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Clay C. C. Wang, PhD

Professor of Pharmacology & Pharmaceutical Sciences and Department Chair

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Phone +1 323 442 1670
Email [email protected]
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Education and Training

  • Harvard College, Cambridge, MA — AB — 1996 — Chemistry
  • California Institute of Technology, Pasadena, CA — PhD — 2001 — Chemistry
  • Stanford University, Stanford, CA — 2003 — Chemistry & Chemical Engineering

Research Funding

  • Exploiting interspecies/interkingdom communication for the discovery and development of novel natural products antifungal therapeutics
    NIH · R21AI127640 · Dec 9, 2016 – Nov 30, 2019 · Role: Principal Investigator
  • Platforms for nonribosomal peptide manipulation (RMI)
    NIH · R01GM075857 · Sep 23, 2005 – Jul 31, 2009 · Role: Principal Investigator
  • Probing the Substrate Specificity of Polyketide Synthase
    NIH · F32GM065035 · Feb 4, 2002 · Role: Principal Investigator

Publications

  • A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation. Chem Commun (Camb). 2023 Nov 21; 59(93):13843-13846.. View in PubMed
  • A heterologous expression platform in Aspergillus nidulans for the elucidation of cryptic secondary metabolism biosynthetic gene clusters: discovery of the Aspergillus fumigatus sartorypyrone biosynthetic pathway. Chem Sci. 2023 Oct 18; 14(40):11022-11032.. View in PubMed
  • Identification of the Neoaspergillic Acid Biosynthesis Gene Cluster by Establishing an In Vitro CRISPR-Ribonucleoprotein Genetic System in Aspergillus melleus. ACS Omega. 2023 May 16; 8(19):16713-16721.. View in PubMed
  • Polystyrene Upcycling into Fungal Natural Products and a Biocontrol Agent. J Am Chem Soc. 2023 03 08; 145(9):5222-5230.. View in PubMed
  • Conversion of Polyethylenes into Fungal Secondary Metabolites. Angew Chem Int Ed Engl. 2023 01 23; 62(4):e202214609.. View in PubMed
  • Manipulation of the Global Regulator mcrA Upregulates Secondary Metabolite Production in Aspergillus wentii Using CRISPR-Cas9 with In Vitro Assembled Ribonucleoproteins. ACS Chem Biol. 2022 10 21; 17(10):2828-2835.. View in PubMed
  • Total Heterologous Biosynthesis of Fungal Natural Products in Aspergillus nidulans. J Nat Prod. 2022 10 28; 85(10):2484-2518.. View in PubMed
  • The International Space Station Environment Triggers Molecular Responses in Aspergillus niger. Front Microbiol. 2022; 13:893071.. View in PubMed
  • Characterization of a silent azaphilone biosynthesis gene cluster in Aspergillus terreus NIH 2624. Fungal Genet Biol. 2022 05; 160:103694.. View in PubMed
  • Genomic Characterization of the Titan-like Cell Producing Naganishia tulchinskyi, the First Novel Eukaryote Isolated from the International Space Station. J Fungi (Basel). 2022 Feb 08; 8(2).. View in PubMed

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