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Nicholas Mancuso, PhD

Associate Professor of Population and Public Health Sciences and Quantitative and Computational Biology

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Email nmancuso@usc.edu
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Overview

My research aims to develop novel computational and statistical approaches to understand the genetic etiology of complex diseases. This includes integrating molecular phenotypes (e.g., gene expression, protein abundance) with large-scale genome-wide association studies, characterizing the genetic architecture of complex disease (e.g., rare vs common variation), and quantifying the role of selection in shaping the effect-size distribution for alleles.

Publications

  • Improved multiancestry fine-mapping identifies cis-regulatory variants underlying molecular traits and disease risk. Nat Genet. 2025 Aug; 57(8):1881-1889.. View in PubMed
  • traceax: a JAX-based framework for stochastic trace estimation. bioRxiv. 2025 Jul 20.. View in PubMed
  • Identifying independent causal cell types for human diseases and risk variants. medRxiv. 2025 Jul 03.. View in PubMed
  • Author Correction: A likelihood-based framework for demographic inference from genealogical trees. Nat Genet. 2025 Jul; 57(7):1787.. View in PubMed
  • The impact of Indigenous American-like ancestry on risk of acute lymphoblastic leukemia in Hispanic/Latino children. medRxiv. 2025 Apr 10.. View in PubMed
  • A likelihood-based framework for demographic inference from genealogical trees. Nat Genet. 2025 Apr; 57(4):865-874.. View in PubMed
  • Efficient count-based models improve power and robustness for large-scale single-cell eQTL mapping. medRxiv. 2025 Mar 05.. View in PubMed
  • The Influence of DNA Repair Genes and Prenatal Tobacco Exposure on Risk of Childhood Acute Lymphoblastic Leukemia: A Gene-Environment Interaction Study. Cancer Epidemiol Biomarkers Prev. 2025 01 09; 34(1):100-107.. View in PubMed
  • Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity. Res Sq. 2024 Dec 16.. View in PubMed
  • Multi-ancestry GWAS of severe pregnancy nausea and vomiting identifies risk loci associated with appetite, insulin signaling, and brain plasticity. medRxiv. 2024 Nov 20.. View in PubMed

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