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Valter D. Longo, PhD

Professor of Gerontology and Biological Sciences, Edna M. Jones Chair in Gerontology

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Phone +1 213 740 6212
Email [email protected]
CTSI Profile

Overview

Dr. Longo is the Edna Jones Professor in Gerontology and Professor in Biological Science. He is also the Director of the USC Longevity Institute. He is interested in understanding the fundamental mechanisms of aging in yeast, mice and humans by using genetics and biochemistry techniques. He is also interested in identifying the molecular pathways conserved from simple organisms to humans that can be modulated to protect against multiple stresses and treat or prevent cancer , Alzheimer’s Disease and other diseases of aging. The focus is on the signal transudation pathways that regulate resistance to oxidative damage in yeast and mice.

Research Funding

  • Fasting mimicking diet and cancer stem cells in Wilms tumor
    NIH · R01CA317076 · Sep 15, 2026 – Aug 31, 2031 · Role: Co-Principal Investigator
  • Dietary Restriction, GH/IGF-1 & Mechanisms of Cellular Protection and Regeneration
    NIH · P01AG055369 · Feb 15, 2018 – Jan 31, 2024 · Role: Principal Investigator
  • Interventions to Slow Aging in Humans: Are We Ready?
    NIH · R13AG046104 · Sep 1, 2013 – Aug 31, 2014 · Role: Principal Investigator
  • Dietary Restriction, GH/IGF-I & Mechanisms of Differential Cellular Protection
    NIH · P01AG034906 · Mar 15, 2011 – Jul 31, 2017 · Role: Principal Investigator
  • Chronological Age-Dependent Genomic Instability in Yeast
    NIH · R01AG025135 · Jul 1, 2006 – Jun 30, 2011 · Role: Principal Investigator
  • Role of Longevity Regulatory Pathways in Age-dependent Macro-molecular Damage in
    NIH · R01AG020642 · Apr 1, 2002 – May 31, 2018 · Role: Principal Investigator
  • 4 iron-4sulfur Clusters in Aging and Alzheimer's Disease
    NIH · K01AG001028 · Sep 30, 2001 – Aug 31, 2005 · Role: Principal Investigator

Media

Publications

  • Exploring the Relationship Between Insulin Resistance, Liver Health, and Restrictive Lung Diseases in Type 2 Diabetes. J Pers Med. 2025 Aug 01; 15(8).. View in PubMed
  • Caloric restriction protects from acute and chronic kidney injury by inhibiting monocyte recruitment. iScience. 2025 Aug 15; 28(8):113094.. View in PubMed
  • Anaphylaxis trend before and during pandemic: COVID-19 did not affect anaphylaxis frequency. Eur Ann Allergy Clin Immunol. 2025 Apr 29.. View in PubMed
  • Dietary Amino Acids and Risk of Stroke Subtypes: Results from 3 Large Prospective Cohort Studies. J Nutr. 2025 05; 155(5):1560-1569.. View in PubMed
  • The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research. Nat Metab. 2025 Mar; 7(3):454-468.. View in PubMed
  • Chemosensory and cardiometabolic improvements after a fasting-mimicking diet: A randomized cross-over clinical trial. Cell Rep Med. 2025 Feb 18; 6(2):101971.. View in PubMed
  • Intermittent and periodic fasting in the treatment of obesity and type 2 diabetes mellitus. Nat Rev Endocrinol. 2025 Feb; 21(2):73-74.. View in PubMed
  • Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling. Drug Resist Updat. 2025 01; 78:101182.. View in PubMed
  • A kidney-specific fasting-mimicking diet induces podocyte reprogramming and restores renal function in glomerulopathy. Sci Transl Med. 2024 10 30; 16(771):eadl5514.. View in PubMed
  • Longevity biotechnology: bridging AI, biomarkers, geroscience and clinical applications for healthy longevity. Aging (Albany NY). 2024 10 16; 16(20):12955-12976.. View in PubMed

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