Stan Louie, PharmD

Professor Of Clinical Pharmacy

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Overview

Dr. Louie is a translational pharmacologist with expertise in advancing hit candidates through preclinical development and into clinical evaluation. His drug discovery strategies is to use metabolomics/lipidomics to identify drug targets. His team has developed four therapeutic modality from benchtop to clinical evaluation. His area of focus include inflammation and development of drug that promote regenerations.

Awards

  • American Society of Health System Pharmacists : Fellow, 2000
  • California Society of Health System Pharmacist: Fellow, 1998
  • Paper of the Year Award, 1997
  • Rho Chi Honor Society, 1985
  • March of Dimes Research Fellowship, 1979-1982

Publications

  • Effects of age on lacrimal gland bioactive lipids Ocul Surf. 2024 Jul; 33:64-73. . View in PubMed
  • Effects of APOE4 on omega-3 brain metabolism across the lifespan Trends Endocrinol Metab. 2024 Apr 11. . View in PubMed
  • Synthesis of site-specific Fab-drug conjugates using ADP-ribosyl cyclases Protein Sci. 2024 Apr; 33(4):e4924. . View in PubMed
  • The mitochondrial biliverdin exporter ABCB10 in hepatocytes mitigates neutrophilic inflammation in alcoholic hepatitis Redox Biol. 2024 Apr; 70:103052. . View in PubMed
  • Unveiling Drivers of Retinal Degeneration in RCS Rats: Functional, Morphological, and Molecular Insights Int J Mol Sci. 2024 Mar 28; 25(7). . View in PubMed
  • Scaling up polarized RPE cell supernatant production on parylene membrane Exp Eye Res. 2024 Mar; 240:109789. . View in PubMed
  • Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats Int J Mol Sci. 2024 Feb 15; 25(4). . View in PubMed
  • Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study Int J Mol Sci. 2024 Feb 08; 25(4). . View in PubMed
  • Synthesis and Preclinical Evaluation of 22-[18F]Fluorodocosahexaenoic Acid as a Positron Emission Tomography Probe for Monitoring Brain Docosahexaenoic Acid Uptake Kinetics ACS Chem Neurosci. 2023 Dec 20; 14(24):4409-4418. . View in PubMed
  • A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation Chem Commun (Camb). 2023 Nov 21; 59(93):13843-13846. . View in PubMed
  • Immunonutrition with Omega-3 Fatty Acid Supplementation in Severe TBI: Retrospective Analysis of Patient Characteristics and Outcomes Res Sq. 2023 Nov 07. . View in PubMed
  • Author Correction: An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model Sci Rep. 2023 Oct 23; 13(1):18120. . View in PubMed
  • Optimization of Nutrition after Brain Injury: Mechanistic and Therapeutic Considerations Biomedicines. 2023 Sep 17; 11(9). . View in PubMed
  • Two staged phase II clinical trial of Eribulin monotherapy in advanced or recurrent cervical cancer Gynecol Oncol. 2023 06; 173:49-57. . View in PubMed
  • Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS Rats Cells. 2023 06 22; 12(13). . View in PubMed
  • Pharmacokinetics comparison of vardenafil as administered by an intranasal spray formulation vs a 10-mg oral tablet J Sex Med. 2023 06 28; 20(7):1004-1009. . View in PubMed
  • Computational optimization of delivery parameters to guide the development of targeted Nasal spray Sci Rep. 2023 03 12; 13(1):4099. . View in PubMed
  • Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development Front Physiol. 2023; 14:1098467. . View in PubMed
  • An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model Sci Rep. 2023 09 23; 13(1):15924. . View in PubMed
  • Alterations in Renin-Angiotensin System (RAS) Peptide Levels in Patients with HIV Metabolites. 2022 Dec 31; 13(1). . View in PubMed
  • Lipidomics in Understanding Pathophysiology and Pharmacologic Effects in Inflammatory Diseases: Considerations for Drug Development Metabolites. 2022 Apr 07; 12(4). . View in PubMed
  • Discovery of an NAD+ analogue with enhanced specificity for PARP1 Chem Sci. 2022 Feb 16; 13(7):1982-1991. . View in PubMed
  • Uncovering mechanisms of brain inflammation in Alzheimer’s disease with APOE4: Application of single cell-type lipidomics Ann N Y Acad Sci. 2022 12; 1518(1):84-105. . View in PubMed
