Keck School Faculty

Helena Chang Chui, MD
Helena Chang Chui, MD
Chair and Professor of Neurology;Raymond and Betty McCarron Chair in Neurology
Neurology
CHP 215 Health Sciences Campus Los Angeles
Dr. Chui is internationally recognized for her research in Alzheimer disease and vascular cognitive impairment. She is the principal investigator for the NIA-funded Alzheimer Disease Research Center, as well as a multi-institutional program project on vascular dementia.

Dr. Chui is the author of over 120 publications and has served on the editorial board for Stroke, Alzheimer Disease and Associated Disorders, and Archives of Neurology. She holds the Raymond and Betty McCarron endowed Chair at the Keck School of Medicine and serves as the Chair of the Department of Neurology.

Pasadena Magazine: Top Doctor, 2011

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes J Neurosci. 2019 Oct 21. . View in PubMed

Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders Alzheimer Dis Assoc Disord. 2019 Sep 10. . View in PubMed

Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nat Genet. 2019 Sep; 51(9):1423-1424. . View in PubMed

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report Brain. 2019 Jun 01; 142(6):1503-1527. . View in PubMed

Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing Nat Genet. 2019 03; 51(3):414-430. . View in PubMed

Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction Nat Med. 2019 02; 25(2):270-276. . View in PubMed

General and domain-specific cognitive reserve, mild cognitive impairment, and dementia risk in older women Alzheimers Dement (N Y). 2019; 5:118-128. . View in PubMed

Association of Docosahexaenoic Acid Supplementation With Alzheimer Disease Stage in Apolipoprotein E e4 Carriers: A Review JAMA Neurol. 2017 Mar 01; 74(3):339-347. . View in PubMed

A T1 and DTI fused 3D corpus callosum analysis in MCI subjects with high and low cardiovascular risk profile Neuroimage Clin. 2017; 14:298-307. . View in PubMed

Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis JAMA Neurol. 2016 Oct 01; 73(10):1208-1216. . View in PubMed

Late-Life Vascular Risk Factors and Alzheimer Disease Neuropathology in Individuals with Normal Cognition J Neuropathol Exp Neurol. 2016 Oct; 75(10):955-962. . View in PubMed

ABCA1-Mediated Cholesterol Efflux Capacity to Cerebrospinal Fluid Is Reduced in Patients With Mild Cognitive Impairment and Alzheimer's Disease J Am Heart Assoc. 2016 Feb 12; 5(2). . View in PubMed

A Multidisciplinary Model of Dementia Care in an Underserved Retirement Community, Made Possible by Telemedicine Front Neurol. 2016; 7:225. . View in PubMed

A Voxel-Based Morphometry Study Reveals Local Brain Structural Alterations Associated with Ambient Fine Particles in Older Women Front Hum Neurosci. 2016; 10:495. . View in PubMed

Differential effects of ischemic vascular disease and Alzheimer's disease on brain atrophy and cognition J Cereb Blood Flow Metab. 2016 Jan; 36(1):204-15. . View in PubMed

Consensus statement for diagnosis of subcortical small vessel disease J Cereb Blood Flow Metab. 2016 Jan; 36(1):6-25. . View in PubMed

Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study Ann Neurol. 2015 Sep; 78(3):466-76. . View in PubMed

A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy JAMA Neurol. 2015 Apr; 72(4):414-22. . View in PubMed

Blood-brain barrier breakdown in the aging human hippocampus Neuron. 2015 Jan 21; 85(2):296-302. . View in PubMed

Clinical and imaging features of mixed Alzheimer and vascular pathologies Alzheimers Res Ther. 2015; 7(1):21. . View in PubMed

Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study JAMA Neurol. 2014 Nov; 71(11):1394-404. . View in PubMed

Diagnostic criteria for vascular cognitive disorders: a VASCOG statement Alzheimer Dis Assoc Disord. 2014 Jul-Sep; 28(3):206-18. . View in PubMed

Cortical thickness mediates the effect of ß-amyloid on episodic memory Neurology. 2014 Mar 04; 82(9):761-7. . View in PubMed

