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Nicholas Mancuso, PhD

Associate Professor of Population and Public Health Sciences and Quantitative and Computational Biology

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Email nmancuso@usc.edu
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Overview

My research aims to develop novel computational and statistical approaches to understand the genetic etiology of complex diseases. This includes integrating molecular phenotypes (e.g., gene expression, protein abundance) with large-scale genome-wide association studies, characterizing the genetic architecture of complex disease (e.g., rare vs common variation), and quantifying the role of selection in shaping the effect-size distribution for alleles.

Publications

  • Identifying independent causal cell types for human diseases and risk variants. Cell Genom. 2026 Sep 09; 6(9):101325.. View in PubMed
  • Genome-wide association study and predictors of neonatal blood cell traits in Hispanic newborns. Am J Hum Genet. 2026 Aug 06; 113(8):1646-1664.. View in PubMed
  • Highly efficient genotype compression leveraging genealogical relatedness. bioRxiv. 2026 May 05.. View in PubMed
  • Publisher Correction: Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting. Nat Genet. 2026 May; 58(5):1186.. View in PubMed
  • Prioritizing context-specific genetic risk mechanisms in 11 solid cancers. J Natl Cancer Inst. 2026 Apr 17.. View in PubMed
  • Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting. Nat Genet. 2026 Apr; 58(4):810-820.. View in PubMed
  • Single-cell full-length transcriptome of human lung reveals genetic effects on isoform regulation beyond gene-level expression. bioRxiv. 2026 Mar 30.. View in PubMed
  • Single-cell lung eQTL dataset of Asian never-smokers highlights the roles of alveolar cells in lung cancer etiology. bioRxiv. 2026 Mar 27.. View in PubMed
  • Prioritizing context-specific genetic risk mechanisms in 11 solid cancers. medRxiv. 2025 Nov 02.. View in PubMed
  • The impact of Indigenous American-like ancestry on the risk of acute lymphoblastic leukemia in Hispanic/Latino children. HGG Adv. 2026 Jan 15; 7(1):100534.. View in PubMed

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