  • Supra-lacrimal protein-based carriers for cyclosporine A reduce Th17-mediated autoimmunity in murine model of Sjögren’s syndrome Biomaterials. 2022 04; 283:121441. . View in PubMed
  • Pro-resolving lipid mediators in traumatic brain injury: emerging concepts and translational approach Am J Transl Res. 2022; 14(3):1482-1494. . View in PubMed
  • Eicosanoid lipidome activation in post-mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia Alzheimers Res Ther. 2022 10 11; 14(1):152. . View in PubMed
  • Development of Moderate Intensity Focused Ultrasound (MIFU) for Ocular Drug Delivery BME Front. 2022; 2022:9840678. . View in PubMed
  • NAP1051, a Lipoxin A4 Biomimetic Analogue, Demonstrates Antitumor Activity Against the Tumor Microenvironment Mol Cancer Ther. 2021 12; 20(12):2384-2397. . View in PubMed
  • Importance of beta-lactam pharmacokinetics and pharmacodynamics on the recovery of microbial diversity in the airway of persons with cystic fibrosis J Investig Med. 2021 10; 69(7):1350-1359. . View in PubMed
  • Site-specific antibody-drug conjugates with variable drug-to-antibody-ratios for AML therapy J Control Release. 2021 08 10; 336:433-442. . View in PubMed
  • Intralacrimal Sustained Delivery of Rapamycin Shows Therapeutic Effects without Systemic Toxicity in a Mouse Model of Autoimmune Dacryoadenitis Characteristic of Sjögren’s Syndrome Biomacromolecules. 2021 03 08; 22(3):1102-1114. . View in PubMed
  • A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins ACS Chem Biol. 2021 02 19; 16(2):389-396. . View in PubMed
  • A poly-ADP-ribose polymer-based antibody-drug conjugate Chem Sci. 2020 Sep 14; 11(34):9303-9308. . View in PubMed
  • Synthesis of site-specific antibody-drug conjugates by ADP-ribosyl cyclases Sci Adv. 2020 06; 6(23):eaba6752. . View in PubMed
  • Activation of the Protective Arm of the Renin Angiotensin System in Demyelinating Disease J Neuroimmune Pharmacol. 2020 06; 15(2):249-263. . View in PubMed
  • Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury Front Chem. 2020; 8:769. . View in PubMed
  • A latent unknown clustering integrating multi-omics data (LUCID) with phenotypic traits Bioinformatics. 2020 02 01; 36(3):842-850. . View in PubMed
  • Cyanine Nanocage Activated by Near-IR Light for the Targeted Delivery of Cyclosporine A to Traumatic Brain Injury Sites Mol Pharm. 2020 12 07; 17(12):4499-4509. . View in PubMed
  • Genome-wide association study of circulating folate one-carbon metabolites Genet Epidemiol. 2019 12; 43(8):1030-1045. . View in PubMed
  • Effect of Vitamin D Supplementation on Bone Turnover Markers During HIV Pre-Exposure Prophylaxis Using Tenofovir Disoproxil Fumarate-Emtricitabine in Men Who Have Sex with Men AIDS Res Hum Retroviruses. 2019 07; 35(7):608-614. . View in PubMed
  • A ribose-functionalized NAD+ with unexpected high activity and selectivity for protein poly-ADP-ribosylation Nat Commun. 2019 09 13; 10(1):4196. . View in PubMed
  • Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer Mol Omics. 2019 02 11; 15(1):21-29. . View in PubMed
  • Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study PLoS One. 2019; 14(3):e0213096. . View in PubMed
  • Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1+ and TIGIT+ CD4 T Cells J Virol. 2019 05 15; 93(10). . View in PubMed
  • Berunda Polypeptides: Biheaded Rapamycin Carriers for Subcutaneous Treatment of Autoimmune Dry Eye Disease Mol Pharm. 2019 07 01; 16(7):3024-3039. . View in PubMed
  • Changes in microbiome diversity following beta-lactam antibiotic treatment are associated with therapeutic versus subtherapeutic antibiotic exposure in cystic fibrosis Sci Rep. 2019 02 22; 9(1):2534. . View in PubMed
  • Facile chemoenzymatic synthesis of a novel stable mimic of NAD Chem Sci. 2018 Nov 28; 9(44):8337-8342. . View in PubMed
  • Simultaneous quantitation of folates, flavins and B6 metabolites in human plasma by LC-MS/MS assay: Applications in colorectal cancer J Pharm Biomed Anal. 2018 Sep 05; 158:66-73. . View in PubMed
  • Relationship of Pulmonary Outcomes, Microbiology, and Serum Antibiotic Concentrations in Cystic Fibrosis Patients J Pediatr Pharmacol Ther. 2018 Sep-Oct; 23(5):379-389. . View in PubMed
