Keck School Faculty

Helena Chang Chui, MD
Helena Chang Chui, MD
Chair and Professor of Neurology;Raymond and Betty McCarron Chair in Neurology
CHP 215 Health Sciences Campus Los Angeles
Dr. Chui is internationally recognized for her research in Alzheimer disease and vascular cognitive impairment. She is the principal investigator for the NIA-funded Alzheimer Disease Research Center, as well as a multi-institutional program project on vascular dementia.

Dr. Chui is the author of over 120 publications and has served on the editorial board for Stroke, Alzheimer Disease and Associated Disorders, and Archives of Neurology. She holds the Raymond and Betty McCarron endowed Chair at the Keck School of Medicine and serves as the Chair of the Department of Neurology.

Pasadena Magazine: Top Doctor, 2011

Pasadena Magazine: Ooops. Something went wrong., 2011

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nat Genet. 2019 Mar; 51(3):414-430. . View in PubMed

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 Jan 14. . View in PubMed

Vascular dysfunction-The disregarded partner of Alzheimer's disease Alzheimers Dement. 2019 Jan; 15(1):158-167. . View in PubMed

Triglycerides are negatively correlated with cognitive function in nondemented aging adults Neuropsychology. 2017 Sep; 31(6):682-688. . View in PubMed

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review JAMA Neurol. 2017 Mar 01; 74(3):339-347. . View in PubMed

Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease Nat Genet. 2017 09; 49(9):1373-1384. . View in PubMed

Vascular Contributions to Cognitive Impairment in Late Life Neurol Clin. 2017 05; 35(2):295-323. . View in PubMed

Neuropsychological Profiles Differentiate Alzheimer Disease from Subcortical Ischemic Vascular Dementia in an Autopsy-Defined Cohort Dement Geriatr Cogn Disord. 2017; 44(1-2):1-11. . View in PubMed

Two Novel Mutations in the First Transmembrane Domain of Presenilin1 Cause Young-Onset Alzheimer's Disease J Alzheimers Dis. 2017; 58(4):1035-1041. . View in PubMed

A T1 and DTI fused 3D corpus callosum analysis in MCI subjects with high and low cardiovascular risk profile Neuroimage Clin. 2017; 14:298-307. . View in PubMed

Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition J Neuropathol Exp Neurol. 2016 Oct; 75(10):955-962. . View in PubMed

Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis JAMA Neurol. 2016 Oct 01; 73(10):1208-1216. . View in PubMed

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease Alzheimers Res Ther. 2016 Jun 30; 8:25. . View in PubMed

ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease J Am Heart Assoc. 2016 Feb 12; 5(2). . View in PubMed

A Multidisciplinary Model of Dementia Care in an Underserved Retirement Community, Made Possible by Telemedicine Front Neurol. 2016; 7:225. . View in PubMed

The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease Alzheimers Res Ther. 2016 06 30; 8:25. . View in PubMed

A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women Front Hum Neurosci. 2016; 10:495. . View in PubMed

Melanopsin retinal ganglion cell loss in Alzheimer disease Ann Neurol. 2016 Jan; 79(1):90-109. . View in PubMed

Differential effects of ischemic vascular disease and Alzheimer's disease on brain atrophy and cognition J Cereb Blood Flow Metab. 2016 Jan; 36(1):204-15. . View in PubMed

Consensus statement for diagnosis of subcortical small vessel disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. . View in PubMed

Trajectories of depressive symptoms in old age: Integrating age-, pathology-, and mortality-related changes Psychol Aging. 2015 Dec; 30(4):940-51. . View in PubMed

Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study Ann Neurol. 2015 Sep; 78(3):466-76. . View in PubMed

A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy JAMA Neurol. 2015 Apr; 72(4):414-22. . View in PubMed

Rarity of the Alzheimer disease-protective APP A673T variant in the United States JAMA Neurol. 2015 Feb; 72(2):209-16. . View in PubMed

Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed

Clinical and imaging features of mixed Alzheimer and vascular pathologies Alzheimers Res Ther. 2015; 7(1):21. . View in PubMed

Measuring future time perspective across adulthood: development and evaluation of a brief multidimensional questionnaire Gerontologist. 2014 Dec; 54(6):1075-88. . View in PubMed

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study JAMA Neurol. 2014 Nov; 71(11):1394-404. . View in PubMed

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):206-18. . View in PubMed

Mapping of ApoE4 Related White Matter Damage using Diffusion MRI Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390H. . View in PubMed

The Power of Hybrid/Fusion Imaging Metrics in Future PACS Systems: A Case Study into the White Matter Hyperintensity Prenumbra using FLAIR and Diffusion MR Proc SPIE Int Soc Opt Eng. 2014 Apr 09; 9039:90390I. . View in PubMed