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis J Neurol Neurosurg Psychiatry. 2014 Mar; 85(3):300-5. . View in PubMed

Change in coping and defense mechanisms across adulthood: longitudinal findings in a European American sample Dev Psychol. 2014 Feb; 50(2):634-48. . View in PubMed

Associations between serum cholesterol levels and cerebral amyloidosis JAMA Neurol. 2014 Feb; 71(2):195-200. . View in PubMed

10-minute delayed recall from the modified mini-mental state test predicts Alzheimer's disease pathology J Alzheimers Dis. 2014; 39(3):575-82. . View in PubMed

Assessment of cerebrovascular reactivity during resting state breathing and its correlation with cognitive function in hypertension Cerebrovasc Dis. 2014; 38(1):10-6. . View in PubMed

Differences in prefrontal, limbic, and white matter lesion volumes according to cognitive status in elderly patients with first-onset subsyndromal depression PLoS One. 2014; 9(1):e87747. . View in PubMed

Cerebral atherosclerosis is associated with cystic infarcts and microinfarcts but not Alzheimer pathologic changes Stroke. 2013 Oct; 44(10):2835-41. . View in PubMed

Alzheimer pathology and angiotension receptor blockers JAMA Neurol. 2013 Mar 01; 70(3):414. . View in PubMed

Associations between white matter hyperintensities and ß amyloid on integrity of projection, association, and limbic fiber tracts measured with diffusion tensor MRI PLoS One. 2013; 8(6):e65175. . View in PubMed

Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series Arch Neurol. 2012 Dec; 69(12):1632-8. . View in PubMed

Associations among vascular risk factors, carotid atherosclerosis, and cortical volume and thickness in older adults Stroke. 2012 Nov; 43(11):2865-70. . View in PubMed

Coronary risk correlates with cerebral amyloid deposition Neurobiol Aging. 2012 Sep; 33(9):1979-87. . View in PubMed

Different associations of white matter lesions with depression and cognition BMC Neurol. 2012 Aug 25; 12:83. . View in PubMed

Evidence for a role of the rare pA152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Hum Mol Genet. 2012 Aug 01; 21(15):3500-12. . View in PubMed

Cerebrovascular disease, ß-amyloid, and cognition in agingNeurobiol Aging. 2012 May; 33(5):1006. e25-36. . View in PubMed

Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial Arch Intern Med. 2012 Mar 12; 172(5):442-4. . View in PubMed

Coronary artery disease is associated with cognitive decline independent of changes on magnetic resonance imaging in cognitively normal elderly adults J Am Geriatr Soc. 2012 Mar; 60(3):499-504. . View in PubMed

Chinese-language montreal cognitive assessment for cantonese or mandarin speakers: age, education, and gender effects Int J Alzheimers Dis. 2012; 2012:204623. . View in PubMed

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease Nat Genet. 2011 May; 43(5):436-41. . View in PubMed

Association of depressed mood and mortality in older adults with and without cognitive impairment in a prospective naturalistic study Am J Psychiatry. 2010 May; 167(5):589-97. . View in PubMed

Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions Nat Genet. 2010 Mar; 42(3):234-9. . View in PubMed

Influences of lobar gray matter and white matter lesion load on cognition and mood Psychiatry Res. 2010 Feb 28; 181(2):90-6. . View in PubMed

Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin-labeling magnetic resonance imaging Alzheimers Dement. 2009 Nov; 5(6):454-62. . View in PubMed

An inverse association of cardiovascular risk and frontal lobe glucose metabolism Neurology. 2009 Feb 24; 72(8):738-43. . View in PubMed

Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease Arch Neurol. 2008 Dec; 65(12):1640-8. . View in PubMed

Cognitive and anatomic contributions of metabolic decline in Alzheimer disease and cerebrovascular disease Arch Neurol. 2008 May; 65(5):650-5. . View in PubMed

Incidence of dementia in long-term hormone users Am J Epidemiol. 2008 Mar 15; 167(6):692-700. . View in PubMed

