgen receptor regulation Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2190-5. . View in PubMed

Ethnic and racial differences in the smoking-related risk of lung cancer N Engl J Med. 2006 Jan 26; 354(4):333-42. . View in PubMed

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A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) Breast Cancer Res. 2006; 8(5):R54. . View in PubMed

Genetic variation in the HSD17B1 gene and risk of prostate cancer PLoS Genet. 2005 Nov; 1(5):e68. . View in PubMed

A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk Cancer Res. 2005 Aug 15; 65(16):7516-22. . View in PubMed

Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort J Clin Endocrinol Metab. 2005 Apr; 90(4):2198-204. . View in PubMed

A candidate gene approach to searching for low-penetrance breast and prostate cancer genes Nat Rev Cancer. 2005 12; 5(12):977-85. . View in PubMed

Polymorphisms in genes involved in estrogen and progesterone metabolism and mammographic density changes in women randomized to postmenopausal hormone therapy: results from a pilot study Breast Cancer Res. 2005; 7(3):R336-44. . View in PubMed

MTHFR polymorphisms, diet, HRT, and breast cancer risk: the multiethnic cohort study Cancer Epidemiol Biomarkers Prev. 2004 Dec; 13(12):2071-7. . View in PubMed

Multiple Polymorphisms in the renin- angiotensin-aldosterone system (ACE, CYP11B2, AGTR1) and their contribution to hypertension in African Americans and Latinos in the multiethnic cohort Am J Med Sci. 2004 Nov; 328(5):266-73. . View in PubMed

Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort Hum Mol Genet. 2004 Oct 15; 13(20):2431-41. . View in PubMed

T29C polymorphism in the transforming growth factor beta1 gene and postmenopausal breast cancer risk: the Multiethnic Cohort Study Cancer Epidemiol Biomarkers Prev. 2004 Mar; 13(3):412-5. . View in PubMed

Genetic variation in angiotensin I-converting enzyme (ACE) and breast cancer risk: the multiethnic cohort Cancer Res. 2003 Oct 15; 63(20):6984-7. . View in PubMed

A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort Hum Mol Genet. 2003 Oct 15; 12(20):2679-92. . View in PubMed

The relationship between twenty missense ATM variants and breast cancer risk: the Multiethnic Cohort Cancer Epidemiol Biomarkers Prev. 2003 Aug; 12(8):733-8. . View in PubMed

Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study Hum Hered. 2003; 55(1):27-36. . View in PubMed

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Dinucleotide repeat in the insulin-like growth factor-I gene is not related to risk of colorectal adenoma Cancer Epidemiol Biomarkers Prev. 2002 Nov; 11(11):1509-10. . View in PubMed

A sequence repeat in the insulin-like growth factor-1 gene and risk of breast cancer Int J Cancer. 2002 Jul 20; 100(3):332-6. . View in PubMed

The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study Cancer Res. 2002 Feb 15; 62(4):1045-9. . View in PubMed

No association between a single nucleotide polymorphism in CYP19 and breast cancer risk Cancer Epidemiol Biomarkers Prev. 2002 Feb; 11(2):215-6. . View in PubMed

Ethnic differences in ovulatory function in nulliparous women Br J Cancer. 2002 Feb 01; 86(3):367-71. . View in PubMed

Genetic determinants of mammographic density Breast Cancer Res. 2002; 4(3):R5. . View in PubMed

The relationship between a polymorphism in CYP17 with plasma hormone levels and prostate cancer Cancer Epidemiol Biomarkers Prev. 2001 Jul; 10(7):743-8. . View in PubMed

Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels Cancer Epidemiol Biomarkers Prev. 2001 Jun; 10(6):711-4. . View in PubMed

A polymorphism in CYP17 and endometrial cancer risk Cancer Res. 2001 May 15; 61(10):3955-60. . View in PubMed

Early, non-psychotic deviant behavior in schizophrenia: a possible endophenotypic marker for genetic studies Psychiatry Res. 2001 Mar 25; 101(2):101-13. . View in PubMed

A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk Int J Cancer. 2000 Jul 15; 87(2):204-10. . View in PubMed

Polymorphic repeat in AIB1 does not alter breast cancer risk Breast Cancer Res. 2000; 2(5):378-85. . View in PubMed

Evidence of a schizotypy subtype in OCD J Psychiatr Res. 2000 Jan-Feb; 34(1):15-24. . View in PubMed

Phenotypic characteristics of Obsessive-Compulsive Disorder ascertained in adulthood J Psychiatr Res. 1999 May-Jun; 33(3):265-73. . View in PubMed

Binge eating before the onset of dieting: a distinct subgroup of bulimia nervosa? Int J Eat Disord. 1999 Mar; 25(2):151-7.. View in PubMed

The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer Cancer Res. 1999 Mar 01; 59(5):1015-20. . View in PubMed

Glutathione S-transferase GSTM1 and GSTT1 polymorphisms and colorectal cancer risk: a prospective study Cancer Epidemiol Biomarkers Prev. 1998 Nov; 7(11):1001-5. . View in PubMed

Does fluoxetine augment the inpatient treatment of anorexia nervosa? Am J Psychiatry. 1998 Apr; 155(4):548-51.. View in PubMed

Christopher Haiman, ScD, is a professor of preventive medicine at the Keck School of Medicine of USC and AFLAC Chair in Cancer Research. He also leads the Cancer Epidemiology Program at USC Norris Comprehensive Cancer Center and the Epidemiology and Genetics division in the Department of Preventive Medicine. Dr. Haiman is a genetic epidemiologist whose research is focused on exploring racial and ethnic disparities in cancer risk, with the goal of developing approaches to reduce these disparities. He is co-principal investigator of the Multiethnic Cohort (MEC), a large prospective study of cancer in primarily non-European ancestry populations (n>215,000) that has been the foundation of his scientific investigation into the genetic risk of cancer, initially through genome-wide association studies (GWAS) and more recently in large-scale genomic consortia in minority populations that employ next-generation sequencing technology. In addition to these leadership and administrative research positions, he has vast experience in directing large consortia and is currently the scientific leader of the African Ancestry Prostate Cancer Consortium (AAPC). He has also served as a steering committee member for numerous NIH consortia, including the NCI GAME-ON Consortium, NHGRI Population Architecture Using Genomics and Epidemiology Consortium (PAGE), NHGRI Gene Environment Association Studies (GENEVA) Consortium and the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). He is also the principal investigator of the RESPOND African-American prostate cancer initiative. He has co-authored more than 450 peer-reviewed publications, with many in prominent journals, including Nature Genetics, The New England Journal of Medicine and Journal of the National Cancer Institute.
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