David R. Freyer, DO, MS

Professor of Clinical Pediatrics, Medicine and Population and Public Health Sciences

Image of David R. Freyer, DO, MS
Is this your profile? Click to edit

Overview

David R. Freyer, DO, MS is Professor of Clinical Pediatrics, Medicine, and Population and Public Health Sciences at the Keck School of Medicine, University of Southern California (USC). He currently serves as Director of the Survivorship and Supportive Care Program in the Cancer and Blood Disease Institute at Children’s Hospital Los Angeles (CHLA), and as Director of the Cancer Survivorship Program and Co-Director of the Adolescent and Young Adult (AYA) Cancer Program at the USC Norris Comprehensive Cancer Center. He is founding Co-Director of the Southern California Center for Young Adult Cancer Survivorship Research, now a three-institution, multi-state research collaborative focused on all aspects of young adult cancer survivorship, including health disparities.

Dr. Freyer’s clinical care and research are concentrated in cancer survivorship, cancer control/supportive care, and AYA oncology with interests in treatment-related toxicity, survivorship care transition, cancer care disparities, and patient-reported outcomes. He continues as PI or Co-I on multiple, federally funded grants in these areas. From 2009-2019 he served as Chair of the Children’s Oncology Group (COG) AYA Oncology Discipline Committee and continues as an active investigator in this and other COG committees. In 2018, Dr. Freyer was honored with the Robert M. McAllister Faculty Mentoring Award in the Keck School of Medicine at USC. In 2023, Dr. Freyer received an NCI Director’s Award for his role in developing and implementing AYA clinical trials in the NCI National Clinical Trials Network. For numerous consecutive years, his clinical expertise has been recognized with citations in “Best Doctors in America.” In 2025, Dr. Freyer was ordained a permanent deacon for the Roman Catholic Archdiocese of Los Angeles.

Research Funding

  • Patient Navigation for Improving Transition Success Among Multiply Disadvantaged Young Adult Survivors of Childhood Cancer
    NIH · R01CA303651 · Sep 10, 2025 – Aug 31, 2029 · Role: Principal Investigator
  • Project Milestones: Young Adult Cancer Survivorship
    NIH · R01CA237230 · Jul 1, 2019 – Dec 31, 2024 · Role: Co-Principal Investigator
  • CHANGE OF GRANTEE INSTITUTION: Creating and Validating Child Adverse Event Reporting in Oncology Trials
    NIH · R01CA175759 · Apr 1, 2013 – Mar 31, 2021 · Role: Co-Principal Investigator

Publications

  • Evaluating the use of hierarchical composite endpoints in pediatric cancer supportive care clinical trials: Illustrative examples from two multi-center phase-III randomized clinical trials. medRxiv. 2026 Jan 23.. View in PubMed
  • Survival Outcomes with Guideline-Concordant Pediatric-Inspired Regimens in Adolescent/Young Adult Acute Lymphoblastic Leukemia: Retrospective Real-World Analysis. Drugs Real World Outcomes. 2026 Mar; 13(1):73-84.. View in PubMed
  • Survivorship Care After Childhood Cancer: A Systematic Review of Reported Barriers and Facilitators. Cancer Control. 2025 Jan-Dec; 32:10732748251401263.. View in PubMed
  • Cancer-Related Impacts on Employment and Strategies for Support Among Long-Term Young Adult Survivors of Hematologic Malignancies. JCO Oncol Pract. 2025 Dec 12.. View in PubMed
  • Prevalence and correlates of short and long sleep duration among majority-Hispanic young adult survivors of childhood cancer. J Cancer Surviv. 2025 Dec 12.. View in PubMed
  • Sedentary behavior in children, adolescents, and young adults treated for cancer: A scoping review of health outcomes and interventions. J Cancer Surviv. 2025 Nov 11.. View in PubMed
  • Erratum: Promoting Resilience in Stress Management: A Randomized Controlled Trial of a Novel Psychosocial Intervention for Adolescents and Young Adults With Advanced Cancer. JCO Oncol Pract. 2026 Sep; 22(9):e6.. View in PubMed
  • Secondary Lung Cancer among Survivors of Adolescent and Young Adult Cancer: A Population-Based Study. Cancer Epidemiol Biomarkers Prev. 2025 Sep 02; 34(9):1618-1626.. View in PubMed
  • Factors Associated With Symptom Burden Among Pediatric Patients With Cancer. JCO Oncol Pract. 2026 Jun; 22(6):1087-1095.. View in PubMed
  • Clinical outcomes and interventions related to sedentary behaviours in childhood, adolescent, and young adult cancer patients and survivors: a scoping review protocol. BMJ Open. 2025 Aug 11; 15(8):e100965.. View in PubMed