Mahnaz Shahidi, PhD

Professor of Ophthalmology and Biomedical Engineering

Vice Chair for Translational Research, Ralph and Angelyn Riffenburgh Professorship in Glaucoma Research

Chair, Faculty Appointments and Promotion Tenure Committee (FAPTC) Panel A

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Overview

The research of Mahnaz Shahidi, PhD, is focused on development and application of prototype optical imaging technologies to study pathophysiology and improve diagnostic evaluation of ocular and systemic diseases. Ongoing research projects include: imaging of retinal oxygen delivery and metabolism in experimental models of retinal diseases, characterization of microvascular hemodynamics in ocular and systemic diseases, identification of image-based biomarkers of diabetic retinopathy, and assessment of retinal neurovascular coupling and oxygen metabolism in diabetic retinopathy, sickle cell retinopathy and glaucoma. Dr. Shahidi’s clinical interests include diabetic retinopathy, sickle cell retinopathy, age-related macular degeneration and glaucoma.

Awards

  • UIC: Faculty of the Year Award, 2014
  • UIC: Inventor of the Year Award, 2012
  • Morton F. Goldberg, MD, FACS Professorship, 2010
  • Research to Prevent Blindness: Senior Scientific Investigator Award, 2009
  • The Whitaker Foundation: Award, 1995
  • Juvenile Diabetes Foundation: Fellowship Award, 1992

