Valter D. Longo, PhD

Dr. Longo is the Edna Jones Professor in Gerontology and Professor in Biological Science. He is also the Director of the USC Longevity Institute. He is interested in understanding the fundamental mechanisms of aging in yeast, mice and humans by using genetics and biochemistry techniques. He is also interested in identifying the molecular pathways conserved from simple organisms to humans that can be modulated to protect against multiple stresses and treat or prevent cancer , Alzheimer’s Disease and other diseases of aging. The focus is on the signal transudation pathways that regulate resistance to oxidative damage in yeast and mice.

• Fasting mimicking diet and cancer stem cells in Wilms tumor
  NIH · R01CA317076 · Sep 15, 2026 – Aug 31, 2031 · Role: Co-Principal Investigator
• Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
  NIH · P01AG055369 · Feb 15, 2018 – Jan 31, 2024 · Role: Principal Investigator
• Interventions to Slow Aging in Humans: Are We Ready?
  NIH · R13AG046104 · Sep 1, 2013 – Aug 31, 2014 · Role: Principal Investigator
• Dietary Restriction, GH/IGF-I & Mechanisms of Differential Cellular Protection
  NIH · P01AG034906 · Mar 15, 2011 – Jul 31, 2017 · Role: Principal Investigator
• Chronological Age-Dependent Genomic Instability in Yeast
  NIH · R01AG025135 · Jul 1, 2006 – Jun 30, 2011 · Role: Principal Investigator
• Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage in
  NIH · R01AG020642 · Apr 1, 2002 – May 31, 2018 · Role: Principal Investigator
• 4 iron-4sulfur Clusters in Aging and Alzheimer's Disease
  NIH · K01AG001028 · Sep 30, 2001 – Aug 31, 2005 · Role: Principal Investigator

• Hamburger Blues (03/11/2014)
• Meat and cheese may be as bad for you as smoking (03/04/2014)
• Rock of Ages (1/8/2014)
• Low-Protein Slows Alzheimer's (02/19/2013)
• Fasting and Radiation Therapy (10/1/2012)
• Fasting Weakens Cancer in Mice (02/09/2012)

• Brandhorst, Sebastian
• Cohen, Pinchas
• Goran, Michael
• Peters, Anne
• Crimmins, Eileen
• Finch, Caleb