Co-registration of In-Vivo Human MRI Brain Images to Postmortem Histological Microscopic Images Int J Imaging Syst Technol. 2008; 18(5-6):325-335. . View in PubMed

Cognitive and neuroimaging predictors of instrumental activities of daily living J Int Neuropsychol Soc. 2007 Sep; 13(5):747-57. . View in PubMed

A community epidemiological survey of generalized anxiety disorder in Hong Kong Community Ment Health J. 2007 Aug; 43(4):305-19. . View in PubMed

Amyloid imaging in distinguishing atypical prion disease from Alzheimer disease Neurology. 2007 Jul 17; 69(3):283-90. . View in PubMed

Diffusion tensor imaging of cingulum fibers in mild cognitive impairment and Alzheimer disease Neurology. 2007 Jan 02; 68(1):13-9. . View in PubMed

Cognitive impact of subcortical vascular and Alzheimer's disease pathology Ann Neurol. 2006 Dec; 60(6):677-87. . View in PubMed

Age effects on atrophy rates of entorhinal cortex and hippocampus Neurobiol Aging. 2006 May; 27(5):733-40. . View in PubMed

Advances in vascular cognitive impairment 2005 Stroke. 2006 Feb; 37(2):323-5. . View in PubMed

Cultural diversity in Alzheimer disease: the interface between biology, belief, and behavior Alzheimer Dis Assoc Disord. 2005 Oct-Dec; 19(4):250-5. . View in PubMed

Category fluency in a latino sample: associations with age, education, gender, and language J Clin Exp Neuropsychol. 2005 Jul; 27(5):591-8. . View in PubMed

Correlates of hippocampal neuron number in Alzheimer's disease and ischemic vascular dementia Ann Neurol. 2005 Jun; 57(6):896-903. . View in PubMed

A standardized method for brain-cutting suitable for both stereology and MRI-brain co-registration J Neurosci Methods. 2004 Oct 30; 139(2):209-15. . View in PubMed

Comparisons between global and focal brain atrophy rates in normal aging and Alzheimer disease: Boundary Shift Integral versus tracing of the entorhinal cortex and hippocampus Alzheimer Dis Assoc Disord. 2004 Oct-Dec; 18(4):196-201. . View in PubMed

Hippocampal volume and retention in Alzheimer's disease J Int Neuropsychol Soc. 2004 Jul; 10(4):639-43. . View in PubMed

A randomized controlled comparison of upper-extremity rehabilitation strategies in acute stroke: A pilot study of immediate and long-term outcomes Arch Phys Med Rehabil. 2004 Apr; 85(4):620-8. . View in PubMed

Higher atrophy rate of entorhinal cortex than hippocampus in AD Neurology. 2004 Feb 10; 62(3):422-7. . View in PubMed

Forgetting in dementia with and without subcortical lacunes Clin Neuropsychol. 2004 Feb; 18(1):32-40. . View in PubMed

Clinical and neuropsychological features in autopsy-defined vascular dementia Clin Neuropsychol. 2004 Feb; 18(1):63-74. . View in PubMed

Different patterns of N-acetylaspartate loss in subcortical ischemic vascular dementia and AD Neurology. 2003 Aug 12; 61(3):358-64. . View in PubMed

Comparison of methods for measuring longitudinal brain change in cognitive impairment and dementia Neurobiol Aging. 2003 Jul-Aug; 24(4):537-44. . View in PubMed

Depression as a risk factor for Alzheimer disease: the MIRAGE Study Arch Neurol. 2003 May; 60(5):753-9. . View in PubMed

Atrophy rates of entorhinal cortex in AD and normal aging Neurology. 2003 Feb 11; 60(3):481-6. . View in PubMed

Effects of subcortical ischemic vascular dementia and AD on entorhinal cortex and hippocampus Neurology. 2002 Jun 11; 58(11):1635-41. . View in PubMed

Executive dysfunction in subcortical ischaemic vascular disease J Neurol Neurosurg Psychiatry. 2002 Feb; 72(2):217-20. . View in PubMed

