Keck School Faculty

Frank Attenello

Frank Attenello

Assistant Professor of Clinical Neurological Surgery
Surgery
HCT 1520 San Pablo St Health Sciences Campus Los Angeles

Postpartum venous thromboembolism readmissions in the United StatesAm J Obstet Gynecol. 2018 10; 219(4):401. e1-401. e14. . View in PubMed

Fragmentation of postpartum readmissions in the United StatesAm J Obstet Gynecol. 2020 08; 223(2):252. e1-252. e14. . View in PubMed

Tobacco Use Is Associated With Increased 90-Day Readmission Among Patients Undergoing Surgery for Degenerative Spine Disease Global Spine J. 2022 Jun; 12(5):787-794. . View in PubMed

5-Aminolevulinic acid-enhanced fluorescence-guided treatment of high-grade glioma using angled endoscopic blue light visualization: technical case series with preliminary follow-up J Neurosurg. 2022 Mar 18; 1-9. . View in PubMed

Disparities in the Surgical Treatment of Adult Spine Diseases: A Systematic ReviewWorld Neurosurg. 2022 02; 158:290-304. e1. . View in PubMed

Neuronal exposure induces neurotransmitter signaling and synaptic mediators in tumors early in brain metastasis Neuro Oncol. 2022 06 01; 24(6):914-924. . View in PubMed

Commentary: Robotic-Assisted Digital Exoscope for Resection of Cerebral Metastases: A Case Series Oper Neurosurg (Hagerstown). 2022 04 01; 22(4):e177-e178. . View in PubMed

Readmissions after ventricular shunting in pediatric patients with hydrocephalus: a Nationwide Readmissions Database analysis J Neurosurg Pediatr. 2021 Aug 20; 28(5):553-562. . View in PubMed

Commentary: Infra-Occipital Supra-Tentorial Approach for Resection of Low-Grade Tumor of the Left Lingual Gyrus: 2-Dimensional Operative Video Oper Neurosurg (Hagerstown). 2021 Aug 16; 21(3):E263-E264. . View in PubMed

Utilization of Discarded Surgical Tissue from Ultrasonic Aspirators to Establish Patient-Derived Metastatic Brain Tumor Cells: A Guide from the Operating Room to the Research Laboratory Curr Protoc. 2021 Jun; 1(6):e140. . View in PubMed

Comorbid depression in surgical cancer patients associated with non-routine discharge and readmission Surg Oncol. 2021 Jun; 37:101533. . View in PubMed

Hospital Admissions from the Emergency Department and Subsequent Critical Care Interventions for Influenza during Pregnancy Am J Perinatol. 2021 May 03. . View in PubMed

Risk for postpartum readmissions and associated complications based on maternal age J Matern Fetal Neonatal Med. 2021 May; 34(9):1375-1381. . View in PubMed

Increasing Prevalence of Frailty and Its Association with Readmission and Mortality Among Hospitalized Patients with IBD Dig Dis Sci. 2021 12; 66(12):4178-4190. . View in PubMed

In vivo CRISPR screening for novel noncoding RNA functional targets in glioblastoma models J Neurosci Res. 2021 09; 99(9):2029-2045. . View in PubMed

Evaluating Medicaid expansion benefits for patients with cancer: National Cancer Database analysis and systematic review J Cancer Policy. 2021 09; 29:100292. . View in PubMed

Complementary and Alternative Medicine for the Treatment of Gliomas: Scoping Review of Clinical Studies, Patient Outcomes, and Toxicity Profiles World Neurosurg. 2021 07; 151:e682-e692. . View in PubMed

A Guide to Annotation of Neurosurgical Intraoperative Video for Machine Learning Analysis and Computer Vision World Neurosurg. 2021 06; 150:26-30. . View in PubMed

Tobacco Use Is Associated with Readmission within 90 Days after Craniotomy Clin Neurol Neurosurg. 2021 01; 200:106383. . View in PubMed

Risk Factors for Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage: A Population-Based Study of 8346 Patients World Neurosurg. 2021 01; 145:e233-e241. . View in PubMed

Postpartum Psychiatric Admissions in the United States Am J Perinatol. 2021 01; 38(2):115-121. . View in PubMed

