Stan Louie, PharmD

Dr. Louie is a translational pharmacologist with expertise in advancing hit candidates through preclinical development and into clinical evaluation. His drug discovery strategies is to use metabolomics/lipidomics to identify drug targets. His team has developed four therapeutic modality from benchtop to clinical evaluation. His area of focus include inflammation and development of drug that promote regenerations.

• American Society of Health System Pharmacists : Fellow, 2000
• California Society of Health System Pharmacist: Fellow, 1998
• Paper of the Year Award, 1997
• Rho Chi Honor Society, 1985
• March of Dimes Research Fellowship, 1979-1982

• Effects of APOE4 on omega-3 brain metabolism across the lifespan Trends Endocrinol Metab. 2024 Apr 11. . View in PubMed
• Synthesis of site-specific Fab-drug conjugates using ADP-ribosyl cyclases Protein Sci. 2024 Apr; 33(4):e4924. . View in PubMed
• The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis Redox Biol. 2024 Apr; 70:103052. . View in PubMed
• Unveiling Drivers of Retinal Degeneration in RCS Rats: Functional, Morphological, and Molecular Insights Int J Mol Sci. 2024 Mar 28; 25(7). . View in PubMed
• Scaling up polarized RPE cell supernatant production on parylene membrane Exp Eye Res. 2024 Mar; 240:109789. . View in PubMed
• Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats Int J Mol Sci. 2024 Feb 15; 25(4). . View in PubMed
• Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study Int J Mol Sci. 2024 Feb 08; 25(4). . View in PubMed
• Synthesis and Preclinical Evaluation of 22-[18F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics ACS Chem Neurosci. 2023 Dec 20; 14(24):4409-4418. . View in PubMed
• A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation Chem Commun (Camb). 2023 Nov 21; 59(93):13843-13846. . View in PubMed
• Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes Res Sq. 2023 Nov 07. . View in PubMed
• Author Correction: An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model Sci Rep. 2023 Oct 23; 13(1):18120. . View in PubMed
• Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations Biomedicines. 2023 Sep 17; 11(9). . View in PubMed
• Two staged phase II clinical trial of Eribulin monotherapy in advanced or recurrent cervical cancer Gynecol Oncol. 2023 06; 173:49-57. . View in PubMed
• An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model Sci Rep. 2023 09 23; 13(1):15924. . View in PubMed
• Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development Front Physiol. 2023; 14:1098467. . View in PubMed
• Computational optimization of delivery parameters to guide the development of targeted Nasal spray Sci Rep. 2023 03 12; 13(1):4099. . View in PubMed
• Pharmacokinetics comparison of vardenafil as administered by an intranasal spray formulation vs a 10-mg oral tablet J Sex Med. 2023 06 28; 20(7):1004-1009. . View in PubMed
• Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS Rats Cells. 2023 06 22; 12(13). . View in PubMed
• Alterations in Renin-Angiotensin System (RAS) Peptide Levels in Patients with HIV Metabolites. 2022 Dec 31; 13(1). . View in PubMed
• Lipidomics in Understanding Pathophysiology and Pharmacologic Effects in Inflammatory Diseases: Considerations for Drug Development Metabolites. 2022 Apr 07; 12(4). . View in PubMed
• Discovery of an NAD+ analogue with enhanced specificity for PARP1 Chem Sci. 2022 Feb 16; 13(7):1982-1991. . View in PubMed
• Uncovering mechanisms of brain inflammation in Alzheimer’s disease with APOE4: Application of single cell-type lipidomics Ann N Y Acad Sci. 2022 12; 1518(1):84-105. . View in PubMed
• Supra-lacrimal protein-based carriers for cyclosporine A reduce Th17-mediated autoimmunity in murine model of Sjögren’s syndrome Biomaterials. 2022 04; 283:121441. . View in PubMed
• Development of Moderate Intensity Focused Ultrasound (MIFU) for Ocular Drug Delivery BME Front. 2022; 2022:9840678. . View in PubMed
• Pro-resolving lipid mediators in traumatic brain injury: emerging concepts and translational approach Am J Transl Res. 2022; 14(3):1482-1494. . View in PubMed
• Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia Alzheimers Res Ther. 2022 10 11; 14(1):152. . View in PubMed
• NAP1051, a Lipoxin A4 Biomimetic Analogue, Demonstrates Antitumor Activity Against the Tumor Microenvironment Mol Cancer Ther. 2021 12; 20(12):2384-2397. . View in PubMed