Publications

  • Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion Neurophotonics. 2023 Jul; 10(3):035001. . View in PubMed
  • Alterations in retinal pulse wave velocity under experimental ocular hypertension Microvasc Res. 2023 07; 148:104535. . View in PubMed
  • The accumulated oxygen deficit as an indicator of the ischemic retinal insult Exp Eye Res. 2023 05; 230:109439. . View in PubMed
  • A retinal imaging system for combined measurement of optic nerve head vascular pulsation and stimulated vasodilation in humans Sci Rep. 2023 10 10; 13(1):17149. . View in PubMed
  • Impairments of retinal hemodynamics and oxygen metrics in ocular hypertension-induced ischemia-reperfusion Exp Eye Res. 2022 Dec; 225:109278. . View in PubMed
  • Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report Case Rep Ophthalmol. 2022 Sep-Dec; 13(3):686-691. . View in PubMed
  • Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer’s Disease Cells. 2022 08 04; 11(15). . View in PubMed
  • Retinal Oxygen Delivery and Metabolism Response to Hyperoxia During Bilateral Common Carotid Artery Occlusion in Rats Invest Ophthalmol Vis Sci. 2022 06 01; 63(6):30. . View in PubMed
  • Assessment of retinal oxygen metabolism, visual function, thickness and degeneration markers after variable ischemia/reperfusion in rats Exp Eye Res. 2021 12; 213:108838. . View in PubMed
  • Assessment of inner retinal oxygen metrics and thickness in a mouse model of inherited retinal degeneration Exp Eye Res. 2021 04; 205:108480. . View in PubMed
  • Relating Retinal Vascular Oxygen Saturation and Microvasculature Morphology at Progressive Stages of Diabetic Retinopathy Transl Vis Sci Technol. 2021 05 03; 10(6):4. . View in PubMed
  • Variability of Retinal Oxygen Metrics in Healthy and Diabetic Subjects Transl Vis Sci Technol. 2021 10 04; 10(12):20. . View in PubMed
  • Rod pathway and cone pathway retinal dysfunction in the 5xFAD mouse model of Alzheimer’s disease Sci Rep. 2021 03 01; 11(1):4824. . View in PubMed
  • Relationship Between Macular Vessel Density and Total Retinal Blood Flow in Primary Open-angle Glaucoma J Glaucoma. 2021 08 01; 30(8):666-671. . View in PubMed
  • Variability of Retinal Vessel Tortuosity Measurements Using a Semiautomated Method Applied to Fundus Images in Subjects With Papilledema Transl Vis Sci Technol. 2021 12 01; 10(14):32. . View in PubMed
  • Classification of advanced and early stages of diabetic retinopathy from non-diabetic subjects by an ordinary least squares modeling method applied to OCTA images Biomed Opt Express. 2020 Aug 01; 11(8):4666-4678. . View in PubMed
  • Assessment of retinal vascular oxygenation and morphology at stages of diabetic retinopathy in African Americans BMC Ophthalmol. 2020 Jul 18; 20(1):295. . View in PubMed
  • Relation of Retinal Oxygen Measures to Electrophysiology and Survival Indicators after Permanent, Incomplete Ischemia in Rats Transl Stroke Res. 2020 12; 11(6):1273-1286. . View in PubMed
  • Control of retinal blood flow levels by selected combinations of cervical arterial ligations in rat Exp Eye Res. 2020 08; 197:108088. . View in PubMed
  • Relating retinal blood flow and vessel morphology in sickle cell retinopathy Eye (Lond). 2020 05; 34(5):886-891. . View in PubMed
  • Retinal Oxygen Delivery, Metabolism, and Extraction Fraction during Long-Term Bilateral Common Carotid Artery Occlusion in Rats Sci Rep. 2020 06 25; 10(1):10371. . View in PubMed
  • Relating glaucomatous visual field loss to retinal oxygen delivery and metabolism Acta Ophthalmol. 2019 Nov; 97(7):e968-e972. . View in PubMed
  • Alterations in Retinal Oxygen Delivery, Metabolism, and Extraction Fraction During Bilateral Common Carotid Artery Occlusion in Rats Invest Ophthalmol Vis Sci. 2019 07 01; 60(8):3247-3253. . View in PubMed
  • Detection of Subclinical Diabetic Retinopathy by Fine Structure Analysis of Retinal Images J Ophthalmol. 2019; 2019:5171965. . View in PubMed
  • Relationship between retinal vessel tortuosity and oxygenation in sickle cell retinopathy Int J Retina Vitreous. 2019; 5:47. . View in PubMed
  • Retinal Oxygen Delivery, Metabolism and Extraction Fraction and Retinal Thickness Immediately Following an Interval of Ophthalmic Vessel Occlusion in Rats Sci Rep. 2019 05 30; 9(1):8092. . View in PubMed
  • A Model for Graded Retinal Ischemia in Rats Transl Vis Sci Technol. 2018 May; 7(3):10. . View in PubMed