Commentary: Early Experience With Virtual and Synchronized Augmented Reality Platform for Preoperative Planning and Intraoperative Navigation: A Case Series Oper Neurosurg (Hagerstown). 2021 10 13; 21(5):E457-E458. . View in PubMed

Letter to the EditorScoring change for Step 1 of the United States Medical Licensing Examination. J Neurosurg. 2021 01 22; 134(6):2012-2013. . View in PubMed

Postpartum hemorrhage and risk for postpartum readmission J Matern Fetal Neonatal Med. 2021 Jan; 34(2):187-194. . View in PubMed

Commentary: Virtual Reality Surgical Rehearsal and 2-Dimensional Operative Video of a Paramedian Supracerebellar Infratentorial Approach Endoscopic Resection of Pineocytoma: 2-Dimensional Operative Video Oper Neurosurg (Hagerstown). 2021 01 13; 20(2):E161-E162. . View in PubMed

Readmission with venous thromboembolism after surgical treatment by primary cancer site Surg Oncol. 2020 Dec; 35:268-275. . View in PubMed

Rate of Intracranial Hemorrhage After Minor Head Injury Cureus. 2020 Sep 25; 12(9):e10653. . View in PubMed

Comparison of Rates and Outcomes of Readmission to Index vs Non-index Hospitals After Intravenous Thrombolysis in Acute Stroke Patients Cureus. 2020 Jul 01; 12(7):e8952. . View in PubMed

Increased 30-day readmission rate after craniotomy for tumor resection at safety net hospitals in small metropolitan areas J Neurooncol. 2020 May; 148(1):141-154. . View in PubMed

Postpartum length of stay and risk for readmission among women with preeclampsia J Matern Fetal Neonatal Med. 2020 Apr; 33(7):1086-1094. . View in PubMed

HOTAIRM1, an enhancer lncRNA, promotes glioma proliferation by regulating long-range chromatin interactions within HOXA cluster genes Mol Biol Rep. 2020 Apr; 47(4):2723-2733. . View in PubMed

Frequency, predictors, and outcomes of readmission to index versus non-index hospitals after mechanical thrombectomy in patients with ischemic stroke J Neurointerv Surg. 2020 Feb; 12(2):136-141. . View in PubMed

Comorbid depression associated with non-routine discharge following craniotomy for low-grade gliomas and benign tumors - a nationwide readmission database analysis Acta Neurochir (Wien). 2020 11; 162(11):2671-2681. . View in PubMed

Predictors of readmission after craniotomy for meningioma resection: a nationwide readmission database analysis Acta Neurochir (Wien). 2020 11; 162(11):2637-2646. . View in PubMed

Effect of Comorbid Depression on Surgical Outcomes After Craniotomy for Malignant Brain Tumors: A Nationwide Readmission Database Analysis World Neurosurg. 2020 10; 142:e458-e473. . View in PubMed

Identifying Disparities in Care in Treating Glioblastoma: A Retrospective Cohort Study of Patients Treated at a Safety-net Versus Private Hospital Setting World Neurosurg. 2020 05; 137:e213-e220. . View in PubMed

Acute Venous Thromboembolism Risk Highest Within 60 Days After Discharge From the Hospital in Patients With Inflammatory Bowel DiseasesClin Gastroenterol Hepatol. 2020 05; 18(5):1133-1141. e3. . View in PubMed

A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes Genome Res. 2020 02; 30(2):155-163. . View in PubMed

Circulating Tumor Cells Exhibit Metastatic Tropism and Reveal Brain Metastasis Drivers Cancer Discov. 2020 01; 10(1):86-103. . View in PubMed

Risk of Stillbirth after Antepartum Hospitalization for Hypertensive Diseases of Pregnancy Am J Perinatol. 2020 01; 37(1):66-72. . View in PubMed

Epigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma J Clin Invest. 2020 11 02; 130(11):5782-5799. . View in PubMed

Characterizing Cell Stress and GRP78 in Glioma to Enhance Tumor Treatment Front Oncol. 2020; 10:608911. . View in PubMed

