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Clay C. C. Wang, PhD

Professor of Pharmacology & Pharmaceutical Sciences and Department Chair

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Phone +1 323 442 1670
Email [email protected]
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Education and Training

  • Harvard College, Cambridge, MA — AB — 1996 — Chemistry
  • California Institute of Technology, Pasadena, CA — PhD — 2001 — Chemistry
  • Stanford University, Stanford, CA — 2003 — Chemistry & Chemical Engineering

Research Funding

  • Exploiting interspecies/interkingdom communication for the discovery and development of novel natural products antifungal therapeutics
    NIH · R21AI127640 · Dec 9, 2016 – Nov 30, 2019 · Role: Principal Investigator
  • Platforms for nonribosomal peptide manipulation (RMI)
    NIH · R01GM075857 · Sep 23, 2005 – Jul 31, 2009 · Role: Principal Investigator
  • Probing the Substrate Specificity of Polyketide Synthase
    NIH · F32GM065035 · Feb 4, 2002 · Role: Principal Investigator

Publications

  • Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi. Methods Enzymol. 2012; 517:303-24.. View in PubMed
  • The chemical identification and analysis of Aspergillus nidulans secondary metabolites. Methods Mol Biol. 2012; 944:97-109.. View in PubMed
  • Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells. PLoS One. 2011; 6(12):e28977.. View in PubMed
  • Engineering of an “unnatural” natural product by swapping polyketide synthase domains in Aspergillus nidulans. J Am Chem Soc. 2011 Aug 31; 133(34):13314-6.. View in PubMed
  • High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. Mol Cell Biol. 2011 Jul; 31(13):2605-17.. View in PubMed
  • Cryptic Aspergillus nidulans antimicrobials. Appl Environ Microbiol. 2011 Jun; 77(11):3669-75.. View in PubMed
  • Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans. J Am Chem Soc. 2011 Mar 23; 133(11):4010-7.. View in PubMed
  • Characterization of a polyketide synthase in Aspergillus niger whose product is a precursor for both dihydroxynaphthalene (DHN) melanin and naphtho-γ-pyrone. Fungal Genet Biol. 2011 Apr; 48(4):430-7.. View in PubMed
  • Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr Opin Chem Biol. 2011 Feb; 15(1):137-43.. View in PubMed
  • Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans. Microbiology (Reading). 2010 Dec; 156(Pt 12):3522-3531.. View in PubMed

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