  • Retinal Vessel Diameters Change Within 1 Hour of Intracranial Pressure Lowering Transl Vis Sci Technol. 2018 Mar; 7(2):6. . View in PubMed
  • Two-photon phosphorescence lifetime microscopy of retinal capillary plexus oxygenation in mice J Biomed Opt. 2018 12; 23(12):1-9. . View in PubMed
  • Retinal tissue oxygen tension and consumption during light flicker stimulation in rat Exp Eye Res. 2018 10; 175:207-211. . View in PubMed
  • Inter-visit variability of conjunctival microvascular hemodynamic measurements in healthy and diabetic retinopathy subjects Microvasc Res. 2018 07; 118:7-11. . View in PubMed
  • A method for volumetric retinal tissue oxygen tension imaging Curr Eye Res. 2018 01; 43(1):122-127. . View in PubMed
  • Association between Visual Acuity and Retinal Layer Metrics in Diabetics with and without Macular Edema J Ophthalmol. 2018; 2018:1089043. . View in PubMed
  • Retinal Oxygen Delivery and Metabolism in Healthy and Sickle Cell Retinopathy Subjects Invest Ophthalmol Vis Sci. 2018 04 01; 59(5):1905-1909. . View in PubMed
  • Assessment of Global and Local Alterations in Retinal Layer Thickness in Ins2 (Akita) Diabetic Mice by Spectral Domain Optical Coherence Tomography J Ophthalmol. 2018; 2018:7253498. . View in PubMed
  • Method for quantitative assessment of retinal vessel tortuosity in optical coherence tomography angiography applied to sickle cell retinopathy Biomed Opt Express. 2017 Aug 01; 8(8):3796-3806. . View in PubMed
  • Assessment of Conjunctival Microvascular Hemodynamics in Stages of Diabetic Microvasculopathy Sci Rep. 2017 04 07; 7:45916. . View in PubMed
  • Pupillary responses in non-proliferative diabetic retinopathy Sci Rep. 2017 03 23; 7:44987. . View in PubMed
  • A Method for Combined Retinal Vascular and Tissue Oxygen Tension Imaging Sci Rep. 2017 09 06; 7(1):10622. . View in PubMed
  • Retinal Vascular and Oxygen Temporal Dynamic Responses to Light Flicker in Humans Invest Ophthalmol Vis Sci. 2017 11 01; 58(13):5666-5672. . View in PubMed
  • Retinal Oximetry and Vessel Diameter Measurements With a Commercially Available Scanning Laser Ophthalmoscope in Diabetic Retinopathy Invest Ophthalmol Vis Sci. 2017 10 01; 58(12):5556-5563. . View in PubMed
  • Inner Retinal Oxygen Delivery, Metabolism, and Extraction Fraction in Ins2Akita Diabetic Mice Invest Ophthalmol Vis Sci. 2016 Nov 01; 57(14):5903-5909. . View in PubMed
  • The Effects of Diabetic Retinopathy Stage and Light Flicker on Inner Retinal Oxygen Extraction Fraction Invest Ophthalmol Vis Sci. 2016 Oct 01; 57(13):5586-5592. . View in PubMed
  • Automated fine structure image analysis method for discrimination of diabetic retinopathy stage using conjunctival microvasculature images Biomed Opt Express. 2016 Jul 01; 7(7):2597-606. . View in PubMed
  • Automated Assessment of Hemodynamics in the Conjunctival Microvasculature Network IEEE Trans Med Imaging. 2016 Feb; 35(2):605-11. . View in PubMed
  • The effect of intravitreal vascular endothelial growth factor on inner retinal oxygen delivery and metabolism in rats Exp Eye Res. 2016 Feb; 143:141-7. . View in PubMed
  • Automated Real-Time Conjunctival Microvasculature Image Stabilization IEEE Trans Med Imaging. 2016 07; 35(7):1670-5. . View in PubMed
  • Alterations in Retinal Layer Thickness and Reflectance at Different Stages of Diabetic Retinopathy by En Face Optical Coherence Tomography Invest Ophthalmol Vis Sci. 2016 07 01; 57(9):OCT341-7. . View in PubMed
  • Inner Retinal Oxygen Extraction Fraction in Response to Light Flicker Stimulation in Humans Invest Ophthalmol Vis Sci. 2015 Oct; 56(11):6633-7. . View in PubMed
  • Conjunctival microvascular hemodynamics following vaso-occlusive crisis in sickle cell disease Clin Hemorheol Microcirc. 2015 Sep 25; 62(4):359-67. . View in PubMed
  • Hemorrhagic Retinopathy after Spondylosis Surgery and Seizure Optom Vis Sci. 2015 Aug; 92(8):e190-3. . View in PubMed
  • Feasibility of assessment of conjunctival microvascular hemodynamics in unilateral ischemic stroke Microvasc Res. 2015 Jul; 100:4-8. . View in PubMed
  • Conjunctival microvascular haemodynamics in sickle cell retinopathy Acta Ophthalmol. 2015 Jun; 93(4):e275-80. . View in PubMed
  • Feasibility of level-set analysis of enface OCT retinal images in diabetic retinopathy Biomed Opt Express. 2015 May 01; 6(5):1904-18. . View in PubMed
  • Posterior segment toxicity after gemcitabine and docetaxel chemotherapy Optom Vis Sci. 2015 May; 92(5):e110-3. . View in PubMed