Commentary: Mini Fronto-Orbital pproach: "Window Opening" Towards the Superomedial Orbit-A Virtual Reality-Planned Anatomic Study Oper Neurosurg (Hagerstown). 2020 09 01; 19(3):E285-E287. . View in PubMed

Increased complication and mortality among non-index hospital readmissions after brain tumor resection is associated with low-volume readmitting hospitals J Neurosurg. 2019 Oct 04; 1-13. . View in PubMed

Nonindex Readmission After Ruptured Brain Aneurysm Treatment Is Associated with Higher Morbidity and Repeat Readmission World Neurosurg. 2019 Oct; 130:e753-e759. . View in PubMed

Early Readmission After Ventricular Shunting in Adults with Hydrocephalus: A Nationwide Readmission Database Analysis World Neurosurg. 2019 Aug; 128:e38-e50. . View in PubMed

Predictors of Venous Thromboembolism After Nonemergent Craniotomy: A Nationwide Readmission Database Analysis World Neurosurg. 2019 Feb; 122:e1102-e1110. . View in PubMed

Venous Thromboembolism After Degenerative Spine Surgery: A Nationwide Readmissions Database Analysis World Neurosurg. 2019 05; 125:e165-e174. . View in PubMed

Hypertensive Postpartum Admissions Among Women Without a History of Hypertension or Preeclampsia Obstet Gynecol. 2019 04; 133(4):712-719. . View in PubMed

Postpartum readmissions among women with opioid use disorder Am J Obstet Gynecol MFM. 2019 03; 1(1):89-98. . View in PubMed

Commentary: Clinical Accuracy of Holographic Navigation Using Point-Based Registration on Augmented-Reality Glasses Oper Neurosurg (Hagerstown). 2019 12 01; 17(6):E229-E230. . View in PubMed

Readmission following inpatient stereotactic radiosurgery for brain tumors J Radiosurg SBRT. 2019; 6(2):101-119. . View in PubMed

Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery Neurosurgery. 2019 03 01; 84(3):726-732. . View in PubMed

Brainstem Gliomas: New Models Recapitulate Human Disease and Deepen Our Understanding Neurosurgery. 2019 08 01; 85(2):E169-E171. . View in PubMed

Characterizing Glioma Genetics Using Cerebrospinal Fluid Neurosurgery. 2019 08 01; 85(2):E196-E197. . View in PubMed

Treatment at Safety-Net Hospitals Is Associated with Delays in Coil Embolization in Patients with Subarachnoid Hemorrhage World Neurosurg. 2018 Dec; 120:e434-e439. . View in PubMed

Predictors of Surgical Site Infection After Nonemergent Craniotomy: A Nationwide Readmission Database Analysis World Neurosurg. 2018 Dec; 120:e440-e452. . View in PubMed

Safety-Net Hospitals Have Higher Complication and Mortality Rates in the Neurosurgical Management of Traumatic Brain Injuries World Neurosurg. 2018 Nov; 119:e284-e293. . View in PubMed

Timing and Risk Factors of Postpartum Stroke Obstet Gynecol. 2018 01; 131(1):70-78. . View in PubMed

Predictors of 30- and 90-day readmission following craniotomy for malignant brain tumors: analysis of nationwide data J Neurooncol. 2018 Jan; 136(1):87-94. . View in PubMed

Factors associated with burnout among US neurosurgery residents: a nationwide survey J Neurosurg. 2018 11 01; 129(5):1349-1363. . View in PubMed

The effect of NACHRI children's hospital designation on outcome in pediatric malignant brain tumors J Neurosurg Pediatr. 2017 Aug; 20(2):149-157. . View in PubMed

Impact of the 2003 ACGME Resident Duty Hour Reform on Hospital-Acquired Conditions: A National Retrospective Analysis J Grad Med Educ. 2017 Apr; 9(2):215-221. . View in PubMed

Pitfalls of administrative database analysis are evident when assessing the 'weekend effect' in stroke Evid Based Med. 2017 03; 22(1):35. . View in PubMed

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells Science. 2017 01 06; 355(6320). . View in PubMed

