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Francesca Mariani, PhD

Associate Professor of Stem Cell Biology and Regenerative Medicine

Director for the Stem Cell Biology and Regenerative Medicine Master's Program

Course Director of Stem Cell Biology Regenerative Medicine

Well-being Director, Stem Cell Biology & Regenerative Medicine

Director of Curriculum

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Phone +1 323 442 7855
Email [email protected]
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Overview

Our laboratory studies the development and repair of the mammalian skeleton, with an emphasis on large-scale regeneration of bone and cartilage. To conduct our experiments, we use standard and conditional knock-out techniques in mouse models and in vitro stem and progenitor cell culture.

Publications

  • A reproducible mouse model of TMJ anterior disc displacement. JBMR Plus. 2026 Feb; 10(2):ziag002.. View in PubMed
  • Skeletal Maturity and Age-Related Changes in Immune Cells and Circulatory Factors Impair Large-Scale Bone Regeneration. Aging Cell. 2025 10; 24(10):e70177.. View in PubMed
  • Histological assessment of microtia cartilage, a potential source of autograft tissue in ear reconstruction. J Anat. 2024 08; 245(2):339-345.. View in PubMed
  • A murine model of large-scale bone regeneration reveals a selective requirement for Sonic Hedgehog. NPJ Regen Med. 2022 May 17; 7(1):30.. View in PubMed
  • On the horizon: Hedgehog signaling to heal broken bones. Bone Res. 2022 Feb 15; 10(1):13.. View in PubMed
  • Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis. Ann Rheum Dis. 2020 12; 79(12):1625-1634.. View in PubMed
  • Skeletal stem cells: insights into maintaining and regenerating the skeleton. Development. 2020 03 11; 147(5).. View in PubMed
  • Sox9+ messenger cells orchestrate large-scale skeletal regeneration in the mammalian rib. Elife. 2019 04 15; 8.. View in PubMed
  • The use of commercially available adhesive tapes to preserve cartilage and bone tissue integrity during cryosectioning. Biotechniques. 2018 10; 65(4):191-196.. View in PubMed
  • A minimally sufficient model for rib proximal-distal patterning based on genetic analysis and agent-based simulations. Elife. 2017 10 25; 6.. View in PubMed

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