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Clay C. C. Wang, PhD

Professor of Pharmacology & Pharmaceutical Sciences and Department Chair

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Phone +1 323 442 1670
Email [email protected]
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Publications

  • Manipulation of Global Regulator mcrA Activates the Fumigermin Pathway in Penicillium camemberti IMV00769. ACS Chem Biol. 2026 Feb 11.. View in PubMed
  • Activation of the Trichodimerol Pathway through Deletion of mcrA in Marine Penicillium rubens YAP001. ACS Chem Biol. 2025 Apr 18; 20(4):823-829.. View in PubMed
  • Discovery of penicillic acid as a chemical probe against tau aggregation in Alzheimer’s disease. Chem Sci. 2024 Dec 11; 15(48):20467-20477.. View in PubMed
  • Discovery of PARP1-Sparing Inhibitors for Protein ADP-Ribosylation. ACS Med Chem Lett. 2024 Nov 14; 15(11):1940-1946.. View in PubMed
  • Composite Recycling with Biocatalytic Thermoset Reforming. J Am Chem Soc. 2024 Nov 06; 146(44):30004-30008.. View in PubMed
  • Transcription Factor Engineering in Aspergillus nidulans Leads to the Discovery of an Orsellinaldehyde Derivative Produced via an Unlinked Polyketide Synthase Gene. J Nat Prod. 2024 Oct 25; 87(10):2384-2392.. View in PubMed
  • Discovery of Uncommon Tryptophan-Containing Diketopiperazines from Aspergillus homomorphus CBS 101889 Using an Aspergillus nidulans Heterologous Expression System. J Nat Prod. 2024 07 26; 87(7):1704-1713.. View in PubMed
  • A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation. Chem Commun (Camb). 2023 Nov 21; 59(93):13843-13846.. View in PubMed
  • A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway. Chem Sci. 2023 Oct 18; 14(40):11022-11032.. View in PubMed
  • Identification of the Neoaspergillic Acid Biosynthesis Gene Cluster by Establishing an In Vitro CRISPR-Ribonucleoprotein Genetic System in Aspergillus melleus. ACS Omega. 2023 May 16; 8(19):16713-16721.. View in PubMed
  • Polystyrene Upcycling into Fungal Natural Products and a Biocontrol Agent. J Am Chem Soc. 2023 03 08; 145(9):5222-5230.. View in PubMed
  • Conversion of Polyethylenes into Fungal Secondary Metabolites. Angew Chem Int Ed Engl. 2023 01 23; 62(4):e202214609.. View in PubMed
  • Total Heterologous Biosynthesis of Fungal Natural Products in Aspergillus nidulans. J Nat Prod. 2022 10 28; 85(10):2484-2518.. View in PubMed
  • Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins. ACS Chem Biol. 2022 10 21; 17(10):2828-2835.. View in PubMed
  • Characterization of a silent azaphilone biosynthesis gene cluster in Aspergillus terreus NIH 2624. Fungal Genet Biol. 2022 05; 160:103694.. View in PubMed
  • Genomic Characterization of Potential Plant Growth-Promoting Features of Sphingomonas Strains Isolated from the International Space Station. Microbiol Spectr. 2022 02 23; 10(1):e0199421.. View in PubMed
  • Genomic Characterization of the Titan-like Cell Producing Naganishia tulchinskyi, the First Novel Eukaryote Isolated from the International Space Station. J Fungi (Basel). 2022 Feb 08; 8(2).. View in PubMed
  • The International Space Station Environment Triggers Molecular Responses in Aspergillus niger. Front Microbiol. 2022; 13:893071.. View in PubMed
  • The sexual spore pigment asperthecin is required for normal ascospore production and protection from UV light in Aspergillus nidulans. J Ind Microbiol Biotechnol. 2021 Dec 23; 48(9-10).. View in PubMed
  • Identification of the pigment and its role in UV resistance in Paecilomyces variotii, a Chernobyl isolate, using genetic manipulation strategies. Fungal Genet Biol. 2021 07; 152:103567.. View in PubMed
  • Advances in space microbiology. iScience. 2021 May 21; 24(5):102395.. View in PubMed
  • An Aspergillus nidulans Platform for the Complete Cluster Refactoring and Total Biosynthesis of Fungal Natural Products. ACS Synth Biol. 2021 01 15; 10(1):173-182.. View in PubMed
