Keck School Faculty

Christopher Haiman, ScD
Christopher Haiman, ScD
Professor of Preventive Medicine;AFLAC Chair in Cancer Research
Cancer Center
NRT 1504 1450 Biggy St. Health Sciences Campus Los Angeles
Christopher Haiman, ScD, is a professor of preventive medicine at the Keck School of Medicine of USC and AFLAC Chair in Cancer Research. He also leads the Cancer Epidemiology Program at USC Norris Comprehensive Cancer Center and the Epidemiology and Genetics division in the Department of Preventive Medicine. Dr. Haiman is a genetic epidemiologist whose research is focused on exploring racial and ethnic disparities in cancer risk, with the goal of developing approaches to reduce these disparities. He is co-principal investigator of the Multiethnic Cohort (MEC), a large prospective study of cancer in primarily non-European ancestry populations (n>215,000) that has been the foundation of his scientific investigation into the genetic risk of cancer, initially through genome-wide association studies (GWAS) and more recently in large-scale genomic consortia in minority populations that employ next-generation sequencing technology. In addition to these leadership and administrative research positions, he has vast experience in directing large consortia and is currently the scientific leader of the African Ancestry Prostate Cancer Consortium (AAPC). He has also served as a steering committee member for numerous NIH consortia, including the NCI GAME-ON Consortium, NHGRI Population Architecture Using Genomics and Epidemiology Consortium (PAGE), NHGRI Gene Environment Association Studies (GENEVA) Consortium and the NCI Breast and Prostate Cancer Cohort Consortium (BPC3). He is also the principal investigator of the RESPOND African-American prostate cancer initiative. He has co-authored more than 450 peer-reviewed publications, with many in prominent journals, including Nature Genetics, The New England Journal of Medicine and Journal of the National Cancer Institute.

Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry Nat Commun. 2019 Jan 17; 10(1):382. . View in PubMed

Author Correction: Large-scale transcriptome-wide association study identifies new prostate cancer risk regions Nat Commun. 2019 Jan 08; 10(1):171. . View in PubMed

Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2019 Jan 08. . View in PubMed

Association of Hypothyroidism With Nonmelanoma Skin Cancer in the Multiethnic Cohort Population-Based Study Dermatol Surg. 2019 Jan; 45(1):154-158. . View in PubMed

A Collaborative Analysis of Individual Participant Data from 19 Prospective Studies Assesses Circulating Vitamin D and Prostate Cancer Risk Cancer Res. 2019 Jan 01; 79(1):274-285. . View in PubMed

Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study Am J Epidemiol. 2019 Jan 01; 188(1):67-76. . View in PubMed

Agnostic Pathway/Gene Set Analysis of Genome-Wide Association Data Identifies Associations for Pancreatic Cancer J Natl Cancer Inst. 2018 Dec 12. . View in PubMed

A collaborative analysis of individual participant data from 19 prospective studies assesses circulating vitamin D and prostate cancer risk Cancer Res. 2018 Nov 13. . View in PubMed

Antibody Responses to Streptococcus Gallolyticus Subspecies Gallolyticus Proteins in a Large Prospective Colorectal Cancer Cohort Consortium Cancer Epidemiol Biomarkers Prev. 2018 Oct; 27(10):1186-1194. . View in PubMed

Association of Hypothyroidism With Nonmelanoma Skin Cancer in the Multiethnic Cohort Population-Based Study Dermatol Surg. 2018 Sep 24. . View in PubMed

Alcohol Intake and Colorectal Cancer Risk in the Multiethnic Cohort Study Am J Epidemiol. 2018 Sep 15. . View in PubMed

Antibody responses to Streptococcus gallolyticus subspecies gallolyticus proteins in a large prospective colorectal cancer cohort consortium Cancer Epidemiol Biomarkers Prev. 2018 Jul 23. . View in PubMed

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer Nat Genet. 2018 Jul; 50(7):968-978. . View in PubMed

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2018 Jul; 50(7):928-936. . View in PubMed

A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer Nat Genet. 2018 Jun 18. . View in PubMed

Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci Nat Genet. 2018 Jun 11. . View in PubMed

A survey of microRNA single nucleotide polymorphisms identifies novel breast cancer susceptibility loci in a case-control, population-based study of African-American women Breast Cancer Res. 2018 Jun 05; 20(1):45. . View in PubMed

Atopic allergic conditions and pancreatic cancer risk: Results from the Multiethnic Cohort Study Int J Cancer. 2018 May 15; 142(10):2019-2027. . View in PubMed