  • Development of angiotensin II (1-7) analog as an oral therapeutic for the treatment of chemotherapy-induced myelosuppression Haematologica. 2018 12; 103(12):e567-e570. . View in PubMed
  • Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition Hepatology. 2018 11; 68(5):1726-1740. . View in PubMed
  • Pharmacokinetics and Adverse Effects of 3 Sustained-release Buprenorphine Dosages in Healthy Guinea Pigs (Cavia porcellus) J Am Assoc Lab Anim Sci. 2017 Nov 01; 56(6):768-778. . View in PubMed
  • Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin Mol Cancer Res. 2017 12; 15(12):1704-1713. . View in PubMed
  • Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder Neuropharmacology. 2017 02; 113(Pt A):60-70. . View in PubMed
  • Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren’s Syndrome Invest Ophthalmol Vis Sci. 2017 01 01; 58(1):372-385. . View in PubMed
  • NorLeu3A(1-7) Accelerates Clear Corneal Full Thickness Wound Healing Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(4):2187-94. . View in PubMed
  • A Pilot Study of the Safety and Initial Efficacy of Ivermectin for the Treatment of Alcohol Use Disorder Alcohol Clin Exp Res. 2016 06; 40(6):1312-20. . View in PubMed
  • Simultaneous plasma and genital pharmacokinetics and pharmacodynamics of atazanavir and efavirenz in HIV-infected women starting therapy J Clin Pharmacol. 2015 Jul; 55(7):798-808. . View in PubMed
  • Effect of combined radiation injury on cell death and inflammation in skin Apoptosis. 2015 Jul; 20(7):892-906. . View in PubMed
  • Molecular characterization of the boron adducts of the proteasome inhibitor bortezomib with epigallocatechin-3-gallate and related polyphenols Org Biomol Chem. 2015 Apr 07; 13(13):3887-99. . View in PubMed
  • Quinoline-based antimalarial drugs: a novel class of autophagy inhibitors Neurosurg Focus. 2015 Mar; 38(3):E12. . View in PubMed
  • Effects of convection-enhanced delivery of bevacizumab on survival of glioma-bearing animals Neurosurg Focus. 2015 Mar; 38(3):E8. . View in PubMed
  • Achieving target voriconazole concentrations more accurately in children and adolescents Antimicrob Agents Chemother. 2015; 59(6):3090-7. . View in PubMed
  • Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy Neurosurg Focus. 2014 Dec; 37(6):E12. . View in PubMed
  • Multiday administration of ivermectin is effective in reducing alcohol intake in mice at doses shown to be safe in humans Neuroreport. 2014 Sep 10; 25(13):1018-23. . View in PubMed
  • Avermectins differentially affect ethanol intake and receptor function: implications for developing new therapeutics for alcohol use disorders Int J Neuropsychopharmacol. 2014 Jun; 17(6):907-16. . View in PubMed
  • Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K/AKT signaling, tumor growth, and metastasis Clin Cancer Res. 2013 Dec 15; 19(24):6802-11. . View in PubMed
  • A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren’s syndrome J Control Release. 2013 Nov 10; 171(3):269-79. . View in PubMed
  • Pharmacological insights into the role of P2X4 receptors in behavioural regulation: lessons from ivermectin Int J Neuropsychopharmacol. 2013 Jun; 16(5):1059-70. . View in PubMed
  • Alteration of endothelial function markers in women with gestational diabetes and their fetuses J Matern Fetal Neonatal Med. 2013 Mar; 26(5):507-12. . View in PubMed
  • Effects of combined radiation and burn injury on the renin-angiotensin system Wound Repair Regen. 2013 Jan-Feb; 21(1):131-40. . View in PubMed
  • Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I PLoS One. 2013; 8(6):e65695. . View in PubMed
  • Inhibition of autophagy and induction of breast cancer cell death by mefloquine, an antimalarial agent Cancer Lett. 2012 Dec 30; 326(2):143-54. . View in PubMed
  • Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors Cancer Lett. 2012 Dec 01; 325(1):63-71. . View in PubMed
  • Perillyl alcohol for the treatment of temozolomide-resistant gliomas Mol Cancer Ther. 2012 Nov; 11(11):2462-72. . View in PubMed
  • Ivermectin reduces alcohol intake and preference in mice Neuropharmacology. 2012 Aug; 63(2):190-201. . View in PubMed