  • Methylobacterium ajmalii sp. nov., Isolated From the International Space Station. Front Microbiol. 2021; 12:639396.. View in PubMed
  • Identification and Validation of an Aspergillus nidulans Secondary Metabolite Derivative as an Inhibitor of the Musashi-RNA Interaction. Cancers (Basel). 2020 Aug 08; 12(8).. View in PubMed
  • Draft Genome Sequences of Tremellomycetes Strains Isolated from the International Space Station. Microbiol Resour Announc. 2020 Jun 25; 9(26).. View in PubMed
  • Draft Genome Sequences of Sphingomonas Species Associated with the International Space Station. Microbiol Resour Announc. 2020 Jun 18; 9(25).. View in PubMed
  • Contributions of Spore Secondary Metabolites to UV-C Protection and Virulence Vary in Different Aspergillus fumigatus Strains. mBio. 2020 02 18; 11(1).. View in PubMed
  • Metabolomic Analysis of Aspergillus niger Isolated From the International Space Station Reveals Enhanced Production Levels of the Antioxidant Pyranonigrin A. Front Microbiol. 2020; 11:931.. View in PubMed
  • Overexpression of an LaeA-like Methyltransferase Upregulates Secondary Metabolite Production in Aspergillus nidulans. ACS Chem Biol. 2019 07 19; 14(7):1643-1651.. View in PubMed
  • Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012-2018). Medchemcomm. 2019 Jun 01; 10(6):840-866.. View in PubMed
  • Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station. mSystems. 2019 Mar-Apr; 4(2).. View in PubMed
  • Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station. Fungal Genet Biol. 2019 03; 124:39-46.. View in PubMed
  • International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans. Appl Microbiol Biotechnol. 2019 Feb; 103(3):1363-1377.. View in PubMed
  • Discovery and Elucidation of the Biosynthesis of Aspernidgulenes: Novel Polyenes from Aspergillus Nidulans by Using Serial Promoter Replacement. Chembiochem. 2019 02 01; 20(3):329-334.. View in PubMed
  • Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions. Front Microbiol. 2019; 10:1013.. View in PubMed
  • Mating-type factor-specific regulation of the fumagillin/pseurotin secondary metabolite supercluster in Aspergillus fumigatus. Mol Microbiol. 2018 12; 110(6):1045-1065.. View in PubMed
  • Hybrid Transcription Factor Engineering Activates the Silent Secondary Metabolite Gene Cluster for (+)-Asperlin in Aspergillus nidulans. ACS Chem Biol. 2018 11 16; 13(11):3193-3205.. View in PubMed
  • Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition. Hepatology. 2018 11; 68(5):1726-1740.. View in PubMed
  • Genome-based deletion analysis in Aspergillus terreus reveals the acetylaranotin bis-thiomethyltransferase gene. Fungal Genet Biol. 2018 10; 119:1-6.. View in PubMed
  • Expanding the Chemical Space of Nonribosomal Peptide Synthetase-like Enzymes by Domain and Tailoring Enzyme Recombination. Org Lett. 2018 09 07; 20(17):5082-5085.. View in PubMed
  • Characterization of Aspergillus niger Isolated from the International Space Station. mSystems. 2018 Sep-Oct; 3(5).. View in PubMed
  • Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan. Fungal Genet Biol. 2017 04; 101:1-6.. View in PubMed
  • Discovery of McrA, a master regulator of Aspergillus secondary metabolism. Mol Microbiol. 2017 01; 103(2):347-365.. View in PubMed
  • The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro. PLoS One. 2017; 12(4):e0175471.. View in PubMed
  • Engineering Fungal Nonribosomal Peptide Synthetase-like Enzymes by Heterologous Expression and Domain Swapping. Org Lett. 2016 12 16; 18(24):6236-6239.. View in PubMed
  • Characterization of Aspergillus fumigatus Isolates from Air and Surfaces of the International Space Station. mSphere. 2016 Sep-Oct; 1(5).. View in PubMed
  • Resistance Gene-Guided Genome Mining: Serial Promoter Exchanges in Aspergillus nidulans Reveal the Biosynthetic Pathway for Fellutamide B, a Proteasome Inhibitor. ACS Chem Biol. 2016 08 19; 11(8):2275-84.. View in PubMed
