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Justin Ichida, PhD

Associate Professor of Stem Cell Biology and Regenerative Medicine

John Douglas French Alzheimer’s Endowed Professor in Regenerative Medicine

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Phone +1 323 442 0063
Email [email protected]
CTSI Profile

Overview

Ichida Lab Website

Research Funding

  • Leveraging Natural Phenotypic Variations of Heterogenous ALS Populations-in-a-Dish to Enable Scalable Drug Discovery
    NIH · R01NS131409 · Sep 18, 2022 – Aug 31, 2027 · Role: Principal Investigator
  • Validating Secretory Autophagy as a Therapeutic Strategy for Diverse Forms of ALS and FTD
    NIH · R01NS097850 · Sep 1, 2016 – Jun 30, 2025 · Role: Principal Investigator
  • Lineage reprogramming for hearing loss: development of drug screening and gene therapy approaches
    NIH · R01DC015530 · Jul 1, 2016 – Jun 30, 2021 · Role: Co-Principal Investigator
  • Conversion of Fibroblasts to fxnal Spinal Motor Neurons Using Defined Factor
    NIH · R00NS077435 · Jan 1, 2013 – Dec 31, 2016 · Role: Principal Investigator
  • Conversion of fibroblasts to functional spinal motor neurons using defined factor
    NIH · K99NS077435 · Sep 30, 2011 – Aug 31, 2013 · Role: Principal Investigator

Publications

  • Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases. Nat Biotechnol. 2026 May; 44(5):845-861.. View in PubMed
  • An ALS assembly modulator signature in peripheral blood mononuclear cells: implications for ALS pathophysiology, therapeutics, and diagnostics. Clin Proteomics. 2025 Apr 28; 22(1):16.. View in PubMed
  • Elucidating the Synergistic Effect of the PrimeC Combination for Amyotrophic Lateral Sclerosis in Human Induced Pluripotent Stem Cell-Derived Motor Neurons and Mouse Models. Pharmaceuticals (Basel). 2025 Apr 03; 18(4).. View in PubMed
  • KCTD20 suppression mitigates excitotoxicity in tauopathy patient organoids. Neuron. 2025 Apr 16; 113(8):1169-1189.e7.. View in PubMed
  • Human iPSC-Derived Motor Neuron Innervation Enhances the Differentiation of Muscle Bundles Engineered with Benchtop Fabrication Techniques. ACS Biomater Sci Eng. 2025 Mar 10; 11(3):1731-1740.. View in PubMed
  • Human iPSC-derived motor neuron innervation enhances the differentiation of muscle bundles engineered with benchtop fabrication techniques. bioRxiv. 2024 Dec 05.. View in PubMed
  • Deconvolution of polygenic risk score in single cells unravels cellular and molecular heterogeneity of complex human diseases. bioRxiv. 2024 May 14.. View in PubMed
  • KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury. Cell Stem Cell. 2024 04 04; 31(4):519-536.e8.. View in PubMed
  • Author Correction: Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance. Nat Neurosci. 2024 Jan; 27(1):208.. View in PubMed
  • Protein Assembly Modulation: A New Approach to Amyotrophic Lateral Sclerosis (ALS) Therapeutics. J Exp Neurol. 2024; 5(4):210-230.. View in PubMed

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