Pat R. Levitt, PhD

Provost Professor of Pediatrics, Pharmacy, Psychology, and Pathology

W.M. Keck Chair in Neurogenetics

Chief Scientific Officer, Senior Vice President, and Director of The Saban Research Institute

Director of the Program in Developmental Neurogenetics at The Saban Research Institute

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Overview

Dr. Levitt received his BA in Biological Sciences from the University of Chicago, PhD in Neuroscience at the University of California, San Diego. He completed a postdoctoral fellowship in Neuroscience at Yale University. Dr. Levitt has held leadership positions at University of Pittsburgh, Vanderbilt University and University of Southern California. Dr. Levitt was elected as a member into the prestigious Institute of Medicine (IOM), part of the National Academy of Sciences. Named a McKnight Foundation Scholar in 2002, Dr. Levitt also was a MERIT awardee from the National Institute of Mental Health and served as a member of the National Advisory Mental Health Council for the National Institute of Mental Health. He is an elected Fellow of the American Association for the Advancement of Science (AAAS), Chair-elect of the Neuroscience Division of the AAAS, and an elected member of the Dana Alliance for Brain Initiatives. He is a Senior Fellow at the Center for the Developing Child at Harvard University, and serves as Scientific Director of the National Scientific Council on the Developing Child, a policy council that brings the best research from child development and neuroscience to assist policy makers and business leaders in making wise program investment decisions. He is a member of a number of scientific advisory boards for foundations and university programs, served as Senior Editor for Journal of Neuroscience, and currently serves on the editorial boards of eLife, Neuron, Cerebral Cortex, Autism Research, Journal of Neurodevelopmental Disorders and Disease Models and Mechanisms. Dr. Levitt’s research focuses on the development of brain architecture that controls learning, emotional and social behavior. His research focuses on genetic and environment factors that increase risk for neurodevelopmental and neuropsychiatric disorders, such as autism and schizophrenia. His clinical research studies address autism heterogeneity by studying children with autism who also have co-occurring medical conditions, such as gastrointestinal disorders, with the goal of developing better diagnostic criteria and personalized treatments. He has published over 250 papers.

