Frank Attenello, MD, MS

Associate Professor of Clinical Neurological Surgery and Cancer Biology

Sloan Family Endowed Professorship in Neurological Surgery

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Overview

Frank Attenello MD, MS is the Sloan Family Endowed Associate Professor of Neurosurgery, Biochemistry and Molecular Medicine at the Keck School of Medicine of USC, specializing in treatment of primary and metastatic brain tumors. He employs multiple surgical modalities to preserve neurologic function in tumor surgery including minimally invasive subcortical surgery (BrainPath) and laser interstitial thermal therapy. Dr. Attenello performs both cranial surgery and stereotactic radiosurgery.

Dr. Attenello received combined BS/MS degrees in Molecular Biochemistry and Biophysics from Yale University. He then received his medical degree from Johns Hopkins University School of Medicine, where he received the institutional Harvey Cushing Neurosurgery Award and the Ronald L. Bittner national Neuro-oncology research award. His work on glioblastoma and neural stem cells at Johns Hopkins was supported by a fellowship from the Howard Hughes Medical Institute. He then completed neurosurgical residency at the University of Southern California, with a postdoctoral fellowship in tumor genetics at the University of California, San Francisco.

Dr. Attenello has authored six neurosurgical book chapters and over 150 peer-reviewed manuscripts including articles in Science, BMJ, and Cancer Discovery. He was appointed Associate Scientific Advisor for Science Translational Medicine, and is an editorial board member of the Journal of Neurosurgery and the Journal of Neuroscience Research.

Dr. Attenello is also principal investigator of a basic science research laboratory studying epigenetic regulation of glioma chemoresistance as well as role of neural stem cells in brain injury (https://sites.usc.edu/attenellolab/). His laboratory is supported by a NIH K08 Research Career Development Award and several NIH and foundational grants, including generous patient support. In addition, Dr. Attenello directs a clinical outcomes laboratory studying factors associated with improved outcome in patients with neurologic disease, as well as factors driving medical trainee burnout. Using data and experience gained in the laboratory, Dr. Attenello is identifying new therapies for improved patient outcomes.

Education and Training

  • Johns Hopkins University School of Medicine, Baltimore, MD — MD — 05/2009 — Medicine
  • Yale University, New Haven, CT — BS, MS — 06/2003 — Molecular BIophysics and Biochemistry

Publications

  • Safety-Net Hospitals Have Higher Complication and Mortality Rates in the Neurosurgical Management of Traumatic Brain Injuries. World Neurosurg. 2018 Nov; 119:e284-e293.. View in PubMed
  • Postpartum venous thromboembolism readmissions in the United States. Am J Obstet Gynecol. 2018 10; 219(4):401.e1-401.e14.. View in PubMed
  • Factors associated with burnout among US neurosurgery residents: a nationwide survey. J Neurosurg. 2018 11 01; 129(5):1349-1363.. View in PubMed
  • Timing and Risk Factors of Postpartum Stroke. Obstet Gynecol. 2018 01; 131(1):70-78.. View in PubMed
  • Predictors of 30- and 90-day readmission following craniotomy for malignant brain tumors: analysis of nationwide data. J Neurooncol. 2018 Jan; 136(1):87-94.. View in PubMed
  • Intramedullary Cervical Spinal Cord Abscess. World Neurosurg. 2017 Oct; 106:1049.e1-1049.e2.. View in PubMed
  • The effect of NACHRI children’s hospital designation on outcome in pediatric malignant brain tumors. J Neurosurg Pediatr. 2017 Aug; 20(2):149-157.. View in PubMed
  • Impact of the 2003 ACGME Resident Duty Hour Reform on Hospital-Acquired Conditions: A National Retrospective Analysis. J Grad Med Educ. 2017 Apr; 9(2):215-221.. View in PubMed
  • CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science. 2017 01 06; 355(6320).. View in PubMed
  • Risk factors associated with the surgical management of craniopharyngiomas in pediatric patients: analysis of 1961 patients from a national registry database. Neurosurg Focus. 2016 Dec; 41(6):E8.. View in PubMed