Saul J. Priceman

Associate Professor of Medicine and Immunology and Immune Therapeutics

Director of the KSOM/NCCC Center for Cancer Cellular Immunotherapy Research

Norman and Mary Pattiz Endowed Chair for Cancer Research

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Overview

Dr. Saul Priceman is an Associate Professor in the Department of Medicine at USC, and the Founding Director of the KSOM/Norris Center for Cancer Cellular Immunotherapy Research. Over the last 14 years, his research has focused on T cell immunobiology and cancer immunotherapies. Dr. Priceman’s laboratory develops CAR T cell therapies and combinatorial approaches for the treatment of solid cancers, bringing several therapies to phase 1 clinical testing. His research has led to high-impact publications in Nature Medicine, Nature Biomedical Engineering, Science Translational Medicine, and Nature Communications, with numerous patents and technologies licensed for further clinical development. Dr. Priceman’s research has been funded with grants from the National Cancer Institute, Department of Defense, California Institute for Regenerative Medicine, and the Prostate Cancer Foundation. He received his B.S. in microbiology at UCSB, his Ph.D. in molecular and medical pharmacology at UCLA, and his postdoctoral research at City of Hope.

Awards

  • Prostate Cancer Foundation: Young Investigator Award, 2015
  • National Comprehensive Cancer Network: Young Investigator Award, 2016

Education and Training

  • University of California Santa Barbara — BS — 2000 — Microbiology
  • California State University Northridge — MS — 2004 — Biology
  • University of California Los Angeles — PhD — 2010 — Molecular and Medical Pharmacology
  • City of Hope — Postdoctoral Fellowship — 2013 — Cancer Immunotherapy and Tumor Immunology

Research Keywords

  • Tumor immunology
  • Cancer cellular immunotherapy

Publications

  • Intracranial metastases from solid tumors: Call to action and consensus from the Society for Neuro-Oncology and American Society of Clinical Oncology collaborative. Neuro Oncol. 2026 Feb 01; 28(2):319-333.. View in PubMed
  • An IL-12 renaissance: Engineering tumor-restricted IL-12 to improve solid tumor T cell therapies. Mol Ther. 2026 Jan 07; 34(1):38-40.. View in PubMed
  • Deciphering Resistance: Beyond the Androgen Paradigm; Report From the 2025 Coffey-Holden Prostate Cancer Academy Meeting. Prostate. 2026 03; 86(4):411-427.. View in PubMed
  • Collagen-binding IL-12-armoured STEAP1 CAR-T cells reduce toxicity and treat prostate cancer in mouse models. Nat Biomed Eng. 2026 Apr; 10(4):630-646.. View in PubMed
  • Solid tumour CAR-T cells engineered with fusion proteins targeting PD-L1 for localized IL-12 delivery. Nat Biomed Eng. 2026 Apr; 10(4):613-629.. View in PubMed
  • Universal off-the-shelf combination immunotherapy using oncolytic viruses to redirect T cell engagers to target solid tumors. J Immunother Cancer. 2025 Aug 11; 13(8).. View in PubMed
  • JAK2/STAT3 Signaling in Myeloid Cells Contributes to Obesity-Induced Inflammation and Insulin Resistance. Cells. 2025 Aug 02; 14(15).. View in PubMed
  • Solid tumor CAR T cells engineered with fusion proteins targeting PDL1 for localized IL-12 delivery. bioRxiv. 2025 May 19.. View in PubMed
  • CD105+ fibroblasts support an immunosuppressive niche in women at high risk of breast cancer initiation. Breast Cancer Res. 2025 May 15; 27(1):81.. View in PubMed
  • Vascularized tumor-on-a-chip to investigate immunosuppression of CAR-T cells. Lab Chip. 2025 05 13; 25(10):2390-2400.. View in PubMed