Darryl Shibata, MD

Professor of Pathology

Vice Chair of Academic Affairs, Department of Pathology,

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Overview

After attending UCLA for his undergraduate degree, Dr. Shibata obtained his medical degree from the Keck School of Medicine of USC. After completing his internship training in pediatrics from UC San Diego, Dr. Shibata returned to USC for his residency and fellowship at LAC+USC Medical Center. Currently, Dr. Shibata has clinical appointments at both LAC+USC Medical Center and USC/Norris Comprehensive Cancer Center. In addition to his wide array of responsibilities in the research, education and practitioner capacities, Dr. Shibata sits on the editorial board of the BMC Cancer Journal and the American Journal of Pathology.

Research Funding

  • Photolithographic Tumor DNA Isolation
    NIH · R21CA267245 · Jul 22, 2022 – May 31, 2025 · Role: Principal Investigator
  • Arizona Cancer and Evolution Center (ACE)
    NIH · U54CA217376 · Apr 12, 2018 – Mar 31, 2024 · Role: Co-Principal Investigator
  • Born to be Bad: Is Abnormal Cell Mobility Already Present At Initiation?
    NIH · R21CA185016 · Jul 30, 2014 – May 31, 2018 · Role: Principal Investigator
  • How Do NSAIDs Prevent Colorectal Cancer
    NIH · R21CA170814 · Sep 13, 2012 – Aug 31, 2015 · Role: Principal Investigator
  • Tumor Diversity As A Biomarker For Colorectal Cancer
    NIH · R21CA149990 · Apr 1, 2010 – Mar 31, 2014 · Role: Principal Investigator
  • How Do Colorectal Cancers Arise Despite Surveillance?
    NIH · R33CA111940 · Aug 1, 2005 – Jun 30, 2010 · Role: Principal Investigator
  • HUMAN COLON STEM CELL AND CRYPT DYNAMICS
    NIH · R21DK061140 · Sep 30, 2001 – Aug 31, 2005 · Role: Principal Investigator
  • Fixing Fixed DNA
    NIH · R21CA091301 · Jul 1, 2001 – Jun 30, 2004 · Role: Principal Investigator
  • Mouse Models of Early Intestinal Neoplasia
    NIH · R01CA080077 · Jan 1, 1999 – Mar 31, 2010 · Role: Principal Investigator
  • PATHOLOGY OF TUMOR GROWTH
    NIH · R01CA070858 · May 21, 1997 – Apr 30, 2001 · Role: Principal Investigator
  • PATHOLOGY OF TUMOR GROWTH
    NIH · R55CA070858 · Sep 15, 1996 – Apr 30, 1997 · Role: Principal Investigator
  • PATHOLOGY OF GASTRIC CANCER
    NIH · R01CA058704 · Feb 1, 1993 – Jan 31, 1999 · Role: Principal Investigator

Publications

  • Fluctuating DNA methylation tracks cancer evolution at clinical scale. Nature. 2025 09; 645(8081):764-773.. View in PubMed
  • Human brain ancestral barcodes. Elife. 2025 Jun 10; 13.. View in PubMed
  • Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life. Nat Commun. 2024 11 26; 15(1):10268.. View in PubMed
  • Human Brain Ancestral Barcodes. bioRxiv. 2024 Nov 12.. View in PubMed
  • Mapping the Temporal Landscape of Breast Cancer Using Epigenetic Entropy. Res Sq. 2024 Oct 28.. View in PubMed
  • Developmental hematopoietic stem cell variation explains clonal hematopoiesis later in life. bioRxiv. 2024 Mar 05.. View in PubMed
  • Editorial Expression of Concern: Adenomatous polyposis coli (APC) regulates miR17-92 cluster through β-catenin pathway in colorectal cancer. Oncogene. 2024 Mar; 43(11):837.. View in PubMed
  • Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer. Cancers (Basel). 2024 Jan 06; 16(2).. View in PubMed
  • Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development. bioRxiv. 2023 Oct 02.. View in PubMed
  • Testing Adaptive Therapy Protocols using Gemcitabine and Capecitabine on a Mouse Model of Endocrine-Resistant Breast Cancer. bioRxiv. 2023 Sep 22.. View in PubMed