Patrick Lyden, MD

Dr. Lyden is the Professor of Physiology & Neuroscience and Neurology at the Zilkha Neurogenetic Institute in the Keck School of Medicine at USC. Dr. Lyden helped lead the pivotal NINDS t-PA for Acute Stroke Trial, the first proven therapy for stroke. He is recognized globally for leadership in stroke therapy, having led large, multi-national trials for NIH and industry. Dr. Lyden is the Principal investigator of the NINDS-sponsored Stroke Preclinical Assessment Network, or SPAN, the first multi-site trial intended to identify candidate treatments likely to succeed in human clinical trials. He is the Chair of the Stroke Council of the American Heart Association/American Stroke Association. Dr. Lyden has been elected a Fellow of the American Academy of Neurology, American Neurology Association, American Heart Association, and the European Stroke Organization. In 2019 he was awarded the prestigious William M. Feinberg Award for Excellence in Clinical Stroke by the American Heart Association. Beginning in 2023 he will lead a 100-center, $20M clinical trial of a new drug for stroke treatment in the NIH funded StrokeNet network.

• Cedars-Sinai Medical Center: Faculty Teaching Award, 2020
• UT Houston: Gladys & George T. Abell Lecturship in Neurology, 2019
• American Heart Association/American Stroke Association: AHA/ASA William M. Feinberg Award for Excellence in Clinical Stroke, 2019
• University of Iowa: Adolf L. Sahs, MD Memorial Visiting Lecturer, 2011
• 2001
   -: Best Doctors in America, 2001
   –
• UCSD: Department of Neurosciences Award for Outstanding Teaching, 2014
• American Heart Association, San Diego Affiliate: Heart of Gold Award, 2002

• UCLA, Los Angeles — BS — 07/1974 — Biochemistry
• Baylor College of Medicine, Houston — MD — 061981 — Medicine
• Mercy Hospital, San Diego — 06/1982 — Internship
• UCSD, San Diego — 06/1985 — Neurology
• UCSD, San Diego — 06/1987 — Vascular Neurology

• Mechanisms and Treatment Implications of Differential Vulnerability in the Central Nervous System
  NIH · RF1NS146594 · Aug 18, 2026 – Jul 31, 2029 · Role: Principal Investigator
• The NIH SPAN Coordinating Center
  NIH · U24NS130600 · Jan 1, 2023 – Dec 31, 2025 · Role: Principal Investigator
• The NIH SPAN Coordinating Center
  NIH · U24NS113452 · Aug 1, 2019 – Jul 31, 2022 · Role: Principal Investigator
• ZZ-3K3A-201: Safety evaluation of 3K3A-APC in ischemic stroke
  NIH · U01NS088312 · Jul 1, 2014 – Jun 30, 2019 · Role: Principal Investigator
• Thrombin mediated cytotoxicity during cerebral ischemia
  NIH · R01NS075930 · Aug 15, 2011 – May 31, 2021 · Role: Principal Investigator
• Quantitation of Early Vascular Leakage after Stroke
  NIH · R21NS052565 · Jul 15, 2005 – Apr 30, 2008 · Role: Principal Investigator
• Role of Angiogenesis Following Stroke
  NIH · R01NS043300 · Dec 15, 2002 – Jun 30, 2008 · Role: Principal Investigator
• Therapeutic Window for Acute Stroke Therapy (P50)
  NIH · P50NS044148 · Jul 1, 2002 – Apr 30, 2015 · Role: Co-Principal Investigator
• MULTIFOCAL CEREBRAL ISCHEMIA
  NIH · R29NS026783 · Aug 1, 1989 – Jul 31, 1994 · Role: Principal Investigator

• Zlokovic, Berislav
• Hirsch, Joshua
• Mack, William
• Towfighi, Amytis
• Sanossian, Nerses
• Winstein, Carolee