Keck School Faculty

Mark S. Humayun

Mark S. Humayun

University Professor of Ophthalmology
Cornelius J. Pings Chair in Biomedical Sciences
Director, Institute for Biomedical Therapeutics
Co-Director USC Roski Eye Institute
Director of Sensory Science Initiatives
HC4 6534B 1450 San Pablo Street Off Campus Los Angeles

: National Academy of Inventors Fellows Medallion, 2017

: USC Presidential Medallion, 2017

: National Medal of Technology and Innovation, 2016

Wills Eye Institute: Richard Ellis Award, 2014

Pasadena Magazine: Top Doctors in Ophthalmology, 2013-2014

UIC Illinois Eye and Ear Infirmary: Morton F. Goldberg Endowed Lecturer Medallion, 2013

U.S. World & News Report: Top 1% of Ophthalmologists, 2011

Castle Connolly Medical Ltd. : America's Top Doctors, 2011

: Popular Mechanics Breakthrough Award, 2010

: Best Doctors in Southern California Award, 2009

The Retina Society: Award of Merit in Retina Research, 2009

: Best Doctors of America Award, 2005-2007

: Strathmore's Who's Who Award, 2005-2006

R&D magazine: Innovator of the Year award, 2005

: Senior Honor Award of the Am. Soc. Retina Specialists, 2004

: Jules Stein Living tribute Award, 2002

: William and Mary Grieve Scholar's Award, 1997-1998

: Richard S. Ross Clinical Scientist Award, 1997-1998

Cyanine Nanocage Activated by Near-IR Light for the Targeted Delivery of Cyclosporine A to Traumatic Brain Injury Sites Mol Pharm. 2020 Aug 19. . View in PubMed

ADVERSE EVENTS OF THE ARGUS II RETINAL PROSTHESIS: Incidence, Causes, and Best Practices for Managing and Preventing Conjunctival Erosion Retina. 2020 Feb; 40(2):303-311. . View in PubMed

Economic Value of Anti-Vascular Endothelial Growth Factor Treatment for Patients With Wet Age-Related Macular Degeneration in the United States JAMA Ophthalmol. 2019 Nov 14. . View in PubMed

Evaluating New Ophthalmic Digital Devices for Safety and Effectiveness in the Context of Rapid Technological Development JAMA Ophthalmol. 2019 Jun 06. . View in PubMed

A Novel Racing Array Transducer for Noninvasive Ultrasonic Retinal Stimulation: A Simulation Study Sensors (Basel). 2019 Apr 17; 19(8). . View in PubMed

Flexible piezoelectric ultrasonic energy harvester array for bio-implantable wireless generator Nano Energy. 2019 Feb; 56:216-224. . View in PubMed

Enhanced Depth Navigation Through Augmented Reality Depth Mapping in Patients with Low Vision Sci Rep. 2019 08 02; 9(1):11230. . View in PubMed

Argus II Retinal Prosthesis Implantation in a Patient With a History Of Strabismus Surgery:A Surgical Technique Ophthalmic Surg Lasers Imaging Retina. 2019 02 01; 50(2):116-119. . View in PubMed

ADVERSE EVENTS OF THE ARGUS II RETINAL PROSTHESIS: Incidence, Causes, and Best Practices for Managing and Preventing Conjunctival Erosion Retina. 2018 Nov 20. . View in PubMed

A new immunodeficient retinal dystrophic rat model for transplantation studies using human-derived cells Graefes Arch Clin Exp Ophthalmol. 2018 Nov; 256(11):2113-2125. . View in PubMed

Development of a KNN Ceramic-Based Lead-Free Linear Array Ultrasonic Transducer IEEE Trans Ultrason Ferroelectr Freq Control. 2018 11; 65(11):2113-2120. . View in PubMed

Chronically Implantable Package Based on Alumina Ceramics and Titanium with High-density Feedthroughs for Medical Implants Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:3382-3385. . View in PubMed

