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Rayudu Gopalakrishna, PhD

Professor of Integrative Anatomical Sciences

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Phone +1 323 442 1770
Email [email protected]
CTSI Profile

Awards

  • National Cancer Institute, NIH: FIRST Award, 1988
     – 1993
  • Keck School of Medicine of USC: Excellence in Teaching Certificate, 1995
  • Keck School of Medicine of USC: Outstanding Teaching Award (year II med)), 1996
  • Keck School of Medicine of USC: Outstanding Teaching Award (year II med), 2000
  • Keck School of Medicine of USC: Outstanding Teaching Award (year I med), 2003
  • Keck School of Medicine of USC: Outstanding teaching Award (year II med), 2004
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2006
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year II med), 2008
  • Keck School of Medicine of USC: Master Teacher, 2008
  • Alpha Omega Alpha: Membership, 2010
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2011
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2014
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year II med), 2014

Education and Training

  • Andhra University, Visakhapatnam, India — B.S. — 09/1973 — Biology
  • Andhra University, Visakhapatnam, India — M.S. — 09/1975 — Biochemistry
  • University of Madras, Chennai, India — Ph.D. — 08/1979 — Biochemistry
  • University of Madras, Chennai, India — Post-doc — 12/1981 — Biochemistry
  • National Cancer Institute, NIH, Bethesda, MD — Post-doc — 11/1983 — Pathophysiology

Research Funding

  • Synergistic white matter injury from diesel exhaust particulate and chronic cerebral hypoperfusion exposures: Interaction between the Nogo/NgR1 receptor pathway and extravascular fibrinogen toxicity
    NIH · RF1NS130681 · Sep 20, 2022 – Aug 31, 2027 · Role: Co-Principal Investigator
  • Translational potential of the internalization of Nogo-A receptor to enhance axonal regeneration after stroke
    NIH · R21NS116720 · Jul 1, 2020 – Jun 30, 2022 · Role: Principal Investigator
  • Prostate cancer prevention by selenium supplementation
    NIH · R01CA099216 · Jul 1, 2009 – May 31, 2015 · Role: Principal Investigator
  • CANCER PREVENTION &IMBALANCE IN PROTEIN PHOSPHORYLATION
    NIH · R01CA062146 · Dec 15, 1993 – Nov 30, 1998 · Role: Principal Investigator
  • TUMOR PROMOTERS AND PROTEIN KINASE C IN CANCER METASTASI
    NIH · R29CA047142 · May 1, 1988 – May 31, 1994 · Role: Principal Investigator

Research Keywords

  • Cancer prevention
  • Natural Products
  • Selenium
  • green tea
  • Stroke prevention and treatment
  • Alzheimer's disease and neuroprotection

Publications

  • Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. J Biol Chem. 2008 Dec 12; 283(50):34519-31.. View in PubMed
  • A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem. 2008 May 23; 283(21):14430-44.. View in PubMed
  • The synthetic estrogen 4-estren-3 alpha,17 beta-diol (estren) induces estrogen-like neuroprotection. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):331-9.. View in PubMed
  • Estrogen activates protein kinase C in neurons: role in neuroprotection. J Neurochem. 2003 Mar; 84(6):1340-8.. View in PubMed
  • Antioxidant regulation of protein kinase C in cancer prevention. J Nutr. 2002 Dec; 132(12):3819S-3823S.. View in PubMed
  • Protein kinase C as a molecular target for cancer prevention by selenocompounds. Nutr Cancer. 2001; 40(1):55-63.. View in PubMed
  • Protein kinase C signaling and oxidative stress. Free Radic Biol Med. 2000 May 01; 28(9):1349-61.. View in PubMed
  • Tumor promoter benzoyl peroxide induces sulfhydryl oxidation in protein kinase C: its reversibility is related to the cellular resistance to peroxide-induced cytotoxicity. Arch Biochem Biophys. 1999 Mar 15; 363(2):246-58.. View in PubMed
  • Differential distribution of protein phosphatase 2A in human breast carcinoma cell lines and its relation to estrogen receptor status. Cancer Lett. 1999 Mar 01; 136(2):143-51.. View in PubMed
  • Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-kappa B activation in the murine macrophage J774A.1 cell line. Arch Biochem Biophys. 1998 Feb 01; 350(1):79-86.. View in PubMed

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