  • Effects of optical blur reduction on equivalent intrinsic blur Optom Vis Sci. 2015 Apr; 92(4):494-9. . View in PubMed
  • Inner and outer retinal thickness mapping of nonproliferative diabetic retinopathy by spectral-domain optical coherence tomography Ophthalmic Surg Lasers Imaging Retina. 2015 Mar; 46(3):316-20. . View in PubMed
  • Macular optical coherence tomography in patients with unilateral optic nerve hypoplasia J AAPOS. 2015 Feb; 19(1):57-61. . View in PubMed
  • Conjunctival and pulmonary hemodynamic properties in sickle cell disease subjects with and without pulmonary hypertension Clin Case Rep. 2015 12; 3(12):1038-41. . View in PubMed
  • Enface Thickness Mapping and Reflectance Imaging of Retinal Layers in Diabetic Retinopathy PLoS One. 2015; 10(12):e0145628. . View in PubMed
  • Changes in Conjunctival Hemodynamics Predict Albuminuria in Sickle Cell Nephropathy Am J Nephrol. 2015; 41(6):487-93. . View in PubMed
  • Wavefront error correction with adaptive optics in diabetic retinopathy Optom Vis Sci. 2014 Oct; 91(10):1238-43. . View in PubMed
  • Response of inner retinal oxygen extraction fraction to light flicker under normoxia and hypoxia in rat Invest Ophthalmol Vis Sci. 2014 Sep 02; 55(9):6055-8. . View in PubMed
  • Correspondence of retinal thinning and vasculopathy in mice with oxygen-induced retinopathy Exp Eye Res. 2014 May; 122:119-22. . View in PubMed
  • Retinal vessel diameter assessment in papilledema by semi-automated analysis of SLO images: feasibility and reliability Invest Ophthalmol Vis Sci. 2014 Apr 03; 55(4):2049-54. . View in PubMed
  • Inner retinal oxygen delivery and metabolism in streptozotocin diabetic rats Invest Ophthalmol Vis Sci. 2014 Mar 13; 55(3):1588-93. . View in PubMed
  • Neural constraints on visual acuity in proliferative diabetic retinopathy Optom Vis Sci. 2014 Feb; 91(2):194-9. . View in PubMed
  • A Method for En Face OCT Imaging of Subretinal Fluid in Age-Related Macular Degeneration J Ophthalmol. 2014; 2014:720243. . View in PubMed
  • Direct regularized estimation of retinal vascular oxygen tension based on an experimental model Ann Biomed Eng. 2013 Nov; 41(11):2285-95. . View in PubMed
  • In vivo retinal vascular oxygen tension imaging and fluorescein angiography in the mouse model of oxygen-induced retinopathy Invest Ophthalmol Vis Sci. 2013 Oct 23; 54(10):6968-72. . View in PubMed
  • Human bulbar conjunctival hemodynamics in hemoglobin SS and SC disease Am J Hematol. 2013 Aug; 88(8):661-4. . View in PubMed
  • Inner retinal oxygen delivery and metabolism under normoxia and hypoxia in rat Invest Ophthalmol Vis Sci. 2013 Jul 24; 54(7):5012-9. . View in PubMed
  • Inner retinal oxygen extraction fraction in rat Invest Ophthalmol Vis Sci. 2013 Jan 21; 54(1):647-51. . View in PubMed
  • Feasibility of conjunctival hemodynamic measurements in rabbits: reproducibility, validity, and response to acute hypotension Microcirculation. 2012 Aug; 19(6):521-9. . View in PubMed
  • Oxygen tension and gradient measurements in the retinal microvasculature of rats Graefes Arch Clin Exp Ophthalmol. 2012 Mar; 250(3):361-7. . View in PubMed
  • Outer retinal oxygen consumption of rat by phosphorescence lifetime imaging Curr Eye Res. 2012 Feb; 37(2):132-7. . View in PubMed
  • Object frequency characteristics of visual acuity Invest Ophthalmol Vis Sci. 2011 Dec 16; 52(13):9534-8. . View in PubMed
  • Feasibility of a method for en face imaging of photoreceptor cell integrityAm J Ophthalmol. 2011 Nov; 152(5):807-14. e1. . View in PubMed
  • Inner retinal metabolic rate of oxygen by oxygen tension and blood flow imaging in rat Biomed Opt Express. 2011 Sep 01; 2(9):2562-8. . View in PubMed
  • Contributions of optical and non-optical blur to variation in visual acuity Optom Vis Sci. 2011 Jun; 88(6):716-23. . View in PubMed
  • Central macular splaying and outer retinal thinning in asymptomatic sickle cell patients by spectral-domain optical coherence tomographyAm J Ophthalmol. 2011 Jun; 151(6):990-994. e1. . View in PubMed
  • Macular thinning associated with unilateral optic nerve hypoplasia Ophthalmic Surg Lasers Imaging. 2011 Feb 01; 42 Online:e6-9. . View in PubMed
  • Thickness mapping of retinal layers by spectral-domain optical coherence tomography Am J Ophthalmol. 2010 Dec; 150(6):849-55. . View in PubMed
  • Retinal tissue oxygen tension imaging in the rat Invest Ophthalmol Vis Sci. 2010 Sep; 51(9):4766-70. . View in PubMed
