Robert Featherstone, PhD

Assistant Professor of Research Psychiatry and the Behavioral Sciences

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Overview

Robert E. Featherstone, Ph.D., is an Assistant Professor of Research in the Department of Psychiatry and Behavioral Sciences at the University of Southern California. His research focuses on the neurobiology, cognitive dysfunction, and treatment of schizophrenia and depression, integrating both preclinical animal models and human clinical research.

Dr. Featherstone’s work examines the neural mechanisms underlying cognitive impairments associated with psychiatric illness and seeks to identify novel therapeutic strategies to improve cognitive and functional outcomes. His research combines behavioral neuroscience, neuropsychopharmacology, and electrophysiology, with particular expertise in EEG and event-related potential (ERP) biomarkers for psychiatric drug discovery and translational neuroscience.

Current projects investigate glutamatergic signaling pathways, NMDA receptor function, and synaptic mechanisms that contribute to cognitive deficits in neuropsychiatric disorders. By integrating behavioral, molecular, and electrophysiological approaches across animal and human studies, his research aims to advance the development of mechanism-based treatments that improve both symptoms and cognitive functioning in individuals with serious mental illness.

Publications

  • Delayed emergence of behavioral and electrophysiological effects following juvenile ketamine exposure in mice. Transl Psychiatry. 2015 Sep 15; 5:e635.. View in PubMed
  • The Role of Nicotine in Schizophrenia. Int Rev Neurobiol. 2015; 124:23-78.. View in PubMed
  • Oxytocin reduces amygdala activity, increases social interactions, and reduces anxiety-like behavior irrespective of NMDAR antagonism. Behav Neurosci. 2015 Aug; 129(4):389-98.. View in PubMed
  • EEG biomarkers of target engagement, therapeutic effect, and disease process. Ann N Y Acad Sci. 2015 May; 1344:12-26.. View in PubMed
  • Mice with subtle reduction of NMDA NR1 receptor subunit expression have a selective decrease in mismatch negativity: Implications for schizophrenia prodromal population. Neurobiol Dis. 2015 Jan; 73:289-95.. View in PubMed
  • Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biol Psychiatry. 2015 Mar 15; 77(6):556-68.. View in PubMed
  • Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits. Neuropsychopharmacology. 2014 Jun; 39(7):1603-13.. View in PubMed
  • Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats. Front Behav Neurosci. 2014; 8:36.. View in PubMed
  • Electroencephalographic and early communicative abnormalities in Brattleboro rats. Physiol Rep. 2013 Oct; 1(5):e00100.. View in PubMed
  • Juvenile exposure to ketamine causes delayed emergence of EEG abnormalities during adulthood in mice. Drug Alcohol Depend. 2014 Jan 01; 134:123-127.. View in PubMed