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Rayudu Gopalakrishna, PhD

Professor of Integrative Anatomical Sciences

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Phone +1 323 442 1770
Email [email protected]
CTSI Profile

Awards

  • National Cancer Institute, NIH: FIRST Award, 1988
     – 1993
  • Keck School of Medicine of USC: Excellence in Teaching Certificate, 1995
  • Keck School of Medicine of USC: Outstanding Teaching Award (year II med)), 1996
  • Keck School of Medicine of USC: Outstanding Teaching Award (year II med), 2000
  • Keck School of Medicine of USC: Outstanding Teaching Award (year I med), 2003
  • Keck School of Medicine of USC: Outstanding teaching Award (year II med), 2004
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2006
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year II med), 2008
  • Keck School of Medicine of USC: Master Teacher, 2008
  • Alpha Omega Alpha: Membership, 2010
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2011
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year I med), 2014
  • Keck School of Medicine of USC: Outstanding Teaching Award (Year II med), 2014

Education and Training

  • Andhra University, Visakhapatnam, India — B.S. — 09/1973 — Biology
  • Andhra University, Visakhapatnam, India — M.S. — 09/1975 — Biochemistry
  • University of Madras, Chennai, India — Ph.D. — 08/1979 — Biochemistry
  • University of Madras, Chennai, India — Post-doc — 12/1981 — Biochemistry
  • National Cancer Institute, NIH, Bethesda, MD — Post-doc — 11/1983 — Pathophysiology

Research Funding

  • Synergistic white matter injury from diesel exhaust particulate and chronic cerebral hypoperfusion exposures: Interaction between the Nogo/NgR1 receptor pathway and extravascular fibrinogen toxicity
    NIH · RF1NS130681 · Sep 20, 2022 – Aug 31, 2027 · Role: Co-Principal Investigator
  • Translational potential of the internalization of Nogo-A receptor to enhance axonal regeneration after stroke
    NIH · R21NS116720 · Jul 1, 2020 – Jun 30, 2022 · Role: Principal Investigator
  • Prostate cancer prevention by selenium supplementation
    NIH · R01CA099216 · Jul 1, 2009 – May 31, 2015 · Role: Principal Investigator
  • CANCER PREVENTION &IMBALANCE IN PROTEIN PHOSPHORYLATION
    NIH · R01CA062146 · Dec 15, 1993 – Nov 30, 1998 · Role: Principal Investigator
  • TUMOR PROMOTERS AND PROTEIN KINASE C IN CANCER METASTASI
    NIH · R29CA047142 · May 1, 1988 – May 31, 1994 · Role: Principal Investigator

Research Keywords

  • Cancer prevention
  • Natural Products
  • Selenium
  • green tea
  • Stroke prevention and treatment
  • Alzheimer's disease and neuroprotection

Publications

  • Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol- and glycosaminoglycan-binding sites in the laminin receptor. Neural Regen Res. 2025 Mar 01; 20(3):819-820.. View in PubMed
  • Resveratrol and its metabolites elicit neuroprotection via high-affinity binding to the laminin receptor at low nanomolar concentrations. FEBS Lett. 2024 05; 598(9):995-1007.. View in PubMed
  • Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity: their action in Alzheimer’s disease prevention. Neural Regen Res. 2023 Dec; 18(12):2675-2676.. View in PubMed
  • Flavonoid quercetin and its glucuronide and sulfate conjugates bind to 67-kDa laminin receptor and prevent neuronal cell death induced by serum starvation. Biochem Biophys Res Commun. 2023 09 03; 671:116-123.. View in PubMed
  • cAMP-induced decrease in cell-surface laminin receptor and cellular prion protein attenuates amyloid-β uptake and amyloid-β-induced neuronal cell death. FEBS Lett. 2022 11; 596(22):2914-2927.. View in PubMed
  • Nogo-A receptor internalization by cyclic adenosine monophosphate in overcoming axonal growth inhibitors after stroke. Neural Regen Res. 2022 Jan; 17(1):91-92.. View in PubMed
  • Cyclic-AMP induces Nogo-A receptor NgR1 internalization and inhibits Nogo-A-mediated collapse of growth cone. Biochem Biophys Res Commun. 2020 03 12; 523(3):678-684.. View in PubMed
  • Cell signaling associated with internalization of 67 kDa laminin receptor (67LR) by soluble laminin and its implication for protection against neurodegenerative diseases. Neural Regen Res. 2019 Sep; 14(9):1513-1514.. View in PubMed
  • Redox regulation of protein kinase C by selenometabolites and selenoprotein thioredoxin reductase limits cancer prevention by selenium. Free Radic Biol Med. 2018 11 01; 127:55-61.. View in PubMed
  • Lowering side effects of NSAID usage in osteoarthritis: recent attempts at minimizing dosage. Expert Opin Pharmacother. 2018 02; 19(2):93-102.. View in PubMed

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