Risk factors associated with the surgical management of craniopharyngiomas in pediatric patients: analysis of 1961 patients from a national registry database Neurosurg Focus. 2016 Dec; 41(6):E8. . View in PubMed

Extracranial to intracranial bypass for the treatment of cerebral aneurysms in the pediatric population J Clin Neurosci. 2016 Dec; 34:6-10. . View in PubMed

Prognostic factors of early outcome and discharge status in patients undergoing surgical intervention following traumatic intracranial hemorrhage J Clin Neurosci. 2016 Sep; 31:152-6. . View in PubMed

Infection rate correlated with time to repair of open neural tube defects (myelomeningoceles): an institutional and national study Childs Nerv Syst. 2016 Sep; 32(9):1675-81. . View in PubMed

Single-cell analysis of long non-coding RNAs in the developing human neocortex Genome Biol. 2016 Apr 14; 17:67. . View in PubMed

Cross-Sectional Analysis on Racial and Economic Disparities Affecting Mortality in Preterm Infants with Posthemorrhagic Hydrocephalus World Neurosurg. 2016 Apr; 88:399-410. . View in PubMed

Evaluation of time to aneurysm treatment following subarachnoid hemorrhage: comparison of patients treated with clipping versus coiling J Neurointerv Surg. 2016 Apr; 8(4):373-7. . View in PubMed

Trends in hospitalization of preterm infants with intraventricular hemorrhage and hydrocephalus in the United States, 2000-2010 J Neurosurg Pediatr. 2016 Mar; 17(3):260-9. . View in PubMed

Reevaluating the weekend effect on patients with hydrocephalus undergoing operative shunt intervention J Neurosurg Pediatr. 2016 Feb; 17(2):156-162. . View in PubMed

Uncovering the roles of long noncoding RNAs in neural development and glioma progression Neurosci Lett. 2016 06 20; 625:70-9. . View in PubMed

Evaluation of weekend admission on the prevalence of hospital acquired conditions in patients receiving thoracolumbar fusions J Clin Neurosci. 2015 Aug; 22(8):1349-54. . View in PubMed

Evaluation of Effect of Weekend Admission on the Prevalence of Hospital-Acquired Conditions in Patients Receiving Cervical Fusions World Neurosurg. 2015 Jul; 84(1):58-68. . View in PubMed

The july effect: an analysis of never events in the nationwide inpatient sample J Hosp Med. 2015 Jul; 10(7):432-8. . View in PubMed

Going Big to Explore the Detail World Neurosurg. 2015 Jun; 83(6):1041-3. . View in PubMed

Racial and socioeconomic disparities in outcomes following pediatric cerebrospinal fluid shunt procedures J Neurosurg Pediatr. 2015 Jun; 15(6):560-6. . View in PubMed

Incidence of "never events" among weekend admissions versus weekday admissions to US hospitals: national analysis BMJ. 2015 Apr 15; 350:h1460. . View in PubMed

Theoretical Basis of Vagus Nerve Stimulation Prog Neurol Surg. 2015; 29:20-8. . View in PubMed

Health disparities in time to aneurysm clipping/coiling among aneurysmal subarachnoid hemorrhage patients: a national study World Neurosurg. 2014 Dec; 82(6):1071-6. . View in PubMed

Prevention of percutaneous spinal cord stimulation electrode migration: a 15-year experience Neuromodulation. 2014 Oct; 17(7):670-6; discussion 676-7. . View in PubMed

The impact of patient age and comorbidities on the occurrence of "never events" in cerebrovascular surgery: an analysis of the Nationwide Inpatient Sample J Neurosurg. 2014 Sep; 121(3):580-6. . View in PubMed

Racial and socioeconomic disparities in incidence of hospital-acquired complications following cerebrovascular procedures Neurosurgery. 2014 Jul; 75(1):43-50. . View in PubMed

Recapitulating flesh with silicon and steel: advancements in upper extremity robotic prosthetics World Neurosurg. 2014 May-Jun; 81(5-6):730-41. . View in PubMed

Supplementing the neurosurgical virtuoso: evolution of automation from mythology to operating room adjunct World Neurosurg. 2014 May-Jun; 81(5-6):719-29. . View in PubMed

