Mark S. Humayun, MD, PhD

University Professor of Ophthalmology, Stem Cell Biology and Regenerative Medicine and Biomedical Engineering

Dennis and Michele Slivinski Chair in Macular Degeneration Research

Director, USC Ginsburg Institute for Biomedical Therapeutics

Co-Director, USC Roski Eye Institute

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Overview

Mark S. Humayun, MD, PhD, received his Bachelors of Science degree from Georgetown University in 1984, his Doctor of Medicine (MD) from Duke University in 1989, and his PhD from the University of North Carolina, Chapel Hill in 1994. He completed his ophthalmology residency at Duke Eye Center and fellowships in both vitreoretinal and retinovascular surgery at Johns Hopkins Hospital. He stayed on as faculty at Johns Hopkins where he rose to the rank of associate professor before moving to USC in 2001.Dr. Humayun has devoted much of his career to clinical and scientific research in ophthalmology and bioengineering, becoming both a biomedical engineer and professor of ophthalmology. Dr. Humayun led a talented and diverse team of interdisciplinary researchers with the ultimate goal of creating the world’s first artificial retina. He assembled a team of world experts with a wide range of proficiency, including biomedical engineering, computer science, medicine, chemistry, biology and business. In clinical trials since 2007 and approved by the FDA in 2013, the Argus II retinal implant, represents the culmination of a visual restoration strategy that offers an unprecedented degree of sight to those with complete retinal blindness. He was elected to the prestigious National Academy of Medicine (NAM) and National Academy of Engineering (NAE) for his pioneering work to restore sight.With over 332 publications and more than 165 patents and patent applications, Dr. Humayun has received several research awards which includes the 2005 Innovator of the Year award. He was also featured as one of the top 10 inventors in Time Magazine in 2013, voted as one of the Best Doctors in America for three years, and one of the top 1% of Doctors by U.S. News & World Report.In 2016, Dr. Humayun received the National Medal of Technology and Innovation from President Barack Obama for his innovative work and development of the Argus II.

Awards

  • The Macula Society: Arnall Patz Medal, 2026
  • Chang Gung Memorial Hospital: Keynote Distinguished Annual Lecture, 2025
  • University of Southern California: Research Day at the Ostrow School of Dentistry, Keynote Speaker, 2024
  • University of Southern California: 1st Annual AI West Med Symposium, Plenary Keynote Speaker, 2024
  • Indo-China Ocular Inflammation Study Group Meeting: 10th Indo-China Ocular Inflammation Study Group Meeting, Plenary Keynote Speaker, 2023
  • USC Roski Eye Institute: Narsing A. Rao, MD Endowed Lecture Award, 2022
  • Association for Research in Vision and Ophthalmology: ARVO Fellows Class of 2022, 2022
  • American Association for the Advancement of Science: American Association for the Advancement of Science (AAAS) Fellow, 2022
  • USC Stevens Center for Innovation: 2020 Technology Commercialization Award, 2021
  • Retina Research Foundation: Retina Research Foundation Award of Merit (The Schepens Lecture), 2021
  • Super Doctors Southern California Magazine: Southern California Super Doctors, 2021
  • American Society of Retina Specialists: Gertrude D. Pyron Award, 2020
  • European Vitreo Retinal Society: The Relja Zivojnovic Award, 2020
  • Institute of Electrical and Electronics Engineers: 2020 IEEE Medal for Innovations in Healthcare Technology, 2020
  • University of Southern California: USC Stevens Center Commercialization Award, 2019
  • Georgetown University: Doctor of Humane Letters, Honoris Causa, 2019
  • Duke Medical Alumni Association: Distinguished Alumnus Award, 2019
  • Farabi Eye Hospital: 2018 Persian Ophthalmologist, 2018
  • Institute of Electrical and Electronics Engineers: IEEE Biomedical Engineering Award, 2018
  • Eye and Ear Foundation, University of Pittsburgh: 2018 Muse Prize in Ophthalmology, 2018
  • Future Vision Foundation: 2018 Future Vision Award, 2018
  • National Academy of Inventors Fellows Medallion, 2017
  • USC Presidential Medallion, 2017
  • National Medal of Technology and Innovation, 2016
  • Wills Eye Institute: Richard Ellis Award, 2014
  • Pasadena Magazine: Top Doctors in Ophthalmology, 2013-2014
  • UIC Illinois Eye and Ear Infirmary: Morton F. Goldberg Endowed Lecturer Medallion, 2013
  • Castle Connolly Medical Ltd.: America’s Top Doctors, 2011
  • U.S. World & News Report: Top 1% of Ophthalmologists, 2011
  • Popular Mechanics Breakthrough Award, 2010
  • Best Doctors in Southern California Award, 2009
  • The Retina Society: Award of Merit in Retina Research, 2009
  • Best Doctors of America Award, 2005-2007
  • Strathmore’s Who’s Who Award, 2005-2006
  • R&D magazine: Innovator of the Year award, 2005
  • Senior Honor Award of the Am. Soc. Retina Specialists, 2004
  • Jules Stein Living tribute Award, 2002
  • Richard S. Ross Clinical Scientist Award, 1997-1998
  • William and Mary Grieve Scholar’s Award, 1997-1998

Publications

  • Noninvasive imaging-guided ultrasonic neurostimulation with arbitrary 2D patterns and its application for high-quality vision restoration. Nat Commun. 2024 May 27; 15(1):4481.. View in PubMed
  • Rescuing Photoreceptors in RPE Dysfunction-Driven Retinal Degeneration: The Role of Small Extracellular Vesicles Secreted from Retinal Pigment Epithelium. bioRxiv. 2024 Apr 13.. View in PubMed
  • Unveiling Drivers of Retinal Degeneration in RCS Rats: Functional, Morphological, and Molecular Insights. Int J Mol Sci. 2024 Mar 28; 25(7).. View in PubMed
  • Scaling up polarized RPE cell supernatant production on parylene membrane. Exp Eye Res. 2024 03; 240:109789.. View in PubMed
  • Integrating a Fundus Camera with High-Frequency Ultrasound for Precise Ocular Lesion Assessment. Biosensors (Basel). 2024 Feb 29; 14(3).. View in PubMed
  • Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats. Int J Mol Sci. 2024 Feb 15; 25(4).. View in PubMed
  • Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study. Int J Mol Sci. 2024 Feb 08; 25(4).. View in PubMed
  • Flow Characterization in a Partially Liquefied Vitreous Humor. Transp Porous Media. 2024 Feb; 151(3):533-558.. View in PubMed
  • Transcorneal electrical stimulation restores DNA methylation changes in retinal degeneration. Front Mol Neurosci. 2024; 17:1484964.. View in PubMed
  • Ultrasound Concave 2-D Ring Array for Retinal Stimulation. IEEE Trans Ultrason Ferroelectr Freq Control. 2023 11; 70(11):1527-1535.. View in PubMed