Longwei Liu, PhD

Assistant Professor of Ophthalmology and Biomedical Engineering

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Education and Training

  • Tsinghua University — PhD — 2018
  • UC San Diego — Postdoc — 2023

Research Keywords

  • Gene Therapy
  • Immunoengineering
  • CAR-T
  • Protein Engineering
  • Live Cell Imaging

Publications

  • Light-gated Integrator for Highlighting Kinase Activity in Living Cells. bioRxiv. 2024 Mar 20.. View in PubMed
  • Engineering a Programmed Death-Ligand 1-Targeting Monobody Via Directed Evolution for SynNotch-Gated Cell Therapy. ACS Nano. 2024 03 19; 18(11):8531-8545.. View in PubMed
  • Far-red chemigenetic biosensors for multi-dimensional and super-resolved kinase activity imaging. bioRxiv. 2024 Feb 11.. View in PubMed
  • Cellular and molecular imaging of CAR-T cell-based immunotherapy. Adv Drug Deliv Rev. 2023 12; 203:115135.. View in PubMed
  • LUNAS: A Rapid and Sensitive Nucleic Acid Detection Assay Using Split NanoLuc Luciferase Complementation. ACS Cent Sci. 2023 Apr 26; 9(4):593-596.. View in PubMed
  • Engineering chimeric antigen receptor T cells for solid tumour therapy. Clin Transl Med. 2022 12; 12(12):e1141.. View in PubMed
  • Balancing activation and co-stimulation of CAR tunes signaling dynamics and enhances therapeutic potency. Mol Ther. 2023 01 04; 31(1):35-47.. View in PubMed
  • Transient nuclear deformation primes epigenetic state and promotes cell reprogramming. Nat Mater. 2022 10; 21(10):1191-1199.. View in PubMed
  • Occurrence of Bensulfuron-Methyl Resistance and Target-Site Resistance Mechanisms in Ammannia auriculata Biotypes from Paddy Fields. Plants (Basel). 2022 Jul 25; 11(15).. View in PubMed
  • Mechanosensor Piezo1 mediates bimodal patterns of intracellular calcium and FAK signaling. EMBO J. 2022 09 01; 41(17):e111799.. View in PubMed