Dementia due to subcortical ischemic vascular disease Clin Cornerstone. 2001; 3(4):40-51. . View in PubMed

Hippocampal and cortical atrophy predict dementia in subcortical ischemic vascular disease Neurology. 2000 Dec 12; 55(11):1626-35. . View in PubMed

Head injury and the risk of AD in the MIRAGE study Neurology. 2000 Mar 28; 54(6):1316-23. . View in PubMed

Clinical criteria for the diagnosis of vascular dementia: a multicenter study of comparability and interrater reliability Arch Neurol. 2000 Feb; 57(2):191-6. . View in PubMed

Cerebral amyloid angiopathy in Alzheimer disease is associated with apolipoprotein E4 and cortical neuron loss Alzheimer Dis Assoc Disord. 1999 Jan; 13(1):1-8. . View in PubMed

Ideomotor apraxia in early Alzheimer's disease: time and accuracy measures Brain Cogn. 1998 Nov; 38(2):220-33. . View in PubMed

Evaluation of dementia: a systematic study of the usefulness of the American Academy of Neurology's practice parameters Neurology. 1997 Oct; 49(4):925-35. . View in PubMed

Eligibility of Alzheimer's disease clinic patients for clinical trials J Am Geriatr Soc. 1997 Aug; 45(8):923-8. . View in PubMed

Elevated risk of Alzheimer's disease among workers with likely electromagnetic field exposure Neurology. 1996 Dec; 47(6):1477-81. . View in PubMed

Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4 Am J Hum Genet. 1996 Sep; 59(3):664-75. . View in PubMed

Localization of amyloid P component in human brain: vascular staining patterns and association with Alzheimer's disease lesions J Comp Neurol. 1995 Jan 30; 352(1):92-105. . View in PubMed

A method to improve interrater reliability of visual inspection of brain MRI scans in dementia Neurology. 1994 Dec; 44(12):2267-76. . View in PubMed

Extrapyramidal signs and psychiatric symptoms predict faster cognitive decline in Alzheimer's disease Arch Neurol. 1994 Jul; 51(7):676-81. . View in PubMed

Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlationsIntraventricular Bethanecol Study Group. Ann Neurol. 1992 Nov; 32(5):625-32. . View in PubMed

Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers Neurology. 1992 Mar; 42(3 Pt 1):473-80. . View in PubMed

Association between vascular basement membrane components and the lesions of Alzheimer's disease J Neurosci Res. 1991 Dec; 30(4):673-81. . View in PubMed

Alzheimer's dementia: performance on parallel forms of the dementia assessment battery J Clin Exp Neuropsychol. 1989 Dec; 11(6):899-912. . View in PubMed

Intracerebroventricular bethanechol chloride infusion in Alzheimer's diseaseResults of a collaborative double-blind study. J Neurosurg. 1989 Oct; 71(4):481-6. . View in PubMed

DementiaA review emphasizing clinicopathologic correlation and brain-behavior relationships. Arch Neurol. 1989 Jul; 46(7):806-14. . View in PubMed

Decreased platelet 3H-imipramine binding in Parkinson's disease Biol Psychiatry. 1988 Jul; 24(3):348-51. . View in PubMed

Functional recoveryA major risk factor for the development of postpoliomyelitis muscular atrophy. Arch Neurol. 1988 Jun; 45(6):645-7. . View in PubMed

Alzheimer's dementia: performance on the Mini-Mental State Examination J Consult Clin Psychol. 1987 Feb; 55(1):96-100. . View in PubMed

Clinical subtypes of dementia of the Alzheimer type Neurology. 1985 Nov; 35(11):1544-50. . View in PubMed

CT criteria of hemisphere asymmetry fail to predict language laterality Neurology. 1984 Aug; 34(8):1086-9. . View in PubMed

Brachial plexus involvement in familial pressure-sensitive neuropathy: electrophysiological and morphological findings Ann Neurol. 1980 Dec; 8(6):620-4. . View in PubMed

Computerized tomographic scan findings in patients with autistic behavior Arch Neurol. 1980 Aug; 37(8):504-10. . View in PubMed

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