William Gauderman, PhD

Dr. Gauderman’s research falls into two distinct areas:

1) developing statistical methods for genetic-epidemiologic analysis of pedigree data; 2) design and analysis of studies relating health outcomes to environmental exposures. In the field of genetic-epidemiology, he has developed models and methods of estimation for complex traits that depend on both genetic and environment causes, possibly interacting. He has evaluated a technique known as joint segregation and linkage analysis and has found it to be an efficient strategy both for detecting linkage and for estimating gene-environment interactions when the disease gene has not yet been identified. He has also compared various case-control designs for studying measured genes (e.g. candidate genes). In the field of environmental health, he works with the Children’s Health Study, a multi-community study of lung function and respiratory health in school-aged children in the Southern California area. The ultimate goal of this research is to determine whether air pollution, or particular components of air pollution such as ozone, is associated with reduced lung growth and increased incidence of asthma, bronchitis, and other respiratory illnesses. He is also the principal investigator of the biostatistics core of the NIEHS Center, and thus is available for statistical consultation for projects involving environmental health.

• An integrative omics approach to investigate gene-environment interaction in colorectal cancer risk
  NIH · R01CA273198 · Jun 1, 2023 – May 31, 2028 · Role: Co-Principal Investigator
• Using functional genomics to inform gene environment interactions for colorectal cancer
  NIH · R01CA201407 · Sep 23, 2016 – Aug 31, 2021 · Role: Co-Principal Investigator
• Statistical Methods for Integrative Genomics in Cancer
  NIH · P01CA196569 · Jul 1, 2016 – Aug 31, 2027 · Role: Co-Principal Investigator
• Gene-Environment Analyses of Early Life Exposures and Asthma in Ethnically Diverse Children
  NIH · R21ES024844 · Dec 1, 2014 – Nov 30, 2017 · Role: Co-Principal Investigator
• Air pollution effects on asthma and lung function in Hispanic children
  NIH · R03ES022719 · Jun 20, 2013 – May 31, 2016 · Role: Principal Investigator
• Detecting GxE Interactions in Genome-wide Association Studies
  NIH · R21HL115606 · Mar 1, 2012 – Feb 29, 2016 · Role: Principal Investigator
• Software to compute sample size for high-volume genetic studies
  NIH · R41CA141852 · Aug 1, 2009 – Jul 31, 2012 · Role: Principal Investigator
• Remote Sensing of Wildfire Smoke Exposures to Assess Health Effects
  NIH · R21ES016986 · Sep 5, 2008 – Aug 31, 2011 · Role: Co-Principal Investigator
• A Genome-wide Association Study of Childhood Respiratory Outcomes
  NIH · R01HL087680 · May 20, 2007 – Apr 30, 2011 · Role: Principal Investigator
• Environmental Genomics
  NIH · T32ES013678 · Apr 30, 2005 – Jun 30, 2025 · Role: Principal Investigator
• STATISTICAL APPROACHES TO THE STUDY OF GXE INTERACTIONS
  NIH · R01ES010421 · May 1, 2000 – Apr 30, 2005 · Role: Principal Investigator
• TRAINING MODULES FOR CLINICAL EPIDEMIOLOGICAL RESEARCH
  NIH · R43CA058240 · Sep 30, 1992 – May 31, 1993 · Role: Principal Investigator
• PEDIGREE ANALYSIS USING GIBBS SAMPLING
  NIH · R43GM048326 · Sep 1, 1992 – Mar 31, 1993 · Role: Principal Investigator

• Peters, Anne
• Haiman, Christopher
• Lenz, Heinz-Josef
• McConnell, Rob
• Chen, Jiu-Chiuan
• Habre, Rima