High-Performance Ultrasound Needle Transducer Based on Modified PMN-PT Ceramic With Ultrahigh Clamped Dielectric Permittivity IEEE Trans Ultrason Ferroelectr Freq Control. 2018 02; 65(2):223-230. . View in PubMed

Disintegrin-Integrin Binding for Attachment of Polymer Substrate to the Retina J Clin Exp Ophthalmol. 2018; 9(5). . View in PubMed

A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration Sci Transl Med. 2018 04 04; 10(435). . View in PubMed

A reversible thermoresponsive sealant for temporary closure of ocular trauma Sci Transl Med. 2017 Dec 06; 9(419). . View in PubMed

Flexible microelectrode array for retinal prosthesis Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:1097-1100. . View in PubMed

High-performance iridium oxide/platinum nano-leaf composite coatings on microelectrodes for neural stimulation/recording Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:1070-1073. . View in PubMed

Development of a new tissue injector for subretinal transplantation of human embryonic stem cell derived retinal pigmented epithelium Int J Retina Vitreous. 2017; 3:41. . View in PubMed

Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models Stem Cells Int. 2017; 2017:9428176. . View in PubMed

An Innovative Surgical Technique for Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium in Yucatan Mini Pigs: Preliminary Results Ophthalmic Surg Lasers Imaging Retina. 2016 Apr 01; 47(4):342-51. . View in PubMed

Five-Year Safety and Performance Results from the Argus II Retinal Prosthesis System Clinical Trial Ophthalmology. 2016 10; 123(10):2248-54. . View in PubMed

Biomimetic Accommodating Intraocular Lens Using a Valved Deformable Liquid Balloon IEEE Trans Biomed Eng. 2016 06; 63(6):1129-35. . View in PubMed

Electrical Stimulation of the Retina to Produce Artificial Vision Annu Rev Vis Sci. 2016 10 14; 2:273-294. . View in PubMed

Fluidics comparison between dual pneumatic and spring return high-speed vitrectomy systems Ophthalmic Surg Lasers Imaging Retina. 2015 Jan; 46(1):68-72. . View in PubMed

Elastic properties of human posterior eye J Biomed Mater Res A. 2014 Jun; 102(6):2001-7. . View in PubMed

Comparison of reaction response time between hand and foot controlled devices in simulated microsurgical testing Biomed Res Int. 2014; 2014:769296. . View in PubMed

A fully intraocular high-density self-calibrating epiretinal prosthesis IEEE Trans Biomed Circuits Syst. 2013 Dec; 7(6):747-60. . View in PubMed

A system verification platform for high-density epiretinal prostheses IEEE Trans Biomed Circuits Syst. 2013 Jun; 7(3):326-37. . View in PubMed

Analysis of a 23-gauge ultra high-speed cutter with duty cycle control Retina. 2013 May; 33(5):933-8. . View in PubMed

Factors Affecting Perceptual Threshold in Argus II Retinal Prosthesis Subjects Transl Vis Sci Technol. 2013 Apr; 2(4):1. . View in PubMed

Fluidics in a dual pneumatic ultra high-speed vitreous cutter system Ophthalmologica. 2013; 229(1):15-20. . View in PubMed

High-resolution OCT: an innovative tool for posterior segment imaging Ophthalmic Surg Lasers Imaging. 2012 Nov-Dec; 43(6 Suppl):S123-34. . View in PubMed

Evaluation of ultrasound-assisted thrombolysis using custom liposomes in a model of retinal vein occlusion Invest Ophthalmol Vis Sci. 2012 Oct 05; 53(11):6920-7. . View in PubMed

Fluorescein angiography, optical coherence tomography, and histopathologic findings in a VEGF(165) animal model of retinal angiogenesis Graefes Arch Clin Exp Ophthalmol. 2012 Oct; 250(10):1421-8. . View in PubMed

Artificial vision through neuronal stimulation Neurosci Lett. 2012 Jun 25; 519(2):122-8. . View in PubMed