A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium Int J Cancer. 2018 Mar 15; 142(6):1182-1188. . View in PubMed

A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer: Results from the Breast and Prostate Cancer Cohort Consortium Int J Cancer. 2018 03 15; 142(6):1182-1188. . View in PubMed

Atopic allergic conditions and pancreatic cancer risk: Results from the Multiethnic Cohort Study Int J Cancer. 2018 05 15; 142(10):2019-2027. . View in PubMed

Body mass index and breast cancer survival: a Mendelian randomization analysis Int J Epidemiol. 2017 Dec 01; 46(6):1814-1822. . View in PubMed

Association of Coffee Consumption With Total and Cause-Specific Mortality Among Nonwhite Populations Ann Intern Med. 2017 Aug 15; 167(4):228-235. . View in PubMed

A priori-defined diet quality indices, biomarkers and risk for type 2 diabetes in five ethnic groups: the Multiethnic Cohort Br J Nutr. 2017 Aug; 118(4):312-320. . View in PubMed

BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer Cancer Res. 2017 06 01; 77(11):2789-2799. . View in PubMed

Body mass index and breast cancer survival: a Mendelian randomization analysis Int J Epidemiol. 2017 12 01; 46(6):1814-1822. . View in PubMed

A functionally significant SNP in TP53 and breast cancer risk in African-American women NPJ Breast Cancer. 2017; 3:5. . View in PubMed

Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study Int J Cancer. 2017 Jan 01; 140(1):75-85. . View in PubMed

Association analysis identifies 65 new breast cancer risk loci Nature. 2017 11 02; 551(7678):92-94. . View in PubMed

Association of breast cancer risk with genetic variants showing differential allelic expression: Identification of a novel breast cancer susceptibility locus at 4q21 Oncotarget. 2016 Dec 06; 7(49):80140-80163. . View in PubMed

Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States JAMA Oncol. 2016 Oct 01; 2(10):1295-1302. . View in PubMed

Association between Adult Height and Risk of Colorectal, Lung, and Prostate Cancer: Results from Meta-analyses of Prospective Studies and Mendelian Randomization Analyses PLoS Med. 2016 Sep; 13(9):e1002118. . View in PubMed

Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry Cancer Causes Control. 2016 May; 27(5):679-93. . View in PubMed

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation Nat Commun. 2016 Apr 07; 7:10979. . View in PubMed

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 Nat Genet. 2016 Apr; 48(4):374-86. . View in PubMed

BRCA2 Polymorphic Stop Codon K3326X and the Risk of Breast, Prostate, and Ovarian Cancers J Natl Cancer Inst. 2016 Feb; 108(2). . View in PubMed

A Meta-analysis of Multiple Myeloma Risk Regions in African and European Ancestry Populations Identifies Putatively Functional Loci Cancer Epidemiol Biomarkers Prev. 2016 12; 25(12):1609-1618. . View in PubMed

An exome-wide analysis of low frequency and rare variants in relation to risk of breast cancer in African American Women: the AMBER Consortium Carcinogenesis. 2016 09; 37(9):870-877. . View in PubMed

A case-control analysis of smoking and breast cancer in African American women: findings from the AMBER Consortium Carcinogenesis. 2016 06; 37(6):607-15. . View in PubMed

Blood lipids and prostate cancer: a Mendelian randomization analysis Cancer Med. 2016 06; 5(6):1125-36. . View in PubMed

Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: Genetic variants as instruments for circulating levels Int J Cancer. 2016 10 01; 139(7):1520-33. . View in PubMed

Admixture Mapping of African-American Women in the AMBER Consortium Identifies New Loci for Breast Cancer and Estrogen-Receptor Subtypes Front Genet. 2016; 7:170. . View in PubMed

An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression Hum Mol Genet. 2016 09 01; 25(17):3863-3876. . View in PubMed

Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort PLoS One. 2016; 11(3):e0150641. . View in PubMed

Association of breast cancer risk loci with breast cancer survival Int J Cancer. 2015 Dec 15; 137(12):2837-45. . View in PubMed

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types J Natl Cancer Inst. 2015 Dec; 107(12):djv279. . View in PubMed

Associations Between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study Am J Epidemiol. 2015 Dec 01; 182(11):945-51. . View in PubMed

CAUSEL: an epigenome- and genome-editing pipeline for establishing function of noncoding GWAS variants Nat Med. 2015 Nov; 21(11):1357-63. . View in PubMed

ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3) Prostate. 2015 Nov; 75(15):1677-81. . View in PubMed

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density Breast Cancer Res. 2015 Aug 16; 17:110. . View in PubMed

A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences Cancer Discov. 2015 Aug; 5(8):878-91. . View in PubMed

Atopic allergic conditions and colorectal cancer risk in the Multiethnic Cohort Study Am J Epidemiol. 2015 Jun 01; 181(11):889-97. . View in PubMed

A genome-wide pleiotropy scan for prostate cancer risk Eur Urol. 2015 Apr; 67(4):649-57. . View in PubMed

A Large-Scale Analysis of Genetic Variants within Putative miRNA Binding Sites in Prostate Cancer Cancer Discov. 2015 Apr; 5(4):368-79. . View in PubMed

Association of Genes, Pathways, and Haplogroups of the Mitochondrial Genome with the Risk of Colorectal Cancer: The Multiethnic Cohort PLoS One. 2015; 10(9):e0136796. . View in PubMed

Body Mass Index Genetic Risk Score and Endometrial Cancer Risk PLoS One. 2015; 10(11):e0143256. . View in PubMed

Age-related clonal hematopoiesis associated with adverse outcomes N Engl J Med. 2014 Dec 25; 371(26):2488-98. . View in PubMed

8q24 risk alleles and prostate cancer in African-Barbadian men Prostate. 2014 Dec; 74(16):1579-88. . View in PubMed

Additive interactions between susceptibility single-nucleotide polymorphisms identified in genome-wide association studies and breast cancer risk factors in the Breast and Prostate Cancer Cohort Consortium Am J Epidemiol. 2014 Nov 15; 180(10):1018-27. . View in PubMed

Association of cancer susceptibility variants with risk of multiple primary cancers: The population architecture using genomics and epidemiology study Cancer Epidemiol Biomarkers Prev. 2014 Nov; 23(11):2568-78. . View in PubMed

A comprehensive examination of breast cancer risk loci in African American women Hum Mol Genet. 2014 Oct 15; 23(20):5518-26. . View in PubMed

A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer Nat Genet. 2014 Oct; 46(10):1103-9. . View in PubMed

2q363 is associated with prognosis for oestrogen receptor-negative breast cancer patients treated with chemotherapy. Nat Commun. 2014 Jun 17; 5:4051. . View in PubMed

Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population JAMA. 2014 Jun 11; 311(22):2305-14. . View in PubMed

A genome-wide association study of prostate cancer in West African men Hum Genet. 2014 May; 133(5):509-21. . View in PubMed

A large-scale assessment of two-way SNP interactions in breast cancer susceptibility using 46,450 cases and 42,461 controls from the breast cancer association consortium Hum Mol Genet. 2014 Apr 01; 23(7):1934-46. . View in PubMed

A genome-wide "pleiotropy scan" does not identify new susceptibility loci for estrogen receptor negative breast cancer PLoS One. 2014; 9(2):e85955. . View in PubMed

Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study Am J Epidemiol. 2013 Sep 01; 178(5):780-90. . View in PubMed

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry Nat Genet. 2013 Jun; 45(6):690-6. . View in PubMed

Analysis of Latino populations from GALA and MEC studies reveals genomic loci with biased local ancestry estimation Bioinformatics. 2013 Jun 01; 29(11):1407-15. . View in PubMed

A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease Hum Mol Genet. 2013 Jan 15; 22(2):408-15. . View in PubMed

A genome-wide scan for breast cancer risk haplotypes among African American women PLoS One. 2013; 8(2):e57298. . View in PubMed

A systematic mapping approach of 16q122/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet. 2013; 9(1):e1003171. . View in PubMed

A genome-wide association study of breast cancer in women of African ancestry Hum Genet. 2013 Jan; 132(1):39-48. . View in PubMed

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11 Hum Mol Genet. 2012 Dec 15; 21(24):5373-84. . View in PubMed

Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium Am J Epidemiol. 2012 Dec 15; 176(12):1121-9. . View in PubMed

Analysis of case-control association studies with known risk variants Bioinformatics. 2012 Jul 01; 28(13):1729-37. . View in PubMed

Admixture mapping identifies a locus on 6q25 associated with breast cancer risk in US Latinas Hum Mol Genet. 2012 Apr 15; 21(8):1907-17. . View in PubMed

A review of cancer in US. Hispanic populations. Cancer Prev Res (Phila). 2012 Feb; 5(2):150-63. . View in PubMed

