Yang Chai, DMD, PhD, DDS

Dean

G. Donald and Marian James Montgomery Professor of Dentistry

University Professor of Dentistry, Stem Cell Biology and Regenerative Medicine, and Otolaryngology-Head & Neck Surgery

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Overview

Yang Chai, DMD, PhD, DDS is the chair of the National Institute of Dental and Craniofacial Research Board of Scientific Counselors.

Professor Chai, who holds the George and Mary Lou Boone Chair in Craniofacial Biology and is the associate dean of research and director of the Center for Craniofacial Molecular Biology at the Ostrow School, has been a member of the board since 2008 and will serve a one-year term as chair. A total of nine board members, including the chair, are selected from among the most accomplished and celebrated experts in biomedical, dental and craniofacial science.

Chai is internationally renowned for his research into the genetics, cellular signaling, and development of cranial and facial structures, including the causes of and potential preventive measures for facial deformities such as cleft palate. Among his many honors, he has received a National Institutes of Health MERIT Award, has been elected as an American Association for the Advancement of Sciences Fellow, has received an International Association for Dental Research Distinguished Scientist Award, and has served on the editorial boards of several scientific journals. He is also an alumnus of the Ostrow School of Dentistry and is an award-winning educator and a practicing dentist at the school.

Awards

  • NIDCR, NIH: Chair of the Board of Scientific Counselors, 2013
  • Craniofacial Biology Research Award: IADR Distinguished Scientist Award, 2011
  • Journal of Bone and Mineral Research: Editorial Board, 2010
     – 2014
  • NIH: NIH MERIT Award, 2010
  • American Association for the Advancement of Sciences (AAAS) Elected Fellow, 2010
  • NIDCR, NIH: Member of the Board of Scientific Counselors, 2008
     – 2012
  • JBMR: Editorial Board DEVELOPMENTAL BIOLOGY, 2007
     – 2014
  • The Chinese Journal of Dental Research: Editorial Board, 2006
     – 2014
  • Regular member of SBDD study section CSR NIH, 2004
     – 2008
  • Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, 2004
  • Chair, Gordon Research Conference on Craniofacial Morphogenesis and Tissue Regeneration, 2006
  • NIH Ad hoc grant reviewer (OBM-2, ODCS) and Reviewer for the Welcome Trust, UK, 2002
     – 2014
  • University of Southern California: Award of Excellence in Teaching, 2001
     – 2003
  • University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 1997
  • University of Southern California: James H. Zumberge Faculty Research and Innovation Award, 2007
  • University of Southern California: Annual Excellence in Teaching Award, 1997
  • OKU Scholarship award for outstanding academic performance, 1996
  • Special Recognition by the Dean for outstanding service and contribution to the University of Southe, 1996
  • University of Southern California, School of Dentistry: Annual Teaching Award, 1995
  • University of Southern California, (GPA 4.0): PHI KAPPA PHI, All-University Honor Society, 1991
  • University of Southern California: Certificate for Outstanding Academic Achievement, 1990