Assessment of MRI issues for the Argus II retinal prosthesis Magn Reson Imaging. 2012 Apr; 30(3):382-9. . View in PubMed

Frequency and amplitude modulation have different effects on the percepts elicited by retinal stimulation Invest Ophthalmol Vis Sci. 2012 Jan 20; 53(1):205-14. . View in PubMed

Acute variations in retinal vascular oxygen content in a rabbit model of retinal venous occlusion PLoS One. 2012; 7(11):e50179. . View in PubMed

A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer Ophthalmic Res. 2012; 48(4):186-91. . View in PubMed

Continuous electrical stimulation decreases retinal excitability but does not alter retinal morphology J Neural Eng. 2011 Aug; 8(4):045003. . View in PubMed

Both electrical stimulation thresholds and SMI-32-immunoreactive retinal ganglion cell density correlate with age in S334ter line 3 rat retina J Neurophysiol. 2011 Jun; 105(6):2687-97. . View in PubMed

Blind subjects implanted with the Argus II retinal prosthesis are able to improve performance in a spatial-motor task Br J Ophthalmol. 2011 Apr; 95(4):539-43. . View in PubMed

A new dual port cutter system for vitrectomy surgery Retina. 2010 Oct; 30(9):1515-9. . View in PubMed

An experimental protocol of the model to quantify traction applied to the retina by vitreous cutters Invest Ophthalmol Vis Sci. 2010 Aug; 51(8):4181-6. . View in PubMed

Effect of multiple injections of small divided doses vs single injection of intravitreal bevacizumab on retinal neovascular model in rabbits Graefes Arch Clin Exp Ophthalmol. 2010 Apr; 248(4):457-66. . View in PubMed

Blood velocity measurement in the posterior segment of the rabbit eye using combined spectral Doppler and power Doppler ultrasound Graefes Arch Clin Exp Ophthalmol. 2010 Jan; 248(1):93-101. . View in PubMed

Brightness as a function of current amplitude in human retinal electrical stimulation Invest Ophthalmol Vis Sci. 2009 Nov; 50(11):5017-25. . View in PubMed

Finite element modeling of retinal prosthesis mechanics J Neural Eng. 2009 Oct; 6(5):055006. . View in PubMed

A passive MEMS drug delivery pump for treatment of ocular diseases Biomed Microdevices. 2009 Oct; 11(5):959-70. . View in PubMed

Conjunctival impression cytology by using a thermosensitive adhesive: polymerized N-isopropyl acrylamide Cornea. 2009 Aug; 28(7):770-3. . View in PubMed

Feasibility study of a retinal prosthesis: spatial vision with a 16-electrode implant Arch Ophthalmol. 2009 Apr; 127(4):398-401. . View in PubMed

Feasibility of rotational scan ultrasound imaging by an angled high frequency transducer for the posterior segment of the eye IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Mar; 56(3):676-80. . View in PubMed

Guillotine performance: duty cycle analysis of vitrectomy systems Retin Cases Brief Rep. 2009; 3(1):64-7. . View in PubMed

Artificial vision: needs, functioning, and testing of a retinal electronic prosthesis Prog Brain Res. 2009; 175:317-32. . View in PubMed

A comparison of retinal prosthesis electrode array substrate materials Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:4140-3. . View in PubMed

Biomimetic image processing for retinal prostheses: peripheral saliency cues Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:4569-72. . View in PubMed

A reversible thermosensitive adhesive for retinal implants: in vivo experience with plasma-deposited poly(N-isopropyl acrylamide) Retina. 2008 Oct; 28(9):1338-43. . View in PubMed

A refillable microfabricated drug delivery device for treatment of ocular diseases Lab Chip. 2008 Jul; 8(7):1027-30. . View in PubMed

An in vitro model of a retinal prosthesis IEEE Trans Biomed Eng. 2008 Jun; 55(6):1744-53. . View in PubMed

Factors affecting perceptual thresholds in epiretinal prostheses Invest Ophthalmol Vis Sci. 2008 Jun; 49(6):2303-14. . View in PubMed

