Keck School Faculty

Nicholas Mancuso

Nicholas Mancuso

Assistant Professor of Population and Public Health Sciences
Medicine
1845 N. Soto Street Health Sciences Campus Los Angeles

Investigating DNA methylation as a mediator of genetic risk in childhood acute lymphoblastic leukemia Hum Mol Genet. 2022 Oct 28; 31(21):3741-3756. . View in PubMed

Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children Haematologica. 2022 Sep 01; 107(9):2266-2270. . View in PubMed

Genome-wide trans-ethnic meta-analysis identifies novel susceptibility loci for childhood acute lymphoblastic leukemia Leukemia. 2022 03; 36(3):865-868. . View in PubMed

Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits Mol Psychiatry. 2022 03; 27(3):1394-1404. . View in PubMed

Interaction between maternal killer immunoglobulin-like receptors and offspring HLAs and susceptibility of childhood ALL Blood Adv. 2022 06 28; 6(12):3756-3766. . View in PubMed

A genealogical estimate of genetic relationships Am J Hum Genet. 2022 05 05; 109(5):812-824. . View in PubMed

A transcriptome-wide association study identifies novel candidate susceptibility genes for prostate cancer risk Int J Cancer. 2022 01 01; 150(1):80-90. . View in PubMed

Correction to: Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes Genome Med. 2021 Aug 30; 13(1):139. . View in PubMed

Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 Mar; 53(3):413. . View in PubMed

Multitrait transcriptome-wide association study (TWAS) tests Genet Epidemiol. 2021 09; 45(6):563-576. . View in PubMed

Leveraging expression from multiple tissues using sparse canonical correlation analysis and aggregate tests improves the power of transcriptome-wide association studies PLoS Genet. 2021 04; 17(4):e1008973. . View in PubMed

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction Nat Genet. 2021 01; 53(1):65-75. . View in PubMed

Integrative genomic analyses identify susceptibility genes underlying COVID-19 hospitalization Nat Commun. 2021 07 27; 12(1):4569. . View in PubMed

Evaluating Polygenic Risk Scores for Breast Cancer in Women of African Ancestry J Natl Cancer Inst. 2021 09 04; 113(9):1168-1176. . View in PubMed

A Hierarchical Approach Using Marginal Summary Statistics for Multiple Intermediates in a Mendelian Randomization or Transcriptome Analysis Am J Epidemiol. 2021 06 01; 190(6):1148-1158. . View in PubMed

Identification of TBX15 as an adipose master trans regulator of abdominal obesity genes Genome Med. 2021 08 02; 13(1):123. . View in PubMed

H3K27ac HiChIP in prostate cell lines identifies risk genes for prostate cancer susceptibility Am J Hum Genet. 2021 12 02; 108(12):2284-2300. . View in PubMed

Integrative analyses identify susceptibility genes underlying COVID-19 hospitalization medRxiv. 2020 Dec 08. . View in PubMed

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms Cell. 2020 Apr 30; 181(3):745. . View in PubMed

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms Cell. 2020 Apr 16; 181(2):484. . View in PubMed

The Role of Genetically Determined Glycemic Traits in Breast Cancer: A Mendelian Randomization Study Front Genet. 2020; 11:540724. . View in PubMed

Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data Am J Hum Genet. 2020 06 04; 106(6):805-817. . View in PubMed

Integrative analysis of Dupuytren's disease identifies novel risk locus and reveals a shared genetic etiology with BMI Genet Epidemiol. 2019 09; 43(6):629-645. . View in PubMed

Accurate estimation of SNP-heritability from biobank-scale data irrespective of genetic architecture Nat Genet. 2019 08; 51(8):1244-1251. . View in PubMed

Probabilistic fine-mapping of transcriptome-wide association studies Nat Genet. 2019 04; 51(4):675-682. . View in PubMed

Opportunities and challenges for transcriptome-wide association studies Nat Genet. 2019 04; 51(4):592-599. . View in PubMed

Genome-Wide Meta-analysis of Gene-Environmental Interaction for Insulin Resistance Phenotypes and Breast Cancer Risk in Postmenopausal Women Cancer Prev Res (Phila). 2019 01; 12(1):31-42. . View in PubMed

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease MechanismsCell. 2019 10 17; 179(3):750-771. e22. . View in PubMed

Post genome-wide gene-environment interaction study: The effect of genetically driven insulin resistance on breast cancer risk using Mendelian randomization PLoS One. 2019; 14(6):e0218917. . View in PubMed

Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights Nat Genet. 2018 04; 50(4):538-548. . View in PubMed

Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum Nat Commun. 2018 03 21; 9(1):1178. . View in PubMed

Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits Am J Hum Genet. 2018 10 04; 103(4):535-552. . View in PubMed

Large-scale transcriptome-wide association study identifies new prostate cancer risk regions Nat Commun. 2018 10 04; 9(1):4079. . View in PubMed

Local Genetic Correlation Gives Insights into the Shared Genetic Architecture of Complex Traits Am J Hum Genet. 2017 Nov 02; 101(5):737-751. . View in PubMed

Targeted mutagenesis in a human-parasitic nematode PLoS Pathog. 2017 Oct; 13(10):e1006675. . View in PubMed

Enhanced methods to detect haplotypic effects on gene expression Bioinformatics. 2017 Aug 01; 33(15):2307-2313. . View in PubMed

Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits Am J Hum Genet. 2017 Mar 02; 100(3):473-487. . View in PubMed

A multi-stage genome-wide association study of uterine fibroids in African Americans Hum Genet. 2017 10; 136(10):1363-1373. . View in PubMed

The contribution of rare variation to prostate cancer heritability Nat Genet. 2016 Jan; 48(1):30-5. . View in PubMed

Accurate viral population assembly from ultra-deep sequencing data Bioinformatics. 2014 Jun 15; 30(12):i329-37. . View in PubMed

Reconstruction of viral population structure from next-generation sequencing data using multicommodity flows BMC Bioinformatics. 2013; 14 Suppl 9:S2. . View in PubMed

My research aims to develop novel computational and statistical approaches to understand the genetic etiology of complex diseases. This includes integrating molecular phenotypes (e.g., gene expression, protein abundance) with large-scale genome-wide association studies, characterizing the genetic architecture of complex disease (e.g., rare vs common variation), and quantifying the role of selection in shaping the effect-size distribution for alleles.
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