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Saul J Priceman

Visiting Associate Professor of Medicine

Director of the KSOM/NCCC Center for Cancer Cellular Immunotherapy Research

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Email priceman@usc.edu
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Publications

  • Nonsignaling extracellular spacer regulates tumor antigen selectivity of CAR T cells Mol Ther Oncol. 2024 Jun 20; 32(2):200789. . View in PubMed
  • PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial Nat Med. 2024 Jun; 30(6):1636-1644. . View in PubMed
  • Using Oncolytic Virus to Retask CD19-Chimeric Antigen Receptor T Cells for Treatment of Pancreatic Cancer: Toward a Universal Chimeric Antigen Receptor T-Cell Strategy for Solid Tumor J Am Coll Surg. 2024 Apr 01; 238(4):436-447. . View in PubMed
  • Dexamethasone potentiates chimeric antigen receptor T cell persistence and function by enhancing IL-7Ra expression Mol Ther. 2024 Feb 07; 32(2):527-539. . View in PubMed
  • Regulation of nuclear transcription by mitochondrial RNA in endothelial cells Elife. 2024 Jan 22; 13. . View in PubMed
  • Chimeric Antigen Receptor-T Cell and Oncolytic Viral Therapies for Gastric Cancer and Peritoneal Carcinomatosis of Gastric Origin: Path to Improving Combination Strategies Cancers (Basel). 2023 Nov 30; 15(23). . View in PubMed
  • Res Sq. 2023 Oct 23. . View in PubMed
  • Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting bioRxiv. 2023 Jan 07. . View in PubMed
  • Development of the oncolytic virus, CF33, and its derivatives for peritoneal-directed treatment of gastric cancer peritoneal metastases J Immunother Cancer. 2023 04; 11(4). . View in PubMed
  • Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy Nat Commun. 2023 04 11; 14(1):2041. . View in PubMed
  • Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting Nat Commun. 2023 08 07; 14(1):4737. . View in PubMed
  • Advancing together and moving forward: Combination gene and cellular immunotherapies Mol Ther Oncolytics. 2022 Jun 16; 25:330-334. . View in PubMed
  • J Immunother Cancer. 2022 06; 10(6). . View in PubMed
  • Off-the-Shelf Prostate Stem Cell Antigen-Directed Chimeric Antigen Receptor Natural Killer Cell Therapy to Treat Pancreatic Cancer Gastroenterology. 2022 04; 162(4):1319-1333. . View in PubMed
  • Hyperthermic Intraperitoneal Chemotherapy-Induced Molecular Changes in Humans Validate Preclinical Data in Ovarian Cancer JCO Precis Oncol. 2022 03; 6:e2100239. . View in PubMed
  • Novel Redirected T-Cell Immunotherapies for Advanced Prostate Cancer Clin Cancer Res. 2022 02 15; 28(4):576-584. . View in PubMed
  • Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control Nat Biomed Eng. 2021 11; 5(11):1348-1359. . View in PubMed
  • Recombinant Orthopoxvirus Primes Colon Cancer for Checkpoint Inhibitor and Cross-Primes T Cells for Antitumor and Antiviral Immunity Mol Cancer Ther. 2021 01; 20(1):173-182. . View in PubMed
  • The Cerebroventricular Environment Modifies CAR T Cells for Potent Activity against Both Central Nervous System and Systemic Lymphoma Cancer Immunol Res. 2021 01; 9(1):75-88. . View in PubMed
  • Pre-conditioning modifies the TME to enhance solid tumor CAR T cell efficacy and endogenous protective immunity Mol Ther. 2021 07 07; 29(7):2335-2349. . View in PubMed
  • STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor GrowthCell Metab. 2020 01 07; 31(1):148-161. e5. . View in PubMed
  • CAR T Cell Therapy Progress and Challenges for Solid Tumors Cancer Treat Res. 2020; 180:297-326. . View in PubMed
  • Effective combination immunotherapy using oncolytic viruses to deliver CAR targets to solid tumors Sci Transl Med. 2020 09 02; 12(559). . View in PubMed
  • Precision Medicine-Enabled Cancer Immunotherapy Cancer Treat Res. 2019; 178:189-205. . View in PubMed
  • PET of Adoptively Transferred Chimeric Antigen Receptor T Cells with 89Zr-Oxine J Nucl Med. 2018 10; 59(10):1531-1537. . View in PubMed
  • Effective Targeting of TAG72+ Peritoneal Ovarian Tumors via Regional Delivery of CAR-Engineered T Cells Front Immunol. 2018; 9:2268. . View in PubMed
  • Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer Oncoimmunology. 2018; 7(2):e1380764. . View in PubMed
  • Regional Delivery of Chimeric Antigen Receptor-Engineered T Cells Effectively Targets HER2+ Breast Cancer Metastasis to the Brain Clin Cancer Res. 2018 01 01; 24(1):95-105. . View in PubMed