Handheld forward-imaging needle endoscope for ophthalmic optical coherence tomography inspection J Biomed Opt. 2008 Mar-Apr; 13(2):020505. . View in PubMed

Determining the acoustic properties of the lens using a high-frequency ultrasonic needle transducer Ultrasound Med Biol. 2007 Dec; 33(12):1971-7. . View in PubMed

Evaluation of lens hardness in cataract surgery using high-frequency ultrasonic parameters in vitro Ultrasound Med Biol. 2007 Oct; 33(10):1609-16. . View in PubMed

Evaluation of a stereoscopic camera-based three-dimensional viewing workstation for ophthalmic surgery Am J Ophthalmol. 2007 May; 143(5):891-2. . View in PubMed

Electrical properties of retinal-electrode interface J Neural Eng. 2007 Mar; 4(1):S24-9. . View in PubMed

Effect of oxygenated intraocular irrigation solutions on the electroretinogram after vitrectomy Retina. 2007 Jan; 27(1):87-94. . View in PubMed

A novel method to oxygenate intraocular irrigation fluids with an in-line oxygenator Retina. 2007 Jan; 27(1):83-6. . View in PubMed

Electrical stimulation in normal and retinal degeneration (rd1) isolated mouse retina Vision Res. 2006 Oct; 46(19):3198-204. . View in PubMed

Electrical stimulation in isolated rabbit retina IEEE Trans Neural Syst Rehabil Eng. 2006 Sep; 14(3):290-8. . View in PubMed

Enucleated eye model for intraocular retinal prosthesis implantation Ophthalmic Surg Lasers Imaging. 2006 Jul-Aug; 37(4):341-3. . View in PubMed

A transcutaneous data telemetry system tolerant to power telemetry interference Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:5884-7. . View in PubMed

A dual band wireless power and data telemetry for retinal prosthesis Conf Proc IEEE Eng Med Biol Soc. 2006; 2006:4392-5. . View in PubMed

A biomimetic retinal stimulating array IEEE Eng Med Biol Mag. 2005 Sep-Oct; 24(5):14-21. . View in PubMed

A wireless phase shift keying transmitter with q-independent phase transition time Conf Proc IEEE Eng Med Biol Soc. 2005; 2005:5238-41. . View in PubMed

A programmable discharge circuitry with current limiting capability for a retinal prosthesis Conf Proc IEEE Eng Med Biol Soc. 2005; 2005:5234-7. . View in PubMed

Electrical stimulation of isolated retina with microwire glass electrodes J Neurosci Methods. 2004 Aug 30; 137(2):265-73. . View in PubMed

Comparison of electrical stimulation thresholds in normal and retinal degenerated mouse retina Jpn J Ophthalmol. 2004 Jul-Aug; 48(4):345-9. . View in PubMed

Effects of intravitreal indocyanine green injection in rabbits Retina. 2004 Feb; 24(1):69-79. . View in PubMed

Effects of indocyanine green injection on the retinal surface and into the subretinal space in rabbits Retina. 2004 Feb; 24(1):80-91. . View in PubMed

DSP based image processing for retinal prosthesis Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:1475-8. . View in PubMed

A test microchip for evaluation of hermetic packaging technology for biomedical prosthetic implants Conf Proc IEEE Eng Med Biol Soc. 2004; 2004:4093-5. . View in PubMed

Characteristics of visual loss by scanning laser ophthalmoscope microperimetry in eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration Am J Ophthalmol. 2003 Dec; 136(6):1067-78. . View in PubMed

Facial recognition using simulated prosthetic pixelized vision Invest Ophthalmol Vis Sci. 2003 Nov; 44(11):5035-42. . View in PubMed

Bilateral neuroretinopathy with multiple retinal arterial aneurysms Arch Ophthalmol. 2003 Aug; 121(8):1206-7. . View in PubMed

Advances in the development of visual prostheses Curr Opin Ophthalmol. 2003 Jun; 14(3):122-7. . View in PubMed

