William Mack, MD

Dr. Mack’s major areas of clinical interest are stroke, brain aneurysms, subarachnoid hemorrhage, arteriovenous malformations (AVMs), arteriovenous fistulas, cavernous malformations, carotid artery disease, intracranial stenosis, and brain tumors. Dr. Mack performs both open surgery and minimally invasive, endovascular procedures for cerebrovascular disorders.

Dr. Mack is a faculty member of the Neuroscience Graduate Program and is the Principal Investigator and Director of the Cerebrovascular Laboratory in the Zilkha Neurogenetic Institute. He receives NIH R01 funding for his laboratory research. Dr. Mack’s scientific interests are focused on translational efforts to treat ischemic and hemorrhagic stroke. Laboratory investigations concentrate on the pathophysiology of cerebral ischemia and inflammatory modulation. Using the information and experience gained in the laboratory, Dr. Mack is working to develop new technologies, techniques, and therapies to directly improve the clinical care administered to stroke patients.

William Mack, MD, received his Bachelor degree with honors from Cornell University. He then attended Columbia University, College of Physicians and Surgeons, where he graduated from medical school (Alpha Omega Alpha) and completed Neurosurgical residency training. During residency, he spent one year performing a post-doctoral cerebrovascular research fellowship under Drs. David J. Pinsky and E. Sander Connolly Jr. at Columbia University. Following residency, Dr. Mack completed an Interventional Neuroradiology/ Neuroendovascular Surgery fellowship at UCLA.

Dr. Mack is board certified by the American Board of Neurological Surgery (FAANS) and is a fellow of the American Heart Association (FAHA) and. He is a committee member on the executive council of the Congress of Neurological Surgeons/ American Association of Neurological Surgeons’ Cerebrovascular Section. Dr. Mack serves as an Associate Editor of the Journal of Neurointerventional Surgery and on the editorial board of World Neurosurgery.

• Synergistic white matter injury from diesel exhaust particulate and chronic cerebral hypoperfusion exposures: Interaction between the Nogo/NgR1 receptor pathway and extravascular fibrinogen toxicity
  NIH · RF1NS130681 · Sep 20, 2022 – Aug 31, 2027 · Role: Principal Investigator
• Activated protein C mechanisms of brain white matter protection and new therapies for brain white matter ischemic injury
  NIH · R01NS117827 · Jul 15, 2020 – Apr 30, 2026 · Role: Principal Investigator
• Translational potential of the internalization of Nogo-A receptor to enhance axonal regeneration after stroke
  NIH · R21NS116720 · Jul 1, 2020 – Jun 30, 2022 · Role: Co-Principal Investigator
• USC Neurosurgery Research and Education Training Program
  NIH · R25NS099008 · Jul 15, 2017 – Jun 30, 2027 · Role: Principal Investigator
• USC Neurosurgery Research and Education Training Program
  NIH · UE5NS099008 · Jul 15, 2017 – Jun 30, 2027 · Role: Principal Investigator
• Neurotoxicity of Airborne Particles: Role of Chronic Cerebral Hypoperfusion
  NIH · R01ES024936 · Jan 15, 2015 – Nov 30, 2020 · Role: Principal Investigator

• Hirsch, Joshua
• Lyden, Patrick
• Peters, Anne
• Demetriades, Demetrios
• Attenello, Frank
• Zlokovic, Berislav