Keith Hazleton

Assistant Professor of Clinical Pediatrics

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Overview

Keith Hazleton, MD, PhD is a pediatric hepatologist in the Division of Gastroenterology, Hepatology and Nutrition at Children’s Hospital Los Angeles and Assistant Professor of Clinical Pediatrics at the Keck School of Medicine of USC. His research interests include gut microbiome dysbiosis in pediatric disease, with a focus on diet-microbiome interactions in Clostridioides difficile infection and emerging work on the gut-liver axis in biliary atresia. His PhD training at Albert Einstein College of Medicine focused on purine salvage pathway enzymology and transition state analogue inhibitor development targeting Plasmodium falciparum.

Dr. Hazleton is dedicated to mentoring medical students, residents, and fellows in pediatric gastroenterology and hepatology. He serves on the NASPGHAN Research Committee, where he previously co-chaired the Grants Subcommittee and currently serves on the Abstracts Subcommittee.

Awards

  • American Gastroenterological Association Institute: Gut Microbiota for Health World Summit Travel Award, 2019
  • Front Range Microbiome Symposium: Best Contributed Presentation, 2019

Education and Training

  • Oregon State University , Corvallis, OR — BS — 04/2002 — Biochemistry/Biophysics
  • The Albert Einstein College of Medicine, Bronx, NY — MD — 05/2013 — Medicine
  • The Albert Einstein College of Medicine, Bronx, NY — PhD — 05/2013 — Biomedical Science
  • Children's Hospital Colorado/University of Colorado , Aurora, CO — 06/2015 — General Pediatrics
  • Children's Hospital Colorado/University of Colorado , Aurora, CO — 06/2019 — Pediatric Gastroenterology
  • Children's Hospital Colorado/University of Colorado , Aurora, CO — 06/2020 — Pediatric Advanced/Transplant Hepatology

Research Funding

  • Dietary and synbiotic strategy to limit gut microbiome dysbiosis and protect against Clostridioides difficile infection
    NIH · U01AI150589 · Apr 23, 2021 – Mar 31, 2026 · Role: Co-Investigator

Publications

  • Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. PLoS One. 2011; 6(11):e26916.. View in PubMed
  • Purine and pyrimidine pathways as targets in Plasmodium falciparum. Curr Top Med Chem. 2011; 11(16):2103-15.. View in PubMed
  • Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Mol Biochem Parasitol. 2010 Jan; 169(1):40-9.. View in PubMed
  • Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum. J Biol Chem. 2008 Nov 21; 283(47):32889-99.. View in PubMed
  • Anopheles gambiae purine nucleoside phosphorylase: catalysis, structure, and inhibition. Biochemistry. 2007 Oct 30; 46(43):12405-15.. View in PubMed
  • Structural characterization of the fusion of two pentapeptide repeat proteins, Np275 and Np276, from Nostoc punctiforme: resurrection of an ancestral protein. Protein Sci. 2007 Apr; 16(4):755-60.. View in PubMed