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Clay C. C. Wang, PhD

Professor of Pharmacology & Pharmaceutical Sciences and Department Chair

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Phone +1 323 442 1670
Email [email protected]
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Education and Training

  • Harvard College, Cambridge, MA — AB — 1996 — Chemistry
  • California Institute of Technology, Pasadena, CA — PhD — 2001 — Chemistry
  • Stanford University, Stanford, CA — 2003 — Chemistry & Chemical Engineering

Research Funding

  • Exploiting interspecies/interkingdom communication for the discovery and development of novel natural products antifungal therapeutics
    NIH · R21AI127640 · Dec 9, 2016 – Nov 30, 2019 · Role: Principal Investigator
  • Platforms for nonribosomal peptide manipulation (RMI)
    NIH · R01GM075857 · Sep 23, 2005 – Jul 31, 2009 · Role: Principal Investigator
  • Probing the Substrate Specificity of Polyketide Synthase
    NIH · F32GM065035 · Feb 4, 2002 · Role: Principal Investigator

Publications

  • Activation of secondary metabolism in Aspergillus and related filamentous fungi through regulatory engineering. RSC Chem Biol. 2026 Sep 02; 7(9):1669-1686.. View in PubMed
  • Discovery of a dimeric isopimarane derivative by reexploring a labdane-related diterpenoid biosynthetic gene cluster in Aspergillus nidulans. Microb Cell Fact. 2026 Jul 13.. View in PubMed
  • Correction: Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s disease. Chem Sci. 2026 Jul 08; 17(26):13212.. View in PubMed
  • Manipulation of Global Regulator mcrA Activates the Fumigermin Pathway in Penicillium camemberti IMV00769. ACS Chem Biol. 2026 03 20; 21(3):558-564.. View in PubMed
  • Activation of the Trichodimerol Pathway through Deletion of mcrA in Marine Penicillium rubens YAP001. ACS Chem Biol. 2025 04 18; 20(4):823-829.. View in PubMed
  • Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s disease. Chem Sci. 2024 Dec 11; 15(48):20467-20477.. View in PubMed
  • Discovery of PARP1-Sparing Inhibitors for Protein ADP-Ribosylation. ACS Med Chem Lett. 2024 Nov 14; 15(11):1940-1946.. View in PubMed
  • Composite Recycling with Biocatalytic Thermoset Reforming. J Am Chem Soc. 2024 Nov 06; 146(44):30004-30008.. View in PubMed
  • Transcription Factor Engineering in Aspergillus nidulans Leads to the Discovery of an Orsellinaldehyde Derivative Produced via an Unlinked Polyketide Synthase Gene. J Nat Prod. 2024 10 25; 87(10):2384-2392.. View in PubMed
  • Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System. J Nat Prod. 2024 07 26; 87(7):1704-1713.. View in PubMed

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