  • The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models Mol Cancer Ther. 2012 Jun; 11(6):1353-64. . View in PubMed
  • Accelerated hematopoietic recovery with angiotensin-(1-7) after total body radiation Int J Radiat Biol. 2012 Jun; 88(6):466-76. . View in PubMed
  • Nonmyeloablative conditioning regimen to increase engraftment of gene-modified hematopoietic stem cells in young rhesus monkeys Mol Ther. 2012 May; 20(5):1033-45. . View in PubMed
  • Toxicological and toxicokinetic analysis of angiotensin (1-7) in two species J Pharm Sci. 2012 Jan; 101(1):373-80. . View in PubMed
  • Noscapine inhibits tumor growth in TMZ-resistant gliomas Cancer Lett. 2011 Dec 22; 312(2):245-52. . View in PubMed
  • Obesity and its impact on drug therapy: are we ready for this change? Clin Pharmacokinet. 2011 Dec 01; 50(12):825-6.. View in PubMed
  • A novel fluorescence-based assay for the rapid detection and quantification of cellular deoxyribonucleoside triphosphates Nucleic Acids Res. 2011 Sep 01; 39(17):e112. . View in PubMed
  • Fatigue and plasma cytokine concentrations at rest and during exercise in patients with sarcoidosis Clin Respir J. 2011 Jul; 5(3):156-64. . View in PubMed
  • The dual EGFR/HER2 inhibitor lapatinib synergistically enhances the antitumor activity of the histone deacetylase inhibitor panobinostat in colorectal cancer models Cancer Res. 2011 May 15; 71(10):3635-48. . View in PubMed
  • Discovery and preclinical evaluation of a novel class of cytotoxic propynoic acid carbamoyl methyl amides (PACMAs) J Med Chem. 2011 Apr 28; 54(8):2902-14. . View in PubMed
  • Green tea epigallocatechin gallate enhances therapeutic efficacy of temozolomide in orthotopic mouse glioblastoma models Cancer Lett. 2011 Mar 28; 302(2):100-8. . View in PubMed
  • Effective conversion of irinotecan to SN-38 after intratumoral drug delivery to an intracranial murine glioma model in vivoLaboratory investigation. J Neurosurg. 2011 Mar; 114(3):689-94. . View in PubMed
  • Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis Tuberc Res Treat. 2011; 2011:346295. . View in PubMed
  • Interleukin-1 as an injury signal mobilizes retinyl esters in hepatic stellate cells through down regulation of lecithin retinol acyltransferase PLoS One. 2011; 6(11):e26644. . View in PubMed
  • Preclinical development of novel anti-glioma drugs targeting the endoplasmic reticulum stress response Curr Pharm Des. 2011; 17(23):2428-38. . View in PubMed
  • Estimation of glomerular filtration rate by using serum cystatin C and serum creatinine concentrations in patients with human immunodeficiency virus Pharmacotherapy. 2010 Oct; 30(10):1004-10. . View in PubMed
  • Interlaboratory measurement differences in intracellular carbovir triphosphate concentrations in HIV-infected patients: sources of variability in processing, shipping, and quantitation J Clin Pharmacol. 2010 Aug; 50(8):968-74. . View in PubMed
  • Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice Pharmacol Res. 2010 May; 61(5):385-90. . View in PubMed
  • Effect of multiple injections of small divided doses vs single injection of intravitreal bevacizumab on retinal neovascular model in rabbits Graefes Arch Clin Exp Ophthalmol. 2010 Apr; 248(4):457-66. . View in PubMed
  • Abacavir and tenofovir disoproxil fumarate co-administration results in a nonadditive antiviral effect in HIV-1-infected patients AIDS. 2010 Mar 13; 24(5):707-16. . View in PubMed
  • Antiangiogenic activities of 2,5-dimethyl-celecoxib on the tumor vasculature Mol Cancer Ther. 2010 Mar; 9(3):631-41. . View in PubMed
  • Cytotoxic effects of celecoxib on Raji lymphoma cells correlate with aggravated endoplasmic reticulum stress but not with inhibition of cyclooxygenase-2 Leuk Res. 2010 Feb; 34(2):250-3. . View in PubMed
  • The dual EGFR/HER-2 tyrosine kinase inhibitor lapatinib sensitizes colon and gastric cancer cells to the irinotecan active metabolite SN-38 Int J Cancer. 2009 Dec 15; 125(12):2957-69. . View in PubMed
  • Adipocytes impair leukemia treatment in mice Cancer Res. 2009 Oct 01; 69(19):7867-74. . View in PubMed
