Jeannie Chen, PhD

Professor of Physiology and Neuroscience

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Research Funding

Genetically Encoded Probes of Huntingtin Misfolding
NIH · R01NS125769 · Aug 1, 2022 – Jul 31, 2027 · Role: Co-Principal Investigator
Molecular Mechanism of Huntingtin Misfolding and its Inhibition by Designed and Cellular Proteins
NIH · R01NS120704 · Sep 17, 2021 – Aug 31, 2026 · Role: Co-Principal Investigator
Innate Immune IL-10/STAT3 Signaling in Alzheimer's Disease
NIH · RF1AG053982 · Sep 1, 2017 – Mar 31, 2022 · Role: Principal Investigator
CALCIUM HOMEOSTASIS IN MAMMALIAN ROD AND CONE PHOTORECEPTORS
NIH · R01EY027387 · Jul 1, 2017 – Jun 30, 2021 · Role: Co-Principal Investigator
Analyses of retinal circuits after rod rescue in a mouse model of human blindness
NIH · R01EY027193 · Sep 1, 2016 – Aug 31, 2021 · Role: Principal Investigator
Peripheral TGF-beta Pathway Inhibitor Therapy in Alzheimer's Rats
NIH · R01NS076794 · Jun 1, 2011 – May 31, 2022 · Role: Principal Investigator
NEW APPROACHES TO THE MECHANISM AND THERAPY FOR MYASTHENIA GRAVIS
NIH · R21NS061184 · Jun 1, 2008 – Apr 30, 2011 · Role: Principal Investigator
Calcium Feedback Mechanisms in Visual Adaptation
NIH · R01EY012703 · Sep 17, 1999 – Nov 30, 2009 · Role: Principal Investigator
Phototransduction in health and disease
NIH · R01EY012155 · Mar 1, 1998 – Feb 29, 2028 · Role: Principal Investigator
RECOVERIN–VISUAL ADAPTATION AND RETINAL DEGENERATION
NIH · F32EY006405 · Aug 28, 1992 · Role: Principal Investigator

Publications

Epitope-specific antibodies can distinguish between soluble huntingtin exon-1 and its diverse cellular aggregates. J Biol Chem. 2026 Feb; 302(2):111048.. View in PubMed
Pleiotropic effects of mutant huntingtin on retinopathy in two mouse models of Huntington’s disease. Neurobiol Dis. 2025 02; 205:106780.. View in PubMed
TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins. J Biol Chem. 2024 09; 300(9):107660.. View in PubMed
Dark continuous noise from mutant G90D-rhodopsin predominantly underlies congenital stationary night blindness. Proc Natl Acad Sci U S A. 2024 May 21; 121(21):e2404763121.. View in PubMed
Light regulation of rhodopsin distribution during outer segment renewal in murine rod photoreceptors. Curr Biol. 2024 04 08; 34(7):1492-1505.e6.. View in PubMed
Arrestin Facilitates Rhodopsin Dephosphorylation in Vivo. J Neurosci. 2022 04 27; 42(17):3537-3545.. View in PubMed
Two Peeling Methods for the Isolation of Photoreceptor Cell Compartments in the Mouse Retina for Protein Analysis. J Vis Exp. 2021 12 07.. View in PubMed
The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx. J Biol Chem. 2018 10 05; 293(40):15332-15346.. View in PubMed
Phenotypic characterization of P23H and S334ter rhodopsin transgenic rat models of inherited retinal degeneration. Exp Eye Res. 2018 02; 167:56-90.. View in PubMed
Separation of photoreceptor cell compartments in mouse retina for protein analysis. Mol Neurodegener. 2017 04 11; 12(1):28.. View in PubMed
Effect of Rhodopsin Phosphorylation on Dark Adaptation in Mouse Rods. J Neurosci. 2016 06 29; 36(26):6973-87.. View in PubMed
Induction of the unfolded protein response by constitutive G-protein signaling in rod photoreceptor cells. J Biol Chem. 2014 Oct 17; 289(42):29310-21.. View in PubMed