African ancestry and its correlation to type 2 diabetes in African Americans: a genetic admixture analysis in three US. population cohorts. PLoS One. 2012; 7(3):e32840. . View in PubMed

A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer Nat Genet. 2011 Oct 30; 43(12):1210-4. . View in PubMed

Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies J Natl Cancer Inst. 2011 Feb 02; 103(3):250-63. . View in PubMed

A common prostate cancer risk variant 5' of microseminoprotein-beta (MSMB) is a strong predictor of circulating beta-microseminoprotein (MSP) levels in multiple populations Cancer Epidemiol Biomarkers Prev. 2010 Oct; 19(10):2639-46. . View in PubMed

A large study of androgen receptor germline variants and their relation to sex hormone levels and prostate cancer riskResults from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium. J Clin Endocrinol Metab. 2010 Sep; 95(9):E121-7. . View in PubMed

A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians Hum Mol Genet. 2010 Aug 01; 19(15):3089-101. . View in PubMed

A systematic approach to understand the functional consequences of non-protein coding risk regions Cell Cycle. 2010 Jan 15; 9(2):256-9. . View in PubMed

An admixture scan in 1,484 African American women with breast cancer Cancer Epidemiol Biomarkers Prev. 2009 Nov; 18(11):3110-7. . View in PubMed

Admixture mapping of 15,280 African Americans identifies obesity susceptibility loci on chromosomes 5 and X PLoS Genet. 2009 May; 5(5):e1000490. . View in PubMed

Association of diabetes with prostate cancer risk in the multiethnic cohort Am J Epidemiol. 2009 Apr 15; 169(8):937-45. . View in PubMed

Association of ESR1 gene tagging SNPs with breast cancer risk Hum Mol Genet. 2009 Mar 15; 18(6):1131-9. . View in PubMed

Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort Breast Cancer Res. 2009; 11(1):R10. . View in PubMed

A promoter polymorphism in the CASP8 gene is not associated with cancer risk Nat Genet. 2008 Mar; 40(3):259-60; author reply 260-1. . View in PubMed

A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the multiethnic cohort BMC Med Genet. 2007 Dec 01; 8:72. . View in PubMed

A high-density admixture scan in 1,670 African Americans with hypertension PLoS Genet. 2007 Nov; 3(11):e196. . View in PubMed

Association of methylenetetrahydrofolate reductase gene polymorphisms and sex-specific survival in patients with metastatic colon cancer J Clin Oncol. 2007 Aug 20; 25(24):3726-31. . View in PubMed

A common genetic risk factor for colorectal and prostate cancer Nat Genet. 2007 Aug; 39(8):954-6. . View in PubMed

A genomewide admixture map for Latino populations Am J Hum Genet. 2007 Jun; 80(6):1024-36. . View in PubMed

A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans Cancer Res. 2007 Apr 15; 67(8):3565-8. . View in PubMed

A common 8q24 variant in prostate and breast cancer from a large nested case-control study Cancer Res. 2007 Apr 01; 67(7):2951-6. . View in PubMed

A systematic assessment of common genetic variation in CYP11A and risk of breast cancer Cancer Res. 2006 Dec 15; 66(24):12019-25. . View in PubMed

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men Proc Natl Acad Sci U S A. 2006 Sep 19; 103(38):14068-73. . View in PubMed

A comprehensive analysis of the androgen receptor gene and risk of breast cancer: results from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3) Breast Cancer Res. 2006; 8(5):R54. . View in PubMed

A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk Cancer Res. 2005 Aug 15; 65(16):7516-22. . View in PubMed

A candidate gene approach to searching for low-penetrance breast and prostate cancer genes Nat Rev Cancer. 2005 12; 5(12):977-85. . View in PubMed

A comprehensive haplotype analysis of CYP19 and breast cancer risk: the Multiethnic Cohort Hum Mol Genet. 2003 Oct 15; 12(20):2679-92. . View in PubMed

A sequence repeat in the insulin-like growth factor-1 gene and risk of breast cancer Int J Cancer. 2002 Jul 20; 100(3):332-6. . View in PubMed

Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels Cancer Epidemiol Biomarkers Prev. 2001 Jun; 10(6):711-4. . View in PubMed

A polymorphism in CYP17 and endometrial cancer risk Cancer Res. 2001 May 15; 61(10):3955-60. . View in PubMed

A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk Int J Cancer. 2000 Jul 15; 87(2):204-10. . View in PubMed

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