  • Characterization of the product of a nonribosomal peptide synthetase-like (NRPS-like) gene using the doxycycline dependent Tet-on system in Aspergillus terreus. Fungal Genet Biol. 2016 Apr; 89:84-88.. View in PubMed
  • Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans. Org Lett. 2016 Mar 18; 18(6):1366-9.. View in PubMed
  • Correction: Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in Penicillium canescens. Chem Sci. 2016 03 01; 7(3):2440.. View in PubMed
  • Microbial metabolomics in open microscale platforms. Nat Commun. 2016 Feb 04; 7:10610.. View in PubMed
  • Development of Genetic Dereplication Strains in Aspergillus nidulans Results in the Discovery of Aspercryptin. Angew Chem Int Ed Engl. 2016 Jan 26; 55(5):1662-5.. View in PubMed
  • Heterologous Expression of Fungal Secondary Metabolite Pathways in the Aspergillus nidulans Host System. Methods Enzymol. 2016; 575:127-42.. View in PubMed
  • Genome mining and molecular characterization of the biosynthetic gene cluster of a diterpenic meroterpenoid, 15-deoxyoxalicine B, in Penicillium canescens. Chem Sci. 2015 Nov 01; 6(11):6537-6544.. View in PubMed
  • Spatial regulation of a common precursor from two distinct genes generates metabolite diversity. Chem Sci. 2015 Oct 01; 6(10):5913-5921.. View in PubMed
  • Azaphilones inhibit tau aggregation and dissolve tau aggregates in vitro. ACS Chem Neurosci. 2015 May 20; 6(5):751-60.. View in PubMed
  • Asperaculanes A and B, two sesquiterpenoids from the fungus Aspergillus aculeatus. Molecules. 2014 Dec 25; 20(1):325-34.. View in PubMed
  • Non-heme dioxygenase catalyzes atypical oxidations of 6,7-bicyclic systems to form the 6,6-quinolone core of viridicatin-type fungal alkaloids. Angew Chem Int Ed Engl. 2014 Nov 17; 53(47):12880-4.. View in PubMed
  • Molecular genetic characterization of terreic acid pathway in Aspergillus terreus. Org Lett. 2014 Oct 17; 16(20):5250-3.. View in PubMed
  • Behavior-selective apoptotic capacity of 4-(3,4,5-Trimethoxyphenoxy) benzoic acid and its methyl derivatives on two breast cancer cell lines. Anticancer Res. 2014 Apr; 34(4):1801-9.. View in PubMed
  • Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases. Org Lett. 2014 Mar 21; 16(6):1676-9.. View in PubMed
  • Recent advances in genome mining of secondary metabolite biosynthetic gene clusters and the development of heterologous expression systems in Aspergillus nidulans. J Ind Microbiol Biotechnol. 2014 Feb; 41(2):433-42.. View in PubMed
  • Modulation of cyclins, p53 and mitogen-activated protein kinases signaling in breast cancer cell lines by 4-(3,4,5-trimethoxyphenoxy)benzoic acid. Int J Mol Sci. 2014 Jan 08; 15(1):743-57.. View in PubMed
  • Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde. Planta Med. 2014 Jan; 80(1):77-85.. View in PubMed
  • Recent advances in genome mining of secondary metabolites in Aspergillus terreus. Front Microbiol. 2014; 5:717.. View in PubMed
  • Prototype of an intertwined secondary-metabolite supercluster. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):17065-70.. View in PubMed
  • VeA and MvlA repression of the cryptic orsellinic acid gene cluster in Aspergillus nidulans involves histone 3 acetylation. Mol Microbiol. 2013 Sep; 89(5):963-74.. View in PubMed
  • Application of an efficient gene targeting system linking secondary metabolites to their biosynthetic genes in Aspergillus terreus. Org Lett. 2013 Jul 19; 15(14):3562-5.. View in PubMed
  • Molecular genetic characterization of the biosynthesis cluster of a prenylated isoindolinone alkaloid aspernidine A in Aspergillus nidulans. Org Lett. 2013 Jun 07; 15(11):2862-5.. View in PubMed
  • An efficient system for heterologous expression of secondary metabolite genes in Aspergillus nidulans. J Am Chem Soc. 2013 May 22; 135(20):7720-31.. View in PubMed
  • Biosynthetic pathway for the epipolythiodioxopiperazine acetylaranotin in Aspergillus terreus revealed by genome-based deletion analysis. J Am Chem Soc. 2013 May 15; 135(19):7205-13.. View in PubMed
