Mahnaz Shahidi, PhD

Professor of Ophthalmology and Biomedical Engineering

Vice Chair for Translational Research, Ralph and Angelyn Riffenburgh Professorship in Glaucoma Research

Chair, Faculty Appointments and Promotion Tenure Committee (FAPTC) Panel A

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Overview

The research of Mahnaz Shahidi, PhD, is focused on development and application of prototype optical imaging technologies to study pathophysiology and improve diagnostic evaluation of ocular and systemic diseases. Ongoing research projects include: imaging of retinal oxygen delivery and metabolism in experimental models of retinal diseases, characterization of microvascular hemodynamics in ocular and systemic diseases, identification of image-based biomarkers of diabetic retinopathy, and assessment of retinal neurovascular coupling and oxygen metabolism in diabetic retinopathy, sickle cell retinopathy and glaucoma. Dr. Shahidi’s clinical interests include diabetic retinopathy, sickle cell retinopathy, age-related macular degeneration and glaucoma.

Awards

  • Juvenile Diabetes Foundation: Fellowship Award, 1992
  • The Whitaker Foundation: Award, 1995
  • Research to Prevent Blindness: Senior Scientific Investigator Award, 2009
  • Morton F. Goldberg, MD, FACS Professorship, 2010
  • UIC: Inventor of the Year Award, 2012
  • UIC: Faculty of the Year Award, 2014

Education and Training

  • University of Illinois — PhD — 1988 — Physics

Research Funding

  • Retinal Ischemia Treatment by Oxygen Nanobubbles
    NIH · R21EY035371 · Sep 30, 2023 – Aug 31, 2025 · Role: Principal Investigator
  • Two-photon Imaging of Oxygen and Blood Flow in Retinal and Cerebral Vasculature
    NIH · R01NS121095 · May 1, 2021 – Apr 30, 2027 · Role: Co-Principal Investigator
  • Two-photon Imaging of Oxygen and Blood Flow in Retinal and Cerebral Vasculature
    NIH · RF1NS121095 · May 1, 2021 – Apr 30, 2024 · Role: Co-Principal Investigator
  • Imaging of Retinal Oxygen Metabolism in Diabetic Retinopathy
    NIH · R01EY030115 · Jan 1, 2020 – Dec 31, 2024 · Role: Principal Investigator
  • Center Core Grant for Vision Research
    NIH · P30EY029220 · Sep 30, 2018 – Jun 30, 2028 · Role: Principal Investigator
  • Ocular Biomarkers of Microvascular, Neural and Metabolic Function in Diabetes
    NIH · DP3DK104393 · Sep 30, 2014 – Aug 31, 2018 · Role: Principal Investigator
  • Investigating Optical and Neural Causes of Vision Loss
    NIH · I01RX000213 · Oct 1, 2009 – Dec 31, 2014 · Role: Principal Investigator
  • Imaging of Retinal Oxygenation and Metabolism
    NIH · R01EY017918 · Dec 1, 2006 – Jan 31, 2024 · Role: Principal Investigator
  • Noninvsive Imaging of Chorio-retinal Oxygen Tension
    NIH · R03EY014917 · Aug 1, 2003 – Jul 31, 2007 · Role: Principal Investigator
  • Retinal Image Quality in Retinal-diseased Eyes
    NIH · R01EY014275 · Sep 1, 2002 – Mar 31, 2012 · Role: Principal Investigator
  • NONINVASIVE IMAGING OF THE CHORIO-RETINAL INTERFACE
    NIH · R29EY010314 · Feb 1, 1996 – Jan 31, 2002 · Role: Principal Investigator
  • P30 Core Grant for Vision Research
    NIH · P30EY001792 · Sep 1, 1978 – Aug 31, 2026 · Role: Co-Principal Investigator

Publications

  • Electric field stimulation directs target-specific axon regeneration and partial restoration of vision after optic nerve crush injury. PLoS One. 2025; 20(1):e0315562.. View in PubMed
  • Inner retinal oxygen delivery and metabolism in progressive stages of diabetic retinopathy. Sci Rep. 2024 02 22; 14(1):4414.. View in PubMed
  • A retinal imaging system for combined measurement of optic nerve head vascular pulsation and stimulated vasodilation in humans. Sci Rep. 2023 10 10; 13(1):17149.. View in PubMed
  • Differential reductions in the capillary red-blood-cell flux between retina and brain under chronic global hypoperfusion. Neurophotonics. 2023 Jul; 10(3):035001.. View in PubMed
  • Alterations in retinal pulse wave velocity under experimental ocular hypertension. Microvasc Res. 2023 07; 148:104535.. View in PubMed
  • The accumulated oxygen deficit as an indicator of the ischemic retinal insult. Exp Eye Res. 2023 05; 230:109439.. View in PubMed
  • Impairments of retinal hemodynamics and oxygen metrics in ocular hypertension-induced ischemia-reperfusion. Exp Eye Res. 2022 12; 225:109278.. View in PubMed
  • Alterations in Retinal Vascular and Oxygen Metrics in Treated and Untreated Proliferative Diabetic Retinopathy: A Case Report. Case Rep Ophthalmol. 2022 Sep-Dec; 13(3):686-691.. View in PubMed
  • Retinal Vascular Physiology Biomarkers in a 5XFAD Mouse Model of Alzheimer’s Disease. Cells. 2022 08 04; 11(15).. View in PubMed
  • Retinal Oxygen Delivery and Metabolism Response to Hyperoxia During Bilateral Common Carotid Artery Occlusion in Rats. Invest Ophthalmol Vis Sci. 2022 06 01; 63(6):30.. View in PubMed