Cortical thickness mediates the effect of ß-amyloid on episodic memory Neurology. 2014 Mar 04; 82(9):761-7. . View in PubMed

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis J Neurol Neurosurg Psychiatry. 2014 Mar; 85(3):300-5. . View in PubMed

Change in coping and defense mechanisms across adulthood: longitudinal findings in a European American sample Dev Psychol. 2014 Feb; 50(2):634-48. . View in PubMed

Associations between serum cholesterol levels and cerebral amyloidosis JAMA Neurol. 2014 Feb; 71(2):195-200. . View in PubMed

The role of carotid intima-media thickness in predicting longitudinal cognitive function in an older adult cohort Cerebrovasc Dis. 2014; 38(6):441-7. . View in PubMed

Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression PLoS One. 2014; 9(1):e87747. . View in PubMed

10-minute delayed recall from the modified mini-mental state test predicts Alzheimer's disease pathology J Alzheimers Dis. 2014; 39(3):575-82. . View in PubMed

Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension Cerebrovasc Dis. 2014; 38(1):10-6. . View in PubMed

Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes Stroke. 2013 Oct; 44(10):2835-41. . View in PubMed

The aging brain and cognition: contribution of vascular injury and aß to mild cognitive dysfunction JAMA Neurol. 2013 Apr; 70(4):488-95. . View in PubMed

Alzheimer pathology and angiotension receptor blockers JAMA Neurol. 2013 Mar 01; 70(3):414. . View in PubMed

Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI PLoS One. 2013; 8(6):e65175. . View in PubMed

Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series Arch Neurol. 2012 Dec; 69(12):1632-8. . View in PubMed

Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults Stroke. 2012 Nov; 43(11):2865-70. . View in PubMed

Coronary risk correlates with cerebral amyloid deposition Neurobiol Aging. 2012 Sep; 33(9):1979-87. . View in PubMed

Different associations of white matter lesions with depression and cognition BMC Neurol. 2012 Aug 25; 12:83. . View in PubMed

Evidence for a role of the rare pA152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 01; 21(15):3500-12. . View in PubMed

Novel late-onset Alzheimer disease loci variants associate with brain gene expression Neurology. 2012 Jul 17; 79(3):221-8. . View in PubMed

Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample Brain Behav. 2012 Jul; 2(4):435-42. . View in PubMed

Preservation of neurons of the nucleus basalis in subcortical ischemic vascular disease Arch Neurol. 2012 Jul; 69(7):879-86. . View in PubMed

Cerebrovascular disease, ß-amyloid, and cognition in agingNeurobiol Aging. 2012 May; 33(5):1006. e25-36. . View in PubMed

Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial Arch Intern Med. 2012 Mar 12; 172(5):442-4. . View in PubMed

Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults J Am Geriatr Soc. 2012 Mar; 60(3):499-504. . View in PubMed

Chinese-language montreal cognitive assessment for cantonese or mandarin speakers: age, education, and gender effects Int J Alzheimers Dis. 2012; 2012:204623. . View in PubMed

Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association Stroke. 2011 Sep; 42(9):2672-713. . View in PubMed

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease Nat Genet. 2011 May; 43(5):436-41. . View in PubMed

Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2 Alzheimers Dement. 2011 Jan; 7(1):35-52. . View in PubMed

Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study Am J Psychiatry. 2010 May; 167(5):589-97. . View in PubMed

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions Nat Genet. 2010 Mar; 42(3):234-9. . View in PubMed

Influences of lobar gray matter and white matter lesion load on cognition and mood Psychiatry Res. 2010 Feb 28; 181(2):90-6. . View in PubMed

Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging Alzheimers Dement. 2009 Nov; 5(6):454-62. . View in PubMed

The Alzheimer's Disease Centers' Uniform Data Set (UDS): the neuropsychologic test battery Alzheimer Dis Assoc Disord. 2009 Apr-Jun; 23(2):91-101. . View in PubMed

Longitudinal changes in memory and executive functioning are associated with longitudinal change in instrumental activities of daily living in older adults Clin Neuropsychol. 2009 Apr; 23(3):446-61. . View in PubMed

Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease Arch Neurol. 2008 Dec; 65(12):1640-8. . View in PubMed

The MRI brain correlates of depressed mood, anhedonia, apathy, and anergia in older adults with and without cognitive impairment or dementia Int J Geriatr Psychiatry. 2008 Oct; 23(10):1040-50. . View in PubMed

Understanding hippocampal sclerosis in the elderly: epidemiology, characterization, and diagnostic issues Curr Neurol Neurosci Rep. 2008 Sep; 8(5):363-70. . View in PubMed

Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease Arch Neurol. 2008 May; 65(5):650-5. . View in PubMed

Incidence of dementia in long-term hormone users Am J Epidemiol. 2008 Mar 15; 167(6):692-700. . View in PubMed

