Christopher P. Gayer, MD, PhD

Associate Professor of Clinical Surgery

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I am interested in bile acid metabolism and how specific bile acid receptors, such as FXR, influence the intestinal epithelial barrier in injury models


  • FXR Deletion Attenuates Intestinal Barrier Dysfunction in Murine Acute Intestinal Inflammation Am J Physiol Gastrointest Liver Physiol. 2024 Jun 11. . View in PubMed
  • Utility of colonic manometry in children with Hirschsprung disease J Pediatr Gastroenterol Nutr. 2024 Jun; 78(6):1217-1224. . View in PubMed
  • Clinical Characteristics of Avoidable Patient Transfers for Suspected Pediatric Appendicitis J Surg Res. 2024 May 24; 300:54-62. . View in PubMed
  • A Standardized Post-gastrostomy Feeding Protocol for Pediatric Patients Reduces Time to Postoperative Goal Feeding Volume Am Surg. 2024 Apr 29; 31348241248789. . View in PubMed
  • Evaluation of Postoperative Outcomes After Enterostomy Closure in Low Body Weight Infants: A Multi-Center Retrospective Analysis Am Surg. 2024 Apr 22; 31348241248788. . View in PubMed
  • Primary Adrenal Malignant Rhabdoid Tumor in a 14-Year-Old Female: A Case Report and Literature Review Int J Surg Pathol. 2022 Apr; 30(2):172-176. . View in PubMed
  • Children with large primary spontaneous pneumothoraxes may benefit from early operative intervention Pediatr Surg Int. 2022 Mar; 38(3):423-429. . View in PubMed
  • Decreased secondary faecal bile acids in children with ulcerative colitis and Clostridioides difficile infection Aliment Pharmacol Ther. 2021 09; 54(6):792-804. . View in PubMed
  • The Pathophysiology of Farnesoid X Receptor (FXR) in the GI Tract: Inflammation, Barrier Function and Innate Immunity Cells. 2021 11 17; 10(11). . View in PubMed
  • The value of prophylactic chest tubes in tracheoesophageal fistula repair Pediatr Surg Int. 2020 Jun; 36(6):687-696. . View in PubMed
  • EP2 Receptor Blockade Attenuates COX-2 Upregulation During Intestinal Inflammation Shock. 2020 09; 54(3):394-401. . View in PubMed
  • Serum bile acids profiling by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and its application on pediatric liver and intestinal diseases Clin Chem Lab Med. 2020 04 28; 58(5):787-797. . View in PubMed
  • Differences in Serum Alkaline Phosphatase Levels in Infants with Spontaneous Intestinal Perforation versus Necrotizing Enterocolitis with Perforation Neonatology. 2020; 117(3):349-357. . View in PubMed
  • Screening for blunt cerebrovascular injuries in pediatric trauma patients J Pediatr Surg. 2019 Sep; 54(9):1861-1865. . View in PubMed
  • Variability in perioperative evaluation and resource utilization in pediatric patients with suspected biliary dyskinesia: A multi-institutional retrospective cohort study J Pediatr Surg. 2019 Jun; 54(6):1118-1122. . View in PubMed
  • Pilot Study of the Effect of Plant-Based Enteral Nutrition on the Gut Microbiota in Chronically Ill Tube-Fed Children JPEN J Parenter Enteral Nutr. 2019 09; 43(7):899-911. . View in PubMed
  • Closing gastroschisis: The good, the bad, and the not-so ugly J Pediatr Surg. 2019 Jan; 54(1):60-64. . View in PubMed
  • Effects of artificially introduced Enterococcus faecalis strains in experimental necrotizing enterocolitis PLoS One. 2019; 14(11):e0216762. . View in PubMed
  • Soybean-derived recombinant human epidermal growth factor protects against experimental necrotizing enterocolitis J Pediatr Surg. 2018 Jun; 53(6):1203-1207. . View in PubMed
  • Liquid chromatography-mass spectroscopy in the diagnosis of biliary atresia in children with hyperbilirubinemia J Surg Res. 2018 08; 228:228-237. . View in PubMed
  • Ursodeoxycholic acid protects against intestinal barrier breakdown by promoting enterocyte migration via EGFR- and COX-2-dependent mechanisms Am J Physiol Gastrointest Liver Physiol. 2018 08 01; 315(2):G259-G271. . View in PubMed
  • Lactobacillus murinus HF12 colonizes neonatal gut and protects rats from necrotizing enterocolitis PLoS One. 2018; 13(6):e0196710. . View in PubMed