Racial and socioeconomic disparities in access to mechanical revascularization procedures for acute ischemic stroke J Stroke Cerebrovasc Dis. 2014 Feb; 23(2):327-34. . View in PubMed

Mechanical thrombectomy in acute stroke: utilization variances and impact of procedural volume on inpatient mortality J Stroke Cerebrovasc Dis. 2013 Nov; 22(8):1263-9. . View in PubMed

Computed tomography for clearance of cervical spine injury in the unevaluable patient World Neurosurg. 2013 Sep-Oct; 80(3-4):405-13. . View in PubMed

Minimally invasive posterior atlantoaxial fusion: a cadaveric and clinical feasibility study World Neurosurg. 2013 Sep-Oct; 80(3-4):414-21. . View in PubMed

Delayed cavernous carotid artery pseudoaneurysm caused by absorbable plate following transsphenoidal surgery: case report and review of the literature J Neurol Surg Rep. 2013 Jun; 74(1):10-6. . View in PubMed

Stem cells in gliomas Handb Clin Neurol. 2012; 104:63-73. . View in PubMed

Chemotherapy for brain tumors with polymer drug delivery Handb Clin Neurol. 2012; 104:339-53. . View in PubMed

Conservative management of ossification of the posterior longitudinal ligamentA review. Neurosurg Focus. 2011 Mar; 30(3):E2. . View in PubMed

Ossification of the posterior longitudinal ligament: genetics and pathophysiology Neurosurg Focus. 2011 Mar; 30(3):E6. . View in PubMed

Hospital costs associated with shunt infections in patients receiving antibiotic-impregnated shunt catheters versus standard shunt catheters Neurosurgery. 2010 Feb; 66(2):284-9; discussion 289. . View in PubMed

A modified frontal-nasal-orbital approach to midline lesions of the anterior cranial fossa and skull base: technical note with case illustrations Neurosurg Rev. 2010 Jan; 33(1):63-70. . View in PubMed

Pathological upstaging during radical cystectomy is associated with worse recurrence-free survival in patients with bacillus Calmette-Guerin-refractory bladder cancer Urology. 2009 Dec; 74(6):1276-80. . View in PubMed

Incidence of symptomatic retethering after surgical management of pediatric tethered cord syndrome with or without duraplasty Childs Nerv Syst. 2009 Sep; 25(9):1085-9. . View in PubMed

Association of preoperative depression and survival after resection of malignant brain astrocytoma Surg Neurol. 2009 Mar; 71(3):299-303discussion 303. . View in PubMed

Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme J Neurosurg. 2009 Mar; 110(3):583-8. . View in PubMed

Suboccipital decompression for Chiari I malformation: outcome comparison of duraplasty with expanded polytetrafluoroethylene dural substitute versus pericranial autograft Childs Nerv Syst. 2009 Feb; 25(2):183-90. . View in PubMed

Comparison of shunt infection incidence in high-risk subgroups receiving antibiotic-impregnated versus standard shunts Childs Nerv Syst. 2009 Jan; 25(1):77-83; discussion 85. . View in PubMed

Independent association of extent of resection with survival in patients with malignant brain astrocytoma J Neurosurg. 2009 Jan; 110(1):156-62. . View in PubMed

Presentation and management of a patient with subcutaneous metastatic transitional cell carcinoma of the bladder Nat Clin Pract Urol. 2008 Dec; 5(12):691-4. . View in PubMed

Symptom recurrence after suboccipital decompression for pediatric Chiari I malformation: analysis of 256 consecutive cases Childs Nerv Syst. 2008 Nov; 24(11):1333-9. . View in PubMed

Extent of surgical resection is independently associated with survival in patients with hemispheric infiltrating low-grade gliomas Neurosurgery. 2008 Oct; 63(4):700-7; author reply 707-8. . View in PubMed

Use of Gliadel (BCNU) wafer in the surgical treatment of malignant glioma: a 10-year institutional experience Ann Surg Oncol. 2008 Oct; 15(10):2887-93. . View in PubMed

Relationship of glioblastoma multiforme to the lateral ventricles predicts survival following tumor resection J Neurooncol. 2008 Sep; 89(2):219-24. . View in PubMed

