Keck School Faculty

Joseph G Hacia, PhD
Joseph G Hacia, PhD
Associate Professor of Biochemistry & Molecular Medicine;Vice Chair for Medical Education
Biochemistry and Molecular Medicine
CSC 261, CSA 210, 2250 Alcazar Street Health Sciences Campus Los Angeles
Joe Hacia, an Associate Professor of Biochemistry and Molecular Medicine, is a medical geneticist who obtained his undergraduate training at Rutgers University and graduate training at the California Institute of Technology. Prior to joining the USC faculty, he obtained his post-doctoral training at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH).

The Hacia laboratory focuses on developing therapies for genetic disorders caused by impaired peroxisome assembly, structure, and function. His group focuses on peroxisome biogenesis disorders (PBDs), which include Zellweger spectrum disorder (PBD-ZSD) and rhizomelic chondrodysplasia punctata (RCDP). Affected children frequently show progressive loss of vision and hearing, impaired neurological and liver functions, and skeletal and enamel defects.

The Hacia laboratory is involved in screening of large chemical libraries for candidate small molecule therapies as well as gene augmentation, gene editing, and cell transplantation therapy projects. As part of these efforts, they developed patient-specific induced pluripotent stem cells (iPSCs) models of peroxisomal disorders. By working closely with physician-scientists and patient advocacy groups, the Global Foundation for Peroxisomal Disorders (GFPD) (http://www.thegfpd.org/) and RhizoKids International (http://www.rhizokids.com/), they seek to translate their research into improved treatments in the near future.

The Hacia laboratory has also used comparative genomic and lipidomic approaches to uncover evidence that peroxisomal metabolic activities has been strongly influenced by diet in primate lineages. They wish to use the knowledge gained from these projects to benefit the health of captive non-human primates and people with peroxisomal disorders.

Research Interests: medical genetics, molecular therapeutics, gene augmentation therapy, gene editing therapy
Diseases Models: cultured fibroblasts, induced pluripotent stem cells, genome-edited cell lines, genetically engineered mice, genetically engineered rats
Consortia: Global Foundation for Peroxisomal Disorders and RhizoKids International

: Co-organized Development of Therapies for Peroxisome Biogenesis Disorders Conference; Washington, DC, 2018

: Co-organized Development of Therapies for Peroxisome Biogenesis Disorders Conference; Washington, DC, 2017-2019

: Member, Medical Advisory Board of RhizoKids International, 2017

: Ooops. Something went wrong., 2017

: Award of Recognition for Excellence in Scientific Community Building for PBD Research by the GFPD, 2017

: Co-organized Development of Therapies for Peroxisome Biogenesis Disorders Conference; Washington, DC, 2017

: Editorial Board BMC Medical Genomics, 2016

: Ooops. Something went wrong., 2016

: Member, Scientific Advisory Board of RhizoKids International, 2016

: Year 1 USC Medical Teaching Award, 2016

: Chaired Session at ‘Leukodystrophies Conference’ in Baltimore, Maryland, 2016

: Master Teacher of the Keck School of Medicine of USC, 2016

: Year 1 Outstanding Course Award for USC Medical Teaching, 2016

: Member of Chemical Gene & Cell Therapy Committee of the American Society of Gene & Cell Therapy, 2015-2018

: Member of X-linked Adrenoleukodystrophy (ALD) Connect Workgroup on Therapy Review, 2015

: Year 2 USC Medical Teaching Award, 2015

: Ooops. Something went wrong., 2015

: Member of Chemical Gene & Cell Therapy Committee of the American Society of Gene & Cell Therapy, 2015

: Chaired Session at ASHG meeting on Targeted Drug Therapies for Progressive Genetic Disorders, 2014

: Ooops. Something went wrong., 2014

: Year 1 USC Medical Teaching Award, 2013

: Ooops. Something went wrong., 2013

: Ooops. Something went wrong., 2012

: External Reviewer, Institute of Medicine Review of California Institute for Regenerative Medicine, 2012

: Ooops. Something went wrong., 2010

: Member, Scientific Advisory Board of the Global Foundation for Peroxisomal Disorders, 2010

: Editorial Board BMC Genomics, 2010

: Chaired Session at ASHG meeting on Early Diagnosis and Treatment of CNS-based Metabolic Disorders, 2010

: Ooops. Something went wrong., 2008-2013

: Member of NIH Comparative Genomics Study Section, 2008-2013

: Editorial Board Nucleic Acids Research, 2008

: Ooops. Something went wrong., 2008

: Ooops. Something went wrong., 2004-2010

: Editorial Board of Genome Research, 2004-2010

: Ooops. Something went wrong., 2002

: V Foundation Scholar, 2002

: Ooops. Something went wrong., 2000

: American Society of Human Genetics (ASHG) Postdoctoral Translational Research Award, 2000

: Howard Hughes Medical Institute Predoctoral Fellow, 1989-1995

: Ooops. Something went wrong., 1989-1995

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