  • Targeting Alpha-Fetoprotein (AFP)-MHC Complex with CAR T-Cell Therapy for Liver Cancer Clin Cancer Res. 2017 Jan 15; 23(2):478-488. . View in PubMed
  • Sphingosine-1-Phosphate Receptor-1 Promotes Environment-Mediated and Acquired Chemoresistance Mol Cancer Ther. 2017 11; 16(11):2516-2527. . View in PubMed
  • Beyond Seed and Soil: Understanding and Targeting Metastatic Prostate Cancer; Report From the 2016 Coffey-Holden Prostate Cancer Academy Meeting Prostate. 2017 02; 77(2):123-144. . View in PubMed
  • L1 Cell Adhesion Molecule-Specific Chimeric Antigen Receptor-Redirected Human T Cells Exhibit Specific and Efficient Antitumor Activity against Human Ovarian Cancer in Mice PLoS One. 2016; 11(1):e0146885. . View in PubMed
  • Regression of Glioblastoma after Chimeric Antigen Receptor T-Cell Therapy N Engl J Med. 2016 12 29; 375(26):2561-9. . View in PubMed
  • Smart CARs engineered for cancer immunotherapy Curr Opin Oncol. 2015 Nov; 27(6):466-74. . View in PubMed
  • STAT3 in CD8+ T Cells Inhibits Their Tumor Accumulation by Downregulating CXCR3/CXCL10 Axis Cancer Immunol Res. 2015 Aug; 3(8):864-870. . View in PubMed
  • CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells J Clin Invest. 2015 Jun; 125(6):2547. . View in PubMed
  • Chimeric antigen receptors with mutated IgG4 Fc spacer avoid fc receptor binding and improve T cell persistence and antitumor efficacy Mol Ther. 2015 Apr; 23(4):757-68. . View in PubMed
  • CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy Cancer Res. 2015 Mar 15; 75(6):950-62. . View in PubMed
  • CD8+ T-cell immunosurveillance constrains lymphoid premetastatic myeloid cell accumulation Eur J Immunol. 2015 Jan; 45(1):71-81. . View in PubMed
  • CTLA4 aptamer delivers STAT3 siRNA to tumor-associated and malignant T cells J Clin Invest. 2014 Jul; 124(7):2977-87. . View in PubMed
  • Pten null prostate epithelium promotes localized myeloid-derived suppressor cell expansion and immune suppression during tumor initiation and progression Mol Cell Biol. 2014 Jun; 34(11):2017-28. . View in PubMed
  • S1PR1 is crucial for accumulation of regulatory T cells in tumors via STAT3 Cell Rep. 2014 Mar 27; 6(6):992-999. . View in PubMed
  • Regulation of adipose tissue T cell subsets by Stat3 is crucial for diet-induced obesity and insulin resistance Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):13079-84. . View in PubMed
  • CSF1R signaling blockade stanches tumor-infiltrating myeloid cells and improves the efficacy of radiotherapy in prostate cancer Cancer Res. 2013 May 01; 73(9):2782-94. . View in PubMed
  • Icaritin inhibits JAK/STAT3 signaling and growth of renal cell carcinoma PLoS One. 2013; 8(12):e81657. . View in PubMed
  • S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites Cancer Cell. 2012 May 15; 21(5):642-654. . View in PubMed
  • In vivo imaging of intraprostatic-specific gene transcription by PET J Nucl Med. 2011 May; 52(5):784-91. . View in PubMed
  • The sympathetic nervous system induces a metastatic switch in primary breast cancer Cancer Res. 2010 Sep 15; 70(18):7042-52. . View in PubMed
  • Mitogen-activated protein kinase phosphatase-1 deficiency decreases atherosclerosis in apolipoprotein E null mice by reducing monocyte chemoattractant protein-1 levels Mol Genet Metab. 2010 Sep; 101(1):66-75. . View in PubMed
  • Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy Blood. 2010 Feb 18; 115(7):1461-71. . View in PubMed
  • Absence of myeloid COX-2 attenuates acute inflammation but does not influence development of atherosclerosis in apolipoprotein E null mice Arterioscler Thromb Vasc Biol. 2010 Feb; 30(2):260-8. . View in PubMed
  • A novel intracellular protein delivery platform based on single-protein nanocapsules Nat Nanotechnol. 2010 Jan; 5(1):48-53. . View in PubMed
  • Titration of variant HSV1-tk gene expression to determine the sensitivity of 18F-FHBG PET imaging in a prostate tumor J Nucl Med. 2009 May; 50(5):757-64. . View in PubMed
  • Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis Cancer Res. 2008 Oct 01; 68(19):7828-37. . View in PubMed
  • ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia Blood. 2007 Apr 15; 109(8):3400-8. . View in PubMed
  • Calcium-dependent upregulation of E4BP4 expression correlates with glucocorticoid-evoked apoptosis of human leukemic CEM cells Biochem Biophys Res Commun. 2006 Jun 02; 344(2):491-9. . View in PubMed

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