Subcortical lacunes are associated with executive dysfunction in cognitively normal elderly Stroke. 2008 Feb; 39(2):397-402. . View in PubMed

Neuropathological basis of magnetic resonance images in aging and dementia Ann Neurol. 2008 Jan; 63(1):72-80. . View in PubMed

Cognitive and neuroimaging predictors of instrumental activities of daily living J Int Neuropsychol Soc. 2007 Sep; 13(5):747-57. . View in PubMed

Subcortical ischemic vascular dementia Neurol Clin. 2007 Aug; 25(3):717-40, vi. . View in PubMed

A community epidemiological survey of generalized anxiety disorder in Hong Kong Community Ment Health J. 2007 Aug; 43(4):305-19. . View in PubMed

Longitudinal MRI and cognitive change in healthy elderly Neuropsychology. 2007 Jul; 21(4):412-8. . View in PubMed

Profiles of neuropsychological impairment in autopsy-defined Alzheimer's disease and cerebrovascular disease Brain. 2007 Mar; 130(Pt 3):731-9. . View in PubMed

Memory in the aging brain: doubly dissociating the contribution of the hippocampus and entorhinal cortex Hippocampus. 2007; 17(11):1134-40. . View in PubMed

Performance of Spanish speakers on the Mattis dementia rating scale (MDRS) Arch Clin Neuropsychol. 2006 Dec; 21(8):827-36. . View in PubMed

Cognitive impact of subcortical vascular and Alzheimer's disease pathology Ann Neurol. 2006 Dec; 60(6):677-87. . View in PubMed

The A431E mutation in PSEN1 causing familial Alzheimer's disease originating in Jalisco State, Mexico: an additional fifteen families Neurogenetics. 2006 Nov; 7(4):277-9. . View in PubMed

The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers Alzheimer Dis Assoc Disord. 2006 Oct-Dec; 20(4):210-6. . View in PubMed

Vascular cognitive impairment: today and tomorrow Alzheimers Dement. 2006 Jul; 2(3):185-94. . View in PubMed

Age effects on atrophy rates of entorhinal cortex and hippocampus Neurobiol Aging. 2006 May; 27(5):733-40. . View in PubMed

Pulse pressure correlates with leukoaraiosis in Alzheimer disease Arch Gerontol Geriatr. 2006 Mar-Apr; 42(2):157-66. . View in PubMed

Advances in vascular cognitive impairment 2005 Stroke. 2006 Feb; 37(2):323-5. . View in PubMed

Cultural diversity in Alzheimer disease: the interface between biology, belief, and behavior Alzheimer Dis Assoc Disord. 2005 Oct-Dec; 19(4):250-5. . View in PubMed

Category fluency in a latino sample: associations with age, education, gender, and language J Clin Exp Neuropsychol. 2005 Jul; 27(5):591-8. . View in PubMed

Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia Ann Neurol. 2005 Jun; 57(6):896-903. . View in PubMed

Validation of multi-stage telephone-based identification of cognitive impairment and dementia BMC Neurol. 2005 Apr 13; 5(1):8. . View in PubMed

Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience Radiology. 2005 Mar; 234(3):851-9. . View in PubMed

Neuropathology lessons in vascular dementia Alzheimer Dis Assoc Disord. 2005 Jan-Mar; 19(1):45-52. . View in PubMed

Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. . View in PubMed

Hippocampal volume and retention in Alzheimer's disease J Int Neuropsychol Soc. 2004 Jul; 10(4):639-43. . View in PubMed

A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: A pilot study of immediate and long-term outcomes Arch Phys Med Rehabil. 2004 Apr; 85(4):620-8. . View in PubMed

Clinical and neuropsychological features in autopsy-defined vascular dementia Clin Neuropsychol. 2004 Feb; 18(1):63-74. . View in PubMed

Forgetting in dementia with and without subcortical lacunes Clin Neuropsychol. 2004 Feb; 18(1):32-40. . View in PubMed

Depression as a risk factor for Alzheimer disease: the MIRAGE Study Arch Neurol. 2003 May; 60(5):753-9. . View in PubMed

Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases Arch Neurol. 2003 Mar; 60(3):337-41. . View in PubMed

Neuron loss in key cholinergic and aminergic nuclei in Alzheimer disease: a meta-analysis Neurobiol Aging. 2003 Jan-Feb; 24(1):1-23. . View in PubMed

Subcortical ischaemic vascular dementia Lancet Neurol. 2002 Nov; 1(7):426-36. . View in PubMed

Quantitative magnetic resonance imaging differences between Alzheimer disease with and without subcortical lacunes Alzheimer Dis Assoc Disord. 2002 Apr-Jun; 16(2):58-64. . View in PubMed

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