Neil Kaplowitz, MD

Professor of Medicine

USC Associates/Thomas H. Brem Chair in Medicine

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Overview

Dr. Kaplowitz’s research interests include drug toxicity, signal transduction, oxidative stress, glutathione metabolism, pathogenesis of alcoholic liver disease, endoplasmic reticulum (ER) stress, and mitochondrial biogenesis.

Dr. Kaplowitz earned his medical degree from New York University School of Medicine. He then went on to complete a Gastroenterology Fellowship at Cornell University Medical College.

Awards

  • Western Gastroenterology: Research Prize, 1986
  • Association of American Physicians: Member, 1988
  • NIH: Merit Award, 1992
  • Department of Veterans Affairs: William S. Middleton Award, 1993
  • New York University School of Medicine: Solomon A. Berson Medical Alumni Achievement Award in Clinical Science, 1994
  • American Liver Foundation: Greater Los Angeles Medical Honoree, 2000
  • American Gastroenterological Association: Foundation Research Mentor Award Honoree, 2005
  • Wadworth VA Alumni Association: William H. Oldendorf Lifetime Achievement Award, 2006
  • American Association for the Study of Liver Diseases: Distinguished Achievement Award, 2006
  • Western Society of Clinical Investigation: Mayo Soley Award, 2007
  • American Liver Foundation: Distinguished Scientific Achievement Award, 2008

Research Funding

  • Targets of JNK in acute hepatotoxicity.
    NIH · R01DK126866 · Sep 18, 2020 – May 31, 2025 · Role: Principal Investigator
  • Retrograde Signaling in Alcohol-Induced Mitochondrial Stress and Biogenesis.
    NIH · R21AA017746 · Sep 15, 2008 – Aug 31, 2010 · Role: Principal Investigator
  • Cellular Mechanisms of Hepatotoxicity.
    NIH · R01DK067215 · Apr 1, 2004 – Feb 28, 2021 · Role: Principal Investigator
  • Homocysteine, ER Stress and Alcoholic Liver Injury.
    NIH · R01AA014428 · Jul 1, 2003 – Mar 31, 2015 · Role: Principal Investigator
  • USC Research Center for Liver Disease
    NIH · P30DK048522 · Mar 1, 1995 – Feb 28, 2021 · Role: Principal Investigator
  • EFFECT OF ETHANOL ON HEPATIC GSH HOMEOSTASIS
    NIH · R01AA009526 · Apr 1, 1993 – Mar 31, 2001 · Role: Principal Investigator
  • ROLE OF CYTOKINE INFLAMMATION
    NIH · R13DK044465 · Sep 30, 1991 – Aug 31, 1992 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01DK030312 · Feb 1, 1982 – May 31, 2005 · Role: Principal Investigator
  • PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R37DK030312 · Feb 1, 1982 – May 31, 2000 · Role: Principal Investigator
  • THE PHYSIOLOGY OF GLUTATHIONE EFFLUX FROM THE LIVER
    NIH · R01AM030312 · Feb 1, 1982 – Jan 31, 1987 · Role: Principal Investigator

Research Keywords

  • Models of acute and chronic liver disease

Publications

  • The contribution of endoplasmic reticulum stress to liver diseases. Hepatology. 2011 May; 53(5):1752-63.. View in PubMed
  • Differential effect of gender on hepatic fat. Pediatr Radiol. 2011 Sep; 41(9):1146-53.. View in PubMed
  • Recurrent drug-induced liver injury (DILI) with different drugs in the Spanish Registry: the dilemma of the relationship to autoimmune hepatitis. J Hepatol. 2011 Oct; 55(4):820-7.. View in PubMed
  • Metabonomic investigation of liver profiles of nonpolar metabolites obtained from alcohol-dosed rats and mice using high mass accuracy MSn analysis. J Proteome Res. 2011 Feb 04; 10(2):705-13.. View in PubMed
  • Regulation of mitochondrial glutathione redox status and protein glutathionylation by respiratory substrates. J Biol Chem. 2010 Dec 17; 285(51):39646-54.. View in PubMed
  • Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria. Mol Interv. 2010 Apr; 10(2):98-111.. View in PubMed
  • Differences in betaine-homocysteine methyltransferase expression, endoplasmic reticulum stress response, and liver injury between alcohol-fed mice and rats. Hepatology. 2010 Mar; 51(3):796-805.. View in PubMed
  • Silencing glycogen synthase kinase-3beta inhibits acetaminophen hepatotoxicity and attenuates JNK activation and loss of glutamate cysteine ligase and myeloid cell leukemia sequence 1. J Biol Chem. 2010 Mar 12; 285(11):8244-55.. View in PubMed
  • Signal transduction pathways involved in drug-induced liver injury. Handb Exp Pharmacol. 2010.. View in PubMed
  • Diagnosis, management and prevention of drug-induced liver injury. Gut. 2009 Nov; 58(11):1555-64.. View in PubMed