Scott E Fraser, PhD

Fraser Lab Website

Professor Scott E. Fraser has a long-standing commitment to quantitative biology, applying the tools of chemistry, engineering and physics to problems in biology and medicine. His personal research centers on imaging and molecular analyses of intact biological systems, with an emphasis on early development, organogenesis, and medical diagnostics. After training in physics (BS, Harvey Mudd College, 1976) and biophysics (PhD, Johns Hopkins University, 1979), he joined the faculty at UC Irvine, and rose through the ranks to become Chair of the Department of Physiology and Biophysics. In 1990 he moved to Caltech to serve as the Anna L. Rosen Professor of Biology, and the Director of the Biological Imaging Center. He is deeply committed to interdisciplinary training and translational research, having helped found the Caltech Brain Imaging Center and the Kavli Institute of Nanoscience, as well as serving as the Director of the Rosen Center for Biological Engineering. In Fall 2012, he moved to USC to take a Provost Professorship in the Dornsife College of Letters, Arts and Sciences, the Children’s Hospital Los Angeles, Keck School of Medicine and the Viterbi School of Engineering. He remains active in interdisciplinary research and serves as the Director of Science Initiatives for the USC campuses.

• In vivo Imaging of the Human Retina at the Molecular Level
  NIH · R01EY032994 · Mar 1, 2024 – Feb 29, 2028 · Role: Co-Principal Investigator
• Early tumorigenesis in vivo imaging, scRNA-seq to functional assays
  NIH · R21CA267849 · Dec 13, 2021 – Nov 30, 2023 · Role: Co-Principal Investigator
• Circuits underlying threat and safety
  NIH · U01NS122082 · Apr 15, 2021 – Mar 31, 2024 · Role: Co-Principal Investigator
• In vivo imaging of tumor heterogeneity generation from endogenous single cells
  NIH · R21CA209012 · Jul 1, 2016 – Jun 30, 2019 · Role: Principal Investigator
• Dynamic mapping of the complete synaptome using recombinant probes
  NIH · R01MH107238 · Sep 25, 2014 – Jul 31, 2020 · Role: Co-Principal Investigator
• Phase Contrast OCT for Non-Invasive Imaging of Retinovascular Disease
  NIH · R42EY021054 · Sep 30, 2010 – May 31, 2016 · Role: Principal Investigator
• Characterization of Exudative Macular Degeneration and Diabetic Retinopathy Using
  NIH · R41EY021054 · Sep 30, 2010 – Jun 29, 2012 · Role: Principal Investigator
• Functional analysis of neural crest & palate: Imaging craniofacial development
  NIH · U01DE020063 · Sep 21, 2009 – Apr 30, 2014 · Role: Principal Investigator
• Center for in Toto Genomic Analysis of Vertebrate Development
  NIH · P50HG004071 · Aug 15, 2006 – Jul 31, 2012 · Role: Principal Investigator
• Hemodynamic Forces in Vascular Remodeling
  NIH · R01HL078694 · Sep 22, 2004 – Aug 31, 2008 · Role: Principal Investigator
• Intravital imaging of neuronal development
  NIH · R01HD043897 · Jan 15, 2003 – Jan 14, 2007 · Role: Principal Investigator
• Santa Cruz Meeting on Developmental Biology
  NIH · R13HD042812 · Jun 5, 2002 – May 31, 2003 · Role: Principal Investigator
• OPTIC NERVE DEMYELINATION STUDY USING MRI
  NIH · R01EY011933 · Sep 30, 1999 – Sep 29, 2003 · Role: Principal Investigator
• GORDON CONFERENCE ON DEVELOPMENTAL BIOLOGY
  NIH · R13HD033376 · Jul 27, 1995 – Jun 30, 1996 · Role: Principal Investigator
• CELLULAR BASES OF COCAINE-INDUCED BRAIN ABNORMALITIES
  NIH · R55DA008689 · Sep 30, 1993 – Aug 31, 1995 · Role: Principal Investigator
• VITAL DYE ANALYSIS OF HINDBRAIN DEVELOPMENT
  NIH · R01HD029304 · Sep 1, 1991 – Aug 31, 1996 · Role: Principal Investigator
• DYNAMIC ASPECTS OF NEURONAL PATTERNING
  NIH · R01EY008363 · Dec 1, 1989 – Nov 30, 1992 · Role: Principal Investigator
• FUNCTIONAL RECONSTRUCTION OF NEURONAL SYSTEMS
  NIH · R01NS025210 · Sep 1, 1987 – Aug 31, 1990 · Role: Principal Investigator

• Crump, Gage
• Chai, Yang
• Chuong, Cheng-Ming
• Toga, Arthur
• Thompson, Paul
• Nayak, Krishna