Angiographic characteristics in patients undergoing macular translocation for subfoveal choroidal neovascularization secondary to age-related macular degeneration Retina. 2003 Apr; 23(2):152-8. . View in PubMed

Heat effects on the retina Ophthalmic Surg Lasers Imaging. 2003 Mar-Apr; 34(2):114-20. . View in PubMed

A new 25-gauge instrument system for transconjunctival sutureless vitrectomy surgery Ophthalmology. 2002 Oct; 109(10):1807-12; discussion 1813. . View in PubMed

Ganglion cell responses to retinal light stimulation in the absence of photoreceptor outer segments from retinal degenerate rodents Curr Eye Res. 2002 Jan; 24(1):26-32. . View in PubMed

Elevated vitreous concentration of monoclonal immunoglobulin manifesting as schlieren in juvenile rheumatoid arthritis-associated uveitis Arch Ophthalmol. 2001 Feb; 119(2):293-6. . View in PubMed

Complications associated with limited macular translocation Am J Ophthalmol. 2000 Dec; 130(6):751-62. . View in PubMed

Bilateral retinoschisis, retinal neovascularization, and severe myopia in a young female Ophthalmic Surg Lasers. 2000 Sep-Oct; 31(5):442-3. . View in PubMed

Bioadhesives for intraocular use Retina. 2000; 20(5):469-77. . View in PubMed

A computational model of electrical stimulation of the retinal ganglion cell IEEE Trans Biomed Eng. 1999 May; 46(5):505-14. . View in PubMed

Allogenic fetal retinal pigment epithelial cell transplant in a patient with geographic atrophy Retina. 1999; 19(6):540-5. . View in PubMed

Artificial vision Eye (Lond). 1998; 12 ( Pt 3b):605-7. . View in PubMed

Can potentials from the visual cortex be elicited electrically despite severe retinal degeneration and a markedly reduced electroretinogram? Ger J Ophthalmol. 1995 Jan; 4(1):57-64.. View in PubMed

Bipolar surface electrical stimulation of the vertebrate retina Arch Ophthalmol. 1994 Jan; 112(1):110-6. . View in PubMed

Changes in the contralateral eye in uncomplicated persistent hyperplastic primary vitreous in adults Am J Ophthalmol. 1985 Feb 15; 99(2):122-4. . View in PubMed

Mark S. Humayun, MD, PhD, received his Bachelors of Science degree from Georgetown University in 1984, his Masters Doctorate from Duke University in 1989, and his PhD from the University of North Carolina, Chapel Hill in 1994. He completed his ophthalmology residency at Duke Eye Center and fellowships in both vitreoretinal and retinovascular surgery at Johns Hopkins Hospital. He stayed on as faculty at Johns Hopkins where he rose to the rank of associate professor before moving to USC in 2001.

Dr. Humayun has devoted much of his career to clinical and scientific research in ophthalmology and bioengineering, becoming both a biomedical engineer and professor of ophthalmology. Dr. Humayun led a talented and diverse team of interdisciplinary researchers with the ultimate goal of creating the world’s first artificial retina. He assembled a team of world experts with a wide range of proficiency, including biomedical engineering, computer science, medicine, chemistry, biology and business. In clinical trials since 2007 and approved by the FDA in 2013, the Argus II retinal implant, represents the culmination of a visual restoration strategy that offers an unprecedented degree of sight to those with complete retinal blindness. He was elected to the prestigious National Academy of Medicine (NAM) and National Academy of Engineering (NAE) for his pioneering work to restore sight.

With over 200 publications and more than 100 patents and patent applications, Dr. Humayun has received several research awards which includes the 2005 Innovator of the Year award. He was also featured as one of the top 10 inventors in Time Magazine in 2013, voted as one of the Best Doctors in America for three years, and one of the top 1% of Doctors by U.S. News & World Report.

In 2016, Dr. Humayun received the National Medal of Technology and Innovation from President Barack Obama for his innovative work and development of the Argus II.
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