  • Enhanced killing of chemo-resistant breast cancer cells via controlled aggravation of ER stress Cancer Lett. 2009 Sep 08; 282(1):87-97. . View in PubMed
  • Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors Blood. 2009 Jun 04; 113(23):5927-37. . View in PubMed
  • Combination effects of SC144 and cytotoxic anticancer agents Anticancer Drugs. 2009 Jun; 20(5):312-20. . View in PubMed
  • Probenecid, but not cystic fibrosis, alters the total and renal clearance of fexofenadine J Clin Pharmacol. 2008 Aug; 48(8):957-65. . View in PubMed
  • Lack of effect of P-glycoprotein inhibition on renal clearance of dicloxacillin in patients with cystic fibrosis Pharmacotherapy. 2008 Jul; 28(7):883-94. . View in PubMed
  • Aggravated endoplasmic reticulum stress as a basis for enhanced glioblastoma cell killing by bortezomib in combination with celecoxib or its non-coxib analogue, 2,5-dimethyl-celecoxib Cancer Res. 2008 Feb 01; 68(3):843-51. . View in PubMed
  • Celecoxib analogs that lack COX-2 inhibitory function: preclinical development of novel anticancer drugs Expert Opin Investig Drugs. 2008 Feb; 17(2):197-208. . View in PubMed
  • Greater tenofovir-associated renal function decline with protease inhibitor-based versus nonnucleoside reverse-transcriptase inhibitor-based therapy J Infect Dis. 2008 Jan 01; 197(1):102-8. . View in PubMed
  • Effects of pharmacists’ interventions on patient outcomes in an HIV primary care clinic Am J Health Syst Pharm. 2007 Dec 15; 64(24):2574-8. . View in PubMed
  • Aralast: an alpha 1-protease inhibitor for the treatment of alpha-antitrypsin deficiency Expert Opin Pharmacother. 2007 Oct; 8(15):2609-14. . View in PubMed
  • Calcium-activated endoplasmic reticulum stress as a major component of tumor cell death induced by 2,5-dimethyl-celecoxib, a non-coxib analogue of celecoxib Mol Cancer Ther. 2007 Apr; 6(4):1262-75. . View in PubMed
  • Hepatitis B virus promotes hepatocarcinogenesis in transgenic mice Hepatology. 2007 Jan; 45(1):16-21. . View in PubMed
  • Pilot study of continuous infusion cefepime in adult patients with cystic fibrosis J Antimicrob Chemother. 2006 May; 57(5):1017-9. . View in PubMed
  • Telbivudine: a novel nucleoside analog for chronic hepatitis B Ann Pharmacother. 2006 Mar; 40(3):472-8. . View in PubMed
  • Absolute bioavailability and intracellular pharmacokinetics of azithromycin in patients with cystic fibrosis Antimicrob Agents Chemother. 2005 Dec; 49(12):5013-7. . View in PubMed
  • Aralast: a new alpha1-protease inhibitor for treatment of alpha-antitrypsin deficiency Ann Pharmacother. 2005 Nov; 39(11):1861-9. . View in PubMed
  • Reproducibility of 3′-deoxy-3′-(18)F-fluorothymidine microPET studies in tumor xenografts in mice J Nucl Med. 2005 Nov; 46(11):1851-7. . View in PubMed
  • Absolute bioavailability and pharmacokinetics of linezolid in hospitalized patients given enteral feedings Antimicrob Agents Chemother. 2005 Sep; 49(9):3676-81. . View in PubMed
  • High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation Cancer Res. 2005 Aug 01; 65(15):6622-30. . View in PubMed
  • Phase I clinical and pharmacokinetic trial of docetaxel and irinotecan administered on a weekly schedule Cancer Chemother Pharmacol. 2005 Jul; 56(1):75-82. . View in PubMed
  • Survival in patients with HIV infection and viral hepatitis B or C: a cohort study AIDS. 2004 Oct 21; 18(15):2039-45. . View in PubMed
  • Pharmacokinetics of Ibuprofen in children with cystic fibrosis Clin Pharmacokinet. 2004; 43(3):145-56. . View in PubMed
  • Stability and antibacterial activity of cefepime during continuous infusion Antimicrob Agents Chemother. 2003 Jun; 47(6):1991-4. . View in PubMed
  • Biological response modifiers in the management of rheumatoid arthritis Am J Health Syst Pharm. 2003 Feb 15; 60(4):346-55. . View in PubMed
  • Potential role of macrolide antibiotics in the management of cystic fibrosis lung disease Curr Opin Pulm Med. 2002 Nov; 8(6):521-8. . View in PubMed
  • Chronic intermittent nicotine delivery via lung alveolar region-targeted aerosol technology produces circadian pharmacokinetics in rats resembling human smokers J Appl Physiol (1985). 2018 11 01; 125(5):1555-1562. . View in PubMed