Intraoperative ultrasonography as a guide to patient selection for duraplasty after suboccipital decompression in children with Chiari malformation Type I J Neurosurg Pediatr. 2008 Jul; 2(1):52-7. . View in PubMed

Correlation of hindbrain CSF flow and outcome after surgical decompression for Chiari I malformation Childs Nerv Syst. 2008 Jul; 24(7):833-40. . View in PubMed

Outcome of Chiari-associated syringomyelia after hindbrain decompression in children: analysis of 49 consecutive cases Neurosurgery. 2008 Jun; 62(6):1307-13; discussion 1313. . View in PubMed

Spinal deformity after resection of cervical intramedullary spinal cord tumors in children Childs Nerv Syst. 2008 Jun; 24(6):735-9. . View in PubMed

Suboccipital decompression for Chiari malformation-associated scoliosis: risk factors and time course of deformity progression J Neurosurg Pediatr. 2008 Jun; 1(6):456-60. . View in PubMed

Endoscopic transcervical odontoidectomy for pediatric basilar invagination and cranial settlingReport of 4 cases. J Neurosurg Pediatr. 2008 Apr; 1(4):337-42. . View in PubMed

Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas Neurosurgery. 2008 08; 63(2):286-91; discussion 291. . View in PubMed

Resection of intramedullary spinal cord tumors in children: assessment of long-term motor and sensory deficits J Neurosurg Pediatr. 2008 Jan; 1(1):63-7. . View in PubMed

Neurological outcome after resection of intramedullary spinal cord tumors in children Childs Nerv Syst. 2008 Jan; 24(1):93-7. . View in PubMed

Oligomeric assembly of native-like precursors precedes amyloid formation by beta-2 microglobulin Biochemistry. 2004 Jun 22; 43(24):7808-15. . View in PubMed

Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques J Neurosci. 2004 May 12; 24(19):4535-40. . View in PubMed

Postoperative surgical site infections in patients undergoing spinal tumor surgery: incidence and risk factors Spine (Phila Pa 1976). 2011 Aug 01; 36(17):1410-9. . View in PubMed

Intramedullary Cervical Spinal Cord AbscessWorld Neurosurg. 2017 Oct; 106:1049. e1-1049. e2. . View in PubMed

Frank Attenello MD, MS is an Assistant Professor of Neurosurgery at the Keck School of Medicine of USC and LAC+USC Medical Center in Los Angeles, CA specializing in treatment of primary and metastatic brain tumors. He employs multiple surgical modalities to map and preserve neurologic function in tumor surgery including exoscopic subcortical surgery (BrainPath) and laser interstitial thermal therapy. Dr. Attenello performs both cranial surgery and stereotactic radiosurgery.

Dr. Attenello received combined BS/MS degrees in Molecular Biochemistry and Biophysics from Yale University. He then received his medical degree from Johns Hopkins University School of Medicine, where he received the institutional Harvey Cushing Neurosurgery Award and the Ronald L. Bittner national Neuro-oncology research award. His work on glioblastoma and neural stem cells at Johns Hopkins was supported by a fellowship from the Howard Hughes Medical Institute. He then completed neurosurgical residency at the University of Southern California, with a postdoctoral fellowship in tumor genetics at the University of California, San Francisco.

Dr. Attenello has authored six neurosurgical book chapters and over 100 peer-reviewed manuscripts including articles in Science, BMJ, and Cancer Discovery. He was appointed Associate Scientific Advisor for Science Translational Medicine, and is an editorial board member for the Journal of Neuroscience Research.

He is Principal Investigator and Director of the Glioma Research Laboratory in the Zilkha Neurogenetic Institute, studying genetics and angiogenesis in glioblastoma as well as role of neural stem cells in brain injury. His laboratory is supported by a NIH K08 Research Career Development Award and several NIH and foundational grants, including generous patient support. In addition, Dr. Attenello directs a clinical outcomes laboratory studying factors associated with improved outcome in patients with neurologic disease, as well as modifiable factors associated with physician trainee success and burnout. Using data and experience gained in the laboratory, Dr. Attenello is identifying genetic and clinical factors, and new therapies for improved patient outcomes.
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