  • Differential macular morphology in patients with RPE65-, CEP290-, GUCY2D-, and AIPL1-related Leber congenital amaurosis Invest Ophthalmol Vis Sci. 2010 May; 51(5):2608-14. . View in PubMed
  • Association between retinal thickness and retinal pigment epithelium elevation in age-related macular degeneration Ophthalmic Surg Lasers Imaging. 2010 Mar-Apr; 41(2):175-81. . View in PubMed
  • Abnormal retinal vascular oxygen tension response to light flicker in diabetic rats Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5444-8. . View in PubMed
  • Regularized estimation of retinal vascular oxygen tension from phosphorescence images IEEE Trans Biomed Eng. 2009 Aug; 56(8):1989-95. . View in PubMed
  • Three-dimensional mapping of chorioretinal vascular oxygen tension in the rat Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):820-5. . View in PubMed
  • Representing the retinal line spread shape with mathematical functions J Zhejiang Univ Sci B. 2008 Dec; 9(12):996-1002. . View in PubMed
  • Thickness profiles of retinal layers by optical coherence tomography image segmentation Am J Ophthalmol. 2008 Nov; 146(5):679-87. . View in PubMed
  • Correlation between microaneurysms and retinal thickness in diabetic macular edema Retina. 2008 Oct; 28(8):1097-103. . View in PubMed
  • Effect of aberrations and scatter on image resolution assessed by adaptive optics retinal section imaging J Opt Soc Am A Opt Image Sci Vis. 2007 May; 24(5):1296-304. . View in PubMed
  • Retinal thickness and visual thresholds measured in patients with retinitis pigmentosa Retina. 2007 Mar; 27(3):349-57. . View in PubMed
  • A method for three-dimensional imaging of the retina in human eyes Ophthalmic Surg Lasers Imaging. 2007 Jan-Feb; 38(1):35-42. . View in PubMed
  • Chorioretinal vascular oxygen tension changes in response to light flicker Invest Ophthalmol Vis Sci. 2006 Nov; 47(11):4962-5. . View in PubMed
  • Nerve fiber layer thickness in glaucoma patients with asymmetric hemifield visual field loss J Glaucoma. 2006 Aug; 15(4):275-80. . View in PubMed
  • A method for chorioretinal oxygen tension measurement Curr Eye Res. 2006 Apr; 31(4):357-66. . View in PubMed
  • A method for differentiating ocular higher-order aberrations from light scatter applied to retinitis pigmentosa Optom Vis Sci. 2005 Nov; 82(11):976-80. . View in PubMed
  • Imaging retinal depression sign in sickle cell anemia using optical coherence tomography and the retinal thickness analyzer Arch Ophthalmol. 2005 Sep; 123(9):1278-9. . View in PubMed
  • Noninvasive assessment of chorioretinal oxygenation changes in experimental carotid occlusion Curr Eye Res. 2005 Sep; 30(9):763-71. . View in PubMed
  • Higher-order wavefront aberrations in retinitis pigmentosa Optom Vis Sci. 2005 Jul; 82(7):623-8. . View in PubMed
  • Quantitative thickness measurement of retinal layers imaged by optical coherence tomography Am J Ophthalmol. 2005 Jun; 139(6):1056-61. . View in PubMed
  • Measurements of ocular aberrations and light scatter in healthy subjects Optom Vis Sci. 2004 Nov; 81(11):853-7. . View in PubMed
  • Is “whole eye” wavefront analysis helpful to corneal refractive therapy? Eye Contact Lens. 2004 Oct; 30(4):186-8; discussion 205-6.. View in PubMed
  • Optical section retinal imaging and wavefront sensing in diabetes Optom Vis Sci. 2004 Oct; 81(10):778-84. . View in PubMed
  • Feasibility of noninvasive imaging of chorioretinal oxygenation Ophthalmic Surg Lasers Imaging. 2004 Sep-Oct; 35(5):415-22. . View in PubMed
  • Relationship of retinal structural and clinical vision parameters to driving performance of diabetic retinopathy patients J Rehabil Res Dev. 2004 May; 41(3A):347-58. . View in PubMed
  • Higher-order wavefront aberrations in corneal refractive therapy Optom Vis Sci. 2003 Dec; 80(12):805-11. . View in PubMed
  • Delay in starting treatment for tuberculosis in east London Commun Dis Public Health. 2003 Jun; 6(2):133-8. . View in PubMed
  • Chorioretinal topography and histopathology in laser-induced choroidal neovascularization Ophthalmic Surg Lasers Imaging. 2003 Jan-Feb; 34(1):38-43. . View in PubMed
  • Relation between retinal thickening and clinically visible fundus pathologies in mild nonproliferative diabetic retinopathy Ophthalmic Surg Lasers. 2002 Mar-Apr; 33(2):127-34. . View in PubMed

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