James B. Dewey, PhD

Assistant Professor of Otolaryngology-Head and Neck Surgery

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Overview

The Dewey Lab studies the mechanical processes that underlie normal hearing and how these processes are affected in hearing-impaired ears. Current topics of investigation include (1) how sound causes the structures within the cochlear spiral to vibrate, (2) how these vibrations are amplified by the sensory outer hair cells, and (3) how this amplification process leads to the emission of sound by the ear.

#Courses

OHNS 500, Neuroanatomy and Neurophysiology in Speech, Language and Hearing (Y1, Fall Semester)

Research Funding

  • Mechanisms of amplification and nonlinearity in the mouse cochlea
    NIH · R01DC021006 · Dec 1, 2023 – Nov 30, 2028 · Role: Principal Investigator
  • Role of tonic outer hair cell motility in cochlear amplification
    NIH · R21DC019209 · Sep 23, 2020 – Aug 31, 2023 · Role: Principal Investigator
  • Influence of hair bundle properties on cochlear mechanics
    NIH · F32DC016211 · Apr 1, 2017 – Mar 31, 2020 · Role: Principal Investigator
  • Auditory Function at the Base of the Human Cochlea
    NIH · F31DC013710 · Jun 1, 2014 – May 31, 2016 · Role: Principal Investigator

Publications

  • Neuroplastin Isoform Np55 Is Expressed in the Stereocilia of Outer Hair Cells and Required for Normal Outer Hair Cell Function. J Neurosci. 2016 08 31; 36(35):9201-16.. View in PubMed
  • Efferent Modulation of Stimulus Frequency Otoacoustic Emission Fine Structure. Front Syst Neurosci. 2015; 9:168.. View in PubMed
  • Effects of contralateral acoustic stimulation on spontaneous otoacoustic emissions and hearing threshold fine structure. J Assoc Res Otolaryngol. 2014 Dec; 15(6):897-914.. View in PubMed
  • Effects of fundamental frequency and vocal-tract length cues on sentence segregation by listeners with hearing loss. J Acoust Soc Am. 2011 Aug; 130(2):1006-19.. View in PubMed