Robert Featherstone, PhD

Assistant Professor of Research Psychiatry and the Behavioral Sciences

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Overview

Robert E. Featherstone, Ph.D., is an Assistant Professor of Research in the Department of Psychiatry and Behavioral Sciences at the University of Southern California. His research focuses on the neurobiology, cognitive dysfunction, and treatment of schizophrenia and depression, integrating both preclinical animal models and human clinical research.

Dr. Featherstone’s work examines the neural mechanisms underlying cognitive impairments associated with psychiatric illness and seeks to identify novel therapeutic strategies to improve cognitive and functional outcomes. His research combines behavioral neuroscience, neuropsychopharmacology, and electrophysiology, with particular expertise in EEG and event-related potential (ERP) biomarkers for psychiatric drug discovery and translational neuroscience.

Current projects investigate glutamatergic signaling pathways, NMDA receptor function, and synaptic mechanisms that contribute to cognitive deficits in neuropsychiatric disorders. By integrating behavioral, molecular, and electrophysiological approaches across animal and human studies, his research aims to advance the development of mechanism-based treatments that improve both symptoms and cognitive functioning in individuals with serious mental illness.

Publications

  • Long-term effects of adolescent risperidone treatment on the mouse cortex. Neuropsychopharmacology. 2026 Sep; 51(10):1844-1854.. View in PubMed
  • Protein-protein interaction-interfering peptide rescues dysregulated NMDA receptor signaling. JCI Insight. 2026 01 23; 11(2).. View in PubMed
  • Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia. bioRxiv. 2024 Mar 08.. View in PubMed
  • The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview. Adv Neurobiol. 2024; 40:285-319.. View in PubMed
  • The impact of integrating behavioral health services into pediatric subspecialty care: A systematic review. J Pediatr Gastroenterol Nutr. 2024 01; 78(1):8-16.. View in PubMed
  • The Power of Potentials. Am J Psychiatry. 2023 Jul 01; 180(7):470-472.. View in PubMed
  • Calcium/calmodulin-dependent protein kinase IIα heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment. Neuroscience. 2022 09 01; 499:104-117.. View in PubMed
  • Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats. Neurobiol Dis. 2022 08; 170:105756.. View in PubMed
  • Early life social instability stress causes lasting cognitive decrement and elevated hippocampal stress-related gene expression. Exp Neurol. 2022 08; 354:114099.. View in PubMed
  • High-beta/low-gamma frequency activity reflects top-down predictive coding during a spatial working memory test. Exp Brain Res. 2019 Jul; 237(7):1881-1888.. View in PubMed