  • Hospital admission unnecessary for successful uncomplicated radiographic reduction of pediatric intussusception Am J Surg. 2017 Dec; 214(6):1203-1207. . View in PubMed
  • Advances in paediatric gastroenterology Lancet. 2017 Sep 09; 390(10099):1072-1082. . View in PubMed
  • Routine post-operative esophagram Is not necessary after repair of esophageal atresia Am J Surg. 2017 Apr; 213(4):640-644. . View in PubMed
  • Re-evaluation of liver transaminase cutoff for CT after pediatric blunt abdominal trauma Pediatr Surg Int. 2017 Mar; 33(3):311-316. . View in PubMed
  • Discussion of: “Hospital admission unnecessary for successful uncomplicated radiographic reduction of pediatric intussusception” Am J Surg. 2017 12; 214(6):1208-1209. . View in PubMed
  • Liquid chromatography-mass spectroscopy as a tool in the rapid diagnosis of biliary atresia: a pilot study J Pediatr Surg. 2016 Jun; 51(6):923-6. . View in PubMed
  • An ectopic renin-secreting adrenal corticoadenoma in a child with malignant hypertension Physiol Rep. 2016 Mar; 4(5). . View in PubMed
  • Bile acids regulate intestinal cell proliferation by modulating EGFR and FXR signaling Am J Physiol Gastrointest Liver Physiol. 2016 Jan 15; 310(2):G81-92. . View in PubMed
  • Liver steatosis induced by small bowel resection is prevented by oral vancomycin Surgery. 2016 12; 160(6):1485-1495. . View in PubMed
  • Limiting chest computed tomography in the evaluation of pediatric thoracic trauma J Trauma Acute Care Surg. 2016 08; 81(2):271-7. . View in PubMed
  • Admission hematocrit predicts the need for transfusion secondary to hemorrhage in pediatric blunt trauma patients J Trauma Acute Care Surg. 2015 Oct; 79(4):555-62. . View in PubMed
  • Images in clinical medicineGastric emphysema. N Engl J Med. 2014 May 29; 370(22):e33. . View in PubMed
  • Recent developments in Hirschsprung’s-associated enterocolitis Curr Gastroenterol Rep. 2013 Aug; 15(8):340. . View in PubMed
  • Necrotizing enterocolitis: contemporary management and outcomes Adv Pediatr. 2013; 60(1):263-79. . View in PubMed
  • Isolated ruptured appendicitis presenting as pneumatosis intestinalis in a premature neonate Pediatr Surg Int. 2012 Apr; 28(4):439-41. . View in PubMed
  • Combined endoscopic and laparoscopic approach to a gastroesophageal tumor JSLS. 2011 Apr-Jun; 15(2):228-31. . View in PubMed
  • ERK regulates strain-induced migration and proliferation from different subcellular locations J Cell Biochem. 2010 Mar 01; 109(4):711-25. . View in PubMed
  • Acute lower gastrointestinal bleeding in 1,112 patients admitted to an urban emergency medical center Surgery. 2009 Oct; 146(4):600-6; discussion 606-7. . View in PubMed
  • The effects of increased extracellular deformation, pressure, and integrin phosphorylation on fibroblast migration J Surg Res. 2009 Sep; 156(1):103-9. . View in PubMed
  • The effects of mechanical forces on intestinal physiology and pathology Cell Signal. 2009 Aug; 21(8):1237-44. . View in PubMed
  • Delineating the signals by which repetitive deformation stimulates intestinal epithelial migration across fibronectin Am J Physiol Gastrointest Liver Physiol. 2009 Apr; 296(4):G876-85. . View in PubMed
  • Strain-induced proliferation requires the phosphatidylinositol 3-kinase/AKT/glycogen synthase kinase pathway J Biol Chem. 2009 Jan 23; 284(4):2001-11. . View in PubMed
  • Increased extracellular pressure enhances cancer cell integrin-binding affinity through phosphorylation of beta1-integrin at threonine 788/789 Am J Physiol Cell Physiol. 2009 Jan; 296(1):C193-204. . View in PubMed
  • Supraphysiologic extracellular pressure inhibits intestinal epithelial wound healing independently of luminal nutrient flow Am J Surg. 2008 Nov; 196(5):683-9. . View in PubMed
  • Repetitive deformation activates Src-independent FAK-dependent ERK motogenic signals in human Caco-2 intestinal epithelial cells Am J Physiol Cell Physiol. 2008 Jun; 294(6):C1350-61. . View in PubMed
  • Clinical evaluation and management of caustic injury in the upper gastrointestinal tract in 95 adult patients in an urban medical center Surg Endosc. 2008 Apr; 22(4):1119-25. . View in PubMed