Research Funding

  • The Regulatory Mechanism of Craniofacial Morphogenesis and Malformations
    NIH · R01DE035453 · Aug 18, 2026 – Jun 30, 2029 · Role: Principal Investigator
  • USC Facebase IV Craniofacial Development and Dysmorpholoy Data Management and Integration Hub (FaceBase IV))
    NIH · U24DE034163 · Aug 15, 2024 – May 31, 2029 · Role: Co-Principal Investigator
  • Center for TMD IMPACT
    NIH · R34DE033572 · Sep 19, 2023 – Sep 18, 2024 · Role: Principal Investigator
  • Mechanisms and rescue of craniosynostosis associated with gene-environment interaction
    NIH · R01DE030901 · Jul 1, 2021 – Apr 30, 2026 · Role: Co-Principal Investigator
  • Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH · U24DE029463 · May 7, 2020 – Apr 30, 2025 · Role: Principal Investigator
  • USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration Hub
    NIH · U01DE028729 · Aug 1, 2019 – Jul 31, 2024 · Role: Co-Principal Investigator
  • Center for Dental, Oral, and Craniofacial Tissue and Organ Regeneration (C-DOCTOR)
    NIH · U24DE026914 · Mar 1, 2017 – Feb 28, 2021 · Role: Co-Principal Investigator
  • Molecular and Cellular Basis of Craniosynostosis
    NIH · R01DE026339 · Jul 1, 2016 – Jul 31, 2026 · Role: Co-Principal Investigator
  • MOLECULAR REGULATORY MECHANISM OF MESENCHYMAL STEM CELLS IN ADULT MOUSE INCISOR
    NIH · R01DE025221 · May 1, 2016 – Dec 31, 2027 · Role: Principal Investigator
  • CENTER FOR DENTAL, ORAL AND CRANIOFACIAL TISSUE ORGAN REGENERATION (C-DOCTOR)
    NIH · R34DE025575 · Sep 1, 2015 – Aug 31, 2017 · Role: Principal Investigator
  • INTEGRATED RESEARCH OF FUNCTIONAL GENOMICS AND CRANIOFACIAL MORPHOGENESIS
    NIH · U01DE024421 · May 12, 2014 – Apr 30, 2020 · Role: Principal Investigator
  • The Molecular Regulatory Mechanism of Tooth Root Development
    NIH · R01DE022503 · Jul 19, 2012 – Apr 30, 2029 · Role: Principal Investigator
  • RESEARCH ON FUNCTIONAL GENOMICS, IMAGE ANALYSIS AND RESCUE OF CLEFT PALATE
    NIH · U01DE020065 · Sep 21, 2009 – Apr 30, 2015 · Role: Principal Investigator
  • Interdisciplinary New Faculty Recruitment in Craniofacial Development
    NIH · P30DE020750 · Sep 17, 2009 – Aug 31, 2013 · Role: Principal Investigator
  • Molecular Regulatory Mechanism of Calvarial Morphogenesis
    NIH · R01DE017007 · Sep 1, 2005 – Aug 31, 2012 · Role: Principal Investigator
  • CRANIOFACIAL MORHOGENESIS AND TISSUE REGENERATION GORDON CONFERENCE
    NIH · R13DE015783 · Jan 1, 2004 – Dec 31, 2008 · Role: Co-Principal Investigator
  • MOLECULAR REGULATORY MECHANISM OF TONGUE MORPHOGENESIS
    NIH · R01DE014078 · Apr 1, 2001 – Jun 30, 2015 · Role: Principal Investigator
  • TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    NIH · R01DE012711 · Jan 1, 1999 – Jul 31, 2024 · Role: Principal Investigator
  • TGF BETA SIGNALING AND CRANIOFACIAL MORPHOGENESIS
    NIH · R37DE012711 · Jan 1, 1999 – Jul 31, 2019 · Role: Principal Investigator

Publications

  • Incidence and Outcomes of Head and Neck Cancer in Patients With Schizophrenia. OTO Open. 2025 Jul-Sep; 9(3):e70164.. View in PubMed
  • Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future. J Pain. 2025 11; 36:105560.. View in PubMed
  • Facet-Engineered (100)-Oriented MoO2 Nanoribbons for Broadband Self-Powered Photodetection. Adv Sci (Weinh). 2025 Nov; 12(43):e10753.. View in PubMed
  • Electrically-Driven Polarized Nano-Light Sources Based on Suspended Graphene Nanoscrolls. ACS Nano. 2025 Aug 26; 19(33):30221-30232.. View in PubMed
  • Rational design of an ultra-high-gain MoS2 phototransistor enabling room-temperature detection of few-photon signals and attomolar-level immunosensing. Sci Bull (Beijing). 2025 Nov 30; 70(22):3812-3821.. View in PubMed
  • RCA-HCR cascade mediated-linear multi-shear site DNA walker (LMDW) to construct an electrochemical biosensor for ultrasensitive detection of Tumor markers. Biosens Bioelectron. 2025 Dec 01; 289:117842.. View in PubMed
  • Entire Near-Infrared-I Electrochemiluminescence Enhancement of Gold Nanoclusters. Angew Chem Int Ed Engl. 2025 Aug 25; 64(35):e202509884.. View in PubMed
  • Piezo2+ mechanosensory neurons orchestrate postnatal development through mechano-chemo-transduction of PDGFA signaling. Proc Natl Acad Sci U S A. 2025 Jul 15; 122(28):e2504103122.. View in PubMed
  • Environment-Friendly MnO2 Quantum Dots with Highly Efficient Electrochemiluminescence for Ultrasensitive Assay of Liver Cancer Markers. Anal Chem. 2025 07 15; 97(27):14815-14821.. View in PubMed
  • Boosting responsivity and speed in 2D material based vertical p-i-n photodiodes with excellent self-powered ability. Nat Commun. 2025 Jul 01; 16(1):5824.. View in PubMed