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Jian Xu, PhD

Associate Professor

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Phone +1 323 442 4835
Email [email protected]
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Awards

  • American Heart Association National Scientist Development Grant, 2011
     – 2014
  • FASEB Biological Methylation Conference Best Seminar Award, 2012
  • Tokyo Global Center of Excellence Retreat Poster Award, 2011
  • Foundation Independent Postdoctoral Research Fellowship, 2009
     – 2010
  • American Heart Association Postdoctoral Fellowship, 2007
     – 2009
  • University of Cincinnati Graduate Student Poster Forum, Poster Award, 2003
  • American Heart Association Pre-doctoral Fellowship, 2001
     – 2003
  • Peking University Health Science Center Undergraduate Dissertation Award, 2000
  • Peking University Outstanding Student Scholarship, 1995
     – 2000

Research Funding

  • Protein methylation pathways that control genetic susceptibility to environmental pollutants in the occurrence of craniofacial defects
    NIH · R01DE030928 · Jul 1, 2021 – Jun 30, 2026 · Role: Principal Investigator
  • Modulation of Runx2 activity by arginine methylation
    NIH · R21DE028617 · Apr 1, 2019 – Mar 31, 2021 · Role: Principal Investigator
  • Methylation signaling in periodontal health and disease
    NIH · R01DE026468 · Jul 1, 2017 – Jun 30, 2022 · Role: Principal Investigator

Publications

  • Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Mar; 15(3):178-96.. View in PubMed
  • Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19.. View in PubMed
  • CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010 Aug; 16(8):872-9.. View in PubMed
  • Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation. 2010 Jan 26; 121(3):419-25.. View in PubMed
  • TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10; 35(1):26-36.. View in PubMed
  • TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb; 19(2):156-72.. View in PubMed
  • Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest. 2007 Nov; 117(11):3198-210.. View in PubMed
  • Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 03; 101(3):313-21.. View in PubMed
  • Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol. 2007 Feb; 18(1):117-31.. View in PubMed
  • Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem. 2006 Apr 07; 281(14):9152-62.. View in PubMed

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