Research Funding

  • Identification of Child Risk and Resilience to Early Life Stress
    NIH · R01HD118103 · Sep 1, 2026 – May 31, 2031 · Role: Principal Investigator
  • 2/24 Healthy Brain and Child Development National Consortium
    NIH · U01DA055362 · Sep 30, 2021 – Jun 30, 2027 · Role: Principal Investigator
  • Impact of Early Life Experience on Vagal Neurons and Circuits
    NIH · R01DK126085 · Apr 12, 2021 – Mar 31, 2025 · Role: Principal Investigator
  • Biological and Environmental Contributions to Healthy Baby Development in Diverse Population
    NIH · R34DA050254 · Sep 30, 2019 – Mar 31, 2021 · Role: Principal Investigator
  • Modeling genetic contributions to phenotype variation and neurodevelopmental disorder susceptibility
    NIH · R21MH118685 · Jun 5, 2019 – Mar 31, 2021 · Role: Principal Investigator
  • Predoctoral Training in Interdisciplinary Neurosciences
    NIH · T32MH111360 · Jul 1, 2016 – Jun 30, 2021 · Role: Principal Investigator
  • Mechanisms of Autonomic Brainstem Development
    NIH · R21NS086413 · May 1, 2014 – Oct 31, 2016 · Role: Principal Investigator
  • Leptin and the Nutritional Programming of Obesity and Diabetes
    NIH · R01DK084142 · Aug 10, 2010 – Mar 31, 2024 · Role: Principal Investigator
  • Autism Research Program
    NIH · P30MH089877 · Sep 30, 2009 – Aug 31, 2012 · Role: Principal Investigator
  • The MET Signaling System,Autism and Gastrointestinal Dysfunction
    NIH · R21HD065289 · Sep 30, 2009 – Aug 31, 2012 · Role: Principal Investigator
  • Transcriptional Atlas of Human Brain Development
    NIH · RC2MH090047 · Sep 30, 2009 – Aug 31, 2012 · Role: Co-Principal Investigator
  • Neurodevelopmental Mechanisms of Social Behavior
    NIH · R01MH080759 · Sep 1, 2007 – Aug 31, 2013 · Role: Principal Investigator
  • Development of Reciprocal Neural Circuitry
    NIH · R01DA022785 · Sep 1, 2007 – Jun 30, 2013 · Role: Principal Investigator
  • 16th Biennial Meeting of the International Society for Developmental Neurobiology
    NIH · R13NS056849 · Jul 1, 2006 – Jun 30, 2007 · Role: Principal Investigator
  • Biobehavioral Intervention in Developmental Disabilities
    NIH · T32MH075883 · Sep 29, 2005 – Aug 31, 2010 · Role: Co-Principal Investigator
  • Function and Structure Adaptations in Forebrain Development
    NIH · R01MH067842 · Jul 1, 2002 – Mar 31, 2025 · Role: Principal Investigator
  • Function and Structure Adaptations in Forebrain Development
    NIH · R56MH067842 · Jul 1, 2002 – Aug 31, 2015 · Role: Principal Investigator
  • FETAL COCAINE AND GENE EXPRESSION DEFECTS IN FOREBRAIN
    NIH · R01DA013792 · Sep 30, 2000 – Jul 31, 2004 · Role: Principal Investigator
  • Brain Structure &Function after Fetal Cocaine Exposure
    NIH · R01DA011165 · Sep 30, 1996 – May 31, 2006 · Role: Principal Investigator
  • MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM
    NIH · S03RR003573 · Mar 12, 1993 – Feb 29, 1996 · Role: Co-Principal Investigator
  • NON-NEURONAL CELLS AND CNS FORMATION AND INJURY
    NIH · R01DA009555 · Aug 15, 1991 – Jun 30, 1999 · Role: Principal Investigator
  • ROLE OF NON-NEURONAL CELLS IN CNS FORMATION &INJURY
    NIH · R01AG010560 · Aug 15, 1991 – Jul 31, 1994 · Role: Principal Investigator
  • Factors Regulating Limbic System Assembly
    NIH · R01MH045507 · Sep 1, 1989 – Apr 30, 2009 · Role: Co-Principal Investigator
  • FACTORS REGULATING LIMBIC SYSTEM ASSEMBLY
    NIH · R37MH045507 · Sep 1, 1989 – Aug 31, 1999 · Role: Principal Investigator
  • RECOGNITION EVENTS BETWEEN VISUAL AND IMMUNE SYSTEMS
    NIH · R03EY006047 · Aug 1, 1985 – Jul 31, 1986 · Role: Principal Investigator
  • GENETIC CONTROL OF MONOAMINERGIC AXON GROWTH
    NIH · R01NS020196 · Dec 1, 1983 – Sep 30, 1990 · Role: Principal Investigator
  • Eunice Kennedy Shriver Intellectual and Developmental Disability Research Center
    NIH · P30HD015052 · Jun 1, 1980 – Jun 30, 2015 · Role: Co-Principal Investigator

Publications

  • Translating the Biology of Adversity and Resilience Into New Measures for Pediatric Practice. Pediatrics. 2022 06 01; 149(6).. View in PubMed
  • Disrupted Timing of MET Signaling Derails the Developmental Maturation of Cortical Circuits and Leads to Altered Behavior in Mice. Cereb Cortex. 2022 04 05; 32(8):1769-1786.. View in PubMed
  • Prenatal Exposure to Air Pollution and Autism Spectrum Disorder: Sensitive Windows of Exposure and Sex Differences. Environ Health Perspect. 2022 01; 130(1):17008.. View in PubMed
  • MET Receptor Tyrosine Kinase Regulates Lifespan Ultrasonic Vocalization and Vagal Motor Neuron Development. Front Neurosci. 2021; 15:768577.. View in PubMed
  • Progressions on the Coexistence of Neuronal and Glial Precursor Cells in the Cerebral Ventricular Zone. J Neurosci. 2021 04 14; 41(15):3301-3306.. View in PubMed
  • Genes, Environments, and Time: The Biology of Adversity and Resilience. Pediatrics. 2021 02; 147(2).. View in PubMed
  • Leveraging the Biology of Adversity and Resilience to Transform Pediatric Practice. Pediatrics. 2021 02; 147(2).. View in PubMed
  • Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling. J Pineal Res. 2021 Mar; 70(2):e12705.. View in PubMed
  • Photoperiodic effects on monoamine signaling and gene expression throughout development in the serotonin and dopamine systems. Sci Rep. 2020 09 22; 10(1):15437.. View in PubMed
  • Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adults. Neurobiol Stress. 2020 Nov; 13:100251.. View in PubMed