• Importance of beta-lactam pharmacokinetics and pharmacodynamics on the recovery of microbial diversity in the airway of persons with cystic fibrosis J Investig Med. 2021 10; 69(7):1350-1359. . View in PubMed
• Site-specific antibody-drug conjugates with variable drug-to-antibody-ratios for AML therapy J Control Release. 2021 08 10; 336:433-442. . View in PubMed
• Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren’s Syndrome Biomacromolecules. 2021 03 08; 22(3):1102-1114. . View in PubMed
• A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins ACS Chem Biol. 2021 02 19; 16(2):389-396. . View in PubMed
• A poly-ADP-ribose polymer-based antibody-drug conjugate Chem Sci. 2020 Sep 14; 11(34):9303-9308. . View in PubMed
• Activation of the Protective Arm of the Renin Angiotensin System in Demyelinating Disease J Neuroimmune Pharmacol. 2020 06; 15(2):249-263. . View in PubMed
• Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases Sci Adv. 2020 06; 6(23):eaba6752. . View in PubMed
• Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury Front Chem. 2020; 8:769. . View in PubMed
• A latent unknown clustering integrating multi-omics data (LUCID) with phenotypic traits Bioinformatics. 2020 02 01; 36(3):842-850. . View in PubMed
• Cyanine Nanocage Activated by Near-IR Light for the Targeted Delivery of Cyclosporine A to Traumatic Brain Injury Sites Mol Pharm. 2020 12 07; 17(12):4499-4509. . View in PubMed
• Genome-wide association study of circulating folate one-carbon metabolites Genet Epidemiol. 2019 12; 43(8):1030-1045. . View in PubMed
• Effect of Vitamin D Supplementation on Bone Turnover Markers During HIV Pre-Exposure Prophylaxis Using Tenofovir Disoproxil Fumarate-Emtricitabine in Men Who Have Sex with Men AIDS Res Hum Retroviruses. 2019 07; 35(7):608-614. . View in PubMed
• A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation Nat Commun. 2019 09 13; 10(1):4196. . View in PubMed
• Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study PLoS One. 2019; 14(3):e0213096. . View in PubMed
• Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells J Virol. 2019 05 15; 93(10). . View in PubMed
• Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis Sci Rep. 2019 02 22; 9(1):2534. . View in PubMed
• Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer Mol Omics. 2019 02 11; 15(1):21-29. . View in PubMed
• Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease Mol Pharm. 2019 07 01; 16(7):3024-3039. . View in PubMed
• Facile chemoenzymatic synthesis of a novel stable mimic of NAD Chem Sci. 2018 Nov 28; 9(44):8337-8342. . View in PubMed
• Simultaneous quantitation of folates, flavins and B6 metabolites in human plasma by LC-MS/MS assay: Applications in colorectal cancer J Pharm Biomed Anal. 2018 Sep 05; 158:66-73. . View in PubMed
• Relationship of Pulmonary Outcomes, Microbiology, and Serum Antibiotic Concentrations in Cystic Fibrosis Patients J Pediatr Pharmacol Ther. 2018 Sep-Oct; 23(5):379-389. . View in PubMed
• Development of angiotensin II (1-7) analog as an oral therapeutic for the treatment of chemotherapy-induced myelosuppression Haematologica. 2018 12; 103(12):e567-e570. . View in PubMed
• Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 11; 68(5):1726-1740. . View in PubMed
• Pharmacokinetics and Adverse Effects of 3 Sustained-release Buprenorphine Dosages in Healthy Guinea Pigs (Cavia porcellus) J Am Assoc Lab Anim Sci. 2017 Nov 01; 56(6):768-778. . View in PubMed
• Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin Mol Cancer Res. 2017 12; 15(12):1704-1713. . View in PubMed
• Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder Neuropharmacology. 2017 02; 113(Pt A):60-70. . View in PubMed
• Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren’s Syndrome Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. . View in PubMed
• NorLeu3A(1-7) Accelerates Clear Corneal Full Thickness Wound Healing Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(4):2187-94. . View in PubMed
• A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder Alcohol Clin Exp Res. 2016 06; 40(6):1312-20. . View in PubMed
• Effect of combined radiation injury on cell death and inflammation in skin Apoptosis. 2015 Jul; 20(7):892-906. . View in PubMed
• Simultaneous plasma and genital pharmacokinetics and pharmacodynamics of atazanavir and efavirenz in HIV-infected women starting therapy J Clin Pharmacol. 2015 Jul; 55(7):798-808. . View in PubMed
• Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols Org Biomol Chem. 2015 Apr 07; 13(13):3887-99. . View in PubMed
• Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals Neurosurg Focus. 2015 Mar; 38(3):E8. . View in PubMed
• Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors Neurosurg Focus. 2015 Mar; 38(3):E12. . View in PubMed
• Achieving target voriconazole concentrations more accurately in children and adolescents Antimicrob Agents Chemother. 2015; 59(6):3090-7. . View in PubMed
• Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy Neurosurg Focus. 2014 Dec; 37(6):E12. . View in PubMed
• Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans Neuroreport. 2014 Sep 10; 25(13):1018-23. . View in PubMed
• Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders Int J Neuropsychopharmacol. 2014 Jun; 17(6):907-16. . View in PubMed
• Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis Clin Cancer Res. 2013 Dec 15; 19(24):6802-11. . View in PubMed
• A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren’s syndrome J Control Release. 2013 Nov 10; 171(3):269-79. . View in PubMed
• Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin Int J Neuropsychopharmacol. 2013 Jun; 16(5):1059-70. . View in PubMed
• Alteration of endothelial function markers in women with gestational diabetes and their fetuses J Matern Fetal Neonatal Med. 2013 Mar; 26(5):507-12. . View in PubMed
• Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I PLoS One. 2013; 8(6):e65695. . View in PubMed
• Effects of combined radiation and burn injury on the renin-angiotensin system Wound Repair Regen. 2013 Jan-Feb; 21(1):131-40. . View in PubMed
• Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent Cancer Lett. 2012 Dec 30; 326(2):143-54. . View in PubMed
• Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors Cancer Lett. 2012 Dec 01; 325(1):63-71. . View in PubMed
• Perillyl alcohol for the treatment of temozolomide-resistant gliomas Mol Cancer Ther. 2012 Nov; 11(11):2462-72. . View in PubMed
• Ivermectin reduces alcohol intake and preference in mice Neuropharmacology. 2012 Aug; 63(2):190-201. . View in PubMed
• The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models Mol Cancer Ther. 2012 Jun; 11(6):1353-64. . View in PubMed
• Accelerated hematopoietic recovery with angiotensin-(1-7) after total body radiation Int J Radiat Biol. 2012 Jun; 88(6):466-76. . View in PubMed
• Nonmyeloablative conditioning regimen to increase engraftment of gene-modified hematopoietic stem cells in young rhesus monkeys Mol Ther. 2012 May; 20(5):1033-45. . View in PubMed
• Toxicological and toxicokinetic analysis of angiotensin (1-7) in two species J Pharm Sci. 2012 Jan; 101(1):373-80. . View in PubMed
• Noscapine inhibits tumor growth in TMZ-resistant gliomas Cancer Lett. 2011 Dec 22; 312(2):245-52. . View in PubMed
• Obesity and its impact on drug therapy: are we ready for this change? Clin Pharmacokinet. 2011 Dec 01; 50(12):825-6.. View in PubMed
• A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates Nucleic Acids Res. 2011 Sep 01; 39(17):e112. . View in PubMed
• Fatigue and plasma cytokine concentrations at rest and during exercise in patients with sarcoidosis Clin Respir J. 2011 Jul; 5(3):156-64. . View in PubMed
• The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models Cancer Res. 2011 May 15; 71(10):3635-48. . View in PubMed
• Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs) J Med Chem. 2011 Apr 28; 54(8):2902-14. . View in PubMed
• Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models Cancer Lett. 2011 Mar 28; 302(2):100-8. . View in PubMed
• Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivoLaboratory investigation. J Neurosurg. 2011 Mar; 114(3):689-94. . View in PubMed
• Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase PLoS One. 2011; 6(11):e26644. . View in PubMed
• Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis Tuberc Res Treat. 2011; 2011:346295. . View in PubMed
• Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response Curr Pharm Des. 2011; 17(23):2428-38. . View in PubMed
• Estimation of glomerular filtration rate by using serum cystatin C and serum creatinine concentrations in patients with human immunodeficiency virus Pharmacotherapy. 2010 Oct; 30(10):1004-10. . View in PubMed
• Interlaboratory measurement differences in intracellular carbovir triphosphate concentrations in HIV-infected patients: sources of variability in processing, shipping, and quantitation J Clin Pharmacol. 2010 Aug; 50(8):968-74. . View in PubMed
• Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice Pharmacol Res. 2010 May; 61(5):385-90. . View in PubMed
• Effect of multiple injections of small divided doses vs single injection of intravitreal bevacizumab on retinal neovascular model in rabbits Graefes Arch Clin Exp Ophthalmol. 2010 Apr; 248(4):457-66. . View in PubMed
• Abacavir and tenofovir disoproxil fumarate co-administration results in a nonadditive antiviral effect in HIV-1-infected patients AIDS. 2010 Mar 13; 24(5):707-16. . View in PubMed
• Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature Mol Cancer Ther. 2010 Mar; 9(3):631-41. . View in PubMed
• Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2 Leuk Res. 2010 Feb; 34(2):250-3. . View in PubMed
• The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38 Int J Cancer. 2009 Dec 15; 125(12):2957-69. . View in PubMed
• Adipocytes impair leukemia treatment in mice Cancer Res. 2009 Oct 01; 69(19):7867-74. . View in PubMed
• Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress Cancer Lett. 2009 Sep 08; 282(1):87-97. . View in PubMed
• Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors Blood. 2009 Jun 04; 113(23):5927-37. . View in PubMed
• Combination effects of SC144 and cytotoxic anticancer agents Anticancer Drugs. 2009 Jun; 20(5):312-20. . View in PubMed
• Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine J Clin Pharmacol. 2008 Aug; 48(8):957-65. . View in PubMed
• Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis Pharmacotherapy. 2008 Jul; 28(7):883-94. . View in PubMed
• Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib Cancer Res. 2008 Feb 01; 68(3):843-51. . View in PubMed
• Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs Expert Opin Investig Drugs. 2008 Feb; 17(2):197-208. . View in PubMed
• Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy J Infect Dis. 2008 Jan 01; 197(1):102-8. . View in PubMed
• Effects of pharmacists’ interventions on patient outcomes in an HIV primary care clinic Am J Health Syst Pharm. 2007 Dec 15; 64(24):2574-8. . View in PubMed
• Aralast: an alpha 1-protease inhibitor for the treatment of alpha-antitrypsin deficiency Expert Opin Pharmacother. 2007 Oct; 8(15):2609-14. . View in PubMed
• Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib Mol Cancer Ther. 2007 Apr; 6(4):1262-75. . View in PubMed
• Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice Hepatology. 2007 Jan; 45(1):16-21. . View in PubMed
• Pilot study of continuous infusion cefepime in adult patients with cystic fibrosis J Antimicrob Chemother. 2006 May; 57(5):1017-9. . View in PubMed
• Telbivudine: a novel nucleoside analog for chronic hepatitis B Ann Pharmacother. 2006 Mar; 40(3):472-8. . View in PubMed
• Absolute bioavailability and intracellular pharmacokinetics of azithromycin in patients with cystic fibrosis Antimicrob Agents Chemother. 2005 Dec; 49(12):5013-7. . View in PubMed
• Aralast: a new alpha1-protease inhibitor for treatment of alpha-antitrypsin deficiency Ann Pharmacother. 2005 Nov; 39(11):1861-9. . View in PubMed
• Reproducibility of 3′-deoxy-3′-(18)F-fluorothymidine microPET studies in tumor xenografts in mice J Nucl Med. 2005 Nov; 46(11):1851-7. . View in PubMed
• Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings Antimicrob Agents Chemother. 2005 Sep; 49(9):3676-81. . View in PubMed
• High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation Cancer Res. 2005 Aug 01; 65(15):6622-30. . View in PubMed
• Phase I clinical and pharmacokinetic trial of docetaxel and irinotecan administered on a weekly schedule Cancer Chemother Pharmacol. 2005 Jul; 56(1):75-82. . View in PubMed
• Survival in patients with HIV infection and viral hepatitis B or C: a cohort study AIDS. 2004 Oct 21; 18(15):2039-45. . View in PubMed
• Pharmacokinetics of Ibuprofen in children with cystic fibrosis Clin Pharmacokinet. 2004; 43(3):145-56. . View in PubMed
• Stability and antibacterial activity of cefepime during continuous infusion Antimicrob Agents Chemother. 2003 Jun; 47(6):1991-4. . View in PubMed
• Biological response modifiers in the management of rheumatoid arthritis Am J Health Syst Pharm. 2003 Feb 15; 60(4):346-55. . View in PubMed
• Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers J Appl Physiol (1985). 2018 11 01; 125(5):1555-1562. . View in PubMed

• Lenz, Heinz-Josef
• Hamm-Alvarez, Sarah
• Lee, Amy
• MacKay, John
• Chen, Thomas
• Humayun, Mark