Longwei Liu, PhD

Assistant Professor of Ophthalmology and Biomedical Engineering

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Education and Training

  • Tsinghua University — PhD — 2018
  • UC San Diego — Postdoc — 2023

Research Keywords

  • Gene Therapy
  • Immunoengineering
  • CAR-T
  • Protein Engineering
  • Live Cell Imaging

Publications

  • Ultrasound controllable and antigen-independent killing via cis-activating CAR T cells. Mol Ther Oncol. 2026 Sep 17; 34(3):201323.. View in PubMed
  • Identifying and reprogramming softness-driven cancer stem-like cells overcomes CAR-T cell resistance in solid tumours. Nat Biomed Eng. 2026 Jul 06.. View in PubMed
  • Ultrasound priming gated by solid tumor hallmarks to guide CAR-T therapy. Sci Adv. 2026 Jun 12; 12(24):eaed0666.. View in PubMed
  • A wearable non-invasive sonogenetic pacemaker. Nat Biomed Eng. 2026 Jun 02.. View in PubMed
  • Engineering programmable CAR and antigen pairing via drug-gated light activation. Nat Commun. 2026 Mar 19; 17(1).. View in PubMed
  • Atlas-guided discovery of transcription factors for T cell programming. Nature. 2026 03; 651(8107):1077-1087.. View in PubMed
  • Frontiers in mechanobiology and mechanomedicine. Med X. 2025; 3(1):23.. View in PubMed
  • Mechano-regulation of cancer cell memory in tumor progression and therapy. Mechanobiol Med. 2026 Mar; 4(1):100165.. View in PubMed
  • Atlas-Guided Discovery of Transcription Factors for T Cell Programming. bioRxiv. 2025 Nov 02.. View in PubMed
  • Tumour priming by ultrasound mechanogenetics for CAR T therapy. Nat Mater. 2026 02; 25(2):310-321.. View in PubMed