  • Reconstitution of the early steps of gliotoxin biosynthesis in Aspergillus nidulans reveals the role of the monooxygenase GliC. Bioorg Med Chem Lett. 2013 Apr 01; 23(7):2155-7.. View in PubMed
  • Engineering fungal nonreducing polyketide synthase by heterologous expression and domain swapping. Org Lett. 2013 Feb 15; 15(4):756-9.. View in PubMed
  • Low-volume toolbox for the discovery of immunosuppressive fungal secondary metabolites. PLoS Pathog. 2013; 9(4):e1003289.. View in PubMed
  • bZIP transcription factors affecting secondary metabolism, sexual development and stress responses in Aspergillus nidulans. Microbiology (Reading). 2013 Jan; 159(Pt 1):77-88.. View in PubMed
  • Prevention of chronic HBV infection induced hepatocellular carcinoma development by using antiplatelet drugs. Hepatobiliary Surg Nutr. 2012 Dec; 1(1):57-8.. View in PubMed
  • Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Org Lett. 2012 Nov 16; 14(22):5684-7.. View in PubMed
  • Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis. Appl Microbiol Biotechnol. 2012 Nov; 96(3):739-48.. View in PubMed
  • Overexpression of the Aspergillus nidulans histone 4 acetyltransferase EsaA increases activation of secondary metabolite production. Mol Microbiol. 2012 Oct; 86(2):314-30.. View in PubMed
  • Identification and molecular genetic analysis of the cichorine gene cluster in Aspergillus nidulans. Medchemcomm. 2012 Aug 01; 3(8).. View in PubMed
  • Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans. J Am Chem Soc. 2012 May 16; 134(19):8212-21.. View in PubMed
  • Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect. Hepatology. 2012 Apr; 55(4):1271-81.. View in PubMed
  • Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans. J Am Chem Soc. 2012 Mar 14; 134(10):4709-20.. View in PubMed
  • Advances in Aspergillus secondary metabolite research in the post-genomic era. Nat Prod Rep. 2012 Mar; 29(3):351-71.. View in PubMed
  • An Aspergillus nidulans bZIP response pathway hardwired for defensive secondary metabolism operates through aflR. Mol Microbiol. 2012 Mar; 83(5):1024-34.. View in PubMed
  • Reengineering an azaphilone biosynthesis pathway in Aspergillus nidulans to create lipoxygenase inhibitors. Org Lett. 2012 Feb 17; 14(4):972-5.. View in PubMed
  • Endoplasmic reticulum stress stimulates p53 expression through NF-κB activation. PLoS One. 2012; 7(7):e39120.. View in PubMed
  • Toward awakening cryptic secondary metabolite gene clusters in filamentous fungi. Methods Enzymol. 2012; 517:303-24.. View in PubMed
  • The chemical identification and analysis of Aspergillus nidulans secondary metabolites. Methods Mol Biol. 2012; 944:97-109.. View in PubMed
  • Engineering of an “unnatural” natural product by swapping polyketide synthase domains in Aspergillus nidulans. J Am Chem Soc. 2011 Aug 31; 133(34):13314-6.. View in PubMed
  • High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. Mol Cell Biol. 2011 Jul; 31(13):2605-17.. View in PubMed
  • Cryptic Aspergillus nidulans antimicrobials. Appl Environ Microbiol. 2011 Jun; 77(11):3669-75.. View in PubMed
  • Characterization of a polyketide synthase in Aspergillus niger whose product is a precursor for both dihydroxynaphthalene (DHN) melanin and naphtho-γ-pyrone. Fungal Genet Biol. 2011 Apr; 48(4):430-7.. View in PubMed
  • Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans. J Am Chem Soc. 2011 Mar 23; 133(11):4010-7.. View in PubMed
  • Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr Opin Chem Biol. 2011 Feb; 15(1):137-43.. View in PubMed
  • Induction of Bcl-2 expression by hepatitis B virus pre-S2 mutant large surface protein resistance to 5-fluorouracil treatment in Huh-7 cells. PLoS One. 2011; 6(12):e28977.. View in PubMed
  • Telomere position effect is regulated by heterochromatin-associated proteins and NkuA in Aspergillus nidulans. Microbiology (Reading). 2010 Dec; 156(Pt 12):3522-3531.. View in PubMed
  • Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis. Basic Clin Pharmacol Toxicol. 2010 Jul; 107(1):583-9.. View in PubMed
