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Joseph G Hacia, PhD

Professor of Cancer Biology

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Phone +1 323 442 3030
Email hacia@usc.edu
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Publications

  • FaceBase: A Community-Driven Hub for Data-Intensive Research J Dent Res. 2022 10; 101(11):1289-1298. . View in PubMed
  • Clinical diagnosis of metabolic disorders using untargeted metabolomic profiling and disease-specific networks learned from profiling data Sci Rep. 2022 04 21; 12(1):6556. . View in PubMed
  • AAV-mediated PEX1 gene augmentation improves visual function in the PEX1-Gly844Asp mouse model for mild Zellweger spectrum disorder Mol Ther Methods Clin Dev. 2021 Dec 10; 23:225-240. . View in PubMed
  • FaceBase 3: analytical tools and FAIR resources for craniofacial and dental research Development. 2020 09 21; 147(18). . View in PubMed
  • Zellweger spectrum disorder patient-derived fibroblasts with the PEX1-Gly843Asp allele recover peroxisome functions in response to flavonoids J Cell Biochem. 2019 03; 120(3):3243-3258. . View in PubMed
  • X-linked adrenoleukodystrophy in a chimpanzee due to an ABCD1 mutation reported in multiple unrelated humans Mol Genet Metab. 2017 11; 122(3):130-133. . View in PubMed
  • MiR-153 Regulates Amelogenesis by Targeting Endocytotic and Endosomal/lysosomal Pathways-Novel Insight into the Origins of Enamel Pathologies Sci Rep. 2017 03 13; 7:44118. . View in PubMed
  • Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients Prostate. 2016 10; 76(14):1239-56. . View in PubMed
  • Peroxisome biogenesis disorders in the Zellweger spectrum: An overview of current diagnosis, clinical manifestations, and treatment guidelines Mol Genet Metab. 2016 Mar; 117(3):313-21. . View in PubMed
  • Derivation of induced pluripotent stem cells from orangutan skin fibroblasts BMC Res Notes. 2015 Oct 16; 8:577. . View in PubMed
  • Induced pluripotent stem cell models of Zellweger spectrum disorder show impaired peroxisome assembly and cell type-specific lipid abnormalities Stem Cell Res Ther. 2015 Aug 29; 6:158. . View in PubMed
  • Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis BMC Genomics. 2014 Nov 19; 15:998. . View in PubMed
  • The Pex1-G844D mouse: a model for mild human Zellweger spectrum disorder Mol Genet Metab. 2014 Apr; 111(4):522-532. . View in PubMed
  • Identification of candidate downstream targets of TGFß signaling during palate development by genome-wide transcript profiling J Cell Biochem. 2013 Apr; 114(4):796-807. . View in PubMed
  • Diverse captive non-human primates with phytanic acid-deficient diets rich in plant products have substantial phytanic acid levels in their red blood cells Lipids Health Dis. 2013 Feb 04; 12:10. . View in PubMed
  • The gene expression profiles of induced pluripotent stem cells from individuals with childhood cerebral adrenoleukodystrophy are consistent with proposed mechanisms of pathogenesis Stem Cell Res Ther. 2012 Oct 04; 3(5):39. . View in PubMed
  • A founder mutation in the PEX6 gene is responsible for increased incidence of Zellweger syndrome in a French Canadian population BMC Med Genet. 2012 Aug 15; 13:72. . View in PubMed
  • The circadian clock modulates enamel development J Biol Rhythms. 2012 Jun; 27(3):237-45. . View in PubMed
  • A TGFß-Smad4-Fgf6 signaling cascade controls myogenic differentiation and myoblast fusion during tongue development Development. 2012 May; 139(9):1640-50. . View in PubMed
  • Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling J Cell Physiol. 2012 May; 227(5):2264-75. . View in PubMed
  • Modulation of noncanonical TGF-ß signaling prevents cleft palate in Tgfbr2 mutant mice J Clin Invest. 2012 Mar; 122(3):873-85. . View in PubMed
  • Fibroblast growth factor 9 (FGF9)-pituitary homeobox 2 (PITX2) pathway mediates transforming growth factor ß (TGFß) signaling to regulate cell proliferation in palatal mesenchyme during mouse palatogenesis J Biol Chem. 2012 Jan 20; 287(4):2353-63. . View in PubMed
  • Gene-expression analysis of early- and late-maturation-stage rat enamel organ Eur J Oral Sci. 2011 Dec; 119 Suppl 1:149-57. . View in PubMed
  • [A case of bullous lupus in black skin] Ann Dermatol Venereol. 2011 Nov; 138(11):792-4. . View in PubMed
  • Human and great ape red blood cells differ in plasmalogen levels and composition Lipids Health Dis. 2011 Jun 17; 10:101. . View in PubMed
  • Nonsense suppressor therapies rescue peroxisome lipid metabolism and assembly in cells from patients with specific PEX gene mutations J Cell Biochem. 2011 May; 112(5):1250-8. . View in PubMed
  • Structural analysis of a repetitive protein sequence motif in strepsirrhine primate amelogenin PLoS One. 2011 Mar 18; 6(3):e18028. . View in PubMed
  • Identification of differences in human and great ape phytanic acid metabolism that could influence gene expression profiles and physiological functions BMC Physiol. 2010 Oct 08; 10:19. . View in PubMed
  • Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations J Cell Biochem. 2010 Mar 01; 109(4):818-27. . View in PubMed
  • Development and evaluation of new mask protocols for gene expression profiling in humans and chimpanzees BMC Bioinformatics. 2009 Mar 05; 10:77. . View in PubMed
  • Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders Hum Mutat. 2009 Mar; 30(3):E467-80. . View in PubMed
  • mtDNA depletion confers specific gene expression profiles in human cells grown in culture and in xenograft BMC Genomics. 2008 Nov 03; 9:521. . View in PubMed
  • Synthesis and anticancer properties of water-soluble zinc ionophores Cancer Res. 2008 Jul 01; 68(13):5318-25. . View in PubMed
  • DNA methylation profiles in diffuse large B-cell lymphoma and their relationship to gene expression status Leukemia. 2008 May; 22(5):1035-43. . View in PubMed
  • Age-related gene expression profiles of rhesus monkey bone marrow-derived mesenchymal stem cells J Cell Biochem. 2008 Mar 01; 103(4):1198-210. . View in PubMed
  • Loss of p53 expression correlates with metastatic phenotype and transcriptional profile in a new mouse model of head and neck cancer Mol Cancer Res. 2007 Apr; 5(4):351-62. . View in PubMed
  • Synthesis and biologic properties of hydrophilic sapphyrins, a new class of tumor-selective inhibitors of gene expression Mol Cancer. 2007 Jan 19; 6:9. . View in PubMed
  • Comparisons of PCR-based genome amplification systems using CpG island microarrays Hum Mutat. 2006 Jun; 27(6):589-96. . View in PubMed
  • Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma Proc Natl Acad Sci U S A. 2006 Feb 14; 103(7):2352-7. . View in PubMed
  • Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines Cancer Res. 2005 Dec 15; 65(24):11676-88. . View in PubMed
  • Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines Cancer Res. 2005 May 01; 65(9):3837-45. . View in PubMed
  • Comparisons of substitution, insertion and deletion probes for resequencing and mutational analysis using oligonucleotide microarrays Nucleic Acids Res. 2005 Feb 18; 33(3):e33. . View in PubMed
  • Leaky ribosomal scanning in mammalian genomes: significance of histone H4 alternative translation in vivo Nucleic Acids Res. 2005; 33(4):1298-308. . View in PubMed
  • Gene expression profiling of glucocorticoid-inhibited osteoblasts J Mol Endocrinol. 2004 Aug; 33(1):175-93. . View in PubMed
  • The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer Nat Genet. 2004 Jul; 36(7):694-9. . View in PubMed
  • Improving the sensitivity and specificity of gene expression analysis in highly related organisms through the use of electronic masks Nucleic Acids Res. 2004 Mar 18; 32(5):e51. . View in PubMed
  • Comparative analysis of gene-expression patterns in human and African great ape cultured fibroblasts Genome Res. 2003 Jul; 13(7):1619-30. . View in PubMed
  • Select your words carefully Heredity (Edinb). 2003 May; 90(5):343-4. . View in PubMed
  • Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphoma Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5372-7. . View in PubMed
  • Molecular pathology of head and neck cancer Histol Histopathol. 2002; 17(3):909-14. . View in PubMed
  • Genome of the apes Trends Genet. 2001 Nov; 17(11):637-45. . View in PubMed
  • Oligonucleotide microarray based detection of repetitive sequence changes Hum Mutat. 2000 Oct; 16(4):354-63. . View in PubMed
  • Design of modified oligodeoxyribonucleotide probes to detect telomere repeat sequences in FISH assays Nucleic Acids Res. 1999 Oct 15; 27(20):4034-9. . View in PubMed
  • Mutational analysis using oligonucleotide microarrays J Med Genet. 1999 Oct; 36(10):730-6. . View in PubMed
  • Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays Nat Genet. 1999 Jun; 22(2):164-7. . View in PubMed
  • Resequencing and mutational analysis using oligonucleotide microarrays Nat Genet. 1999 Jan; 21(1 Suppl):42-7. . View in PubMed
  • Strategies for mutational analysis of the large multiexon ATM gene using high-density oligonucleotide arrays Genome Res. 1998 Dec; 8(12):1245-58. . View in PubMed
  • Enhanced high density oligonucleotide array-based sequence analysis using modified nucleoside triphosphates Nucleic Acids Res. 1998 Nov 01; 26(21):4975-82. . View in PubMed
  • Applications of DNA chips for genomic analysis Mol Psychiatry. 1998 Nov; 3(6):483-92. . View in PubMed
  • Two color hybridization analysis using high density oligonucleotide arrays and energy transfer dyes Nucleic Acids Res. 1998 Aug 15; 26(16):3865-6. . View in PubMed
  • New approaches to BRCA1 mutation detection Breast Dis. 1998 Apr; 10(1-2):45-59. . View in PubMed
  • Structure of a stereoregular phosphorothioate DNA/RNA duplex Nat Struct Biol. 1998 Apr; 5(4):271-6. . View in PubMed
  • Evolutionary sequence comparisons using high-density oligonucleotide arrays Nat Genet. 1998 Feb; 18(2):155-8. . View in PubMed
  • Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis Nat Genet. 1996 Dec; 14(4):441-7. . View in PubMed
  • Inhibition of Klenow fragment DNA polymerase on double-helical templates by oligonucleotide-directed triple-helix formation Biochemistry. 1994 May 24; 33(20):6192-200. . View in PubMed
  • Phosphorothioate oligonucleotide-directed triple helix formation Biochemistry. 1994 May 10; 33(18):5367-9. . View in PubMed
  • Overproduction of a selenocysteine-containing polypeptide in Escherichia coli: the fdhF gene product Mol Microbiol. 1992 Mar; 6(6):781-5. . View in PubMed

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