  • Unraveling polyketide synthesis in members of the genus Aspergillus. Appl Microbiol Biotechnol. 2010 May; 86(6):1719-36.. View in PubMed
  • Characterization of the Aspergillus nidulans monodictyphenone gene cluster. Appl Environ Microbiol. 2010 Apr; 76(7):2067-74.. View in PubMed
  • Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans. Mol Biosyst. 2010 Mar; 6(3):587-93.. View in PubMed
  • Unlocking fungal cryptic natural products. Nat Prod Commun. 2009 Nov; 4(11):1505-10.. View in PubMed
  • Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. Chembiochem. 2009 Aug 17; 10(12):1965-8.. View in PubMed
  • Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res. 2009 Jul 15; 69(14):5699-706.. View in PubMed
  • Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. J Am Chem Soc. 2009 Jul 08; 131(26):9347-53.. View in PubMed
  • Chromatin-level regulation of biosynthetic gene clusters. Nat Chem Biol. 2009 Jul; 5(7):462-4.. View in PubMed
  • A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. J Am Chem Soc. 2009 Mar 04; 131(8):2965-70.. View in PubMed
  • Identification and characterization of the asperthecin gene cluster of Aspergillus nidulans. Appl Environ Microbiol. 2008 Dec; 74(24):7607-12.. View in PubMed
  • Complete sequence of biosynthetic gene cluster responsible for producing triostin A and evaluation of quinomycin-type antibiotics from Streptomyces triostinicus. Biotechnol Prog. 2008 Nov-Dec; 24(6):1226-31.. View in PubMed
  • Norsolorinic acid inhibits proliferation of T24 human bladder cancer cells by arresting the cell cycle at the G0/G1 phase and inducing a Fas/membrane-bound Fas ligand-mediated apoptotic pathway. Clin Exp Pharmacol Physiol. 2008 Nov; 35(11):1301-8.. View in PubMed
  • Molecular genetic mining of the Aspergillus secondary metabolome: discovery of the emericellamide biosynthetic pathway. Chem Biol. 2008 Jun; 15(6):527-32.. View in PubMed
  • Norsolorinic acid from Aspergillus nidulans inhibits the proliferation of human breast adenocarcinoma MCF-7 cells via Fas-mediated pathway. Basic Clin Pharmacol Toxicol. 2008 Jun; 102(6):491-7.. View in PubMed
  • Diversity of polyketide synthases found in the Aspergillus and Streptomyces genomes. Mol Pharm. 2008 Mar-Apr; 5(2):226-33.. View in PubMed
  • Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells. Cancer Lett. 2008 Jan 18; 259(1):82-98.. View in PubMed
  • Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture. Biotechnol Prog. 2008 Jan-Feb; 24(1):134-9.. View in PubMed
  • Development of Tyrocidine A analogues with improved antibacterial activity. Bioorg Med Chem. 2007 Nov 01; 15(21):6667-77.. View in PubMed
  • Enzymatic synthesis of aromatic polyketides using PKS4 from Gibberella fujikuroi. J Am Chem Soc. 2007 Sep 05; 129(35):10642-3.. View in PubMed
  • Investigation of early tailoring reactions in the oxytetracycline biosynthetic pathway. J Biol Chem. 2007 Aug 31; 282(35):25717-25.. View in PubMed
  • Completion of a Programmable DNA-Binding Small Molecule Library. Tetrahedron. 2007 Jul 02; 63(27):6146-6151.. View in PubMed
  • A comprehensive and engaging overview of the type III family of polyketide synthases. Curr Opin Chem Biol. 2007 Jun; 11(3):279-86.. View in PubMed
  • Heterologous biosynthesis of amidated polyketides with novel cyclization regioselectivity from oxytetracycline polyketide synthase. J Nat Prod. 2006 Nov; 69(11):1633-6.. View in PubMed
  • Biosynthesis of lovastatin analogs with a broadly specific acyltransferase. Chem Biol. 2006 Nov; 13(11):1161-9.. View in PubMed
  • Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nat Chem Biol. 2006 Aug; 2(8):423-8.. View in PubMed
  • Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl Environ Microbiol. 2003 Nov; 69(11):6698-702.. View in PubMed
  • Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. J Biol Chem. 2003 Oct 24; 278(43):42020-6.. View in PubMed

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